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| 1 | SlMYB75,an MYB-type transcription factor,promotes anthocyanin accumulation and enhances volatile aroma production in tomato fruits显示文摘Genetic manipulation of genes to upregulate specific branches of metabolic pathways is a method that is commonly used to improve fruit quality.However,the use of a single gene to impact several metabolic pathways is difficult.Here,we show that overexpression of the single gene SlMYB75(SlMYB75-OE)is effective at improving multiple fruit quality traits.In these engineered fruits,the anthocyanin content reached 1.86mg g−1 fresh weight at the red-ripe stage,and these SlMYB75-OE tomatoes displayed a series of physiological changes,including delayed ripening and increased ethylene production.In addition to anthocyanin,the total contents of phenolics,flavonoids and soluble solids in SlMYB75-OE fruits were enhanced by 2.6,4,and 1.2 times,respectively,compared to those of wild-type(WT)fruits.Interestingly,a number of aroma volatiles,such as aldehyde,phenylpropanoid-derived and terpene volatiles,were significantly increased in SlMYB75-OE fruits,with some terpene volatiles showing more than 10 times higher levels than those in WT fruits.Consistent with the metabolic assessment,transcriptomic profiling indicated that the genes involved in the ethylene signaling,phenylpropanoid and isoprenoid pathways were greatly upregulated in SlMYB75-OE fruits.Yeast one-hybrid and transactivation assays revealed that SlMYB75 is able to directly bind to the MYBPLANT and MYBPZM cis-regulatory elements and to activate the promoters of the LOXC,AADC2 and TPS genes.The identification of SlMYB75 as a key regulator of fruit quality attributes through the transcriptional regulation of downstream genes involved in several metabolic pathways opens new avenues towards engineering fruits with a higher sensory and nutritional quality. | Wei Jian Haohao Cao Shu Yuan Yudong Liu Juanfang Lu Wang Lu Ning Li Jianhui Wang Jian Zou Ning Tang Chan Xu Yulin Cheng Yanqiang Gao Wanpeng Xi Mondher Bouzayen Zhengguo Li | 2019 | Horticulture Research2019，6，1： | 39 |
| 2 | Effects of Traditional Chinese Medicine Shensong Yangxin Capsules on Heart Rhythm and Function in Congestive Heart Failure Patients with Frequent Ventricular Premature Complexes:A Randomized, Double-blind, Multicenter Clinical Trial显示文摘 | Xi Wang Dan HU Song Dang He Huang Cong-Xin Huang Ming-Jie Yuan Yan-Hong Tang Qing-Shan Zheng Fang Yin Shu Zhang Bo-Li Zhang Run-Lin Gao | 2017 | Chinese Medical Journal2017，，14： | 33 |
| 3 | Case-based learning in education of Traditional Chinese Medicine: a systematic review显示文摘OBJECTIVE:To assess the effect of case-based learning(CBL)in the education of Traditional Chinese Medicine(TCM).METHODS:The studies concerning TCM courses designed with CBL were included by searching the databases of EBSCO,Pubmed,Science Citation Index,China National Knowledge Infrastructure,Chongqing VIP database.The valid data was extracted in accordance with the included criteria.The quality of the studies was assessed with Gemma Flores-Masteo.RESULTS:A total of 22 articles were retrieved that met the selection criteria:one was of high quality;two were of low quality;the rest were categorized as moderate quality.The majority of the studiesdemonstrated the better effect produced by CBL,while a few studies showed no difference,compared with the didactic format.All included studies confirmed the favorable effect on learners'attitude,skills and ability.CONCLUSION:CBL showed the desirable results in achieving the goal of learning.Compared to didactic approach,it played a more active role in promoting students'competency.Since the quality of the articles on which the study was based was not so high,the findings still need further research to become substantiated. | Ji Chen Ying Li Yong Tang Fang Zeng Xi Wu Fanrong Liang | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 30 |
