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| 1 | Current and future medical therapeutic strategies for the functional repair of spinal cord injury显示文摘Spinal cord injury(SCI) leads to social and psychological problems in patients and requires costly treatment and care. In recent years, various pharmacological agents have been tested for acute SCI. Large scale, prospective, randomized, controlled clinical trials have failed to demonstrate marked neurological benefit in contrast to their success in the laboratory. Today, the most important problem is ineffectiveness of nonsurgical treatment choices in human SCI that showed neuroprotective effectsin animal studies. Recently, attempted cellular therapy and transplantations are promising. A better understanding of the pathophysiology of SCI started in the early 1980 s. Research had been looking at neuroprotection in the 1980 s and the first half of 1990 s and regeneration studies started in the second half of the 1990 s. A number of studies on surgical timing suggest that early surgical intervention is safe and feasible, can improve clinical and neurological outcomes and reduce health care costs, and minimize the secondary damage caused by compression of the spinal cord after trauma. This article reviews current evidence for early surgical decompression and nonsurgical treatment options, including pharmacological and cellular therapy, as the treatment choices for SCI. | Tevfik Y?lmaz Erkan Kaptano?lu | 2015 | World Journal of Orthopedics2015，6，1： | 19 |
| 2 | Fructose as a key player in the development of fatty liver disease显示文摘We aimed to investigate whether increased consumption of fructose is linked to the increased prevalence of fatty liver.The prevalence of nonalcoholic steatohepatitis(NASH) is 3% and 20% in nonobese and obese subjects,respectively.Obesity is a low-grade chronic inflam-m-atory condition and obesity-related cytokines such as interleukin-6,adiponectin,leptin,and tumor necrosis factor-α may play important roles in the developm-ent of nonalcoholic fatty liver disease(NAFLD).Additionally,the prevalence of NASH associated with both cirrhosis and hepatocellular carcinom-a was reported to be high am-ong patients with type 2 diabetes with or without obesity.Our research group previously showed that consumption of fructose is associated with adverse alterations of plasma lipid profiles and metabolic changes in m-ice,the Am-erican Lifestyle-Induced Obesity Syndrom-e m-odel,which included consum-ption of a high-fructose corn syrup in amounts relevant to that consum-ed by som-e Am-ericans.The observation reinforces the concerns about the role of fructose in the obesity epidem-ic.Increased availability of fructose(e.g.,high-fructose corn syrup) increases not only abnorm-al glucose flux but also fructose m-etabolism-in the hepatocyte.Thus,the anatomic position of the liver places it in a strategic buffering position for absorbed carbohydrates and am-ino acids.Fructose was previously accepted as a beneficial dietary com-ponent because it does not stim-ulate insulin secretion.However,since insulin signaling plays an important role in central m-echanism-s of NAFLD,this property of fructose m-ay be undesirable.Fructose has a selective hepatic m-etabolism,and provokes a hepatic stress response involving activation of c-Jun N-term-inal kinases and subsequent reduced hepatic insulin signaling.As high fat diet alone produces obesity,insulin resistance,and som-e degree of fatty liver with m-inim-al inflam-m-ation and no fibrosis,the fast food diet which includes fructose and fats produces a gene expression signature of increased hepatic fibrosis,inflam-m-ation,endoplasm-ic reticulumstress and lipoapoptosis.Hepatic de novo lipogenesis(fatty acid and triglyceride synthesis) is increased in patients with NAFLD.Stable-isotope studies showed that increased de novo lipogenesis(DNL) in patients with NAFLD contributed to fat accum-ulation in the liver and the developm-ent of NAFLD.Specifically,DNL was responsible for 26% of accum-ulated hepatic triglycerides and 15%-23% of secreted very low-density lipoprotein triglycerides in patients with NAFLD com-pared to an estim-ated less than 5% DNL in healthy subjects and 10% DNL in obese people with hyperinsulinem-ia.In conclusion,understanding the underlying causes of NAFLD form-s the basis for rational preventive and treatm-ent strategies of this m-ajor form-of chronic liver disease. | Metin Basaranoglu Gokcen Basaranoglu Tevfik Sabuncu Hakan Sentürk | 2013 | World Journal of Gastroenterology2013，19，8： | 14 |
