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| 1 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 2 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 3 | Neural Mechanisms of Mental Fatigue Revisited: New Insights from the Brain Connectome显示文摘Maintaining sustained attention during a prolonged cognitive task often comes at a cost: high levels of mental fatigue. Heuristically, mental fatigue refers to a feeling of tiredness or exhaustion, and a disengagement from the task at hand;it manifests as impaired cognitive and behavioral performance. In order to effectively reduce the undesirable yet preventable consequences of mental fatigue in many real-world workspaces, a better understanding of the underlying neural mechanisms is needed, and continuous efforts have been devoted to this topic. In comparison with conventional univariate approaches, which are widely utilized in fatigue studies, convergent evidence has shown that multivariate functional connectivity analysis may lead to richer information about mental fatigue. In fact, mental fatigue is increasingly thought to be related to the deviated reorganization of functional connectivity among brain regions in recent studies. In addition, graph theoretical analysis has shed new light on quantitatively assessing the reorganization of the brain functional networks that are modulated by mental fatigue. This review article begins with a brief introduction to neuroimaging studies on mental fatigue and the brain connectome, followed by a thorough overview of connectome studies on mental fatigue. Although only a limited number of studies have been published thus far, it is believed that the brain connectome can be a useful approach not only for the elucidation of underlying neural mechanisms in the nascent field of neuroergonomics, but also for the automatic detection and classification of mental fatigue in order to address the prevention of fatigue-related human error in the near future. | Peng Qi Hua Ru Lingyun Gao Xiaobing Zhang Tianshu Zhou Yu Tian Nitish Thakor Anastasios Bezerianos Jinsong Li Yu Sun | 2019 | Engineering2019，5，2： | 5 |
| 4 | Genomic profiling and the impact of MUC19 mutation in hepatoid adenocarcinoma of the stomach显示文摘Dear Editor,Hepatoid adenocarcinoma(HAC)is a rare pathological subtype of extrahepatic tumor,featured by hepatoid differentiation andα-fetoprotein(AFP)-production[1,2].Hepatoid adenocarcinoma of the stomach(HAS),accounting for 0.3%to 1.0%of all gastric cancers(GCs),has attracted increasing attention due to its high degree of malignancy[3].Compared with classic GC,HAS showed a higher rate of vascular invasion,lymph node metastasis,and liver metastasis,with only 9.0%survival rate at 5 years[4].Currently,there is no effective treatment for HAS,and little is known about its pathogenesis.Herein,we investigated the molecular features of HAS and identified potential therapeutic targets for HAS. | Mengxuan Zhu Erbao Chen Shan Yu Chen Xu Yiyi Yu Xin Cao Wei Li Pengfei Zhang Yan Wang Baofeng Lian Shuirong Zhang Yueting Qu Lujia Huang Weiwei Shi Yuehong Cui Li Qian Tianshu Liu | 2022 | Cancer Communications2022，42，10： | 3 |
| 5 | Toripalimab in advanced biliary tract cancer显示文摘Gemcitabine combined with platinum/fluorouracil drugs is the standard firstline treatment for advanced biliary tract cancers(BTCs).We explored the safety and efficacy of toripalimab plus gemcitabine and S-1(GS)as the first-line treatment for advanced BTCs.At a one-sided significance level of 0.025,a total of 50 patients could provide 80%power to show the efficacy at targeted progression-free survival(PFS)rate at 6 months of 70%versus 40%for the combined treatment.This single-arm,phase II study enrolled 50 patients with advanced BTCs who previously received no systemic treatment.The regimen was as follows:toripalimab(240 mg,i.v.,d1),gemcitabine(1,000 mg/m2,i.v.,d1 and d8),and S-1(40–60 mg bid p.o.,d1–14,Q21d).The primary endpoint was progression-free survival.The secondary endpoints included overall survival(OS),objective response rate(ORR),duration of response(DOR),and safety.The associations between response with PDL1 expression,tumor mutational burden(TMB),and genetic variations were explored.Patients were enrolled from January 2019 to August 2020,with a median follow-up time of 24.0 months(IQR:4.3–31.0 months). | Wei Li Yueqi Wang Yiyi Yu Qian Li Yan Wang Chenlu Zhang Xiaojing Xu Xi Guo Yu Dong Yuehong Cui Qing Hao Lujia Huang Houbao Liu Tianshu Liu | 2022 | The Innovation2022，3，4： | 1 |
| 6 | Low-expression of microRNA-107 inhibits cell apoptosis in glioma by upregulation of SALL4显示文摘 | Jie He Wanyu Zhang Qiangqiang Zhou Tianshu Zhao Yuwen Song Li Chai Yu Li | 2013 | International Journal of Biochemistry and Cell Biology2013，，： | 1 |