| 4 | Behaviors and kinetics of toluene adsorption-desorption on activated carbons with varying pore structure显示文摘This work was undertaken to investigate the behaviors and kinetics of toluene adsorption and desorption on activated carbons with varying pore structure. Five kinds of activated carbon from different raw materials were selected. Adsorption isotherms and breakthrough curves for toluene were measured. Langmuir and Freundlich equations were fitted to the equilibrium data, and the Freundlich equation was more suitable for simulating toluene adsorption. The process consisted of monolayer, multilayer and partial active site adsorption types. The effect of the pore structure of the activated carbons on toluene adsorption capacity was investigated. The quasi-first-order model was more suitable for describing the process than the quasi-second-order model. The adsorption data was also modeled by the internal particle diffusion model and it was found that the adsorption process could be divided into three stages. In the external surface adsorption process, the rate depended on the specific surface area. During the particle diffusion stage, pore structure and volume were the main factors affecting adsorption rate. In the final equilibrium stage, the rate was determined by the ratio of meso-and macro-pores to total pore volume. The rate over the whole adsorption process was dominated by the toluene concentration. The desorption behavior of toluene on activated carbons was investigated,and the process was divided into heat and mass transfer parts corresponding to emission and diffusion mechanisms, respectively. Physical adsorption played the main role during the adsorption process. | Xi Yang Honghong Yi Xiaolong Tang Shunzheng Zhao Zhongyu Yang Yueqiang Ma Tiecheng Feng Xiaoxu Cui | 2018 | Journal of Environmental Sciences2018，30，5： | 28 |
| 5 | Evaluation of Seven Function-Known Candidate Genes for their Effects on Improving Drought Resistance of Transgenic Rice under Field Conditions显示文摘许多强调应答的基因在在温室条件下面在模型植物改进压力抵抗上与效果被报导了。向为干旱抵抗繁殖的基因的鉴定,七很好记录了基因( CBF3 , SOS2 , NCED2 , NPK1 , LOS5 , ZAT10 ,并且 NHX1 )在应力,抵抗在这研究被选择并且在组成的倡导者 Actin1 和一个米饭 HVA22 相当或相同的事物,和转基因的米饭的压力可诱导的倡导者的控制下面转变了成米饭栽培变种 Zhonghua 11 在领域条件下面为干旱抵抗被测试。1598 独立转基因的 T0 植物的一个总数被产生。transgenes 的单个拷贝和表示的百分比分别地是 36.7% 和 57.6% 。为每基因构造,有 transgene 的表示的 30 个 T1 家庭为在领域里在繁殖阶段测试的干旱抵抗被选择,并且他们中的 10 个在一样的阶段与一个定义压力协议在 PVC 管子中被测试。相对产量和相对小穗状花小穗富饶被用作二个主要标准因为显著地减少的产量在 T1 产生被观察,评估干旱抵抗性能。八构造的转基因的家庭( HVA22P : CBF3 , HVA22P : NPK1 , Actin1 : LOS5 , HVA22P : LOS5 , Actin1 : ZAT10 , HVA22P : ZAT10 , Actin1 : NHX1 ,并且 HVA22P : NHX1 )比的显示出显著地更高的 RY 野类型( WT )在两个干旱压力下面,地和 PVC 试管调节。9 构造的转基因的家庭(HVA22P : 由两个倡导者的 SOS2 和 CBF3, LOS5, ZAT10,和 NHX1 ) 在这块地或 PVC 管子里比 WT 显示出显著地更高的相对小穗状花小穗富饶。在 T2 测试的地干旱抵抗,家庭们与相对更低的收益减少源于 T1 家庭,七构造的转基因的家庭( HVA22P : CBF3 , Actin1 : NPK1 , HVA22P : NPK1 , Actin1 : LOS5 , HVA22P : LOS5 , Actin1 : ZAT10 ,并且 HVA22P : ZAT10 )比九构造的 WT ,和家庭每工厂显示出显著地更高的产量( Actin1 : CBF3 , HVA22P : CBF3 , HVA22P : SOS2 , HVA22P : NPK1 , Actin1 : LOS5 , HVA22P : LOS5 , Actin1 : ZAT10 , HVA22P : ZAT10 ,并且 Actin1 : NHX1 )比 WT 有更高的小穗状花小穗富饶。一般来说, LOS5 和 ZAT10 在在地条件下面改进转基因的大米的干旱抵抗比另外的五基因显示出相对更好的效果。从这研究获得的结果和经验能是为在米饭设计的干旱抵抗的一本有用参考书。 | Ben-Ze Xiao Xi Chen Cheng-Bin Xiang Ning Tang Qi-Fa Zhang Li-Zhong Xiong | 2009 | Molecular Plant2009，2，1： | 24 |