| 3 | Associating liver partition and portal vein ligation for staged hepatectomy for extensive alveolar echinococcosis:First case report in the literature显示文摘Alveolar echinococcosis(AE) is a zoonotic disease that is caused by Echinococcus multilocularis that affects liver and a variety of organs and tissues. It differs from other echinococcal disease because it shows tumor like behavior in the affected organ and tissues. The treatment of choice is concomitant medical therapy and resection with negative margins. Nevertheless, resection with the intent of negative margins(R0) may lead to serious complications such as liver failure. In the present case report, we used Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy(ALPPS) procedure, which was defined in 2012 by Schnitzbauer et al, in a 28-year-old male patient to avoid complications of major liver resection in order to treat alveolar echinococcosis. Until now, we have not encountered any study using ALPPS procedure for the treatment of alveolar echinococcosis. In the present case report we aimed to show that ALPPS procedure can be safely performed for marginnegative resection of primary or recurrent AE that shows a tumor like behavior. It is our opinion that this procedure should be performed in centers that have expertise and sufficient technical capacity to perform liver transplantation and advanced liver surgery. | Sami Akbulut Egemen Cicek Mehmet Kolu Tevfik Tolga Sahin Sezai Yilmaz | 2018 | World Journal of Gastrointestinal Surgery2018，10，1： | 10 |
| 4 | Microstructure, mechanical properties and formability of friction stir welded dissimilar materials of IF-steel and 6061 Al alloy显示文摘AA 6061 alloy and interstitial-free(IF)steel plates were joined by the friction stir welding(FSW)method,and the microstructure,mechanical properties,and biaxial stretch formability of the friction stir welded(FSWed)parts were investigated.The results indicate that the FSWed parts showed optimum tensile strength during FSW with the 0.4-mm offset position of the tool.The Fe4Al13 intermetallic compound formed in the defect-free intersection of AA 6061 and IF-steel plates during FSW.The hardness of the IF-steel part of the FSWed region increased almost 90%relative to its initial hardness of HV0.2 105.The tensile and yield strengths of FSWed regions were approximately 170 MPa and 145 MPa,respectively.According to the formability tests,the Erichsen Index(EI)of the IF-steel,AA 6061,and the FSWed samples were determined to be 2.9 mm,1.9 mm,and 2.1 mm,respectively.The EI of the FSWed sample was almost the same as that of the AA 6061 alloy.However,it decreased compared with that of the IF-steel.The force at EI(FEI)was approximately 1180 N for the FSWed condition.This value is approximately 70%higher than that of AA 6061 alloy. | Semih Mahmut Aktarer Dursun Murat Sekban Tevfik Kucukomeroglu Gencaga Purcek | 2019 | International Journal of Minerals,Metallurgy and Materials2019，26，6： | 7 |
| 5 | Current and future surgery strategies for spinal cord injuries显示文摘Spinal cord trauma is a prominent cause of mortality and morbidity. In developed countries a spinal cord injury(SCI) occurs every 16 min. SCI occurs due to tissue destruction, primarily by mechanical and secondarily ischemic. Primary damage occurs at the time of the injury. It cannot be improved. Following the primary injury, secondary harm mechanisms gradually result in neuronal death. One of the prominent causesof secondary harm is energy deficit, emerging from ischemia, whose main cause in the early stage, is impaired perfusion. Due to the advanced techniques in spinal surgery, SCI is still challenging for surgeons. Spinal cord doesn't have a self-repair property. The main damage occurs at the time of the injury primarily by mechanical factors that cannot be improved. Secondarily mechanisms take part in the following sections. Spinal compression and neurological deficit are two major factors used to decide on surgery. According to advanced imaging techniques the classifications systems for spinal injury has been changed in time. Aim of the surgery is to decompress the spinal channel and to restore the spinal alinement and mobilize the patient as soon as possible. Use of neuroprotective agents as well as methods to achieve cell regeneration in addition to surgery would contribute to the solution. | Sedat Dalbayrak Onur Yaman Tevfik Y?lmaz | 2015 | World Journal of Orthopedics2015，6，1： | 7 |
