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| 1 | Conversion of human umbilical cord mesenchymal stem cells in Wharton's jelly to dopaminergic neurons in vitro: potential therapeutic application for Parkinsonism显示文摘 | Fu YS Cheng YC Lin MY Cheng H Chu PM Chou SC Shih YH Ko MH Sung MS | 2006 | 中国生物学文摘2006，20，10： | 138 |
| 2 | 中国煤中砷的含量分布、赋存状态、富集及环境意义显示文摘砷是煤中有害微量元素之一,在煤加工利用过程中,砷会以各种形式释放出来,进入环境。本文在全面分析现有资料和文献的基础上,结合作者对中国煤中砷的研究成果,分析了中国煤中砷的含量与分布、赋存状态、富集因素以及环境意义。通过研究和分析可知,中国煤中砷的平均值约为5μg/g,但在不同地区、不同时代以及不同类型的煤中有较大的差异,除中国西南地区含量异常高外,一般含量均在10μg/g以内;煤中砷的赋存状态多种多样,主要以无机态的硫化物结合为主,并常与黄铁矿等矿物伴生,也存在有机态结合的砷;中国煤中砷的来源和富集主要是以陆源母岩、成煤植物、沉积环境和构造裂隙—热液作用等为主的多种因素综合控制的结果;在煤燃烧过程中,煤中的砷释放出来,并对长期生活在燃煤地区的环境和人体产生影响。本文还提出今后煤中砷研究的主要方向,以为煤中砷的研究提供参考资料。 | 郑刘根 刘桂建 CHOU Chenlin 高连芬 彭子成 | 2006 | 地球学报2006，27，4： | 56 |
| 3 | 煤中微量元素研究进展显示文摘煤炭是我国的主要能源 ,在煤炭开采、运输、洗选、淋溶 (滤 )、燃烧等其它加工利用过程中 ,煤中的微量元素要发生迁移、析出 ,并入侵到大气、水、土壤和生态环境中 ,最终影响人类生存和生活环境。煤中微量元素十分重要 ,是因为它们与环境问题、动、植物及人类健康密切相关。在研究微量元素时必须考虑微量元素的性质及毒性 ,它们主要依靠其含量、种类、存在形式、pH值、氧化—还原条件及其它因素。在全面综合国内外研究文献的基础上 ,分析了煤中微量元素的发现、分布规律、赋存状态、成因机理及微量元素的应用等方面研究的历史、现状 ,并对今后研究的重点内容和发展方向进行了较为详细的论述和分析 ,并指出在进一步深入研究煤中微量元素地球化学的基础上 ,加强微量元素环境学方面的研究是今后煤中微量元素环境地球化学研究的重要内容。 | 刘桂建 彭子成 王桂梁 杨萍月 Chou Cheng lin | 2002 | 地球科学进展2002，17，1： | 54 |
| 4 | Path planning for mobile robot using self-adaptive learning particle swarm optimization显示文摘As a challenging optimization problem, path planning for mobile robot refers to searching an optimal or near-optimal path under different types of constrains in complex environments. In this paper, a self-adaptive learning particle swarm optimization(SLPSO) with different learning strategies is proposed to address this problem. First, we transform the path planning problem into a minimisation multi-objective optimization problem and formulate the objective function by considering three objectives: path length, collision risk degree and smoothness. Then, a novel self-adaptive learning mechanism is developed to adaptively select the most suitable search strategies at different stages of the optimization process, which can improve the search ability of particle swarm optimization(PSO). Moreover, in order to enhance the feasibility of the generated paths, we further apply the new bound violation handling schemes to restrict the velocity and position of each particle. Finally, experiments respectively with a simulated robot and a real robot are conducted and the results demonstrate the feasibility and effectiveness of SLPSO in solving mobile robot path planning problem. | Guangsheng LI Wusheng CHOU | 2018 | Science China(Information Sciences)2018，61，5： | 46 |
| 5 | 鄂尔多斯盆地东北缘准格尔煤田煤中超常富集勃姆石的发现显示文摘运用X射线衍射分析(XRD)、带能谱仪的扫描电镜(SEM-EDX)和光学显微镜等技术,首次在鄂尔多斯盆地东北缘准格尔矿区6号巨厚煤层中发现了超常富集的勃姆石及其特殊的矿物组合,勃姆石含量可高达13.1%,与勃姆石伴生的矿物有磷锶铝石、锆石、金红石、菱铁矿、方铅矿、硒铅矿和硒方铅矿。重矿物的组合特征与华北地区本溪组铝土矿中的重矿物组合特征相似,高含量的勃姆石主要来源于聚煤盆地北偏东方向本溪组风化壳铝土矿,三水铝石以胶体溶液的形式从铝土矿中被短距离带入泥炭沼泽中,在泥炭聚积阶段和成岩作用早期经压实作用脱水凝聚而形成勃姆石。 | 代世峰 任德贻 李生盛 CHOU Chenlin | 2006 | 地质学报2006，80，2： | 40 |
