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| 1 | Prolyl isomerase Pin1 in cancer显示文摘指导脯氨酸的 phosphorylation 是在调整是有帮助的从血浆膜发信号到原子核的 posttranslational 修正,并且它的 dysregulation 贡献癌症开发。蛋白质交往与从未在里面有丝分裂 A1 ( Pin1 )是在癌症的许多类型的 overexpressed , isomerizes 在许多底层蛋白质的特定的 phosphorylated Ser/Thr-Pro 契约包括 glycolytic 酶,蛋白质 kinases ,蛋白质磷酸酶, methyltransferase ,类脂化合物 kinase , ubiquitin E3 ligase , DNA endonuclease , RNA 聚合酶,并且抄写使活跃之物和管理者。这调停 Pin1 的异构化改变这些蛋白质,从而调整的房间新陈代谢,房间活动性,房间周期前进,房间增长,房间幸存, apoptosis 和肿瘤开发的结构和活动。 | Zhimin LU Tony Hunter | 2014 | Cell Research2014，24，9： | 17 |
| 2 | Parkin mitochondrial translocation is achieved through a novel catalytic activity coupled mechanism显示文摘Pink1, mitochondrial kinase,和 Parkin, E3 ubiquitin ligase,在 mitochondrial 工作维护。Pink1 在动摇线粒体上积累,在它招募的地方主要导致外部膜蛋白质并且最后的连接 K63 的链 ubiquitination 的 Parkin mitophagy。Parkin 属于 RBR E3 ligase 家庭。最近, RBR 领域经由 cysteine^ubiquitin 酶中介把 ubiquitin 转移到目标,这被建议了,以类似于 HECT 领域 E3 ligases 的一种方式。然而,在 vivo 为 Parkin 的家为 ubiquitin 转移机制和它的重要性指导证据功能仍然是失踪的。这里,我们报导那项 Parkin E3 活动在 mitophagy 期间依靠调停半胱氨酸的 ubiquitin 转移。变异到丝氨酸(Parkin C431S ) 的通常认为的催化半胱氨酸套住 ubiquitin,并且令人惊讶地,也废除 Parkin mitochondrial translocation,显示那项 E3 活动为 Parkin translocation 是必要的。我们发现 Parkin 能绑在连接 K63 的 ubiquitin 链,并且那指向的 K63-mimicking ubiquitin 锁住到线粒体恢复 Parkin C431S 本地化。我们建议 Parkin translocation 通过一项新奇催化活动被完成联合机制。 | Xinde Zheng Tony Hunter | 2013 | Cell Research2013，23，7： | 6 |
| 3 | Colour compound lenses for a portable fluorescence microscope显示文摘In this article,we demonstrated a handheld smartphone fluorescence microscope(HSFM)that integrates dualfunctional polymer lenses with a smartphone.The HSFM consists of a smartphone,a field-portable illumination source,and a dual-functional polymer lens that performs both optical imaging and filtering.Therefore,compared with the existing smartphone fluorescence microscope,the HSFM does not need any additional optical filters.Although fluorescence imaging has traditionally played an indispensable role in biomedical and clinical applications due to its high specificity and sensitivity for detecting cells,proteins,DNAs/RNAs,etc.,the bulky elements of conventional fluorescence microscopes make them inconvenient for use in point-of-care diagnosis.The HSFM demonstrated in this article solves this problem by providing a multifunctional,miniature,small-form-factor fluorescence module.This multifunctional fluorescence module can be seamlessly attached to any smartphone camera for both bright-field and fluorescence imaging at cellular-scale resolutions without the use of additional bulky lenses/filters;in fact,the HSFM achieves magnification and light filtration using a single lens.Cell and tissue observation,cell counting,plasmid transfection evaluation,and superoxide production analysis were performed using this device.Notably,this lens system has the unique capability of functioning with numerous smartphones,irrespective of the smartphone model and the camera technology housed within each device.As such,this HSFM has the potential to pave the way for realtime point-of-care diagnosis and opens up countless possibilities for personalized medicine. | Bo Dai Ziao Jiao Lulu Zheng Hunter Bachman Yongfeng Fu Xinjun Wan Yule Zhang Yu Huang Xiaodian Han Chenglong Zhao Tony Jun Huang Songlin Zhuang Dawei Zhang | 2019 | Light(Science & Applications)2019，8，1： | 3 |
| 4 | PRC1显示文摘 | Wei Jiang Gretchen Jimenez Nicholas J Wells Thomas J Hope Geoffrey M Wahl Tony Hunter Rikiro Fukunaga | 1998 | Molecular Cell1998，，： | 1 |
| 5 | Signaling -2000 and Beyond显示文摘 | Tony Hunter | 2000 | Cell2000，100，1： | 1 |
| 6 | p27,a novel inhibitor of G1 cyclin CDK protein kinase activity,is related to p21显示文摘 | Hiedo Toyoshima Tony Hunter | 1994 | Cell1994，78，： | 1 |
| 7 | Cyclins and Cancer 显示文摘 | Tony Hunter Pines | 1994 | Cell1994，79，： | 1 |