| 6 | Kinetic study on leaching of nickel from Turkish lateritic ore in nitric acid solution显示文摘Dissolution kinetics of nickel from lateritic ore in nitric acid solution was investigated. Experimental parameters used were stirring speed(100-600 r/min), temperature(40-96 °C), nitric acid concentration(0.1-2 mol/L) and particle size(<106 μm). The shrinking core model was applied to the results of experiments investigating the effects of leaching temperature in the range of 40-90 °C and nitric acid concentration in range of 0.1-2 mol/L on nickel dissolution rate. The kinetic analysis shows that the nickel dissolution from lateritic ore could be described by diffusion model. The activation energy(E_a) for the dissolution reaction is calculated as 79.52 kJ/mol. | Tevfik AGACAYAK Veysel ZEDEF Ali ARAS | 2016 | Journal of Central South University2016，23，1： | 4 |
| 7 | Adipokines and ghrelin in gastric cancer cachexia显示文摘AIM:To investigate the roles of the adipocytokines,ghrelin and leptin in gastric cancer cachexia. METHODS:Resistin,ghrelin,leptin,adiponectin,insulin and insulin-like growth factor(IGF-Ⅰ),were measured in 30 healthy subjects,and 60 gastric cancer patients of which 30 suffered from cancer-induced cachexia and 30 served as a control group. The relationships between hormones,body mass index(BMI) loss ratio,age,gender,and Glasgow Prognostic Score(GPS) were investigated. RESULTS:Cachexia patients had higher tumor stage and GPS when compared with non-cachexia patients(P < 0.05). Ghrelin,resistin,leptin,adiponectin and IGF-Ⅰ,showed a significant correlation with BMI loss ratio and GPS(P < 0.05). A strong correlation was seen between GPS and BMI loss(R = -0.570,P < 0.0001). Multivariate analysis indicated that BMI loss was significantly independent as a predictor of ghrelin,resistin,leptin and IGF-Ⅰ(P < 0.05). Existence of an important significant relationship between resistin and insulin resistance was also noted. CONCLUSION:These results showed that serum ghrelin,leptin,adiponectin,and IGF-Ⅰ play important roles in cachexia-related gastric cancers. No relationshipwas found between resistin and cancer cachexia. Also,because of the correlation between these parameters and GPS,these parameters might be used as a predictor factor. | Mustafa Kerem Zafer Ferahkose Utku Tonguc Yilmaz Hatice Pasaoglu Ebru Ofluoglu Abdulkadir Bedirli Bulent Salman Tevfik Tolga Sahin Murat Akin | 2008 | World Journal of Gastroenterology2008，14，23： | 4 |
| 8 | Laryngopharyngeal reflux and Helicobacter pylori显示文摘Laryngopharyngeal reflux(LPR) occurs when gastric contents pass the upper esophageal sphincter, causing symptoms such as hoarseness, sore throat, coughing, excess throat mucus, and globus. The pattern of reflux is different in LPR and gastroesophageal reflux. LPR usually occurs during the daytime in the upright position whereas gastroesophageal reflux disease more often occurs in the supine position at night-time or during sleep. Ambulatory 24-h double pH-probe monitoring is the gold standard diagnostic tool for LPR. Acid suppression with proton pump inhibitor on a long-term basis is the mainstay of treatment. Helicobacter pylori(H. pylori) is found in many sites including laryngeal mucosa and interarytenoid region. In this paper, we aim to present the relationship between LPR and H. pylori and review the current literature. | Taner Yllmaz Münir Demir Bajin Rlza nder Günayd?n Serdar zer Tevfik Szen | 2014 | World Journal of Gastroenterology2014，20，27： | 4 |
| 9 | COVID-19 pandemic:Its impact on liver disease and liver transplantation显示文摘Severe pulmonary disease caused by the novel coronavirus[severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)],has devastated many countries around the world.It has overwhelmed the medical system.The priorities of many institutions have changed to manage critically ill corona virus infectious disease-2019(COVID-19)patients,which affected the working style of many departments.Hepatologists and transplant surgeons look after a very sensitive patient group.Patients with liver disease need special attention and continuous follow-up.Similarly,transplant candidates also need special care.Healthcare professionals in the field of hepatology face the overwhelming task of taking care of COVID-19 patients with hepatic complications,liver disease or transplant patients who are SARS-CoV-2 positive,and the patients on routine surveillance who do not have COVID-19.This review will evaluate COVID-19 from the perspective of its effect on the liver and its possible effects on patients with liver disease.Furthermore,the level of care for liver transplant recipients during the pandemic will be discussed. | Tevfik Tolga Sahin Sami Akbulut Sezai Yilmaz | 2020 | World Journal of Gastroenterology2020，26，22： | 4 |
