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| 1 | Transradial approach for acute stroke intervention: technical procedure and clinical outcomes显示文摘background and purpose Radial artery catheterisation is an alternate route of access that has recently started to gain more widespread use for neuroendovascular procedures,including acute stroke intervention.In this small case series,we present our institution’s outcomes in patients undergoing acute stroke interventions via transradial access.Materials and methods We present a retrospective study of 15 patients who underwent acute stroke intervention via radial artery access.We analyse these patients’periprocedural and clinical outcomes after undergoing mechanical thrombectomy.results A total of 15 consecutive patients were included in the study(9 males and 6 females),and all patients were able to successfully undergo mechanical thrombectomy via radial artery access.The mean time of arterial puncture to reperfusion was 50±28 min(range:15-104).A TICI 2b/3 revascularisation was achieved in 13/15 patients(87%);a TICI 1 and TICI 2a outcome was achieved on the other two patients.One patient incurred an iatrogenic vessel dissection during the procedure.Eight of out 15 patients(53%)had favourable mRS(0-3)at the time of discharge from the hospital.Conclusion Radial artery catheterisation is technically feasible for performing acute stroke interventions with favourable time to revascularisation and good overall clinical outcomes. | Omaditya Khanna Nikolaos Mouchtouris Ahmad Sweid Nohra Chalouhi Ritam Ghosh Fadi Al Saiegh Michael R Gooch Stavropoula Tjoumakaris Robert H Rosenwasser Victor Romo Pascal Jabbour | 2020 | Stroke & Vascular Neurology2020，5，1： | 4 |
| 2 | Waixenicin A,a marine-derived TRPM7 inhibitor:a promising CNS drug lead显示文摘Ion channels are the third largest class of targets for therapeutic drugs.The pharmacology of ion channels is an important research area for identifying new treatment options for human diseases.The past decade or so has seen increasing interest in an ion channel protein belonging to the transient receptor potential(TRP)family,namely the melastatin subfamily member 7(TRPM7),as an emerging drug target.TRPM7 is a bifunctional protein with a magnesium and calcium-conducting divalent ion channel fused with an active kinase domain.TRPM7 is ubiquitously expressed in human tissues,including the brain,and regulates various cell biology processes such as magnesium and calcium homeostasis,cell growth and proliferation,and embryonic development.TRPM7 provides a link between cellular metabolic status and intracellular calcium homeostasis in neurons due to TRPM7’s unique sensitivity to fluctuating intracellular Mg·ATP levels.Thus,the protein plays a key role in ischemic and hypoxic neuronal cell death and brain injury,and is one of the key nonglutamate mechanisms in cerebral ischemia and stroke.Currently,the most potent and specific TRPM7 inhibitor is waixenicin A,a xenicane diterpenoid from the Hawaiian soft coral Sarcothelia edmondsoni.Using waixenicin A as a pharmacological tool,we demonstrated that TRPM7 is involved in promoting neurite outgrowth in vitro.Most recently,we found that waixenicin A reduced hypoxic-ischemic brain injury and preserved long-term behavioral outcomes in mouse neonates.We here suggest that TRPM7 is an emerging drug target for CNS diseases and disorders,and waixenicin A is a viable drug lead for these disorders. | Hong-Shuo Sun F.David Horgen Daniel Romo Kenneth G.Hull Sigrid A.Kiledal Andrea Fleig Zhong-Ping Feng | 2020 | Acta Pharmacologica Sinica2020，41，12： | 2 |
