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| 1 | Human immune cells' behavior and survival under bioenergetically restricted conditions in an in vitro fracture hematoma model显示文摘骨头骨折愈合的起始的煽动性的阶段为愈合的过程的结果代表关键步。然而,开始这个煽动性的阶段的机制和在破裂地点在场的有免疫力的房间的功能糟糕被理解。以便在破裂 hematoma 以内学习早事件,我们建立了一在里面 vitro 破裂 hematoma 模型:我们有教养的 hematomas 在 bioenergetically 控制的条件下面在 vitro 在全部的新潮的关节造形术(THA ) 期间在腿节的截骨术(人工的骨头破裂) 期间形成。这个模型允许我们在跟随破裂的早阶段期间监视有免疫力的房间人口,房间幸存和 cytokine 表示。而且,这个模型使我们能改变 bioenergetical 条件以便模仿在里面 vivo 状况,它被假定被组织缺氧描绘并且限制了营养素的数量。用这个模型,我们发现有免疫力的房间经由 angiogenic 因素, chemoattractants 和支持 inflammatory 分子的表示适应组织缺氧。另外,联合了氧的限制,滋养的供应与 myeloid 的比较提高了淋巴细胞的选择幸存导出的房间(即, neutrophils ) 。笔记,非限制的 bioenergetical 条件没关于 cytokine 表示或有免疫力的房间子集的不同幸存率显示出任何类似的效果。在结论,我们发现 bioenergetical 条件在导致骨折愈合的起始的煽动性的阶段的关键因素之中并且因此是为在早破裂 hematoma 影响有免疫力的房间的幸存和功能的一个关键步骤。 | Paula Hoff Patrick Maschmeyer Timo Gaber Tabea Schiitze Tobias Raue Katharina Schmidt-Bleek Rene Dziurla Saskia Schellmann Ferenz Leonard Lohanatha Eric Rohner Andrea Ode Gerd-Riidiger Burmester Georg N Duda Carsten Perka Frank Buttgereit | 2013 | Cellular & Molecular Immunology2013，10，2： | 3 |
| 2 | 16S rRNA targeted sandwich hybridization method for direct quantification of mycobacteria in soils 显示文摘 | Timo N Jaakko P Irina T | 2004 | Journal of Microbiological Methods2004，67，： | 1 |
| 3 | Application of Artificial Neural Networks in Process Fault Diagnosis显示文摘 | | 1993 | Automatica1993，29，： | 1 |
| 4 | TIMP-1/-2 and transient elastography allow non invasive diagnosis of cystic fibrosis associated liver disease显示文摘 | Timo Rath Katrin Menendez Menendez Marion Kügler Lisa Hage Christian Wenzel Richard Schulz Jürgen Graf Lutz N?hrlich Elke Roeb Martin Roderfeld | 2012 | Digestive and Liver Disease2012，，9： | 1 |
| 5 | A randomized outcome study of enteral versus intravenous nimodipine in 171 patients after acute aneurysmal subarachnoid hemorrhage显示文摘 | VILLE S PETROS N K TIMO K | 2012 | World Neurosurg2012，78，12： | 1 |
| 6 | Subcortical ischaemic vascular dementia显示文摘 | Gustavo C Román Timo Erkinjuntti Anders Wallin Leonardo Pantoni Helena C Chui | 2002 | Lancet Neurology2002，，7： | 1 |
| 7 | Subcortical ischaemic vascular dementia显示文摘 | Gustavo C Román Timo Erkinjuntti Anders Wallin Leonardo Pantoni Helena C Chui | 2002 | Lancet Neurology2002，，： | 1 |
| 8 | Molecu- lar diversity of a north Carolina wastewater treatment plant as revealed by pyrosequencing 显示文摘 | SANAPAREDDY N HAMP TIMO'I}I JT GONZALFI CL | 2009 | Applied and Enviromnental Microbiology2009，75，6： | 1 |
| 9 | Neural Networks in Process Fault Diagnosis,Systems,Man and Cybernetics 显示文摘 | TIMO S HEIIKKI N K HANNU K | 1991 | IEEE Transactions on[J]1991，21，4： | 1 |
| 10 | Neural Networks in Process Fault Diagnosis显示文摘 | Timo S Heikki N K Hannu K | 1991 | IEEE Trans on SMC1991，21，4： | 1 |
| 11 | Neural networks in process fault diagnosis显示文摘 | Heikki N Koivo Hannu Koivisto | 1991 | IEEE Transactions on System Man and Cybernetics1991，21，4： | 1 |
| 12 | Neural networks in process fault diagnosis显示文摘 | Timo S Heikki N K Annu K H | 1991 | IEEE Trans on SMC1991，21，4： | 1 |
| 13 | The Hyperdense Posterior Cerebral Artery Sign : A Computed Tomography Marker of Acute Ischemia in the Posterior Cerebral Artery Territory 显示文摘 | Timo K Dagmar N Michael M | 2006 | Stroke2006，37，： | 1 |
| 14 | High density lipoprotoin cholesterol andtriglycerides as markers of angiographically assessed coroner artery disease显示文摘 | Matti N Timo K Kari N | 1990 | Br Heart J1990，63，： | 1 |
| 15 | Optical tweezers computational toolbox显示文摘 | TIMO A N VINCENT L Y L ALEXANDER B | 2007 | Journal of Op- tics A: Pure and Applied Optics2007，9，8： | 1 |
| 16 | The significance of information frameworks in integrated risk assessment and management显示文摘 | Timo Assmuth Mikael Hildén | 2007 | Environmental Science and Policy2007，，1： | 1 |
| 17 | Assessing ecological quality of shallow lakes: Does knowledge of transparency suffice?显示文摘 | Edwin T.H.M. Peeters Rob J.M. Franken Erik Jeppesen Brian Moss Eloy Bécares Lars-Anders Hansson Susana Romo Timo Kairesalo Elisabeth M. Gross Ellen van Donk Tiina N?ges Kenneth Irvine Ryszard Kornijów Marten Scheffer | 2008 | Basic and Applied Ecology2008，，1： | 1 |
| 18 | Modelling bark thickness of Picea abies with taper curves显示文摘 | Jouko Laasasenaho Timo Melkas Sari Aldén | 2004 | Forest Ecology and Management2004，，1： | 1 |
| 19 | The role of phospholipase a2 in pancreatic acinar cell injury显示文摘 | Antti J. Hietaranta Zoltán G. Lászik Heikki J. A ho Pirjo T. Kortesuo Timo J. Nevalainen | 1991 | International Journal of Pancreatology1991，，2： | 1 |
| 20 | Does ignoring multidestination trips in the travel cost method cause a systematic bias显示文摘 | TIMO K ELEONORA N JUSTUS W | 2003 | The Australian Journal of Agricultural and Resource Economics2003，48，4： | 1 |
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