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| 1 | Aquaporin-dependent excessive intrauterine fluid accumulation is a major contributor in hyper-estrogen induced aberrant embryo implantation显示文摘 | Ying Zhang Qi Chen He Zhang Qiang Wang Rong Li Yaping Jin Haibin Wang Tonghui Ma Jie Qiao Enkui Duan | 2015 | Cell Research2015，25，1： | 14 |
| 2 | Aquaporin3 is a sperm water channel essential for postcopulatory sperm osmoadaptation and migration显示文摘在到女繁殖的道的从男性的旅行,哺乳动物的精子经验自然渗透的减少(例如在老鼠,从 ~ 在到 ~ 的尾 epididymis 的 415 mOsm 在子宫的洞的 310 mOsm ) 。精子演变为活动性激活利用这张力减退的暴露,同时高效地沉默张力减退的房间胀大的否定影响。以前的生理并且药理学研究显示出那个离子控制隧道的水流入 / 流出活跃地涉及精子的过程体积规定;然而,没有特定的精子蛋白质为这快速的 osmoadaptation 被发现负责。这里,我们报导 aquaporin3 (AQP3 ) 是在老鼠和人的一条精子水隧道。Aqp3 缺乏的精子响应张力减退显示出正常活动性激活,但是显示增加的危险到张力减退的房间胀大,在进入以后,由增加的尾巴弯曲描绘了子宫。精子缺点是在男性女性的繁殖的道转变期间响应生理的张力减退的应力胀大的损害精子体积规定和进步房间的结果。微速摄影的成像表明房间体积扩大在细胞质的微滴开始,强迫尾巴到有角并且由于机械膜段形成像发卡的结构。尾巴变丑妨碍了精子移植进输卵管,导致损害授精并且减少了男富饶。这些数据为精子作为一条必要的膜小径建议 AQP3 平衡 “ 的规章的卷减少(RVD ) ; trade-off”在在生理的张力减退之上胀大的精子活动性和房间之间,从而优化 postcopulatory 精子行为。 | Qi Chen Hongying Peng Li Lei Ying Zhang Haibin Kuang Yujing Cao Qi-xian Shi Tonghui Ma Enkui Duan | 2011 | Cell Research2011，21，6： | 13 |
| 3 | Effects of rainfall patterns on annual plants in Horqin Sandy Land, Inner Mongolia of China显示文摘Growth of annual plants in arid environments depends largely on rainfall pulses. An increased understanding of the effects of different rainfall patterns on plant growth is critical to predicting the potential responses of plants to the changes in rainfall regimes, such as rainfall intensity and duration, and length of dry intervals. In this study, we investigated the effects of different rainfall patterns(e.g. small rainfall event with high frequency and large rainfall event with low frequency) on biomass, growth characteristics and vertical distribution of root biomass of annual plants in Horqin Sandy Land, Inner Mongolia of China during the growing season(from May to August) of 2014. Our results showed that the rainfall patterns, independent of total rainfall amount, exerted strong effects on biomass, characteristics of plant growth and vertical distribution of root biomass. Under a constant amount of total rainfall, the aboveground biomass(AGB), belowground biomass(BGB), plant cover, plant height, and plant individual and species number increased with an increase in rainfall intensity. Changes in rainfall patterns also altered the percentage contribution of species biomass to the total AGB, and the percentage of BGB at different soil layers to the total BGB. Consequently, our results indicated that increased rainfall intensity in future may increase biomass significantly, and also affect the growth characteristics of annual plants. | YUE Xiangfei ZHANG Tonghui ZHAO Xueyong LIU Xinping MA Yunhua | 2016 | Journal of Arid Land2016，8，3： | 8 |
| 4 | Expression of aquaporin-1 in SMMC-7221 liver carcinoma cells promotes cell migration显示文摘Migration of tumor cells is a crucial step in tumor invasion and metastasis. Here we provide evidence that aquaporin expression is involved in tumor cell migration. RT-PCR, immunofluorescence and Western blot analysis demonstrated the AQP1 protein expression on the plasma membrane of SMMC-7221 human hepatoma cells. SMMC-7221 cell clones with high (SMMC-7221hPf) and low (SMMC-7221lPf) water permeability were identified by functional assays with corresponding high and low AQP1 expression. Cell migration rate was remarka- bly higher in SMMC-7221hPf cells than SMMC-7221l Pf cells, assessed by Boyden chamber and wound healing assays, whereas cell growth and adhesion were not different. Adenovirus-mediated AQP1 ex- pression in SMMC-7221lPf cells increased their water permeability and migration rate. These results pro- vide the first evidence that aquaporin-mediated membrane water permeability enhances tumor cell migration and may be associated with tumor invasion and metastasis. | LI Yongming FENG Xuechao YANG Hong MA Tonghui | 2006 | Chinese Science Bulletin2006，51，20： | 5 |