| 3 | Acute ischaemic stroke interventions: large vessel occlusion and beyond显示文摘Care for acute ischaemic stroke is one of the most rapidly evolving fields due to the robust outcomes achieved by mechanical thrombectomy.Large vessel occlusion(LVO)accounts for up to 38%of acute ischaemic stroke and comes with devastating outcomes for patients,families and society in the pre-intervention era.A paradigm shift and a breakthrough brought mechanical thrombectomy back into the spotlight for acute ischaemic stroke;this was because five randomised controlled trials from several countries concluded that mechanical thrombectomy for acute stroke offered overwhelming benefits.This review article will present a comprehensive overview of LVO management,techniques and devices used,and the future of stroke therapy.In addition,we review our institution experience of mechanical thrombectomy for posterior and distal circulation occlusion. | Ahmad Sweid Batoul Hammoud Sunidhi Ramesh Daniella Wong Tyler D Alexander Joshua Harrison Weinberg Maureen Deprince Jaime Dougherty Dimitri Jean-Mickael Maamari Stavropoula Tjoumakaris Hekmat Zarzour Michael R Gooch Nabeel Herial Victor Romo David M Hasan Robert H Rosenwasser Pascal Jabbour | 2020 | Stroke & Vascular Neurology2020，5，1： | 2 |
| 4 | Assessment of an alternative to deep foundations in compressible clays: the structural cell foundation显示文摘为粘土似的土壤扔的浸透的、可压缩低的力量上的大楼的深基础的新类型,名牌的结构的房间实质上由一个僵硬具体最高的平板组成,在结构上与围住自然土壤的加固的具体的外部墙(隔膜) 连接了。因此,作为在内的限制软泥土的起始的体积,侧面的生硬隔膜将在装载之上仍然保持不变,凹陷结构的房间将被转变成比自然软粘土似的土壤的稍微高统一重量的一个很大的剖面图支柱。这类基础似乎是磨擦堆积盒子基础的一种高度有竞争力的选择(广泛地在墨西哥城市泥土使用) ,由于它的经济、环境的优点。例如,经济因此源于巨大的挖掘的缺席 sparing 保留结构的土的需要。进一步的积蓄源于为比磨擦堆积盒子地基造结构的房间要求的有点更小的具体体积;而且,前者的构造时间比后者的短得多。关于到环境的影响,更少的空气污染从交通阻塞和土壤挖掘有点减少的事实列在后面。就关于安排的这些事实和其它而言,代替基础的这种新类型在主人计划工程指定的 48 磨擦堆积盒子基础被决定。在一个五年的时期上的这些房间基础的全面行为从近视觉的观察并且他们在他们的构造以后在开始的三年期间铺平被做。 | Sergio A. MARTINEZ-GALVAN Miguel P. ROMO | 2018 | Frontiers of Structural and Civil Engineering2018，12，1： | 2 |
| 5 | Rejuvenation of the aging lip with an injectable acellular dermal graft 显示文摘 | Sclafani AP Romo T Jacono AA | 2002 | Arch Facial Plast Surg2002，4，4： | 1 |
| 6 | hPTTG is Over-expressed in Pituitary Adenomas and Other Primary Epithelial neoplasias显示文摘 | SAEZ C JAPON M A ROMOS MORALES F | 1999 | Oncogene1999，18，39： | 1 |
| 7 | Purification of trypsin- like enzymes from Antarctic krill processing wastewater显示文摘 | BUSTOS R O ROMO C R HEALY M | 1999 | Process Biochemistry1999，35，3： | 1 |
| 8 | Myotonometer Intra and Interrater Reliabilities显示文摘 | Leonard CT Deshner WP Romo JW | 2003 | Arch Phys Med Rehabil2003，84，6： | 1 |
| 9 | Extraction of phenols from aqueous solutions by β-cyclodextrin polymers: Comparison of sorptive capacities with other sorbents显示文摘 | Romo A Penas F J Isasi J R | 2008 | Reactive and Functional Polymers2008，68，1： | 1 |
| 10 | Fluctuant bearing capacity of shallow foundations during earthquakes 显示文摘 | Mertos J Romo M P | 2006 | Soil Dynamics and Earthquake Engineering2006，26，： | 1 |
| 11 | Reconstruction of congenital microtia-atresia:outcomes with the Medpor/bone-anchored hearing aid-approach显示文摘 | ROMO T MORRIS L G REITZEN S D | 2009 | Ann Plast Surg2009，62，4： | 1 |
| 12 | Madpor alternative for microtia repair显示文摘 | Romo T Ⅲ Presti PM Yalamanchili HR | 2006 | Facial Plast Surg Clin North Am2006，14，1： | 1 |
| 13 | Aesthetic microtia reconstruction with Medpor显示文摘 | ROMO T REITZEN S D | 2008 | Facial Plast Surg2008，24，1： | 1 |
| 14 | Lymph node pathol- ogy:Benign proliferative, lymphpma and metastatic dis- ease显示文摘 | Sakai O Curtin HD Romo LV | 2000 | Radiol Clin North Am2000，38，6： | 1 |
| 15 | NKp46 and DNAM-1 NK-cell receptors drive the response to human cytom_egalovims-infected myeloid dendritic cells overcoming viral immune evasion strategies 显示文摘 | Magri G MuntaseU A Romo N | 2011 | Blood2011，117，3： | 1 |
| 16 | Holomogous collagen dispersion (dermalogen)as a dermal filler:persistence and histology compared with bovine collagen显示文摘 | Slafani AP Romo T 3^rd Parker A | 2002 | Ann Plast Surg2002，49，2： | 1 |
| 17 | Study of genetic expression of intrauterine growth factors IGF-Ⅰ and EGFR in placental tissue from pregnancies with intrauterine growth retardation显示文摘 | Calvo MT Romo A Gutierrez JJ | 2004 | Pediatr Endocrinol Metab2004，17，3： | 1 |
| 18 | Reconstruction of con- genital microtia-atresia: outcomes with the Medpor/bone-anchored hearing aid approach显示文摘 | Romo T 3rd Morris LG Reitzen SD | 2009 | Ann Plast Surg2009，62，4： | 1 |
| 19 | Aesthetic Microtia Reconstruction with Medpor显示文摘 | Thomas Romo Shari Reitzen | 2008 | Facial plast Surg2008，，01： | 1 |
| 20 | Cavitation and highvelocity slurry erosion resistance of welded Stellite 6alloy显示文摘 | Romo S A Santa J F Giraldo J E | 2012 | Tribology International2012，47，： | 1 |
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