| 7 | Flexible and flame-retarding phosphorylated MXene/polypropylene composites for efficient electromagnetic interference shielding显示文摘Flame-retardant composites with high electromagnetic interference(EMI)shielding performance are desirable for electronic device packaging.Despite great potential of MXene for high EMI,it still remains a great challenge to develop high-performance flame-retardant polymer/MXene composites with excellent EMI shielding effectiveness because of the poor oxidative stability of MXene.Herein,phosphorylated MXene/polypropylene(PP)composites are prepared by coating phosphorylated MXene on PP fabric followed by spraying polyethylenimine(PEI)and hot-pressing.The phosphorylated MXene proves to be more durable against oxidation than pure MXene due to the protection effect of polyphosphates.Upon hot-pressing,melted PP fibers are fused together at their contact points and thus as-prepared composites are bi-continuous with two interpenetrating phases.The composites show significantly improved thermal stability and flame retardancy relative to pure PP,with a low total heat release(THR)of 3.7 kJ/g and a heat release rate(HRR)of 50.0 W/g,which are reduced by 78%and 87%,respectively.In addition,the composites exhibit a high electrical conductivity of~36,700 S/m and an EMI shielding performance of~90 d B over the whole frequency range of 8–12 GHz with a thickness of~400μm.The as-developed PP/MXene composites hold great promise for reliable protection of next-generation electronic devices working in complex environments. | Tingting Tang Shanchi Wang Yue Jiang Zhiguang Xu Yu Chen Tianshu Peng Fawad Khan Jiabing Feng Pingan Song Yan Zhao | 2022 | Journal of Materials Science & Technology2022，，16： | 1 |
| 8 | Boron-modified perhydropolysilazane towards facile synthesis of amorphous SiBN ceramic with excellent thermal stability显示文摘SiBN ceramics are widely considered to be the most promising material for microwavetransparent applications in harsh environments owing to its excellent thermal stability and low dielectric constant.This work focuses on the synthesis and ceramization of single-source precursors for the preparation of SiBN ceramics as well as the investigation of the corresponding microstructural evolution at high temperatures including molecular dynamic simulations.Carbon-and chlorine-free perhydropolysilazanes were reacted with borane dimethyl sulfide complex at different molar ratios to synthesize single-source precursors,which were subsequently pyrolyzed and annealed under N2 atmosphere(without ammonolysis)to prepare SiBN ceramics at 1100,1200,and 1300℃with high ceramic yield in contrast to previously widely-used ammonolysis synthesis process.The obtained amorphous SiBN ceramics were shown to have remarkably improved thermal stability and oxidation resistance compared to amorphous silicon nitride.Particularly,the experimental results have been combined with molecular dynamics simulation to further study the amorphous structure of SiBN and the atomic-scale diffusion behavior of Si,B,and N at 1300℃.Incorporation of boron into the Si–N network is found to suppress the crystallization of the formed amorphous silicon nitride and hence improves its thermal stability in N2 atmosphere. | Ying ZHAN Wei LI Tianshu JIANG Claudia FASEL Emmanuel III RICOHERMOSO Jan BERNAUER Zhaoju YU Zhenghao WU Florian MÜLLER-PLATHE Leopoldo MOLINA-LUNA Ralf GROTTENMÜLLER Ralf RIEDEL | 2022 | Journal of Advanced Ceramics2022，11，7： | 1 |
| 9 | Hard and tough novel high-pressure γ-Si_(3)N_(4)/Hf_(3)N_(4) ceramic nanocomposites显示文摘Cubic silicon nitride(-Si_(3)N_(4))is superhard and one of the hardest materials after diamond and cubic boron nitride(cBN),but has higher thermal stability in an oxidizing environment than diamond,making it a competitive candidate for technological applications in harsh conditions(e.g.,drill head and abrasives).Here,we report the high-pressure synthesis and characterization of the structural and mechanical properties of a γ-Si_(3)N_(4)/Hf_(3)N_(4) ceramic nanocomposite derived from single-phase amorphous silicon(Si)-hafnium(Hf)-nitrogen(N)precursor.The synthesis of the-Si_(3)N_(4)/Hf_(3)N_(4) nanocomposite is performed at~20 GPa and ca.1500 ℃ in a large volume multi anvil press.The structural evolution of the amorphous precursor and its crystallization to-Si_(3)N_(4)/Hf_(3)N_(4) nanocomposites under high pressures is assessed by the in situ synchrotron energy-dispersive X-ray diffraction(ED-XRD)measurements at~19.5 GPa in the temperature range of ca.1000-1900℃.The fracture toughness(K_(IC))of the two-phase nanocomposite amounts~6/6.9 MPa·m^(1/2) and is about 2 times that of single-phaseγ-Si_(3)N_(4),while its hardness of ca.30 GPa remains high.This work provides a reliable and feasible route for the synthesis of advanced hard and tough-Si_(3)N_(4)-based nanocomposites with excellent thermal stabililty. | Wei Li Zhaoju Yu Leonore Wiehl Tianshu Jiang Ying Zhan Emmanuel III Ricohermoso Martin Etter Emanuel Ionescu Qingbo Wen Christian Lathe Robert Farla Dharma Teppala Teja Sebastian Bruns Marc Widenmeyer Anke Weidenkaff Leopoldo Molina-Luna Ralf Riedel Shrikant Bhat | 2023 | Journal of Advanced Ceramics2023，12，7： | 0 |
