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| 1 | Cost-utility of molecular adsorbent recirculating system treatment in acute liver failure显示文摘AIM:To determine the short-term cost-utility of mo-lecular adsorbent recirculating system(MARS) treatment in acute liver failure(ALF).METHODS:A controlled retrospective study was conducted with 90 ALF patients treated with MARS from 2001 to 2005.Comparisons were made with a historical control group of 17 ALF patients treated from 2000 to 2001 in the same intensive care unit(ICU) specializing in liver diseases.The 3-year outcomes and number of liver transplantations were recorded.All direct liver disease-related medical expenses from 6 mo before to 3 years after ICU treatment were determined for 31 MARS patients and 16 control patients.The health-related quality of life(HRQoL) before MARS treatment was estimated by a panel of ICU doctors and after MARS using a mailed 15D(15-dimensional generic healthrelated quality of life instrument) questionnaire.The HRQoL,cost,and survival data were combined and the incremental cost/quality-adjusted life years(QALYs) was calculated.RESULTS:In surviving ALF patients,the health-related quality of life after treatmeant was generally high and comparable to the age-and gender-matched general Finnish population.Compared to the controls,the average cost per QALY was considerably lower in the MARS group(64 732€ vs 133 858€) within a timeframe of 3.5 years.The incremental cost of standard medical treatment alone compared to MARS was 10 928€,and the incremental number of QALYs gained by MARS was 0.66.CONCLUSION:MARS treatment combined with standard medical treatment for ALF in an ICU setting is more cost-effective than standard medical treatment alone. | Taru Kantola Suvi Mklin Anna-Maria Koivusalo Pirjo Rsnen Anne Rissanen Risto Roine Harri Sintonen Krister Hckerstedt Helena Isoniemi | 2010 | World Journal of Gastroenterology2010，16，18： | 3 |
| 2 | 受多氯联苯污染的淡水湖泊野生鱼类的组织病理学显示文摘本研究的目的是利用组织病理学作为终点,来评估野生鱼类长期暴露于多氯联苯(PCBs)非致死浓度时潜在的中毒影响。生活在多氟联苯污染的淡水湖泊中的欧鳊(Abramis brama)和赤梢鱼(Aspius aspius)的组织病理学研究揭示了两种鱼的肾小球细胞的异常细胞改变。肾小球毛细管扩张症(DGC)、肾小球膜水肿(ME)、鲍曼管即肾小球囊内脏层和腔壁层之间的粘连(ABC)和鲍曼管空间的充塞(FBS)是湖鱼的高度流行特征。在参考点捕到的鱼中,每种损伤的发生率很低,或者说几乎没有见到这类损伤。肝、鳃、生殖腺、脾和肠的细胞变化均与季节变化有关。研究结果表明,所观察到的肾小球体有一些有组织病理改变,特别是肾小球毛细管扩张症和肾小球膜水肿,这可能表明是由多氯联苯和相关化合物引起的长期化学应激反应造成的,也可能是长期暴露于多氯联苯从而抑制和减弱了鱼的免疫系统,使它们易遭继发性寄生虫的感染。 | Kari Koponen Mark S.Myers Ossi Ritola Sirpa E.Huuskonen Pirjo Lindstrm-Sepp 李康民 | 2001 | AMBIO-人类环境杂志2001，30，3： | 2 |
| 3 | 瑞士驻沪总领事馆和德国驻上海总领事馆文化教育处的室内空间显示文摘瑞士总领事馆和德国驻沪领事馆文化教育处两个项目由上海意迅装饰设计工程有限公司(Shanghai laction Decoration Design & Engineering Co.Ltd. )的建筑设计师Pirjo kiefer设计。两个项目的并置,可以看到设计师在处理室内不同吊顶高度条件限制情况下的不同设计方法。 | Pirjo Kiefer 张晓春 | 2003 | 时代建筑2003，46，6： | 2 |
| 4 | Statin use and non-alcoholic steatohepatitis in at risk individuals显示文摘 | Paola Dongiovanni Salvatore Petta Ville Mannisto Rosellina Margherita Mancina Rosaria Pipitone Vesa Karja Marco Maggioni Pirjo Kakela Olov Wiklund Enrico Mozzi Stefania Grimaudo Dorota Kaminska Raffaela Rametta Antonio Craxi Silvia Fargion Valerio Nobili | 2015 | Journal of Hepatology2015，，3： | 2 |