| 6 | Effect of severe acute pancreatitis on pharmacokinetics of Da-Cheng-Qi Decoction components显示文摘AIM:To investigate the effect of severe acute pan- creatitis(SAP)on pharmacokinetics of Da-Cheng-Qi Decoction(DCQD)components in rats. METHODS:Rats were divided into SAP group and sham-operation group as a control group(n=6). Rhein,chrysophanol,rheochrysidin,magnolol,hesperidin and naringin in DCQD were quantified in rat serum by high performance liquid chromatography tandem mass spectrometry for studying their pharmacokinetics. RESULTS:Early absorption of each DCQD component was tended to degrade in SAP group after treatment with DCQD by gavage.The Cmax(chrysophanol,P= 0.0059;rheochrysidin,P=0.0288;magnolol,P= 0.0487;hesperidin,P=0.0277;naringin,P=0.0023) and AUC(rhein,P=0.0186;chrysophanol,P=0.0013; magnolol,P=0.001;hesperidin,P=0.0081;naringin, P=0.0272)of DCQD component were obviously lower in SAP group than in control group.The T1/2α of chrysophanol and rheochrysidin(P=0.0467 and 0.0005,respectively)and Tmax of chrysophanol and rheochrysidin(P=0.0101 and 0.0037,respectively) lasted longer in SAP group than in control group. CONCLUSION:SAP can significantly impact the ab-sorption of DCQD components in rats and their phar-macokinetic parameters. | Han-Lin Gong Wen-Fu Tang Qin Yu Jin Xiang Qing xia Guang-Yuan Chen Xi Huang Mao-Zhi Liang | 2009 | World Journal of Gastroenterology2009，15，47： | 16 |
| 7 | Identification of mouse liver mitochondria-associated miRNAs and their potential biological functions显示文摘 | Zhen Bian Li-Min Li Rui Tang Dong-Xia Hou Xi Chen Chen-Yu Zhang Ke Zen | 2010 | Cell Research2010，20，9： | 15 |
| 8 | Artemisinin derivatives prevent obesity by inducing browning of WAT and enhancing BAT function显示文摘 | Ping Lu Fu-chuang Zhang Shu-wen Qian Xi Li Zhao-meng Cui Yong-jun Dang Qi-qun Tang | 2016 | Cell Research2016，26，10： | 15 |
| 9 | Effect of Shensong Yangxin on the Progression of Paroxysmal Atrial Fibrillation is Correlated with Regulation of Autonomic Nerve Activity显示文摘 | Hong-Yi Zhao Shu-Di Zhang Kai Zhang Xi Wang Qing-Yan Zhao Shu-Juan Zhang Zi-Xuan Dai Yong-Sheng Qian You-Jing Zhang Hao-Tian Wei Yan-Hong Tang Cong-Xin Huang | 2017 | Chinese Medical Journal2017，，2： | 15 |
| 10 | High HIV incidence epidemic among men who have sex with men in china: results from a multi-site cross-sectional study显示文摘Background:Recent upsurge of new HIV infections among men who have sex with men(MSM)is a major concern in China.Paucity of national-level information regarding the burden and predictors of this progressive epidemic of new infections called for a multi-centric,timely and comprehensive investigation.Methods:Mixed methods were used to recruit MSM from seven cities in China between 2012 and 2013.Recent and established HIV infections were estimated by Western Blot and BED HIV-1 capture enzyme immunoassay.Syphilis and herpes simplex virus-2(HSV-2)were also tested.Results:A total of 4496 eligible MSM were recruited.The majority was aged≤35 years(77.5%),migrants(60.3%),never married(69.8%),and played receptive role in anal sex(70.5%).The HIV prevalence was 9.9%,and 41.9%were recently infected,with sensitivity/specificity adjusted HIV incidence of 8.9(95%CI:7.6-10.2)/100 Person-Years.The prevalence