| 8 | The Integration of Informatics Content in Baccalaureate and Graduate Nursing Education: A Status Report显示文摘 | Kathleen Hunter Dee McGonigle Toni Hebda | 2013 | Nurse Educator2013，，3： | 1 |
| 9 | Protein kinases and phosphatases: The Yin and Yang of protein phosphorylation and signaling显示文摘 | Tony Hunter | 1995 | Cell1995，，2： | 1 |
| 10 | PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis显示文摘 | Weiwei Yang Yan Xia David Hawke Xinjian Li Ji Liang Dongming Xing Kenneth Aldape Tony Hunter W.K. Alfred Yung Zhimin Lu | 2012 | Cell2012，，4： | 1 |
| 11 | P27 a novel inhibitor of G1 cyclin-CDK protein kinase activity is related to P21显示文摘 | Hideo Toyoshima Tony Hunter | 1994 | Cell1994，78，： | 1 |
| 12 | Protein kinases and phosphatases: The Yin and Yang of protein phosphorylation and signaling显示文摘 | Tony Hunter | 1995 | Cell1995，，80： | 1 |
| 13 | Essential role of tuberous sclerosis genes TSC1 and TSC2 in NF-κB activation and cell survival显示文摘 | Sourav Ghosh Vinay Tergaonkar Carla V. Rothlin Ricardo G. Correa Virginie Bottero Pradeep Bist Inder M. Verma Tony Hunter | 2006 | Cancer Cell2006，，3： | 1 |
| 14 | Electric scooter injuries:Incidence and injury patterns at a level I trauma center显示文摘Purpose:Electric scooters(e-scooters)have become an increasingly popular mode of public transportation in recent years.As the incidence of related injuries rises,it is important to understand specific fracture patterns unique to e-scooters and electric bikes(e-bikes)to help guide management.The purpose of this study was to review the prevalence and describe specific fracture patterns of e-scooter and ebike related injuries at the busiest level 1 trauma center in the borough of Manhattan.Methods:Chart review to determine mechanism of injury was performed on all patients for whom an orthopedic consult was requested from 1/1/2021 to 12/31/2021.All patients whose injuries were sustained due to an e-scooter or e-bike were further reviewed for demographics,injury characteristics including fracture pattern,and definitive injury management.Any patients who had an orthopedic consult placed for a reason other than an acute injury were excluded.Descriptive statistics are reported as frequency(percentage)for categorical variables and means for continuous variables.Results:Of the 1815 orthopedic consults requested,1357(74.8%)were for acute injury management.Of those with acute injuries,119(8.8%)sustained 136 e-scooter or e-bike related injuries.There were 92(77.3%)males at an average age of(33.8±15.7)years.Approximately one-fifth of all patients presented in June 2021(26,21.8%).There was a 9.2%rate of open fractures.The 136 injuries were evenly split between the upper and lower extremities,with 57(47.9%)upper extremity,57(47.9%)lower extremity injuries,and 5(4.2%)concomitant upper and lower extremity injuries.The most common fracture patterns were ankle fractures(16,11.7%),followed by tibial shaft(14,10.2%),tibial plateau(13,9.5%),and radial head fractures(11,8.0%).There was a 33.3%incidence of associated posterior malleolar fractures in the spiral tibial shaft fractures,31.0%of posterior malleolar involvement and 18.8%of isolated vertical medial malleolar fractures in the ankle fractures,and 61.5%of posterior comminution in the tibial plateau fractures.Conclusion:E-scooter and e-bike related injuries have a high incidence of tibial shaft fractures,ankle fractures,tibial plateau fractures,and radial head fractures.There should be a high index of suspicion for posterior and medial involvement in lower extremity fractures sustained due to e-scooter or e-bikes.Identifying specific fracture patterns seen in e-scooter and e-bike related mechanisms will help guide management of these injuries. | Nina D.Fisher Ekenedilichukwu Nwakoby Hunter Hernandez Toni M.McLaurin | 2023 | Chinese Journal of Traumatology2023，26，6： | 0 |
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