| 5 | Sustained reduction in the incidence of type 2 diabetes by lifestyle intervention:follow-up of the Finnish Diabetes Prevention Study显示文摘 | Jaana LD Pirjo IP Markku P | 2006 | Lancet2006，368，9548： | 1 |
| 6 | Electrospun nanofibers prepared by two methods:in situ emulsion polymerized PVA/nanoTiO2 and mixing of functional-PVA with mno TiO2显示文摘 | Noora Ristolainen Pirjo Heikkilá Ali Harlin | 2008 | Autex Research Journal2008，8，2： | 1 |
| 7 | Luteinizing hormone receptor eetodomain splice variant misroutes the full- length receptor into a subcompartment of the endoplasmic reticulum 显示文摘 | Pirjo M A Jussi T T Maritta E | 2006 | Mol Biol Cell2006，17，： | 1 |
| 8 | The history of awake craniotomy for brain tumor and its spread into Asia显示文摘 | Julius July Pirjo Manninen Jacob Lai Zhenhai Yao Mark Bernstein | 2009 | Surgical Neu- rology2009，71，5： | 1 |
| 9 | Influencing public nutrition for non-communicable disease prevention : from community intervention to national programme-experiences from Finland显示文摘 | Pekka P Pirjo P Ulla U | 2002 | Public Health Nutri2002，5，1： | 1 |
| 10 | A method for estimating the frequency and cost of voltage sags显示文摘 | Pirjo Heine Pasi Pohjanheimo Matti Lehtonen | 2002 | IEEE Trans on Power System2002，17，2： | 1 |
| 11 | Responses of biotransformation and antioxidant enzymes in lemna minor and oncorhynchus mykiss exposed simultaneously to hexachlorobenzene显示文摘 | Sashwati R Pirjo L S Sirpa H | 1995 | Chemosphere1995，30，8： | 1 |
| 12 | Value added intellectual coefficient(VAIC) :a critical analy- sis 显示文摘 | Pirjo Stahle Sten Stahle Samuli Aho | 2011 | The Journal of Intellectual Capital2011，，4： | 1 |
| 13 | Selective hydrolysis of hexenuronic acid groups and its application in ECF and TCF bleaching of kraft pulps显示文摘 | Vuorinen Tapani Fagerstrom Pirjo Buchert Johnanna | 1999 | J Pulp Paper Sci1999，5，： | 1 |
| 14 | Overexpression of Multiple Dehydrin Genes Enhances Tolerance to Freezing Stress in Arabidopsis显示文摘 | Tuula Puhakainen Michael W. Hess Pirjo M?kel? Jan Svensson Pekka Heino E. Tapio Palva | 2004 | Plant Molecular Biology2004，，5： | 1 |
| 15 | Stage-specific vascular markers revealed by phage display in a mouse model of pancreatic islet tumorigenesis显示文摘 | Johanna A Joyce Pirjo Laakkonen Michele Bernasconi Gabriele Bergers Erkki Ruoslahti Douglas Hanahan | 2003 | Cancer Cell2003，，5： | 1 |
| 16 | Impact of processing on bioactive proteins and peptides 显示文摘 | HANNU K ANNE PIHLANTO-L PIRJO R | 1998 | Trends in Food Science & Technology1998，9，89： | 1 |
| 17 | Press Felts Coated with Electrospun Nanofibres显示文摘 | Tomi Hakala Pirjo Heikkila | 2011 | FIBRES & TEXTILES in Eastern Europe2011，19，1： | 1 |
| 18 | Comparison of HPLC method and commercial ELISA assay for asymmetric dimethylarginine (ADMA) determination in human serum显示文摘 | Pirjo Valtonen Jouni Karppi Kristiina Nyyssonen | 2008 | Journal of Chromatography B2008，828，2： | 1 |
| 19 | Maternal separation at birthand schizophrenia-a long-term follow-up of the Finnish Christ-mas Seal Home Children显示文摘 | Pirjo M Juha V Matti J | 2003 | Schizophr Res2003，60，1： | 1 |
| 20 | Phenolic acids in potatoes, vegetables, and some of their products显示文摘 | Mattila Pirjo Hellstrom Jarkko | 2007 | Journal of Food Composition and Analysis2007，20，： | 1 |
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