of history HSV-2 and syphilis were 12.5%and 8.5%,respectively.Recent HIV infection was associated with having multiple male partners(aOR=1.4,95%CI 1.1-1.9),recreational drug use(aOR=2.2,95%CI 1.6-3.0),anal bleeding(aOR=2.1,95%CI 1.4-3.0),syphilis infection(aOR=2.8,95%CI 1.9-4.3)and history HSV-2 infection(aOR=2.3,95%CI 1.5-3.3).Conclusion:High rate of recent HIV infection is potentially resulting in progressive deterioration of the overall HIV epidemic among MSM in China.Targeted interventions to address high-risk MSM including those having multiple partners,history of recreational drug use and syphilis or HSV-2 infection seemed to be the need of the hour. | Jun-Jie Xu Wei-Ming Tang Hua-Chun Zou Tanmay Mahapatra Qing-Hai Hu Geng-Feng Fu Zhe Wang Lin Lu Ming-Hua Zhuang Xi Chen Ji-Hua Fu Yan-Qiu Yu Jin-Xin Lu Yong-Jun Jiang Wen-Qing Geng Xiao-Xu Han Hong Shang | 2016 | Infectious Diseases of Poverty2016，5，1： | 14 |
| 11 | Evaluation on the accuracy of digital elevation models显示文摘There is a growing interest in investigating the accuracy of digital elevation model (DEM). However people usually have an unbalanced view on DEM errors. They emphasize DEM sampling errors, but ignore the impact of DEM resolution and terrain roughness on the accuracy of terrain representation. This research puts forward the concept of DEM terrain representation error (Et) and then investigates the generation, factors, measurement and simulation of DEM terrain representation errors. A multi-resolution and multi-relief comparative approach is used as the major methodology in this research. The experiment reveals a quantitative relationship between the error and the variation of resolution and terrain roughness at a global level. Root mean square error (RMS Et) is regressed against surface profile curvature (V) and DEM resolution (R) at 10 resolution levels. It is found that the RMS Et may be expressed as RMS Et = (0.0061 ( V+ 0.0052) ( R - 0.022 ( V + 0.2415. This result may be very useful in forecasting DEM accuracy, as well as in determining the DEM resolution related to the accuracy requirement of particular application. | TANG Guo-an~1, Josef Strobl~2, GONG Jian-ya~3, ZHAO Mu-dan~1, CHEN Zhen-jiang~1 (1. Department of Geography, Northwest University, Xi’an 710069, China 2. Department of Geography and Geoinformation, Salzburg University, Hellbrunnerstr. 34, A-5020 Salzb | 2001 | Journal of Geographical Sciences2001，11，2： | 13 |
| 12 | A multicenter hospital-based diagnosis study of automated breast ultrasound system in detecting breast cancer among Chinese women显示文摘Objective: The automated breast ultrasound system(ABUS) is a potential method for breast cancer detection;however, its diagnostic performance remains unclear. We conducted a hospital-based multicenter diagnostic study to evaluate the clinical performance of the ABUS for breast cancer detection by comparing it to handheld ultrasound(HHUS) and mammography(MG).Methods: Eligible participants underwent HHUS and ABUS testing; women aged 40–69 years additionally underwent MG. Images were interpreted using the Breast Imaging Reporting and Data System(BI-RADS).Women in the BI-RADS categories 1–2 were considered negative. Women classified as BI-RADS 3 underwent magnetic resonance imaging to distinguish true-and false-negative results. Core aspiration or surgical biopsy was performed in women classified as BI-RADS 4–5, followed by a pathological diagnosis. Kappa values and agreement rates were calculated between ABUS, HHUS