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| 1 | Overexpression of HSP27 and HSP70 is associated with decreased survival among patients with esophageal adenocarcinoma显示文摘BACKGROUND Overexpression of heat shock proteins(HSPs) is associated with several malignancies and contributes to the development, progression, and metastasis of cancer, in addition to the inhibition of cellular death. In recent years, there has been active research into using HSP inhibitors in several malignancies. Due to the poor prognosis of esophageal adenocarcinoma(EAC), it would be valuable to find new biomarkers for the development of cancer treatments.AIM To evaluate the expressions of HSP27 and HSP70 and their effect on survival in EAC.METHODS Immunohistochemical analyses and evaluations of HSP27 and HSP70 expression were performed on all available samples from 93 patients diagnosed with EACbetween 1990 and 2007 at two university hospitals. Fifteen cases with Barrett's metaplasia and 5 control cases from the same patient population were included in the analysis. HSP expression was quantitatively assessed and classified as high or low. Kaplan-Meier analyses and Cox regression models adjusting for age and sex as well as tumor site, stage, and grade were used to evaluate the effect on survival.RESULTS Tumor stage and surgical treatment were the main prognostic factors. High HSP27 expression in cancer cases was a strong negative predictive factor, with a mean survival of 23 mo compared to the 49 mo in cases with a low expression(P= 0.018). The results were similar for HSP70, with a poorer survival of 17 mo in cases with high HSP70 expression, in contrast to 40 mo(P = 0.006) in cases with a low expression. A Cox regression survival analysis was performed, adjusting for possible confounding factors, and higher HSP27 and HSP70 expressions remained an independent negative prognostic factor. The HSPs' correlation with survival was not affected by cancer treatments. When the analysis was adjusted for all factors, the odds ratios for HSP27 and HSP70 were 3.3(CI: 1.6–6.6, P =0.001) and 2.2(CI: 1.2–3.9, P = 0.02), respectively.CONCLUSION HSP27 and HSP70 overexpression is associated with poor survival in EAC, which is, to the best of our knowledge, reported for the first time. | Henna K S?derstr?m Juha T Kauppi Niku Oksala Timo Paavonen Leena Krogerus Jari R?s?nen Tuomo Rantanen | 2019 | World Journal of Clinical Cases2019，7，3： | 7 |
| 2 | Deceleration capacity of heart rate as a predictor of mortality after myocardial infarction: cohort study显示文摘 | Axel Bauer Jan W Kantelhardt Petra Barthel Raphael Schneider Timo M?kikallio Kurt Ulm Katerina Hnatkova Albert Sch?mig Heikki Huikuri Armin Bunde Marek Malik Georg Schmidt | 2006 | The Lancet2006，，9523： | 3 |
| 3 | Modelling of the spread of a potential invasive pest,the Siberian moth (Dendrolimus sibiricus) in Europe显示文摘Background:The Siberian moth(Dendrolimus sibiricus)(SM) defoliates several tree species from the genera Larix,Picea and Abies in northern Asia,east of the Urals.The SM is a potential invasive forest pest in Europe because Europe has several suitable host species and climatic conditions of central and northern Europe are favourable for the SM.Methods:This study developed a grid-based spatio-temporal model for simulating the spread of the SM in case it enters Europe from Russia via border stations.The spread rate was modeled as a function of the spatial distribution of host species,climatic suitability of different locations for the SM,human population density,transportation of moth-carrying material,'and flying of moths from tree to tree.Results and conclusions:The simulations showed that the SM is most likely to spread in the forests of northeast Belarus,the Baltic countries,and southern and central Finland.Climatic conditions affected the occurrence of the SM more than human population density and the coverage of suitable host species. | Timo Mykkynen Timo Pukkala | 2014 | Forestry Studies in China2014，16，2： | 2 |