| 10 | Effect of Refrigerant on the Performance of a C3/MRC Liquefaction Process显示文摘The Mixed Refrigerant(MR)component is an important factor influencing the performances of natural gas lique-faction processes.However,there is a lack of systematic research about the utilization of propane pre-cooled(C3/MRC).In this paper,this mixed refrigerant cycle liquefaction process is simulated using the HYSYS software and the main influential parameters involved in the process are varied to analyze their influence on the liquefaction rate and power consumption.The results show that an effective way for lowering the power consumption of the compressor consists of reducing the flow through the compressor through optimization of the percentage of mixed refrigerant.The power consumption of the compressor in the hybrid refrigeration process is affected by both flow and pressure ratios.Its specific power consumption can be reduced by increasing the flow and decreasing the pressure ratio at the same time.The increase in refrigerant pressure at the high-pressure end can significantly mitigate the energy loss of the heat exchanger and compressor. | Xiao Wu Zhaoting Wang Longfei Dong Yanping Xin Tianshu Yu | 2023 | Fluid Dynamics & Materials Processing2023，19，1： | 0 |
| 11 | Carbon footprint of crop production in Heilongjiang land reclamation area,China显示文摘In the context of global warming,agriculture,as the second-largest source of greenhouse gas emissions after industry,had attracted widespread attention from all walks of life to reduce agricultural emissions.The carbon footprint of the planting production system of the Heilongjiang Land Reclamation Area(HLRA),an important commodity grain base in China,was evaluated and analyzed in this paper.On this basis,this paper sought feasible strategies to reduce carbon emissions from two aspects:agronomic practices and cropping structure adjustment,which were particularly crucial to promote the low-carbon and sustainable development of agriculture in HLRA.Therefore,using the accounting methods in IPCC and Low Carbon Development and Guidelines for the Preparation of Provincial Greenhouse Gas Inventories compiled by the Chinese government,relevant data were collected from 2000 to 2017 in HLRA and accounted for the carbon emissions of the planting production system in four aspects:carbon emissions from agricultural inputs,N_(2)O emissions from managed soils,CH_(4) emissions from rice cultivation and straw burning emissions.Then carbon uptake consisted of seeds and straws.Finally,with farmers'incomes were set as the objective function and carbon emissions per unit of gross production value was set as the constraint,this paper simulated and optimized the cropping structure in HLRA.The results showed that there was a“stable-growing-declining”trend in the total carbon emissions and carbon uptake of the planting production system in HLRA,with total carbon emissions of 2.84×10^(10) kg and total carbon uptake of 7.49×10^(10) kg in 2017.In the past 18 years,carbon emissions per unit area and carbon emissions per unit of gross production had both shown a decreasing trend.To achieve further efficiency gains and emission reductions in the planting production system,it was recommended that the local governments strengthen the comprehensive use of straw resources,optimize irrigation and fertilization techniques,and adjust the cropping structure,i.e.,increase the planting area of maize and soybeans and reduce the planting area of rice,and increase subsidies to protect the economic returns of planters. | Tianshu Chu Lu Yu Derui Wang Zengling Yang | 2022 | International Journal of Agricultural and Biological Engineering2022，15，1： | 0 |
| 12 | China enters CAR-T cell therapy era显示文摘The emerging individualized and living-cell-based genetic engineering chimeric antigen receptor T(CAR-T)therapy demonstrates great curative effects in some hematological tumor treatments,thus it is turning out to be a star immunotherapy method of the world.1 Recently,the China NationalMedical Products Administration(NMPA)approved launching applications of two CAR-T cell cancer products,Axicabtagene Ciloleucel(FKC876)and Relmacabtagene Autoleucel(Carteyva),which marked the beginning of the of CAR-T cell therapy era in China(Figure 1). | Xin Cao Wei Li Yiyi Yu Tianshu Liu Yuhong Zhou | 2022 | The Innovation2022，3，1： | 0 |