and MG.Results: A total of 1,973 women were included in the final analysis. Of these, 1,353(68.6%) and 620(31.4%)were classified as BI-RADS categories 1–3 and 4–5, respectively. In the older age group, the agreement rate and Kappa value between the ABUS and HHUS were 94.0% and 0.860(P<0.001), respectively; they were 89.2% and0.735(P<0.001) between the ABUS and MG, respectively. Regarding consistency between imaging and pathology results, 78.6% of women classified as BI-RADS 4–5 based on the ABUS were diagnosed with precancerous lesions or cancer; which was 7.2% higher than that of women based on HHUS. For BI-RADS 1–2, the false-negative rates of the ABUS and HHUS were almost identical and were much lower than those of MG.Conclusions: We observed a good diagnostic reliability for the ABUS. Considering its performance for breast cancer detection in women with high-density breasts and its lower operator dependence, the ABUS is a promising option for breast cancer detection in China. | Xi Zhang Xi Lin Yanjuan Tan Ying Zhu Hui Wang Ruimei Feng Guoxue Tang Xiang Zhou Anhua Li Youlin Qiao | 2018 | Chinese Journal of Cancer Research2018，30，2： | 13 |
| 13 | Saline soil enzyme activities of four plant communities in Sangong River basin of Xinjiang,China显示文摘Soil enzyme activity plays an important role in the conversion of soil organic carbon into inorganic carbon,which is significant for the global carbon cycle.In this study,we investigated the soil enzyme activities of two ligninolytic enzymes(peroxidase and polyphenol oxidase)and five non-ligninolytic enzymes(α-1,4-glucosidase(AG);β-1,4-glucosidase(BG);N-acetyl-β-glucosaminidase(NAG);β-D-cellobiosidase(CBH);andβ-xylosidase(BXYL))in four plant communities of the Sangong River basin in Fukang,North Xinjiang,China.The four typical plant communities were dominated by Haloxylon ammodendron,Reaumuria soongonica,Salsola passerina,and Tamarix rarmosissima,respectively,with saline soils of varied alkalinity.The results showed that the soil peroxidase activity decreased seasonally.The activities of the five non-ligninolytic enzymes decreased with increasing soil depths,while those of the two ligninolytic enzymes did not show such a trend.In the four plant communities,BG had the highest activity among the five non-ligninolytic enzymes,and the activities of the two ligninolytic enzymes were higher than those of the four non-ligninolytic ones(AG,NAG,CBH,and BXYL).The community of H.ammodendron displayed the highest activity with respect to the two ligninolytic enzymes in most cases,but no significant differences were found among the four plant communities.The geometric mean of soil enzyme activities of the four plant communities was validated through an independently performed principal component analysis(PCA),which indicated that different plant communities had different soil enzyme activities.The correlation analysis showed that soil polyphenol oxidase activity was significantly positively correlated with the activities of the five non-ligninolytic enzymes.The soil pH value was positively correlated with the activities of all soil enzymes except peroxidase.Soil microbial carbon content also showed a significant positive correlation(P<0.01)with the activities of all soil enzymes except polyphenol oxidase.The results suggested that the H.ammodendron community has the highest ability to utilize soil organic carbon,and glucoside could be the most extensively utilized non-ligninolytic carbon source in the saline soil of arid areas in Xinjiang. | ZhengJun GUAN Qian LUO Xi CHEN XianWei FENG ZhiXi TANG Wei WEI YuanRun ZHENG | 2014 | Journal of Arid Land2014，6，2： | 11 |
