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| 1 | Adipokines and ghrelin in gastric cancer cachexia显示文摘AIM:To investigate the roles of the adipocytokines,ghrelin and leptin in gastric cancer cachexia. METHODS:Resistin,ghrelin,leptin,adiponectin,insulin and insulin-like growth factor(IGF-Ⅰ),were measured in 30 healthy subjects,and 60 gastric cancer patients of which 30 suffered from cancer-induced cachexia and 30 served as a control group. The relationships between hormones,body mass index(BMI) loss ratio,age,gender,and Glasgow Prognostic Score(GPS) were investigated. RESULTS:Cachexia patients had higher tumor stage and GPS when compared with non-cachexia patients(P < 0.05). Ghrelin,resistin,leptin,adiponectin and IGF-Ⅰ,showed a significant correlation with BMI loss ratio and GPS(P < 0.05). A strong correlation was seen between GPS and BMI loss(R = -0.570,P < 0.0001). Multivariate analysis indicated that BMI loss was significantly independent as a predictor of ghrelin,resistin,leptin and IGF-Ⅰ(P < 0.05). Existence of an important significant relationship between resistin and insulin resistance was also noted. CONCLUSION:These results showed that serum ghrelin,leptin,adiponectin,and IGF-Ⅰ play important roles in cachexia-related gastric cancers. No relationshipwas found between resistin and cancer cachexia. Also,because of the correlation between these parameters and GPS,these parameters might be used as a predictor factor. | Mustafa Kerem Zafer Ferahkose Utku Tonguc Yilmaz Hatice Pasaoglu Ebru Ofluoglu Abdulkadir Bedirli Bulent Salman Tevfik Tolga Sahin Murat Akin | 2008 | World Journal of Gastroenterology2008，14，23： | 4 |
| 2 | Effects of Nuclear Factor-κB Inhibitors on Colon Anastomotic Healing in Rats 1显示文摘 | Abdulkadir Bedirli Bulent Salman Hatice Pasaoglu Ebru Ofluoglu Omer Sakrak | 2011 | Journal of Surgical Research2011，，1： | 1 |
| 3 | Administration of Chlorella sp. microalgae reduces endotoxemia, intestinal oxidative stress and bacterial translocation in experimental biliary obstruction显示文摘 | Abdulkadir Bedirli Mustafa Kerem Ebru Ofluoglu Bulent Salman Hikmet Katircioglu Nurdan Bedirli Demet Y?lmazer Murat Alper Hatice Pasaoglu | 2009 | Clinical Nutrition2009，，6： | 1 |
| 4 | Role of Ghrelin and Leptin in Predicting the Severity of Acute Pancreatitis显示文摘 | Mustafa Kerem Abdulkadir Bedirli Hatice Pasaoglu Cigdem Unsal Tonguc Utku Yilmaz Ebru Ofluoglu Tevfik Tolga Sahin | 2007 | Digestive Diseases and Sciences2007，，4： | 1 |
| 5 | Effects of microalgae chlorella species crude extracts on intestinal adaptation in experimental short bowel syndrome显示文摘AIM: To evaluate the effects of chlorella crude extract (CCE) on intestinal adaptation in rats subjected to short bowel syndrome (SBS). METHODS: Wistar rats weighing 230-260 g were used in the study. After anesthesia a 75% small bowel resection was performed. Rats were randomized and divided into groups. Control group (n = 10): where 5% dextrose was given through a gastrostomy tube, Enteral nutrition (EN) group (n = 10): Isocaloric and isonitrogen EN (Alitraq, Abbott, USA), study group (n = 10): CCE was administrated through a gastrostomy tube. Rats were sacrif iced on the f ifteenth postoperative day and blood and tissue samples were taken. Histopathologic evaluation, intestinal mucosal protein and DNA levels, intestinal proliferation and apoptosis were determined in intestinal tissues, and total protein, albumin andcitrulline levels in blood were studied. RESULTS: In rats receiving CCE, villus lengthening, crypt depth, mucosal DNA and protein levels, intestinal proliferation, and serum citrulline, protein and albumin levels were found to be significantly higher than those in control group. Apoptosis in CCE treated rats was significantly reduced when compared to EN group rats. CONCLUSION: CCE has benef icial effects on intestinal adaptation in experimental SBS. | Mustafa Kerem Bulent Salman Hatice Pasaoglu Abdulkadir Bedirli Murat Alper Hikmet Katircioglu Tahir Atici E Ferda Perin Ebru Ofluoglu | 2008 | World Journal of Gastroenterology2008，14，28： | 0 |
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