| 6 | 贵州大方煤田主采煤层的矿物学异常及其对元素地球化学的影响显示文摘运用电感耦合等离子体质谱(ICP-MS)、X射线荧光光谱(XRF)、带能谱仪的扫描电镜(SEM-EDX)、逐级化学提取(SCEP)和光学显微镜等方法,对贵州大方煤田11号煤层的地球化学和矿物学进行了研究。结果表明,大方煤田11号煤层中有高含量的脉状石英(11.4%)和脉状铁白云石(10.2%),铁白云石周边常被针铁矿所包裹,在脉状石英中发现有热液成因的黄铜矿、闪锌矿和硒方铅矿,此外,还有少量高岭石充填在脉中,这7种矿物常常同脉共存。脉状石英和脉状铁白云石分别来源于硅质和富铁的钙质低温热液流体,形成温度分别为180℃和85℃。脉状石英早于脉状铁白云石形成。根据Ca/Sr和Fe/Mn值,确定出铁白云石的形成至少经历了3个时期。这7种矿物按照从早到晚的生成顺序为硫化物、石英、高岭石、铁白云石和针铁矿。铁白云石是煤中Mn、Cu、Ni、Pb和Zn富集的主要原因,这5种微量元素的含量分别为0.09%、74.0μg/g、33.6μg/g、185μg/g和289μg/g。脉状石英是煤中铂族元素Pd、Pt和Ir的主要载体,它们在煤中的含量分别为1.57μg/g、0.15μg/g和0.007μg/g。另外,黄铜矿、闪锌矿和硒方铅矿亦是11号煤层中Cu、Zn和Pb的重要载体。 | 代世峰 任德贻 李丹 Chen-Lin CHOU 雒昆利 | 2006 | 地质学报2006，80，4： | 36 |
| 7 | Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures显示文摘 | Bin-Kuan Chou Prashant Mali Xiaosong Huang Zhaohui Ye Sarah N Dowey Linda MS Resar Chunlin Zou Alex Zhang Jay Tong Linzhao Cheng | 2011 | Cell Research2011，21，3： | 38 |
| 8 | Regional ozone pollution and key controlling factors of photochemical ozone production in Pearl River Delta during summer time显示文摘An intensive field campaign including measurements from the environmental monitoring network and from two super sites took place in the Pearl River Delta region in summer 2006.Using routinely measured O3 and NOx concentrations,the spatial and temporal variation of O3 and of the total oxidant concentrations was characterized.According to the spatial variability of NO2/NO,the two super sites were found to be representative of polluted urban and downwind suburban conditions.In addition,both sites were located in high O3 regions.In-depth diagnostic of photochemical ozone production processes and their key controlling factors are achieved with an observation-based model(OBM) to gain regional perspectives.Budget analysis and sensitivity model runs show that aldehyde and HONO chemistry had significant impacts on local photochemical ozone production rates.The analysis of calculated Relative Incremental Reactivities shows that photochemical ozone production rates are mainly sensitive to anthropogenic hydrocarbons(HCs) in the polluted urban areas.In the suburban areas,sensitivity to nitrogen oxide(NO) concentrations dominated.Key anthropogenic HCs in both areas are alkenes and aromatics.Significant differences of ozone production efficiencies are identified between the urban and suburban regions,consistent with the OBM diagnosed results. | CHANG ChihChung CHOU C.K.Charles Andreas Wahner | 2010 | Science China Chemistry2010，53，3： | 34 |
| 9 | Ursolic acid induces human hepatoma cell line SMMC-7721 apoptosis via p53-dependent pathway显示文摘背景 Ursolic 酸(UA ) 是在有在 vitro 并且在 vivo 被显示出的特定的 anticancer 效果的植物王国的一个无所不在的分子。尽管 UA 能禁止肝癌症房间的增长并且导致肿瘤房间的许多类型的 apoptosis,它的 anti-hepatoma 活动的分子的机制仍然不是明确的。这研究的目的是调查禁止的效果,人的 hepatoma 房间上的 UA 的机制衬里 SMMC-7721。在有 UA 的治疗以后的方法, SMMC-7721 细胞的生长抑制被 MTT 估计试金。在他们被 UA 劝诱以后,房间被流动 cytometric 分析,染色的 Wright-Giemasa, Hoechst 33258 染色和传播电子显微镜也评估。DNA microarray 技术被用来调查暴露于 UA 40 pmol/L 的 SMMC-7721 房间的基因表示模式。房间死亡的分子的机制被即时 RT-PCR 和西方的 blotting.Results 分析 SMMC-7721 房间的增长显著地在 UA 治疗以后在一个剂量依赖者和时间依赖者举止被禁止。UA 导致了房间周期拘捕和 apoptosis。DNA microarray 分析显示 64 基因被发现到,包括下面表示的 GDF15, SOD2, ATF3,和 fos 是显著地 up-expressed, 或。西方的弄污的结果显示出 apoptotic 蛋白质 p53,当 anti-apoptotic 蛋白质 Bcl-2 是 down-regulated.Real-time RT-PCR 时, Bax 是起来调整的证实的 UA 能起来调整 GDF15, SOD2, ATF3 和下面调整的 mRNA 表情 fos 的 mRAN 表示。同时,这些效果被预告的处理部分与 p53 小径的 p53 禁止者 Pft-.Conclusion 激活堵住涉及 SMMC-7721 人的 hepatocellular 癌房间生长和 apoptosis 的正式就职的 UA 抑制。 | YU Yan-xia GU Zhen-lun YIN Jiang-lin CHOU Wen-hsien KWOK Chi-yi QIN Zheng-hong LIANG Zhong-qin | 2010 | Chinese Medical Journal2010，，14： | 32 |