| 14 | Outcomes in refractory diffuse large B-cell lymphoma:results fromamulticenter real-world study in China显示文摘Background:Diffuse large B-cell lymphoma(DLBCL)patients refractory to rituximab-based immunochemotherapy have a dismal prognosis.However,the definition of refractory DLBCL remains inconsistent and no large cohort study data is available from Asian countries.To validate the definition and outcomes of refractory DLBCL in China,we conducted a multicenter,retrospective cohort study.Methods:The REtrospective AnaLysis of Treatment REspoNse of refractory DLBCL(REAL-TREND)study was performed using real-world data from 8 centers in China.DLBCL patients with curative intent were included in the REAL-TREND dataset.Overall survival(OS)was estimated using the Kaplan-Meier method and compared by the log-rank test.Due to heterogeneity in response rates among different centers,the response rates of refractory patients were pooled using random-effect models.Multivariate survival analysis was performed using the Cox regression model.Results:A total of 2778 DLBCL patients diagnosed between January,2010 and December,2015 were enrolled to this study.After validating previous definitions,the SCHOLAR-1 study was most suitable to define refractory DLBCL.The estimated 5-year cumulative incidence of refractory patients was 20%(95% confidence Interval[CI]=18%-22%).After the determination of refractory disease,overall response rate and complete remission rate were 30%(95%CI=22%-38%)and 9%(95%CI=4%-15%),respectively.Patients with either no response to immunochemotherapy or relapse within 12 months after stem-cell transplantation had inferior survival with a median OS of 5.9 months(95%CI=5.5-7.1 months)and 2-year OS rate of 16%(95%CI=12%-20%).International prognostic index score 4-5(hazard ratio[HR]=2.22;95%CI=1.47-3.35),central nervous systemrelapse(HR=1.43;95%CI=1.04-1.97),and best response status(HR=2.68;95%CI=1.42-5.03 for partial remission.HR=5.97,95%CI=3.21-11.11 for stable disease/progressive disease)were independent unfavorable prognostic factors.Conclusions:This is the first large-scale Asian cohort study focusing on outcomes of refractory DLBCL.The definition of the SCHOLAR-1 study identifies patients with homogenously inferior survival,thus is appropriate to select refractory DLBCL.Due to poor clinical outcomes in the rituximab era,patients with refractory DLBCL may be potential candidates for novel treatment modalities. | Shuo Wang Li Wang Jianda Hu Wenbin Qian Xi Zhang Yu Hu Qi Zhu Bobin Chen Depei Wu Chung-Chou H.Chang Pengpeng Xu Xiaoyun Zheng Juying Wei Yao Liu Guohui Cui Yong Tang Yan Ma Haiwen Huang Hongmei Yi Weili Zhao | 2021 | Cancer Communications2021，41，3： | 10 |
| 15 | Extraction, identification, and antioxidant property evaluation of limonin from pummelo seeds显示文摘Limonin, the main bioactive phytochemical constituent of limonoids with multi-functions, is enriched in citrus fruits and often found at a high concentration in citrus seeds. The present study was attempted to introduce a new and efficient extraction method to isolate limonoids from pummelo seeds, and to evaluate the antioxidant property of the main constituent limonin in Hep G2 cells. Three key single factors were identified for the extraction of limonoids from pummelo seeds using the Box-Behnken experiment design of response surface