| 13 | Dynamic State Estimation for DFIG with Unknown Inputs Based on Cubature Kalman Filter and Adaptive Interpolation显示文摘Dynamic state estimation(DSE)accurately tracks the dynamics of power systems and demonstrates the evolution of the system state in real time.This paper proposes a DSE approach for a doubly-fed induction generator(DFIG)with unknown inputs based on adaptive interpolation and cubature Kalman filter(AICKF-UI).DFIGs adopt different control strategies in normal and fault conditions;thus,the existing DSE approaches based on the conventional control model of DFIG are not applicable in all cases.Consequently,the DSE model of DFIGs is reformulated to consider the converter controller outputs as unknown inputs,which are estimated together with the DFIG dynamic states by an exponential smoothing model and augmented-state cubature Kalman filter.Furthermore,as the reporting rate of existing synchro-phasor data is not sufficiently high to capture the fast dynamics of DFIGs,a large estimation error may occur or the DSE approach may diverge.To this end,in this paper,a local-truncation-error-guided adaptive interpolation approach is developed.Extensive simulations conducted on a wind farm and the modified IEEE 39-bus test system show that the proposed AICKF-UI can(1)effectively address the divergence issues of existing cubature Kalman filters while being computationally more efficient;(2)accurately track the dynamic states and unknown inputs of the DFIG;and(3)deal with various types of system operating conditions such as time-varying wind and different system faults. | Maolin Zhu Hao Liu Junbo Zhao Bendong Tan Tianshu Bi Samson Shenglong Yu | 2023 | Journal of Modern Power Systems and Clean Energy2023，11，4： | 0 |
| 14 | JUNB mediates oxaliplatin resistance via the MAPK signaling pathway in gastric cancer by chromatin accessibility and transcriptomic analysis显示文摘tients,and chemotherapy resistance is one of the main reasons for treatment failure.Thus,it is important to reveal the mechanism of oxaliplatin resistance and to seek effective intervention strategies to improve chemotherapy sensitivity,thereby improving the survival and prognosis of gastric cancer patients.To understand the molecular mechanisms of oxaliplatin resistance,we generate an oxaliplatin-resistant gastric cancer cell line and conduct assay for transposase-accessible chromatin sequencing(ATAC-seq)and RNA sequencing(RNA-seq)for both parental and oxaliplatin-resistant AGS cells.A total of 3232 genomic regions are identified to have higher accessibility in ox-aliplatin-resistant cells,and DNA-binding motif analysis identifies JUNB as the core transcription factor in the regulatory network.JUNB is overexpressed in oxaliplatin-resistant gastric cancer cells,and its upregulation is associated with poor prognosis in gastric cancer patients,which is validated by our tissue microarray data.Moreover,chromatin immunoprecipitation sequencing(ChIP-seq)analysis reveals that JUNB binds to the tran-scriptional start site of key genes involved in the MAPK signaling pathway.Knockdown of JUNB inhibits the MAPK signaling pathway and restores sensitivity to oxaliplatin.Combined treatment with the ERK inhibitor piperlongu-mine or MEK inhibitor trametinib effectively overcomes oxaliplatin resistance.This study provides evidence that JUNB mediates oxaliplatin resistance in gastric cancer by activating the MAPK pathway.The combination of MAPK inhibitors with oxaliplatin overcomes resistance to oxaliplatin,providing a promising treatment opportunity for oxaliplatin-resistant gastric cancer patients. | Suyao Li Yichou Wei Xun Sun Mengling Liu Mengxuan Zhu Yitao Yuan Jiayu Zhang Yu Dong Keshu Hu Sining Ma Xiuping Zhang Bei Xu Hesheng Jiang Lu Gan Tianshu Liu | 2023 | Acta Biochimica et Biophysica Sinica2023，55，11： | 0 |
| 15 | Pilot Protection Based on Amplitude Comparison for Renewable Power Teed Lines显示文摘Fault behaviors of inverter-interfaced renewable energy generators(IIREGs)are quite diverse from those of synchronous generators(SGs).They show the variable system impedance,the limited current and low inertia,so the proportional brake differential protection installed on the transmission line has a high risk of failure for phase-phase failures.To cope with this adaptive problem,a new pilot protection is proposed considering the huge differences in both current amplitudes.Also,an improved criterion is presented for a scenario with a teed line.The existing protection principles focus excessively on the fault current characteristics of IIREGs,so they cannot operate correctly once IIREGs do not output their fault current.This happens when IIREGs produce no power or the circuit breakers exactly reclose on permanent failures.However,the proposed method has good performance for the above cases.The proposed method only requires current amplitude information,and in this case the strict synchronizing measurement is not necessary.Case studies are performed under different fault conditions,and they confirm the proposed method has good performance under different fault conditions.Furthermore,it is also verified using field-testing data. | Ke Jia Zhe Yang Yu Fang Zhengxuan Zhu Liming Zheng Tianshu Bi Ali Hooshyar | 2022 | CSEE Journal of Power and Energy Systems2022，8，6： | 0 |