| 10 | 淮北煤田二叠纪煤中稀土元素地球化学研究显示文摘从淮北煤田二叠系10,7,5,4和3煤层中采集34个样品,采用等离子体质谱(ICPMS)、中子活化(INNA)、等离子体发射光谱(ICPAES)等方法对样品中主量元素和稀土元素进行了测试,利用X射线衍射等方法对煤中矿物质及其煤质参数进行了测定。在各种测试的基础上,全面分析了稀土元素含量特征、空间分布规律、地球化学参数和分布模式,探讨了淮北煤田二叠纪煤中稀土元素的主要来源及其在煤中的主要赋存方式。研究表明:与华北和国内外其他地区相比,本区煤层中稀土元素相对富集;产于石盒子组煤中的稀土元素含量高于山西组的,在同一煤层中自下而上稀土元素含量有增高趋势,在顶底板中可能出现富集。Ce呈正异常,Eu明显负异常,不同煤层稀土元素的分布模式相似,稀土元素和灰分具有较好的正相关,∑REE与灰分、灰分中的主要元素以及典型陆源灰分中的微量元素正相关,与反映海相的低灰组分相关性较差。结合煤中矿物质的X射线衍射结果,分析获知,淮北煤田二叠纪成煤环境基本不受海水影响,稀土元素主要由陆源供给,而且主要赋存在以高岭石、伊利石为主的粘土矿物中。 | 郑刘根 刘桂建 张浩原 高连芬 薛翦 Chou Chen-lin | 2006 | 高校地质学报2006，12，1： | 30 |
| 11 | Tetramethylpyrazine suppresses HIF-1α,TNF-α,and activated caspase-3 expression in middle cerebral artery occlusion-induced brain ischemia in rats显示文摘瞄准:检验详细机制位于禁止的效果 oftetramethylpyrazine (TMPZ ) 下面在煽动性并且 apoptotic 回答在 rats.Methods 由中间的服的 arteryocclusion (MCAO ) 导致了:在老鼠的导致 MCAO 的焦点的服的局部缺血在 thisstudy.The 被使用组织缺氧可诱导的 factor-1alpha (HIF-1alpha ) , caspase-3 的激活,和在 ischemic 区域的 TNF-alpha mRNAtranscription 被 immunoblotting andRT-PCR 检测, respectively.Anti 氧化的活动用 thiobarbituric acid-reactivesubstance (TBARS ) 被调查老鼠大脑 homogenate preparations.Results 的测试:我们显示出溶剂的梗塞区域的 statisticalresults --并且 TMPZ ( 20 mg/kg )在在在有 TMPZ ( 20 mg/kg )的 rats.Treatment 的 导致MCAO 的焦点的服的局部缺血的正面的杆显著地减少了的各种各样的 distancesfrom 对待组在所有区域的梗塞区域,在特别,第三显著地与 ischemic regions.These expressionswere 的 caspase-3 ,以及 TNF-alpha 抄写的 HIF-1alpha 和 theactivation 的增加被联系到 导致fifthsections.MCAO 的焦点的服的局部缺血我 neuroprotective effectof TMPZ 可以至少被 EOF-1alpha 和 TNF-alphaactivations 的抑制的部分调停,由 apoptosis 形成(活跃 caspase-3 )的抑制列在后面,在 ischemia-reperfusion 大脑 injury.Thus 在梗塞体积导致 areduction , TMPZ 处理 mayrepresent 在 ischemia-reperfusionbrain 降低风险或改善功能的一条理想的途径损害相关的混乱。 | Yi CHANG George HSIAO Seu-hwa CHEN Yi-cheng CHEN Jiing-han LIN Kuang-hung LIN Duen-suey CHOU Joen-rong SHEU | 2007 | Acta Pharmacologica Sinica2007，28，3： | 30 |
| 12 | Short-chain fatty acids act as antiinflammatory mediators by regulating prostaglandin E_2 and cytokines显示文摘AIM:To investigate the effect of short-chain fatty ac-ids (SCFAs) on production of prostaglandin E2 (PGE2),cytokines and chemokines in human monocytes.METHODS:Human neutrophils and monocytes were isolated from human whole blood by using 1-Step Polymorph and RosetteSep Human Monocyte Enrich-ment Cocktail,respectively. Human GPR41 and GPR43 mRNA expression was examined by quantitative real-time polymerase chain reaction. The calcium flux assay was used to examine the biological activities of SCFAs in human neutrophils and monocytes. The effect ofSCFAs on human monocytes and peripheral blood mononuclear cells (PBMC) was studied by measuring PGE2,cytokines and chemokines in the supernatant. The effect of SCFAs in vivo was examined by intraplantar injection into rat paws.RESULTS:Human GPR43 is highly expressed in human neutrophils and monocytes. SCFAs induce robust calcium flux in human neutrophils,but not in human monocytes. In this study,we show that SCFAs can in-duce human monocyte release of PGE2 and