methodology(RSM), and the optimized extraction parameters were treatment with 89.68 m L of anhydrous acetone for 4.62 h at 78.94C, while the yield of limonoids was 11.52 mg/g. The structure of isolated main constituent of the limonoids was further identified as limonin by Fourier transform infrared(FT-IR) spectrometer and nuclear magnetic resonance(NMR)spectrum. Moreover, the molecular data in Hep G2 cells revealed that limonin exerted its anti-oxidant property mainly by the activation of nuclear factor(erythroid-2)-like 2(Nrf2)/kelch-like ECHassociated protein 1(Keap1)-antioxidant response element(ARE) pathway in the form of transcriptional regulation of Nrf2 m RNA and posttranscriptional regulation of Nrf2/Keap1 system. These results demonstrate that pummelo seeds are an ideal source of limonoids, and limonin is proved to exert its anti-oxidant property by the activation of Nrf2/Keap1 pathway. | Si Qin Chenghao Lv Qingshan Wang Zhibing Zheng Xi Sun Minyi Tang Fangming Deng | 2018 | Animal Nutrition2018，，3： | 10 |
| 16 | A fnite element parametric modeling technique of aircraft wing structures显示文摘A fnite element parametric modeling method of aircraft wing structures is proposed in this paper because of time-consuming characteristics of fnite element analysis pre-processing.The main research is positioned during the preliminary design phase of aircraft structures.A knowledgedriven system of fast fnite element modeling is built.Based on this method,employing a template parametric technique,knowledge including design methods,rules,and expert experience in the process of modeling is encapsulated and a fnite element model is established automatically,which greatly improves the speed,accuracy,and standardization degree of modeling.Skeleton model,geometric mesh model,and fnite element model including fnite element mesh and property data are established on parametric description and automatic update.The outcomes of research show that the method settles a series of problems of parameter association and model update in the process of fnite element modeling which establishes a key technical basis for fnite element parametric analysis and optimization design. | Tang Jiapeng Xi Ping Zhang Baoyuan Hu Bifu | 2013 | Chinese Journal of Aeronautics2013，26，5： | 9 |
| 17 | Effects of continuous intermedin infusion on blood pressure and hemodynamic function in spontaneously hypertensive rats显示文摘ObjectiveTo 检验外长地管理的 intermedin 的效果( IMD , adrenomedullin-2 )在动脉的血压上,在自发地高血压的老鼠( SHR )象一样的心脏的功能和心血管的 IMD 受体系统星期旧的雄的老鼠在 Wistar 京都( WKY )组被划分调查联系 mechanisms.MethodsThirteen ( n = 12 ), SHR 组( n = 12 ), IMD 组( SHR 每小时与 IMD 1-47 灌输了 500 ng/kg , n = 12 ),并且 ADM 组(与 adrenomedullin 灌输的 SHR 500 ng/kg 每dp/dt 最大 ), 在 SHR 离开了室的收缩压力和心率。而且, IMD 也禁止了心血管的 IMD 受体,心肌的受体修改活动的蛋白质(RAMP1 和 RAMP2 ) ,大动脉的 RAMP1, RAMP2, RAMP3,和 calcitonin 的蛋白质在表示上像受体的受体(CRLR ) ;大动脉的 RAMP1, RAMP2, RAMP3 和 CRLR 基因表示的压制的起来规定;并且显著地提高了 mRNA 许多心肌的 atrial natriuretic 肽(ANP ) 和心肌的大脑 natriuretic 肽(BNP ) 。另外,在 SHR 的 IMD 1-47 管理增加了大动脉的营地集中和减少的心肌的营地 concentration.ConclusionThese 调查结果支持作为心血管的活跃的肽, IMD 在高血压期间涉及血压减小和心脏的功能改善的推测。位于这效果下面的机制可以包含形成由的受体建筑群有约束力的 IMD 斜面和 CRLR,和营地层次和另外的心血管的活跃因素的结果的规定,例如 ANP 和 BNP。 | Ying Yuan Xi Wang Qiang Zeng Hong-Mei Wu Yong-Fen Qi Chao-Shu Tang | 2012 | Journal of Geriatric Cardiology2012，9，1： | 9 |
