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| 1 | Oxygen radical formation does not have an impact in the treatment of severe acute experimental pancreatitis using free cellular hemoglobin显示文摘瞄准:Microcirculatory 机能障碍和免费的氧激进分子是在严重尖锐胰腺炎的致病的重要因素。另外的氧交货可能每氧化提高类脂化合物,但是可以也改进胰腺的微循环。这研究在严重尖锐胰腺炎的一个啮齿类动物模型在氧激进分子和微循环的形成上估计免费细胞的牛的血红素的效果。方法:在尖锐胰腺炎 Wistar 老鼠的正式就职以后的十五分钟收到了任何一个 0.8 mL 牛的血红素(HBOC-200 ) , hydroxyethyl 淀粉(HES ) 或保证血量正常替换的生理盐水的 2.4 mL。在检查的 6 h 以后,胰每氧化产品 malondialdehyde (MDA ) 为类脂化合物的间接测量被切除并且很快处理了并且在胰腺的织物减少了谷胱甘肽(GSH ) 。结果:HBOC-200 的单个申请改进了胰腺的微循环并且显著地减少了组织病理学说的织物损坏。MDA 的织物集中没在这些组之间不同。另外,在 GSH 层次的差别都没被检测。结论:不过 HBOC-200 和 HES 的单个申请改进胰腺的微循环,在类脂化合物的没有差别每氧化,产品被检测。另外的氧供应(HBOC-200 ) 的有益的效果不每氧化导致提高的类脂化合物。 | Helge Kleinhans Oliver Mann Paulus G Schurr Jussuf T Kaifi Bente Hansen Jakob R Izbicki Tim Strate | 2006 | World Journal of Gastroenterology2006，12，18： | 6 |
| 2 | 肺泡复张策略复合高水平呼气末正压通气不影响血容量充足的病态肥胖患者的血流动力学显示文摘我们观察了20例血容量充足,准备行腹腔镜手术的病态肥胖(体重指数为50±9kg/m^2)患者,评估肺泡复张策略复合高水平呼气末正压通气(posidveend-expiratorypressure,PEEP)对其血流动力学的影响。肺泡复张策略是在有气腹和无气腹的情况下序贯进行,将PEEP水平逐渐升高,使平台压达到50—60cmH2O,呼吸10次/分,然后将PEEP水平逐渐降低。通过体循环和肺动脉导管的监测,没有发现肺泡复张及高水平PEEP对血流动力学产生显著的影响。经食管超声心动图显示左室舒张末期面积未发生变化,也无局部室壁运动异常的迹象。 | Stephan H. Bohm, MD Oliver C. Thamm, MD Alexandra von Sandersleben, MD Katrin Bangert, MD Thomas E. Langwieler, MD Gerardo Tusman, MD Tim G. Strate, MD, PhD Thomas G. Standl, MD, PhD 邓希锦(译) | 2011 | 麻醉与镇痛2011，7，3： | 1 |
| 3 | Aggressive Surgery Improves Long-term Survival in Neuroendocrine Pancreatic Tumors: An Institutional Experience显示文摘 | Paulus G. Schurr Tim Strate Kim Rese Jussuf T. Kaifi Uta Reichelt Susanne Petri Helge Kleinhans Emre F. Yekebas Jakob R. Izbicki | 2007 | Annals of Surgery2007，，2： | 1 |
| 4 | Resection vs Drainage in Trealment of Chronic Pancreatitis: Long-term Resuits of a Randomized Trial 显示文摘 | Tim Strate Kai Baehmann Philipp Busch | 2008 | Gastroenterology2008，134，5： | 1 |
| 5 | Impact of different modalities of continuous venovenous hemofiltration on sepsis-induced alterations in experimental pancreatitis显示文摘 | Emre F Tim Strate Sharam Z | 2002 | Kidney Int2002，62，： | 1 |
| 6 | Surgical outcome of laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass for resolution of type 2 diabetes mellitus:A systematic review and meta-analysis显示文摘BACKGROUND Bariatric procedures are considered superior to medical therapies in managing type 2 diabetes mellitus(T2DM).Laparoscopic Roux-en-Y gastric bypass(LRYGB)and laparoscopic sleeve gastrectomy(LSG)are the most commonly used procedures for weight loss and comorbidity resolution worldwide.However,it is not yet known whether the degree of T2DM is influenced by the choice of bariatric procedure.AIM To quantitatively compare T2DM resolution over 1-5 years follow-up by LRYGB and LSG in morbidly obese patients.METHODS We searched the selected databases for full-text English language clinical studies that compared the effectiveness of LRYGB and LSG for T2DM resolution.Review manager 5.3 was used for data analysis,and the overall effect summary was represented in a forest plot.RESULTS From 1,650 titles retrieved by an initial search,we selected nine studies for this research.We found insignificant differences for T2DM resolution by LRYGB and LSG,with an odds ratio of 0.93(95%CI:0.64-1.35,Z statistics=0.38,P=0.71).Additionally,subset analyses for T2DM resolution showed insignificant differences after 24 mo(χ^2=1.24,df=4,P=0.87,overall Z effect=0.23),36 mo(χ^2=0.41,df=2,P=0.81,overall Z effect=0.51),and 60 mo(χ^2=4.75,df=3,P=0.19,overall Z effect=1.20)by LRYGB and LSG.This study reports a T2DM remission rate of 82.3%by LRYGB and 80.7%by LSG.CONCLUSION This study reports similar T2DM resolution rates by both LRYGB and LSG during 1-5 years of follow-up.However,long-term follow-up of 10 years is needed to further substantiate these findings. | Salman Yousuf Guraya Tim Strate | 2020 | World Journal of Gastroenterology2020，26，8： | 1 |