| 16 | Immune Checkpoint Inhibitor-associated Myocarditis with Myasthenia Gravis:A Case Report显示文摘Immune checkpoint inhibitors(ICIs)have revolutionized the management of various cancers.However,myocarditis is a rare but severe complication associated with ICI use.We describe the case of a 62-year-old woman who presented with ICI-associated myocarditis alongside myasthenia gravis.Consequently,the patient was treated with initial high doses of corticosteroids combined with immunosuppressive therapy,and improved outcomes and clinical remission were observed.The overlap of myocarditis with myasthenia gravis is associated with high morbidity and mortality.The early administration of high dose of corticosteroids combined with immunosuppressive therapy was associated with improved outcomes in our patient. | Qing LIU Jinyi LIN Tianshu LIU Yiyi YU | 2022 | Clinical Cancer Bulletin2022，1，3： | 0 |
| 17 | Landscape influences and management countermeasures of ginseng planting near Changbai mountain nature reserve显示文摘Ginseng planting in Northeast China brings economic benefits but affects forest landscape integrity and native ecological processes.In order to quantify the impacts of ginseng planting on the forest landscape,Fusong County in Jilin Province was selected as a study area.The number and distribution of ginseng fields over different time was quantified based on remote sensing and ground surveys.Grid analysis and multiple regression analysis were used to study the impacts of ginseng planting on the landscape.The results showed that altitudes and slopes of ginseng fields increased and became increasingly scattered and smaller closer to the Changbai Mountain Nature Reserve.Ginseng fields and abandoned fields increased total patches and total area of the local forested landscape,and shared edge lengths between ginseng fields and forests,resulting in continuous fragmentation of the landscape.Although the total area of existing and abandoned ginseng fields accounts for a small fraction of the total landscape,their negative impacts on ecosystem conservation is significant.The local government needs to rationally plan ginseng planting,scientifically implement the restoration of abandoned ginseng lands,and enhance awareness of ginseng farmers to environmental stewardship.Our study has important significance for maintaining the healthy and stable development of the local ginseng industry and for improving the quality of regional ecological environment. | Mingfang Tang Sha Qiu Lijie Liu Tao Li Shanlin Li Tianshu Yu | 2022 | Journal of Forestry Research2022，33，6： | 0 |
| 18 | Negative correlation between acetyl-CoA acyltransferase 2 and cetuximab resistance in colorectal cancer显示文摘The emergence of anti-EGFR therapy has revolutionized the treatment of colorectal cancer(CRC).However,not all patients respond consistently well.Therefore,it is imperative to conduct further research to identify the molecular mechanisms underlying the development of cetuximab resistance in CRC.In this study,we find that the expressions of many metabolism-related genes are downregulated in cetuximab-resistant CRC cells compared to their sensitive counterparts.Specifically,acetyl-CoA acyltransferase 2(ACAA2),a key enzyme in fatty acid metabolism,is downregulated during the development of cetuximab resistance.Silencing of ACAA2 promotes proliferation and increases cetuximab tolerance in CRC cells,while overexpression of ACAA2 exerts the opposite effect.RTK-Kras signaling might contribute to the downregulation of ACAA2 expression in CRC,and ACAA2 predicts CRC prognosis in patients with Kras mutations.Collectively,our data suggest that modulating ACAA2 expression contributes to secondary cetuximab resistance in Kras wild-type CRC patients.ACAA2 expression is related to Kras mutation and demonstrates a prognostic role in CRC patients with Kras mutation.Thus,ACAA2 is a potential target in CRC with Kras mutation. | Yitao Yuan Xun Sun Mengling Liu Suyao Li Yu Dong Keshu Hu Jiayu Zhang Bei Xu Sining Ma Hesheng Jiang Pengcong Hou Yufu Lin Lu Gan Tianshu Liu | 2023 | Acta Biochimica et Biophysica Sinica2023，55，9： | 0 |
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