| 5 | Effects of Caragana microphylla plantations on organic carbon sequestration in total and labile soil organic carbon fractions in the Horqin Sandy Land, northern China显示文摘Afforestation is conducive to soil carbon(C) sequestration in semi-arid regions. However, little is known about the effects of afforestation on sequestrations of total and labile soil organic carbon(SOC) fractions in semi-arid sandy lands. In the present study, we examined the effects of Caragana microphylla Lam. plantations with different ages(12-and 25-year-old) on sequestrations of total SOC as well as labile SOC fractions such as light fraction organic carbon(LFOC) and microbial biomass carbon(MBC). The analyzed samples were taken from soil depths of 0–5 and 5–15 cm under two shrub-related scenarios: under shrubs and between shrubs with moving sand dunes as control sites in the Horqin Sandy Land of northern China. The results showed that the concentrations and storages of total SOC at soil depths of 0–5 and 5–15 cm were higher in 12-and 25-year-old C. microphylla plantations than in moving sand dunes(i.e., control sites), with the highest value observed under shrubs in 25-year-old C. microphylla plantations. Furthermore, the concentrations and storages of LFOC and MBC showed similar patterns with those of total SOC at the same soil depth. The 12-year-old C. microphylla plantations had higher percentages of LFOC concentration to SOC concentration and MBC concentration to SOC concentration than the 25-year-old C. microphylla plantations and moving sand dunes at both soil depths. A significant positive correlation existed among SOC, LFOC, and MBC, implying that restoring the total and labile SOC fractions is possible by afforestation with C. microphylla shrubs in the Horqin Sandy Land. At soil depth of 0–15 cm, the accumulation rate of total SOC under shrubs was higher in young C. microphylla plantations(18.53 g C/(m^2·a); 0–12 years) than in old C. microphylla plantations(16.24 g C/(m^2·a); 12–25 years), and the accumulation rates of LFOC and MBC under shrubs and between shrubs were also higher in young C. microphylla plantations than in old C. microphylla plantations. It can be concluded that the establishment of C. microphylla in the Horqin Sandy Land may be a good mitigation strategy for SOC sequestration in the surface soils. | SHANG Wen LI Yuqiang ZHAO Xueyong ZHANG Tonghui MA Quanlin TANG Jinnian FENG Jing SU Na | 2017 | Journal of Arid Land2017，9，5： | 3 |
| 6 | Cytotoxic effect of evodiamine in SGC-7901 human gastric adenocarcinomacells via simultaneous induction of apoptosis and autophagy显示文摘 | Azhar Rasul Bo Yu Lili Zhong Muhammad Khan Hong Yang Tonghui Ma | 2012 | Oncology Reports2012，，5： | 1 |
| 7 | Identification of Cinobufagin and Resibufogenin as Inhibitors of Enterovirus 71 Infection显示文摘 | CHEN Jiawen XU Lin SUN Shiyang ZHANG Huafei MA Tonghui SU Weiheng JIANG Chunlai | 2014 | Chemical Research in Chinese Universities2014，30，6： | 1 |