that this effect can be enhanced in the presence of lipopolysac-charide (LPS). In addition,we demonstrate that PGE2 production induced by SCFA was inhibited by pertussis toxin,suggesting the involvement of a receptor-mediated mechanism. Furthermore,SCFAs can specifi cally inhibit constitutive monocyte chemotactic protein-1 (MCP-1) production and LPS-induced interleukin-10 (IL-10) production in human monocytes without affecting the secretion of other cytokines and chemokines examined. Similar activities were observed in human PBMC for the release of PGE2,MCP-1 and IL-10 after SCFA treatment. In addition,SCFAs inhibit LPS-induced production of tumor necrosis factor-α and interferon-γ in human PBMC. Finally,we show that SCFAs and LPS can induce PGE2 production in vivo by intraplantar injection into rat paws (P < 0.01). CONCLUSION:SCFAs can have distinct antiinflammatory activities due to their regulation of PGE2,cytokine and chemokine release from human immune cells. | Mary Ann Cox James Jackson Michaela Stanton Alberto Rojas-Triana Loretta Bober Maureen Laverty Xiaoxin Yang Feng Zhu Jianjun Liu Suke Wang Frederick Monsma Galya Vassileva Maureen Maguire Eric Gustafson Marvin Bayne Chuan-Chu Chou Daniel Lundell Chung-Her Jenh | 2009 | World Journal of Gastroenterology2009，15，44： | 30 |
| 13 | 迷走神经磁调制治疗脑卒中后吞咽困难显示文摘中风涉及脑干引起广泛的神经系统缺陷,包括口腔咽部吞咽困难(OD)。随着迷走神经刺激在脑卒中动物中的研究显示运动功能的改善,本研究探讨重复经颅磁刺激(rTMS)在人类卒中后吞咽功能恢复中的作用。这项假对照,双盲,平行研究包括30例缺血性或出血性中风,所有患者均表现为慢性延髓表现。在干预组中,TMS线圈放置在左侧乳突刺激迷走神经,2个星期内每天10次。 | 柏和风 顾旭东 Lin WS Chou CL Chang MH | 2018 | 中国康复2018，33，3： | 30 |
| 14 | Electroporative interleukin-10 gene transfer ameliorates carbon tetrachlo-ride-induced murine liver fibrosis by MMP and TIMP modulation显示文摘瞄准:肝纤维变性代表响应长期的肝损伤愈合并且结疤的一个过程。为肝纤维变性的有效治疗正在缺乏。Interleukin-10 (IL-10 ) 是 cytokine 下面调整支持 inflammatory 回答并且在肝的纤维发生上有调节效果。这研究的目的是调查 electroporative IL-10 基因治疗是否在老鼠上有肝的 fibrolytic 效果。方法:肝的纤维变性被在老鼠管理四氯化碳(CCl4 ) 10 个星期导致。在肝的纤维变性被建立以后,人的 IL-10 表示原生质标志经由 electroporation 被交付。组织病理学说,反向的抄写聚合酶链反应(RT-PCR ) ,弄污的免疫,和明胶 zymography 被用来调查 IL-10 的行动的可能的机制。结果:人的 IL-10 基因治疗在老鼠颠倒了导致 CCl4 的肝纤维变性。RT-PCR 表明那 IL-10 基因治疗稀释了肝 TGF-beta1,骨胶原 alpha1, fibronectin,和房间粘附分子在规定上面的 mRNA。后面的基因转移,两个都, alpha 光滑的肌肉肌动朊和 cyclooxygenase-2 的激活显著地被稀释。而且, IL-10 显著地禁止了矩阵 metalloproteinase-2 (MMP-2 ) 和矩阵 metalloproteinase (TIMP ) 的织物禁止者在 CCl4 沉醉以后的激活。结论:我们证明那 IL-10 基因治疗在老鼠稀释了导致 CCl4 的肝纤维变性。在调整 fibrogenic 和支持 inflammatory 基因回答上面阻止的 IL-10。它的溶胶原效果可以被归因于 MMP 和 TIMP 调整。IL-10 基因治疗可以是对有潜在的临床的使用的肝纤维变性的一种有效治疗学的形式。 | Wen-ying CHOU Cheng-nan LU Tsung-hsing LEE Chia-ling WU Kung-sheng HUNG Allan M CONCEJERO Bruno JAWAN Cheng-haung WANG | 2006 | Acta Pharmacologica Sinica2006，27，4： | 25 |
| 15 | Thalidomide-based multidisciplinary treatment for patients with advanced hepatocellular carcinoma:A retrospective analysis显示文摘AIM:To evaluate the efficacy of thalidomide in combination with other therapies to treat patients with advanced hepatocellular carcinoma (HCC).METHODS:We performed a retrospective analysis of all patients with HCC who were treated with thalidomide for at least two months.The medical records of patients with HCC who were treated at our institution between April 2003 and March 