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| 1 | A reactive oxygen species burst causes haploid induction in maize显示文摘Haploid induction (HI) is an important tool in crop breeding. Phospholipase A1 (ZmPLA1)/NOT LIKE DAD (NLD)/MATRILINEAL (MTL) is a key gene controlling HI in maize;however, the underlying molecular mechanism remains unclear. In this study, to dissect why loss of ZmPLA1 function could mediate HI we performed a comprehensive multiple omics analysis of zmpla1 mutant anthers by integrating transcriptome, metabolome, quantitative proteome, and protein modification data. Functional classes of significantly enriched or differentially abundant molecular entities were found to be associated with the oxidative stress response, suggesting that a reactive oxygen species (ROS) burst plays a critical role in HI. In support of this, we further discovered that a simple chemical treatment of pollen with ROS reagents could lead to HI. Moreover, we identified ZmPOD65, which encodes a sperm-specific peroxidase, as a new gene controlling HI. Taken together, our study revealed a likely mechanism of HI, discovered a new gene controlling HI, and created a new method for HI in maize, indicating the importance of ROS balance in maintaining normal reproduction and providing a potential route to accelerate crop breeding. | Chenglin Jiang Ju Sun Rui Li Shijuan Yan Wei Chen Liang Guo Guochen Qin Pengcheng Wang Cheng Luo Wenjie Huang Qinghua Zhang Alisdair R.Fernie David Jackson Xiang Li Jianbing Yan | 2022 | Molecular Plant2022，15，6： | 2 |
| 2 | The effects of the source composition on the origin of orthopyroxenebearing adakitic granitoid in West Qinling,Central China显示文摘Orthopyroxene-bearing granodiorite(sometimes referred to as‘charnockite’)with an adakitic affinity is a rare type of granitoid.It is generally accepted that the stabilization of orthopyroxene in igneous charnockites essentially requires low aH_(2)O and/or high temperatures in a closed system.However,orthopyroxene can be an antecryst in a trans-crustal magmatic system.In this regard,orthopyroxenebearing granitoids are somewhat analogous to pseudo-charnockites,where the orthopyroxene stems from a mafic reservoir.On the other hand,the source compositions of continental adakites can vary,which is often ignored in the interpretation of their contribution to the adakitic geochemical signature.In this study,we have investigated a rare orthopyroxene-bearing felsic pluton from the Zhuyuan area of West Qinling,Central China.The Zhuyuan pluton was emplaced in the Middle–Late Triassic(222–217 Ma)and is mainly composed of metaluminous to weakly peraluminous granodiorites belonging to the high-K calc-alkaline series.Moreover,they are characterized by high Mg#values(49.7–60.9)and Sr contents(471–697 ppm),low Y(12.2–15.4 ppm)and Yb(1.03–1.24 ppm)contents,high Sr/Y(33.2–46.2)and(La/Yb)_(N)(15.3–21.4)ratios,and weakly negative Eu anomalies(Eu/Eu^(*)=0.78–0.89).The Zhuyuan adakitic granodiorites exhibit fairly limited Sr–Nd–Pb isotopic ratios and variable zircon initial Hf isotopes,indicating a major contribution from the Neoproterozoic basement of the Qinling Orogenic Belt.There is no evidence of any formation through high-pressure magmatic processes,and we propose that the adakitic signature of the Zhuyuan pluton could have been inherited from its source rocks(i.e.,from the Neoproterozoic basement).The orthopyroxenes in the Zhuyuan granodiorites display poikilitic textures with high MgO,NiO and Cr_(2)O_(3) contents,indicating that they have an antecrystic origin.Studies of regional tectonic evolution have shown that the Zhuyuan granodiorites formed during the tearing stage of the A’nimaque–Mianlue oceanic subduction slab.Therefore,this study emphasizes the effect of source inheritance on the formation of pseudo-charnockite with an adakitic signature. | Yuanhui Xie Xiaowei Li Xuanxue Mo Guochen Dong Yuqin Sun Wei Shan | 2023 | Geoscience Frontiers2023，14，3： | 1 |