| 7 | Long-term Follow-up of a Randomized Trial Comparing the Beger and Frey Procedures for Patients Suffering From Chronic Pancreatitis显示文摘 | Tim Strate Zohre Taherpour Christian Bloechle Oliver Mann Jens P. Bruhn Claus Schneider Thomas Kuechler Emre Yekebas Jakob R. Izbicki | 2005 | Annals of Surgery2005，，4： | 1 |
| 8 | Extrahepatic Portal Hypertension in Chronic Pancreatitis: An Old Problem Revisited显示文摘 | Jakob R. Izbicki Emre F. Yekebas Tim Strate Claus F. Eisenberger Stefan B. Hosch Katharina Steffani Wolfram T. Knoefel | 2002 | Annals of Surgery2002，，1： | 1 |
| 9 | Prolonged hyperthermic intraperitoneal chemotherapy duration with 90 minutes cisplatin might increase overall survival in gastric cancer patients with peritoneal metastases显示文摘BACKGROUND Advanced gastric cancer with synchronous peritoneal metastases(GC-PM)is associated with a poor prognosis.Although cytoreductive surgery with hyperthermic intraperitoneal chemotherapy(CRS-HIPEC)is a promising approach,only a limited number of Western studies exist.AIM To investigate the clinicopathological outcomes of patients who underwent CRSHIPEC for GC-PM.METHODS A retrospective analysis of patients with GC-PM was conducted.All patients were seen at the Department of General and Visceral Surgery,Hospital Barmherzige Brüder,Regensburg,Germany between January 2011 and July 2021 and underwent CRS-HIPEC.Preoperative laboratory results,the use of neoadjuvant trastuzumab,and the details of CRS-HIPEC,including peritoneal carcinomatosis index,completeness of cytoreduction,and surgical procedures were recorded.Disease-specific(DSS),and overall survival(OS)of patients were calculated.RESULTS A total of 73 patients were included in the study.Patients treated with neoadjuvant trastuzumab(n=5)showed longer DSS(P=0.0482).Higher white blood cell counts(DSS:P=0.0433)and carcinoembryonic antigen levels(OS and DSS:P<0.01),and lower hemoglobin(OS and DSS:P<0.05)and serum total protein(OS:P=0.0368)levels were associated with shorter survival.Longer HIPEC duration was associated with more advantageous median survival times[60-min(n=59):12.86 mo;90-min(n=14):27.30 mo],but without statistical difference.To obtain additional data from this observation,further separation of the study population was performed.First,propensity score-matched patient pairs(n=14 in each group)were created.Statistically different DSS was found between patient pairs(hazard ratio=0.2843;95%confidence interval:0.1119-0.7222;P=0.0082).Second,those patients who were treated with trastuzumab and/or had human epidermal growth factor receptor 2 positivity(median survival:12.68 mo vs 24.02 mo),or had to undergo the procedure before 2016(median survival:12.68 mo vs 27.30 mo;P=0.0493)were removed from the original study population.CONCLUSION Based on our experience,CRS-HIPEC is a safe and secure method to improve the survival of advanced GC-PM patients.Prolonged HIPEC duration may serve as a good therapy for these patients. | Heinrich Steinhoff Miklos Acs Sebastian Blaj Magdolna Dank Magdolna Herold Zoltan Herold Jonas Herzberg Patricia Sanchez-Velazquez Tim Strate Attila Marcell Szasz Pompiliu Piso | 2023 | World Journal of Gastroenterology2023，29，18： | 0 |
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