| 4 | Feature modeling by incremental feature recognition显示文摘 | Timo L Martti M | 1993 | Computer-Aided Design1993，25，8： | 1 |
| 5 | Does finn size make a difference? Analysing the effectiveness of R&D subsidies in east Germany 显示文摘 | Bjtirn A Timo M Janina R Gerhard U | 2012 | German Economic Review2012，13，2： | 1 |
| 6 | Positive colle- lation of galanin with glucose in type 2 diabetes 显示文摘 | Loannis L Timos M Theodoros M | 2005 | Diabetes-Care2005，28，3： | 1 |
| 7 | Multiresolu- tion gray-scale and rotation invariant texture classification with local binary patterns显示文摘 | Timo Ojala Matti Pietika inen Topi M a enpa a | 2002 | IEEE Transactions on Pattern Analysis and Machine Intelligence2002，24，： | 1 |
| 8 | Rotation invariant im- age description with local binary pattern histogram Fourier features显示文摘 | Timo A Jiri M Chu H | 2009 | Lecture Notes in Computer Sci- ence2009，，5575： | 1 |
| 9 | Does firm size make a difference? Analysising the effectiveness of R&D subsidies in east Germany 显示文摘 | BJORN A TIMO M JANINA R | 2012 | German Economic Review2012，，2： | 1 |
| 10 | The bacterial ghost platform system production and applications 显示文摘 | Timo L Verena J K Abbas M | 2010 | Bioengineered Bugs2010，1，5： | 1 |
| 11 | Multiresolution gray-scale and rotation invariant texture classification with local binary patterns显示文摘 | Timo O Matti P Topi M | 2002 | IEEE transactions on pattern analysis and machine intelligence2002，24，7： | 1 |
| 12 | Feature modeling by incremental feature recognition显示文摘 | Timo L Martti M | 1993 | Computer-Aided Design1993，25，8： | 1 |
| 13 | Fibrosis and stenosis of the long penetrating cerebral arteries:the cause of the white matter pathology in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy显示文摘 | Qing M Timo P Susanna T | 2004 | Brain Pathology2004，14，4： | 1 |
| 14 | 释放智能网联汽车数据全生命周期价值潜力显示文摘车辆数据可在价值链各环节助力出行行业相关企业,但有效借力需要企业立刻行动起来。智能网联汽车能在提供独特客户体验的同时,帮助OEM、供应商、经销商、保险公司、车队和科技公司等实现降本增效。然而,上述公司并未充分重视利用网联车辆数据带来的变现机会。考虑到其他行业正在积极挖掘数据价值,这种疏忽对汽车行业企业而言十足可惜。纵观全球十大最有价值的企业,数据相关服务已为其中7家带去数十亿美元的利润,其中既有行业颠覆者,也有科技公司。 | Michele Bertoncello Christopher Martens Timo Möller Tobias Schneiderbauer 陈晴 | 2022 | 机器人产业2022，，2： | 1 |
| 15 | Schools as Mediators of Neighbourhood Effects on Choice between Vocational and Academic Tracks of Secondary Education in Helsinki显示文摘 | Timo M Kauppinen | 2008 | European Sociological Review2008，24，3： | 1 |
| 16 | Robust texture classification by subsets of local binary patterns显示文摘 | Timo O Matti P Maricor S | 2000 | Pattern Recognition2000，3，： | 1 |
| 17 | Multi-resolution gray-scale and rotation invariant texture classification with local binary patterns 显示文摘 | Timo O Pietikainen M | 2002 | IEEE Transactions on Pattern Analysis and Machine Intelligence2002，24，7： | 1 |
| 18 | Positive col elation of galanin with glucose in type 2 diabetes显示文摘 | Loannis L Timos M Theodoros M | | 0，，03： | 1 |
| 19 | Expression of matrix metalloproteinases-2, -8, -13, -26, and tissue inhibitors of metalloproteinase-1 in human osteosarcoma显示文摘 | Jarkko T. Korpi Jaana Hagstr?m Niko Lehtonen Jyrki Parkkinen Timo Sorsa Tuula Salo Minna Laitinen | 2010 | Surgical Oncology2010，，1： | 1 |
| 20 | A rat extremity soft tissue sarcoma model for the study of systemic treatment with Stealth? liposome-encapsulated tumor necrosis factor-α and cytotoxic agents显示文摘 | Timo LM Alexander M | 1997 | Adv Drug Delivery Rev1997，24，32： | 1 |
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