| 10 | Liver transplantation for hepatocellular carcinoma:Historical evolution of transplantation criteria显示文摘Liver transplantation(LT) for hepatocellular carcinoma is still a hot topic,and the main factor that is associated with the success of treatment is to determine the patients who will benefit from LT.Milan criteria have been defined 25 years ago and still is being used for patient selection for LT.However,in living donor LT,the Milan criteria is being extended.Current criteria for patient selection do not only consider morphologic characteristics such as tumor size and number of tumor nodules but also biologic markers that show tumor aggressiveness is also being considered.In the present review article,we have summarized all the criteria and scoring systems regarding LT for hepatocellular carcinoma.All criteria have 5-year overall survival rates that were comparable to the Milan Criteria and ranged between 60%-85%.On the other hand,it was seen that the recurrence rates had increased as the Milan criteria were exceeded;the 5-year recurrence rates ranged between 4.9% to 39.9%.Treatment of hepatocellular carcinoma needs a multidisciplinary approach.Ideal selection criteria are yet to be discovered.The same is true for treatment modalities.The goal will be achieved by a harmonic interplay between basic science researchers and clinicians. | Volkan Ince Tevfik Tolga Sahin Sami Akbulut Sezai Yilmaz | 2022 | World Journal of Clinical Cases2022，10，29： | 2 |
| 11 | Comment on: Statin use and risk of diabetes mellitus显示文摘In manuscript named 'Statin use and risk of diabetes mellitus' by Chogtu et al, authors defined that pravastatin 40 mg/dL reduced the risk of diabetes by 30% in West of Scotland Coronary Prevention study. In fact, pravastatin 40 mg/d L reduced coronary heart disease risk approximately 30% in mentioned study. | Mehmet Ali Eren Tevfik Sabuncu Hüseyin Karaaslan | 2016 | World Journal of Diabetes2016，7，8： | 2 |
| 12 | Recent innovation in benchmark rates (BMR):evidence from influential factors on Turkish Lira Overnight Reference Interest Rate with machine learning algorithms显示文摘Some countries have announced national benchmark rates,while others have been working on the recent trend in which the London Interbank Offered Rate will be retired at the end of 2021.Considering that Turkey announced the Turkish Lira Overnight Reference Interest Rate(TLREF),this study examines the determinants of TLREF.In this context,three global determinants,five country-level macroeconomic determinants,and the COVID-19 pandemic are considered by using daily data between December 28,2018,and December 31,2020,by performing machine learning algorithms and Ordinary Least Square.The empirical results show that(1)the most significant determinant is the amount of securities bought by Central Banks;(2)country-level macroeconomic factors have a higher impact whereas global factors are less important,and the pandemic does not have a significant effect;(3)Random Forest is the most accurate prediction model.Taking action by considering the study’s findings can help support economic growth by achieving low-level benchmark rates. | Öer Depren Mustafa Tevfik Kartal Serpil KılıçDepren | 2021 | Financial Innovation2021，7，1： | 2 |
| 13 | Comparison of retrograde intrarenal surgery, shockwave lithotripsy, and percutaneous nephrolithotomy for treatment of medium-sized radiolucent renal stones显示文摘 | Berkan Resorlu Ali Unsal Tevfik Ziypak Akif Diri Gokhan Atis Selcuk Guven Ahmet Ali Sancaktutar Abdulkadir Tepeler Omer Faruk Bozkurt Derya Oztuna | 2013 | World Journal of Urology2013，，6： | 2 |
