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| 1 | The role of Epstein-Barr virus infection in the pathogenesis of nasopharyngeal carcinoma显示文摘Nasopharyngeal carcinoma(NPC) is closely associated with Epstein-Barr virus(EBV) infection. EBV episomes are detected in almost all NPC cells. The role of EBV in NPC pathogenesis has long been postulated but remains enigmatic. In contrast to infection of B lymphocytes, EBV infection does not directly transform nasopharyngeal epithelial cells into proliferative clones with malignant potential. EBV infection of normal pharyngeal epithelial cells is predominantly lytic in nature. Genetic alterations in premalignant nasopharyngeal epithelium, in combination with inflammatory stimulation in the nasopharyngeal mucosa, presumably play essential roles in the establishment of a latent EBV infection in infected nasopharyngeal epithelial cells during the early development of NPC. Establishment of latent EBV infection in premalignant nasopharyngeal epithelial cells and expression of latent viral genes, including the BART transcripts and BART-encoded micro RNAs, are crucial features of NPC. Expression of EBV genes may drive further malignant transformation of premalignant nasopharyngeal epithelial cells into cancer cells. The difficulties involved in the establishment of NPC cell lines and the progressive loss of EBV epsiomes in NPC cells propagated in culture strongly implicate the contribution of host stromal components to the growth of NPC cells in vivo and maintenance of EBV in infected NPC cells. Defining the growth advantages of EBV-infected NPC cells in vivo will lead to a better understanding of the contribution of EBV infection in NPC pathogenesis, and may lead to the identification of novel therapeutic targets for NPC treatment. | Chi Man Tsang Sai Wah Tsao | 2015 | Virologica Sinica2015，30，2： | 26 |
| 2 | Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial显示文摘 | Ann-Lii Cheng Yoon-Koo Kang Zhendong Chen Chao-Jung Tsao Shukui Qin Jun Suk Kim Rongcheng Luo Jifeng Feng Shenglong Ye Tsai-Sheng Yang Jianming Xu Yan Sun Houjie Liang Jiwei Liu Jiejun Wang Won Young Tak Hongming Pan Karin Burock Jessie Zou Dimitris Volio | 2009 | Lancet Oncology2009，，1： | 23 |
| 3 | Video-assisted thoracoscopic surgery (VATS) for bilateral primary spontaneous pneumothorax显示文摘目的将由帮助录像的 thoracoscopic 外科(大桶) 考察我们双边的主要自发的气胸(PSP ) 的治疗的经验。回顾的图表评论被在诊所上或电话会见跟随的材料和方法。病人们被在乎为由在四个医学中心的一位胸的外科医生或在北、中央的台湾的社区医院。有双边的 PSP 的 13 个病人从 1994 年 7 月同时或顺序经历了双边的大桶到 2005 年 12 月。结果与从 15 ~ 36 年(平均数 23.1 年)的年龄, 12 男性和男性女性同时为双边的 PSP 与大桶被对待,在双边的 pneumothoracis 的指示下面(n=4 ) 或顺序(n=9 ) 。在为非同时的 PSP 病人的第一和第二个相反地侧面的大桶过程之间的间隔从 7 d 到 6 年。13 个病人(84.6%) 中的十一个有突出的肺的 bullae/blebs,并且与机械或化学的 pleurodesis 经历了 bullae 切除术。吝啬的起作用的时间是( 45.6 ±1 8.3 ) min (范围 25 ~9 6 min )并且( 120.6 ±2 8.7 ) min (范围 84 ~1 66 min )分别地为非同时(为在第一个大桶以后的相反地侧面的方面的复发的第二个大桶)并且同时(双边的大桶在里面一操作)过程。没有手术后的死亡。然而,延长了漏气(>7 d ) 在在保守治疗以后恢复了的一个病人(7.7%) 发生了。胸试管排水的吝啬的持续时间是 3.1 d 并且中部在时期上面列在后面是 3.4 年。结论大桶是在双边的 PSP 的治疗的一个安全、有效的过程。因为甚至与可见 bullae,复发的发生不在我的组并且在某以前的文学那么高,双边的大桶仅仅与同时双边的 PSP 为病人被推荐。在一个仰卧的位置的双边的大桶应该仅仅在选择情况中被使用,因为可能的肋膜的粘附或在以后的方面上隐藏 bullae。 | Yi-jen CHEN Shi-ping LUH Kun-yen HSU Cheng-ren CHEN Thomas Chang-yao TSAO Jia-yuh CHEN | 2008 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2008，9，4： | 20 |
| 4 | Whole brain radiotherapy for the treatment of multiple brain metastases显示文摘 | Tsao M Lloyd N Wong R Chow E Rakovitch E Laperriere N | 2006 | 中国神经肿瘤杂志2006，4，2： | 17 |
| 5 | 车前草中苯乙醇苷化合物的电喷雾多级串联质谱研究显示文摘利用电喷雾多级串联质谱技术研究了车前草药材中的苯乙醇苷化合物,根据其在负离子条件下表现出的特征质谱行为,提出了车前草中的苯乙醇苷类化合物可能的电喷雾质谱碎裂规律,建立了车前草中苯乙醇苷化合物的快速分析、鉴定方法. | 李丽 刘志强 刘春明 Tsao Rong 吕磊 刘淑莹 | 2006 | 高等学校化学学报2006，27，8： | 9 |
| 6 | Long-term hepatic consequences of chemotherapy-related HBV reactivation in lymphoma patients显示文摘AIM: To investigate the long-term consequences of chemotherapy-related HBV reactivation in patients with lymphoma.METHODS: This study was based on the database of published prospective study evaluating HBV reactivation in HBV lymphoma patients during chemotherapy.Deteriorated liver reserve (DLR) was defined as development of either one of the following conditions during follow-up: (1) newly onset parenchyma liver disease, splenomegaly or ascites without evidence of lymphoma involvement; (2) decrease of the ratio (albumin/globulin ratio) to less than 0.8 or increase of the ratio of INR of prothrombin time to larger than 1.2 without evidence of malnutrition or infection. Liver