2008 were reviewed.Image studies performed before and after treatment,tumor response,overall survival,and the decrease in α-fetoprotein (AFP) levels were evaluated.RESULTS:A total of 53 patients with HCC received either 100 or 200 mg/d of thalidomide.The patient population consisted of 9 women and 44 men with a median age of 61 years.Thirty patients (56.6%) were classified as Child-Pugh A,and 12 patients (22.6%) were classified as Child-Pugh B.Twenty-six patients had portal vein thrombosis (49.1%),and 25 patients had extrahepatic metastasis (47.1%).The median duration of thalidomide treatment was 6.0 mo.Six of the 53 patients achieved a confirmed response (11.3%),one achieved a complete response (1.9%) and 5 achieved a partial response (9.4%).The disease control rate (CR + PR + SD) was 28.3% (95% CI:17.8-42.4),and the median overall survival rate was 10.5 mo.The 1-and 2-year survival rates were 45% and 20%,respectively.Only one complete response patient showed an improved overall survival rate of 66.8 mo.Sixteen patients (30.2%) showed more than a 50% decrease in their serum AFP levels from baseline,indicating a better response rate (31.3%),disease control rate (43.8%),and overall survival time (20.7 mo).The therapy was well tolerated,and no significant toxicities were observed.CONCLUSION:Thalidomide was found to be safe for advanced HCC patients,demonstrating anti-tumor activity including response,survival,and AFP decreases of greater than 50% from baseline. | Yang-Yuan Chen Hsu-Heng Yen Kun-Ching Chou Shun-Sheng Wu | 2012 | World Journal of Gastroenterology2012，18，5： | 25 |
| 16 | Thermodynamics and kinetics of phase transformation in rare earth–magnesium alloys:A critical review显示文摘Magnesium and its alloys are significant superior metallic materials for structural components in automobile and aerospace industries due to their excellent physicomechanical properties.The Mg–rare earth(RE)systems have attracted great interests because RE additions can improve both the deformability and the strength of Mg alloys through solid solution strengthening and precipitation hardening mechanisms.This paper focuses on the interface stability,together with thermodynamics and kinetics of nucleation and growth of the key phases and matrix phases in Mg–RE alloys.In this paper,the theory and recent advances on Mg–RE alloys,especially for the interface stability,thermodynamics and kinetics of nucleation and growth of the key phases and matrix phases,together with their relationships with micro-structures,and macroscopic properties,are reviewed.By combining the thermodynamics/kinetics integrated simulations with various advanced experimental techniques,“reverse”design of Mg–RE alloys starting from the target service performance is put forward as a kind of scientific paradigm with rational design. | Qun Luo Yanlin Guo Bin Liu Yujun Feng Jieyu Zhang Qian Li Kuochih Chou | 2020 | Journal of Materials Science & Technology2020，44，9： | 26 |
