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| 1 | Folic acid supplementation inhibits recurrence of colorectal adenomas:A randomized chemoprevention trial显示文摘AIM: To determine whether folic acid supplementation will reduce the recurrence of colorectal adenomas, the precursors of colorectal cancer, we performed a double-blind placebo-controlled trial in patients with adenomatous polyps. METHODS: In the current double-blind, placebo-controlled trial at this VA Medical Center, patients with colorectal adenomas were randomly assigned to receive either a daily 5 mg dose of folic acid or a matched identical placebo for 3 years. All polyps were removed at baseline colonoscopy and each patient had a follow up colonoscopy at 3 years. The primary endpoint was a reduction in the number of recurrent adenomas at 3 years. RESULTS: Of 137 subjects, who were eligible after confirmation of polyp histology and run-in period to conform compliance, 94 completed the study; 49 in folic acid group and 45 in placebo group. Recurrence of adenomas at 3-year was compared between the two groups. The mean number of recurrent polyps at 3-year was 0.36 (SD, 0.69) for folic acid treated patients compared to 0.82 (SD, 1.17) for placebo treated subjects, resulting in a 3-fold increase in polyp recurrence in the placebo group. Patients below 70 years of age and those with left-sided colonicadenomas or advanced adenomas responded better to folic acid supplementation. CONCLUSION: High dose folic acid supplementation is associated with a signif icant reduction in the recurrence of colonic adenomas suggesting that folic acid may be an effective chemopreventive agent for colorectal neoplasia. | Richard Jaszewski Sabeena Misra Martin Tobi Nadeem Ullah Jo Ann Naumoff Omer Kucuk Edi Levi Bradley N Axelrod Bhaumik B Patel Adhip PN Majumdar | 2008 | World Journal of Gastroenterology2008，14，28： | 10 |
| 2 | Biosensor Technology addressing Agricultural Problems显示文摘 | Maria N Velasco Garcia Toby Mottram | 2003 | Biosystems Engineering2003，84，1： | 1 |
| 3 | Current status of pulmonary thromboembolic disease:pathophysiology,diagnosis,prevention and treatment显示文摘 | WILLIAM R TOBY L ALBUQUERQUE N | 1992 | Am H J1992，103，2： | 1 |
| 4 | The green tea polyphenol, epigallocatechin-3-gallate, protects against the oxidative cellular and genotoxic damage of UVA radiation显示文摘 | Tobi SE Gilbert M Paul N | 2002 | Int J Cancer2002，102，5： | 1 |
| 5 | On the relation between NDVI, fractional vegetation cover, and leaf area index 显示文摘 | Toby N Carlson David A Ripley | 1997 | Remote Sense Environ1997，62，： | 1 |
| 6 | Genomewide Association Study Using a High-Density Single Nucleotide Polymorphism Array and Case-Control Design Identifies a Novel Essential Hypertension Susceptibility Locus in the Promoter Region of Endothelial NO Synthase显示文摘 | Erika Salvi Zoltán Kutalik Nicola Glorioso Paola Benaglio Francesca Frau Tatiana Kuznetsova Hisatomi Arima Clive Hoggart Jean Tichet Yury P. Nikitin Costanza Conti Jitka Seidlerova Valérie Tikhonoff Katarzyna Stolarz-Skrzypek Toby Johnson Nabila Devos Lau | 2012 | Hypertension2012，，2： | 1 |
| 7 | A Modification to the NOAH LSM to Simulate Heat Mitigation Strategies in the New York City Metropolitan Area显示文摘 | Lynn Barry H Carlson Toby N Rosenzweig Cynthia Goldberg Richard Druyan Leonard Cox Jennifer Gaffin Stuart Parshall Lily Civerolo Kevin | 2009 | Journal of Applied Meteorology and Climatology2009，，2： | 1 |
| 8 | Transistor paint:high mobilities in small bandgap polymer semiconductor based on the strong acceptor,diketopyrrolopyrrole and strong donor,dithienopyrrole显示文摘 | Toby L N Tomasz M Y Jun Y L Mishra S P Belot J A Balliet C L Javier A E Kowalewski T McCullough R D | 2010 | Advanced Materials2010，22，41： | 1 |
| 9 | On the relation between NDVI,fractional vegetation cover,and leaf area index显示文摘 | TOBY N | 1997 | Remote Sensing of Environment1997，62，3： | 1 |
| 10 | On the Relation between NDVI,Fractional Vegetation Cover,and Leaf Area Index显示文摘 | Toby N | 1997 | Remote Sensing of Environment1997，62，： | 1 |
| 11 | On the relation between NDVI,fractional vegetation cover and leaf area Index显示文摘 | Toby N Carlson David A | 1997 | Remote Sensing of Environment1997，62，3： | 1 |
| 12 | The impact of land use-land cover change due to urbanization on surface microclimate and hydrology: A satellite perspective 显示文摘 | Toby N C Arthur S T | 2000 | Global and Planetary Change2000，25，1： | 1 |
| 13 | On the relation between NDVI,fractional vegetation cover,and leaf area index显示文摘 | Toby N Carlson David A Ripley | 1997 | Remote Sensing of Environment1997，62，： | 1 |
| 14 | On the relation between NDVI, fractional vegetation cover, and leaf area index 显示文摘 | Toby N C David A R | 1997 | Remote Sensing of Environment1997，61，： | 1 |
| 15 | On the relation between NDVI, fractional vegetation cover, and leaf area index 显示文摘 | Toby N C David A R | 1997 | Remote Sensing of Environment1997，62，3： | 1 |
| 16 | Executive Summary of the Stages of Reproductive Aging Workshop + 10: Addressing the Unfinished Agenda of Staging Reproductive Aging显示文摘 | Siobán D. Harlow Margery Gass Janet E. Hall Roger Lobo Pauline Maki Robert W. Rebar Sherry Sherman Patrick M. Sluss Tobie J. de Villiers | 2012 | The Journal of Clinical Endocrinology & Metabolism2012，，4： | 1 |
| 17 | The green tea polyphenol,epigaliocatechin-3-gallate,protects against the oxidative cellular and genotoxic damage of UVA radiation显示文摘 | Tobi SE Gilbert M Paul N | 2002 | Int J Cancer2002，102，： | 1 |
| 18 | The green tea polyphenol,epigallocatechin-3-gallate,protects against the oxidative cellular and genotoxic damage of UVA radiation显示文摘 | Tobi SE Gilbert M Paul N | 2002 | Int J Cancer2002，102，5： | 1 |
| 19 | On the relation between NDVI,fractional vegetation cover and leaf area Index显示文摘 | Toby N Carlson David A | 1997 | Remote Sensing of Environment1997，62，3： | 1 |
| 20 | The green tea polyphenol,epigallocatechin-3-gallate, protects against the oxidative cellular and genotoxic damage of UVA radiation 显示文摘 | Tobi S E Gilbert M Paul N | 2002 | Int J Cancer2002，102，5： | 1 |
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