| 3 | Magnetic resonance diffusion tensor imaging-based evaluation of optic-radiation shape and position in meningioma显示文摘Employing magnetic resonance diffusion tensor imaging, three-dimensional white-matter imaging and conventional magnetic resonance imaging can demonstrate the tumor parenchyma, peritumoral edema and compression on surrounding brain tissue. A color-coded tensor map and three-dimensional tracer diagram were applied to clearly display the optic-radiation location, course and damage. Results showed that the altered anisotropy values of meningioma patients corresponded with optic-radiation shape, size and position on both sides. Experimental findings indicate that the magnetic resonance diffusion tensor imaging technique is a means of tracing and clearly visualizing the optic radiation. | Xueming Lv Xiaolei Chen Bainan Xu Jiashu Zhang Gang Zheng Jinjiang Li Fangye Li Guochen Sun | 2012 | Neural Regeneration Research2012，7，9： | 1 |
| 4 | Characteristics of TP53 germline variants and their correlations with Li-Fraumeni syndrome or Li-Fraumeni-like syndrome in Chinese tumor patients显示文摘Li-Fraumeni syndrome(LFS),a rare autosomal-dominant inheritance condition,is associated with a family cancer history as well as pathogenic/likely-pathogenic TP53 germline variants(P/LP TP53 GV).The current clinical methods for detecting LFS are limited.Here,we retrospectively investigate P/LP TP53 GV among Chinese cancer patients by next-generation sequencing and evaluate its relationship with a family cancer history.A total of 270 out of 19,226 cancer patients have TP53 GV,including 53 patients with P/LP TP53 GV.Patients with P/LP TP53 GV are mainly found in male with glioma,lung cancer or sarcoma.The median age of diagnosis for P/LP TP53 GV patients is significantly lower than that of non-P/LP TP53 GV patients(31-years vs.53-years;P<0.01).One LFS patient and 3 Li-Fraumeni-like syndrome(LFL)patients are among the 26 followed-up P/LP TP53 GV patients.Among 25 types of P/LP TP53 GV,the highest variant frequencies occurred at codon 175 and 248.p.M237 I,p.R158 H,p.C238 Y and p.C275 R,are firstly identified among the Chinese LFS/LFL patients.This study reports the(P/LP)TP53 GV characteristics of Chinese pan-cancer patients.These findings suggest analyzing the P/LP TP53 GV in cancer patients is an effective strategy for identifying cancer predisposition syndrome. | Panwen Tian Xiaoyan Zhang Sheng Yang Yu Fang Hongling Yuan Wei Li Honglin Zhu Fangping Zhao Jinlei Ding Yunshu Zhu Sizhen Wang Guochen Sun Hongbin Ni Tonghui Ma Ting Lei | 2022 | Journal of Genetics and Genomics2022，49，7： | 0 |
| 5 | Smartphone-based rapid and visual pathological diagnosis of glioma using perovskite probes显示文摘Histopathology plays a great role in diagnosing various diseases,which is considered as a golden standard for tumor identification.The tissue constituents must be stained by visible labels for microscopic analysis by medical experts.However,this process is time-consuming,labor-intensive,and expensive,which requires rapid pathological approaches for diagnosis in the operating room.Here,we present an easy-to-process and high-performance perovskite biological probes for rapid and visual pathological diagnosis of glioma.Perovskite quantum dots can be encapsulated by the copolymer into nanocrystals(PNCs)with a diameter of 100 nm,which is modified with chlorotoxin to achieve the specific recognition of glioma.Benefiting from the super photoluminescence quantum yield(above 93%)of EVA@PNCs aqueous solution,the glioma can be clearly imaged and captured via a smartphone under the excitation of a handheld UV lamp.To demonstrate the visualization