| 8 | Importance of NPA motifs in the expression and function of water channel aquaporin-1显示文摘The asparagine-proline-alanine sequences (NPA motifs) are highly conserved in aquaporin water channel family. Crystallographic studies of AQP1 structure demonstrated that the two NPA motifs are in the narrow central constriction of the channel, serving to bind water molecules for selective and effi-cient water passage. To investigate the importance of the two NPA motifs in the structure, function and biogenesis of aquaporin water channels, we generated AQP1 mutations with NPA1 deletion, NPA2 de-letion and NPA1,2 double deletion. The coding sequences of the three mutated cDNAs were subcloned into the mammalian expression vector pcDNA3.1 to form expression plasmids. We established stably transfected CHO cell lines expressing these AQP1 mutants. Immunofluorescence indicated that all the three mutated AQP1 proteins are expressed normally on the plasma membrane of stably transfected CHO cells, suggesting that deletion of NPA motifs does not influence the expression and intracellular processing of AQP1. Functional analysis demonstrated that NPA1 or NPA2 deletion reduced AQP1 water permeability by 49.6% and 46.7%, respectively, while NPA1,2 double deletion had little effect on AQP1 water permeability. These results provide evidence that NPA motifs are important for water per-meation but not essential for the expression, intracellular processing and the basic structure of AQP1 water channel. | JIANG Yong MA TongHui | 2007 | Chinese Science Bulletin2007，52，6： | 1 |
| 9 | Cytotoxic effect of evodiamine in SGC-7901 human gastric adenocarcinomacells via simultaneous induction of apoptosis and autophagy显示文摘 | Azhar Rasul Bo Yu Lili Zhong Muhammad Khan Hong Yang Tonghui Ma | 2012 | Oncology Reports2012，，5： | 1 |
| 10 | Fourfold reduction of water permeability in inner medullary collecting duct of aquaporin-4 knockout mice显示文摘 | CHOU C L MA Tonghui YANG Baoxue | | 0，，： | 1 |
| 11 | The response of Caragana microphylla seedlings to water table changes in Horqin Sandy Land,China显示文摘This paper focuses on the growth response of Caragana microphylla seedlings to changes of artificially controlled water table in Horqin Sandy Land, China. Monitoring results of soil water content shows that soil moisture is closely correlated to groundwater depths. Soil volumetric water increased rapidly when close to water sources and finally stabilized in a saturated state. The soil moisture trend of CK(control) increased gradually at 0–50 cm of soil depth then decreased to 4% below 50 cm soil depth. C. microphylla can adapt to different soil environments by changes in ecological and physiological characteristics. By comparing the ecological characteristics of C. microphylla seedlings at various water tables, we found that a shallow water table of 40 cm depth inhibited seedling growth because of weak ecological characteristics. A groundwater depth of 120 cm was more advantageous for plant height and canopy growth of C. microphylla seedlings. During the first two years, the most suitable water depth for root biomass was 120 cm, and 180 cm for root length. The growth of vertical roots is positively correlated with groundwater depth, and root thickness is the determinate factor for root biomass while the fine root is the determinate factor for root length. A thick root would grow much more in a natural drought environment while access to ground water promotes the growth of fine roots. | YunHua Ma TongHui Zhang XinPing Liu Wei Mao XiangFei Yue | 2015 | Research in Cold and Arid Regions2015，7，1： | 1 |
| 12 | Reguirement of aquaporin-1 for NaCl-driven water transport across decend- ing vasa recta 显示文摘 | Pallone TL Edwards A Tonghui Ma | 2000 | J Clin Invest2000，105，： | 1 |
| 13 | Lung fluid transport in aquaporin-5 knockout mice显示文摘 | Ma Tonghui Fukuda N Song Yuanlin | 2000 | J Clin Invest2000，105，1： | 1 |