| 17 | Adhesive small bowel obstruction: How long can patients tolerate conservative treatment?显示文摘AIM: To evaluate how long patients with small bowel obstruction caused by postoperative adhesions can tolerate conservative treatment.METHODS: The records of patients with small bowel obstruction due to postoperative adhesions were retrospectively reviewed. Data collected included the number of admissions, type of management for each admission,duration of conservative treatment, number of repeat laparotomies, and operative findings.RESULTS: One hundred fifty-five patients with this condition from January 1999 to December 2001, for a total of 293 admissions were enrolled in this study. Medical treatment alone was given in 220 admissions, and repeat laparotomy was performed in 73 admissions. The period of observation in patients managed medically ranged from 2 to 12 days (average: 6.9 days), while for those who underwent surgery,the range was 1 to 14 days (average 5.4 days). At surgery,adhesions were the only finding in 46 cases, while there were intestinal complications in 27, or 9.2 % of all 293admissions. Fever and leukocytosis greater than 15 000/mm3were prediction of intestinal complications.CONCLUSION: With closely monitoring, most patients with small bowel obstruction due to postoperative adhesions could tolerate supportive treatment and recover well averagely within 1 week, although some patients require more than 10 days of observation. | Shou-Chuan Shih Kuo-Shyang Jeng Shee-Chan Lin Chin-Roa Kao Sun-Yen Chou Horng-Yuan Wang Wen-Hsiung Chang Cheng-Hsin Chu Tsang-En Wang | 2003 | World Journal of Gastroenterology2003，9，3： | 26 |
| 18 | Effect of ginger Effect of ginger on gastric motility and symptoms of functional dyspepsiaon gastric motility and symptoms of functional dyspepsia显示文摘AIM:To evaluate the effects of ginger on gastric motility and emptying,abdominal symptoms,and hormones that influence motility in dyspepsia.METHODS:Eleven patients with functional dyspepsia were studied twice in a randomized double-blind manner.After an 8-h fast,the patients ingested three capsules that contained ginger(total 1.2 g) or placebo,followed after 1 h by 500 mL low-nutrient soup.Antral area,fundus area and diameter,and the frequency of antral contractions were measured using ultrasound at frequent intervals,and the gastric half-emptying time was calculated from the change in antral area.Gastrointestinal sensations and appetite were scored using visual analog questionnaires,and blood was taken for measurement of plasma glucagon-like peptide-1(GLP-1),motilin and ghrelin concentrations,at intervals throughout the study.RESULTS:Gastric emptying was more rapid after ginger than placebo [median(range) half-emptying time 12.3(8.5-17.0) min after ginger,16.1(8.3-22.6) min after placebo,P ≤ 0.05].There was a trend for more antral contractions(P = 0.06),but fundus dimensions and gastrointestinal symptoms did not differ,nor did serum concentrations of GLP-1,motilin and ghrelin.CONCLUSION:Ginger stimulated gastric emptying and antral contractions in patients with functional dyspepsia,but had no impact on gastrointestinal symptoms or gut peptides. | Ming-Luen Hu Christophan K Rayner Keng-Liang Wu Seng-Kee Chuah Wei-Chen Tai Yeh-Pin Chou Yi-Chun Chiu King-Wah Chiu Tsung-Hui Hu | 2011 | World Journal of Gastroenterology2011，17，1： | 19 |