and efficiency of PNC probes,different malignant grades of brain tumor sections can be distinguished in no more than 5 min.This strategy provides a general auxiliary diagnosis platform for achieving the histopathology analysis near the operating bed,which is currently not feasible with standard histochemical staining methods. | Dongdong Wu Jimei Chi Junzhen Fan Lijun Cheng Xuning Wang Xu Yang Meng Zhang Zewei Lian Zengqi Huang Huadong Wang Hongfei Xie Sisi Chen Qi Pan Zeying Zhang Bingda Chen Guochen Sun Bainan Xu Meng Su Yanlin Song | 2023 | InfoMat2023，5，11： | 0 |
| 6 | Large-Scale Expensive Optimization with a Switching Strategy显示文摘Some optimization problems in scientific research,such as the robustness optimization for the Internet of Things and the neural architecture search,are large-scale in decision space and expensive for objective evaluation.In order to get a good solution in a limited budget for the large-scale expensive optimization,a random grouping strategy is adopted to divide the problem into some low-dimensional sub-problems.A surrogate model is then trained for each sub-problem using different strategies to select training data adaptively.After that,a dynamic infill criterion is proposed corresponding to the models currently used in the surrogate-assisted sub-problem optimization.Furthermore,an escape mechanism is proposed to keep the diversity of the population.The performance of the method is evaluated on CEC’2013 benchmark functions.Experimental results show that the algorithm has better performance in solving expensive large-scale optimization problems. | Mai Sun Chaoli Sun Xiaobo Li Guochen Zhang Farooq Akhtar | 2022 | Complex System Modeling and Simulation2022，2，3： | 0 |
| 7 | Petrogenesis of granitic pegmatite veins:Perspectives from major element and B isotope in tourmalines,Chakabeishan,Northern Tibetan Plateau显示文摘The petrogenesis of regionally zoned granitic pegmatite veins remains debated.Because of the economic significance,we carried out a study on the Chakabeishan(CKBS)pegmatite-type Li-Be deposit,eastern North Qaidam Tectonic Belt,Northern Tibetan Plateau,by means of in-situ major element and B isotope compositions of tourmalines in the beryl-bearing and spodumene-bearing pegmatite veins.Tourmalines(Tur-Be)from the beryl-bearing pegmatite are homogeneous schorl with low Mg/(Mg+Fe),high Na/(Na+Ca)and Y Al,suggesting that they are of magmatic origin.Two generations of tourmalines(TurLi)from the spodumene-bearing pegmatite are identified:(i)the crystal cores(mostly elbaite and Lirich schorl with subordinate schorl)are consistent with being of magmatic origin crystallized at the magmatic stage;(ii)the crystal rims(schorl)are best understood as the overgrowth at the later hydrothermal stage.Tur-Be and Tur-Li show an obvious difference in core-to-rim B isotopic variation trend with d11B decrease in Tur-Be and increase in Tur-Li.The core-to-rim d11B decrease in Tur-Be results from degassing during its host pegmatitic melt evolution,whereas the core-to-rim d11B increase in Tur-Li is related to fluid exsolution.The estimated d11B values for the initial melts of the beryl-bearing and spodumenebearing pegmatites are10.46‰and10.78‰,respectively,indicating that they most likely originate from protracted fractional crystallization/differentiation of granitic intrusions rather than partial melting of metapelite.Both Mg/(Mg+Fe)ratios and Li abundances in the cores of Tur-Be are lower than those of Tur-Li,suggesting that Tur-Li crystallizes from chemically more evolved melts. | Wenli Sun Zhidan Zhao Yaoling Niu Chunjing Wei Guochen Dong Xiaowei Li Wanming Yuan Tao Wang Bingzhang Wang Tong Pan Jie Han Hongliang Cao Yan Tang Dicheng Zhu | 2023 | Geoscience Frontiers2023，14，5： | 0 |
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