| 14 | Cytotoxic effect of evodiamine in SGC-7901 human gastric adenocarcinomacells via simultaneous induction of apoptosis and autophagy显示文摘 | Azhar Rasul Bo Yu Lili Zhong Muhammad Khan Hong Yang Tonghui Ma | 2012 | Oncology Reports2012，，5： | 1 |
| 15 | Alantolactone Induces Apoptosis in HepG2 Cells through GSH Depletion, Inhibition of STAT3 Activation, and Mitochondrial Dysfunction显示文摘 | Muhammad Khan Ting Li Muhammad Khalil Ahmad Khan Azhar Rasul Faisal Nawaz Meiyan Sun Yongchen Zheng Tonghui Ma D. M. Clarke | 2012 | BioMed Research International2012，，： | 1 |
| 16 | Characteristics of TP53 germline variants and their correlations with Li-Fraumeni syndrome or Li-Fraumeni-like syndrome in Chinese tumor patients显示文摘Li-Fraumeni syndrome(LFS),a rare autosomal-dominant inheritance condition,is associated with a family cancer history as well as pathogenic/likely-pathogenic TP53 germline variants(P/LP TP53 GV).The current clinical methods for detecting LFS are limited.Here,we retrospectively investigate P/LP TP53 GV among Chinese cancer patients by next-generation sequencing and evaluate its relationship with a family cancer history.A total of 270 out of 19,226 cancer patients have TP53 GV,including 53 patients with P/LP TP53 GV.Patients with P/LP TP53 GV are mainly found in male with glioma,lung cancer or sarcoma.The median age of diagnosis for P/LP TP53 GV patients is significantly lower than that of non-P/LP TP53 GV patients(31-years vs.53-years;P<0.01).One LFS patient and 3 Li-Fraumeni-like syndrome(LFL)patients are among the 26 followed-up P/LP TP53 GV patients.Among 25 types of P/LP TP53 GV,the highest variant frequencies occurred at codon 175 and 248.p.M237 I,p.R158 H,p.C238 Y and p.C275 R,are firstly identified among the Chinese LFS/LFL patients.This study reports the(P/LP)TP53 GV characteristics of Chinese pan-cancer patients.These findings suggest analyzing the P/LP TP53 GV in cancer patients is an effective strategy for identifying cancer predisposition syndrome. | Panwen Tian Xiaoyan Zhang Sheng Yang Yu Fang Hongling Yuan Wei Li Honglin Zhu Fangping Zhao Jinlei Ding Yunshu Zhu Sizhen Wang Guochen Sun Hongbin Ni Tonghui Ma Ting Lei | 2022 | Journal of Genetics and Genomics2022，49，7： | 0 |
| 17 | Boosting alkaline hydrogen electrooxidation on an unconventional fcc-Ru polycrystal显示文摘Precisely controlling the crystalline phase structure and exposed facets at the atomic level opens up a new avenue for efficient catalyst design.Along this line,we report an unconventional face-centered cubic(fcc)Ru with twinned structure and stacking-fault defects as a competent electrocatalyst towards alkaline hydrogen oxidation reaction(HOR),which is now a major obstacle for the commercialization of anion exchange membrane fuel cells(AEMFC).With conventional hexagonal close packing(hcp)Ru as the counterpart,a novel scope from the phase-engineering is introduced to identify the activity origin and provide fundamental understanding of the sluggish HOR kinetics in alkaline medium.Systematic electrochemical analysis assisted by deconvoluting the hydrogen(H)desorption peaks indicates the superior performance of fcc Ru origins from the structure defects and higher proportion of the most active sites.DFT calculations,together with CO-stripping voltammograns further corroborate the stronger hydroxyl species(OH^(*))affinity lead to the higher activity on these sites.Meanwhile,it also demonstrates the H^(*)adsorption/desorption on polycrystalline Ru among the conventional'hydrogen region'is accompanied by the surface bound OH^(*)in alkaline medium,which is of great significance for subsequent alkaline HOR exploration and catalyst design. | Tonghui Zhao Dongdong Xiao Yi Chen Xi Tang Mingxing Gong Shaofeng Deng Xupo Liu Jianmin Ma Xu Zhao Deli Wang | 2021 | Journal of Energy Chemistry2021，30，10： | 0 |