| 19 | Transcatheter arterial embolization treatment in patients with hepatocellular carcinoma and risk of pulmonary metastasis显示文摘AIM: To investigate the relationship between transcatheterarterial embolization (TAE) and pulmonary metastasis insubjects with hepatocellular carcinoma (HCC).
METHODS: A total of 287 patients with HCC followed upfor more than 1 week were included. 102 patients underwenttranscatheter arterial embolization (TAE group) and 185received conservative treatment(control group). Thepatients' chest x-rays and chest CT scans were examinedfor pulmonary metastasis.RESULTS: Patients with TAE had a median survival of 19.3months while that of the control group was only 10.0 months(P<0.05). Pulmonary metastasis occurred in 14 (13.7 %)patients in the TAE group and 14 (7.6 %) patients in the control group, there was no significant difference (P>0.05).The 1-year, 2-year and 5-year cumulative incidence of pulmonary metastasis was 11.8 %, 17.6 % and 24.0 % in the TAE group and 7.0 %, 13.0 % and 21.7 % in the control group, respectively (P>0.05). On the univariate analysis,tumor size, abnormal serum alanine aminotransferase levels and heterogeneity on sonography were significantly associated with pulmonary metastasis. However, on the multivariate analysis, only tumor size was significantly predictive of pulmonary metastasis.CONCLUSION: TAE is effective on prolonging survival of patients with HCC. It does not significantly increase the risk of pulmonary metastasis. Tumor size is the only significant predictive factor associated with lung metastasis. | Shee-Chan Lin Shou-Chuan Shih Chin-Roa Kao Sun-Yen Chou | 2003 | World Journal of Gastroenterology2003，9，6： | 18 |
| 20 | Strategy and methodology of dynamical analogue prediction显示文摘In order to effectively improve numerical prediction level by using current models and data, the strategy and methodology of dynamical analogue prediction (DAP) is deeply studied in the present paper. A new idea to predict the prediction errors of dynamical model on the basis of historical analogue information is put forward so as to transform the dynamical prediction problem into the estimation problem of prediction errors. In terms of such an idea, a new prediction method of final analogue correction of errors (FACE) is developed. Furthermore, the FACE is applied to extra-seasonal prediction experiments on an operational atmosphere-ocean coupled general circulation model. Prediction results of summer mean circulation and total precipitation show that the FACE can to some extent reduce prediction errors, recover prediction variances, and improve prediction skills. Besides, sensitive experiments also show that predictions based on the FACE are evidently influenced by the number of analogues, analogue-selected variables and analogy metric. | REN HongLi1,2? & CHOU JiFan1 1 College of Atmospheric Sciences, Lanzhou University, Lanzhou 730000, China 2 Laboratory for Climate Studies, National Climate Center, China Meteorological Administration, Beijing 100081, China | 2007 | Science China Earth Sciences2007，50，10： | 17 |
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