| 18 | Plasma metabolomic and lipidomic alterations associated with COVID-19显示文摘The pandemic of the coronavirus disease 2019(COVID-19)has become a global public health crisis.The symptoms of COVID-19 range from mild to severe,but the physiological changes associated with COVID-19 are barely understood.In this study,we performed targeted metabolomic and lipidomic analyses of plasma from a cohort of patients with COVID-19 who had experienced different symptoms.We found that metabolite and lipid alterations exhibit apparent correlation with the course of disease in these patients,indicating that the development of COVID-19 affected their whole-body metabolism.In particular,malic acid of the TCA cycle and carbamoyl phosphate of the urea cycle result in altered energy metabolism and hepatic dysfunction,respectively.It should be noted that carbamoyl phosphate is profoundly down-regulated in patients who died compared with patients with mild symptoms.And,more importantly,guanosine monophosphate(GMP),which is mediated not only by GMP synthase but also by CD39 and CD73,is significantly changed between healthy subjects and patients with COVID-19,as well as between the mild and fatal cases.In addition,dyslipidemia was observed in patients with COVID-19.Overall,the disturbed metabolic patterns have been found to align with the progress and severity of COVID-19.This work provides valuable knowledge about plasma biomarkers associated with COVID-19 and potential therapeutic targets,as well as an important resource for further studies of the pathogenesis of COVID-19. | Di Wu Ting Shu Xiaobo Yang Jian-Xin Song Mingliang Zhang Chengye Yao Wen Liu Muhan Huang Yuan Yu Qingyu Yang Tingju Zhu Jiqian Xu Jingfang Mu Yaxin Wang Hong Wang Tang Tang Yujie Ren Yongran Wu Shu-Hai Lin Yang Qiu Ding-Yu Zhang You Shang Xi Zhou | 2020 | National Science Review2020，7，7： | 9 |
| 19 | Anomaly Models of Spatial Structures for Copper-Molybdenum Ore Deposits and their Application显示文摘This paper discusses the enrichment and depletion regularities for porphyry copper-molybdenum ore deposits in different regions and varied deposit genetic types in the same area, taking three porphyry copper-molybdenum ore deposits (i.e., the Chengmenshan in Jiangxi, Wunugetushan in Inner Mongolia, Baishantang in Gansu) and two copper deposits in Gansu Province (the Huitongshan skarn deposit and Gongpoquan composite deposit) as case studies. The results show that porphyry Cu-Mo deposits or skarn copper deposits include both enrichment of the ore-forming elements and associated elements, and depletion of some lithophile dispersed elements, rare earth elements (REE) and some major elements. And the depleted elements vary with deposits, having generality and their own features. On a deposit scale, the positive anomalies of enriched elements and negative anomalies of depleted elements follow in a sequence to comprise regular anomaly models of spatial structures. The exploration in the Tongchang deposit in Jiangxi and Huitongshan deposit in Gansu suggests that anomaly models play a key role in the identification of mineral occurrences and deposits compared to one single enriched element anomaly. And the anomaly models exert a critical effect on the optimization of prospecting targets and their potential evaluation. | MA Shengming ZHU Lixin LIU Chongmin XI Mingjie TANG Shixin | 2013 | Acta Geologica Sinica(English Edition)2013，87，3： | 9 |
| 20 | 西安北郊龙首村西汉墓发掘简报显示文摘1991年夏季,中国社会科学院考古研究所在西安北郊龙首村发掘了两座西汉墓。其中一座(M2)保存较好,为带斜坡墓道的土洞墓。M2南北总长19.88米,由墓道、甬道、耳室、墓室四部分组成,出有陶、铜、铁、银器等随葬品。其中,最重要的是贴饰金银的铁甲胄的发现,对西安关中地区汉墓的研究增添了新资料。 | Xi’an Tang City Archaeological Team, IA, CASS, | 2002 | 考古2002，，5： | 8 |
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