| 18 | Detection of anti-aquaporin-4 autoantibodies in the sera of Chinese neuromyelitis optica patients显示文摘In this study,we recruited 10 neuromyelitis optica patients,two multiple sclerosis patients and two myelitis patients.Chinese hamster lung fibroblast (V79) cells transfected with a human aquaporin-4-mCherry fusion protein gene were used to detect anti-aquaporin-4 antibody in neuromyelitis optica patient sera by immunofluorescence.Anti-aquaporin-4 autoantibody was stably detected by immunofluorescence in neuromyelitis optica patient sera exclusively.The sensitivity of the assay for neuromyelitis optica was 90% and the specificity for neuromyelitis optica was 100%.The anti-aquaporin-4 antibody titers in sera were tested with serial dilutions until the signal disappeared.A positive correlation was detected between Expanded Disability Status Scale scores and serum anti-aquaporin-4 antibody titers.The anti-aquaporin-4 antibody assay is highly sensitive and specific in the sera of Chinese neuromyelitis optica patients.Detection of aquaporin-4 autoantibody is important for the diagnosis and treatment of neuromyelitis optica. | Miao Li Weiheng Su Jie Wang Francesco Pisani Antonio Frigeri Tonghui Ma | 2013 | Neural Regeneration Research2013，8，8： | 0 |
| 19 | EFFECTS OF TRANSPORT STRESS ON THE INTESTINES INVOLVING NEURONAL NITRIC OXIDE SYNTHASE显示文摘Transport stress is commonly suffered by animals with gastrointestinal dysfunction a common symptom.Currently,the mechanisms of transport stress-induced intestine impairment are largely unknown.The aim of this study was to investigate the effects of transport stress on the expression of neuronal nitric oxide synthase(nNOS)and the distribution of nNOS-positive neurons of the intestines in rats and to explore the neuroendocrine mechanism of transport stress.In this study,Sprague Dawley rats(n=6)were subjected on a constant temperature shaker for 1(S1d)or 3 d(S3d).Rats exhibited increased serum glucose and diminished total number of leukocytes,in which lymphocytes level was also decreased in the S1d group(P<0.05).Also,normal intestinal morphology was disrupted in the S1d rats,and the thickness of muscle layers was decreased in duodenum,jejunum and colon of S3d rats.In addition,it was found that nNOS expression,as well as the number of nNOSpositive neurons in the myenteric plexus were downregulated in duodenum,jejunum and colon of S3d rats compared with that of unstressed rats(P<0.05).These data reveals that transport stress induced intestinal damage and uncovers potential action mechanisms that nNOS-positive neurons and nNOS expression might be involved in modulating this process. | Jing LAN Tonghui MA Peng YIN Kedao TENG Yunfei MA | 2023 | Frontiers of Agricultural Science and Engineering2023，10，2： | 0 |
| 20 | Progress in studies of angio-statin and its anti-tumor effects显示文摘Angiostatin is a 38 ku circulating angiogenesis inhibitor purified from the serum and urine of mice bearing a murine Lewis lung carcinoma. It is regarded as an internal fragment of plasminogen containing the first 4 Kringle structures. In vitro, angiostatin specifically inhibits endothe-lial cell proliferation. In vivo, it inhibits angiogenesis and suppresses the growth of such primary tumors as Lewis lung carcinoma and hemangioendotheliolma in mice. | Hong Yang Yin Wu Yuxin Li Tonghui Ma Baiqu Huang | 2001 | Chinese Science Bulletin2001，46，6： | 0 |
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