| 14 | Safety of hydroimplantation in cataract surgery in patients with pseudoexfoliation syndrome显示文摘AIM:To evaluate the safety of hydroimplantation in cataract surgery in patients with pseudoexfoliation syndrome.METHODS:This prospective randomized study comprised 100 eyes of 100 consecutive patients who underwent cataract surgery and implantation of foldable intraocular lens(IOL). Each eye was assigned to group 1 or group 2. Hydroimplantation without using viscoelastic agent as group 1(n=50), and hydroxypropylmethylcellulose(Eyevisc, Biotech, India) was used in group 2(n=50). RESULTS:There were no statistically significant differences in central corneal thickness(CCT) and corneal endothelial cell count(ECC) between both groups at each visit and percentage change in CCT and ECC(P>0.05). The mean intraocular pressure(IOP) at postoperative 5h increased statistically significantly in group 2(P<0.001). There was no statistically significant difference in IOP between two groups, before and after surgery excluding the 24 h postoperative IOP, but patients in group 2 had higher IOP than that in the group 1 at 24 h after surgery(P=0.035). No case in either group experienced posterior capsular rupture, or zonular dialysis. Fixation of the globe during IOL implantation was better in group 1 than that in group 2.CONCLUSION:Hydroimplantation has advantages in terms of IOP changes and duration of the surgery and seems to be safe in patients with pseudoexfoliation syndrome. | Tevfik Ogurel Reyhan Ogurel Zafer Onaran Kemal Ornek | 2017 | International Journal of Ophthalmology(English edition)2017，10，5： | 2 |
| 15 | Carrier frequency offset compensation with successive cancellation in uplink OFDMA systems显示文摘 | Tevfik Y Huseyin A | 2007 | IEEE Trans on Wireless Commun2007，6，10： | 1 |
| 16 | Adipose-derived stem cells in the treatment of hepatobiliary diseases and sepsis显示文摘Determination of the mesenchymal stem cells is one of the greatest and most exciting achievements that tissue engineering and regenerative medicine have achieved.Adipose-derived mesenchymal stem cells(AD-MSC)are easily isolated and cultured for a long time before losing their stem cell characteristics,which are self-renewal and pluripotency.AD-MSC are mesenchymal stem cells that have pluripotent lineage characteristics.They are easily accessible,and the fraction of stem cells in the adipose tissue lysates is highest among all other sources of mesenchymal stem cells.It is also HLA-DR negative and can be transplanted allogenically without the need for immunosuppression.These advantages have popularized its use in many fields including plastic reconstructive surgery.However,in the field of hepatology and liver transplantation,the progress is slower.AD-MSC have the potential to modulate inflammation,ameliorate ischemia-reperfusion injury,and support liver and biliary tract regeneration.These are very important for the treatment of various hepatobiliary diseases.Furthermore,the anti-inflammatory potential of these cells has paramount importance in the treatment of sepsis.We need alternative therapeutic approaches to treat end-stage liver failure.AD-MSC can provide a means of therapy to bridge to definitive therapeutic alternatives such as liver transplantation.Here we propose to review theoretic applications of AD-MSC in the treatment of hepatobiliary diseases and sepsis. | Basri Satilmis Gizem Selen Cicek Egemen Cicek Sami Akbulut Tevfik Tolga Sahin Sezai Yilmaz | 2022 | World Journal of Clinical Cases2022，10，14： | 1 |
| 17 | A Survey of Spectrum Algorithms for Cognitive Radio Applications 显示文摘 | Tevfik Yucek Huseyin Arslan | 2009 | IEEE Communications Surveys & Tutorials2009，11，1： | 1 |
| 18 | Potential of Dual Time Point FDG-PET Imaging in Differentiating Malignant from Benign Pleural Disease显示文摘 | Ayse Mavi Sandip Basu Tevfik F. Cermik Muammer Urhan Mehdi Bathaii Dhurairaj Thiruvenkatasamy Mohamed Houseni Simin Dadparvar Abass Alavi | 2009 | Molecular Imaging and Biology2009，，5： | 1 |
| 19 | Carrier frequency offset compensation with successive cancellation in uplink OFDMA systems显示文摘 | Tevfik Y Huseyin A | 2007 | IEEE Transactions on Wireless Communications2007，6，10： | 1 |
| 20 | Screening of Antioxidant, Antimicrobial Activities and Chemical Contents of Edible Mushrooms Wildly Grown in the Black Sea Region of Turkey显示文摘 | Tevfik Ozen Cihan Darcan Oznur Aktop Ibrahim Turkekul | 2011 | Combinatorial Chemistry & High Throughput Screening2011，，2： | 1 |
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