cirrhosis was diagnosed by imaging studies.RESULTS: A total of 49 patients were included. The median follow-up was 6.2 years (range, 3.9-8.1 years).There were 31 patients with and 18 patients without HBV reactivation. Although there was no difference of overall survival (OS) and chemotherapy response rate between the two groups, DLR developed more frequently in patients with HBV reactivation (48.4% vs 16.7%; P= 0.0342). Among the HBV reactivators, HBV genotype C was associated with a higher risk of developing DLR (P = 0.0768) and liver cirrhosis (P = 0.003). Four of five patients with sustained high titer of HBV DNA and two of three patients with multiple HBV reactivation developed DLR. Further, patients with a sustained high titer of HBV DNA had the shortest OS among the HBV reactivators (P= 0.0000). No patients in the non-HBV reactivation group developed hepatic failure or liver cirrhosis.CONCLUSION: Chemotherapy-related HBV reactivation is associated with the long-term effect of deterioration of hepatic function. | Chi-Chung Wen Chao A.Hsiung Ih-Jen Su Ann-Lii Cheng Ming-Chih Chang Chao-Jung Tsao Woei-Yao Kao Wu-Ching Uen Chiun Hsu Chih-Hung Hsu Yen-Shen Lu Hwei-Fan Tien Tsu-Yi Chao Li-Tzong Chen Jacqueline Whang-Peng Pei-Jer Chen | 2005 | World Journal of Gastroenterology2005，11，34： | 8 |
| 7 | Epstein-Barr virus infection and persistence in nasopharyngeal epithelial cells显示文摘Epstein-Barr virus(EBV) infection is closely associated with undifferentiated nasopharyngeal carcinoma(NPC), strongly implicating a role for EBV in NPC pathogenesis; conversely, EBV infection is rarely detected in normal nasopharyngeal epithelial tissues. In general, EBV does not show a strong tropism for infecting human epithelial cells, and EBV infection in oropharyngeal epithelial cells is believed to be lytic in nature. To establish life-long infection in humans, EBV has evolved efficient strategies to infect B cells and hijack their cellular machinery for latent infection. Lytic EBV infection in oropharyngeal epithelial cells, though an infrequent event, is believed to be a major source of infectious EBV particles for salivary transmission. The biological events associated with nasopharyngeal epithelial cells are only beginning to be understood with the advancement of EBV infection methods and the availability of nasopharyngeal epithelial cell models for EBV infection studies. EBV infection in human epithelial cells is a highly inefficient process compared to that in B cells, which express the complement receptor type 2(CR2) to mediate EBV infection. Although receptor(s) on the epithelial cell surface for EBV infection remain(s) to be identified, EBV infection in epithelial cells could be achieved via the interaction of glycoproteins on the viral envelope with surface integrins on epithelial cells, which might trigger membrane fusion to internalize EBV in cells. Normal nasopharyngeal epithelial cells are not permissive for latent EBV infection, and EBV infection in normal nasopharyngeal epithelial cells usually results in growth arrest. However, genetic alterations in premalignant nasopharyngeal epithelial cells, including p16 deletion and cyclin D1 overexpression, could override the growth inhibitory effect of EBV infection to support stable and latent EBV infection in nasopharyngeal epithelial cells. The EBV episome in NPC is clonal in nature, suggesting that NPC develops from a single EBV-infected nasopharyngeal epithelial cell, and the establishment of persistent and latent EBV infection in premalignant nasopharyngeal epithelium may represent an early and critical event for NPC development. | Chi Man Tsang Wen Deng Yim Ling Yip Mu-Sheng Zeng Kwok Wai Lo Sai Wah Tsao | 2014 | Chinese Journal of Cancer2014，33，11： | 8 |
| 8 | Rotary ultrasonic-assisted milling of brittle materials显示文摘In order to improve the machining efficiency of ultrasonic milling,the easiest and most effective approach was started with the improvement of tool design.The main objective of this research was to utilize rotary ultrasonic machining (RUM's) effectiveness in removing brittle materials to extend the applications of this independent,innovative manufacturing method (self-driving rotary ultrasonic machining),and to experimentally investigate its milling application on brittle materials.The designed tool was used in the conjunction with previously established RUM machine tools,and glass was selected as workpiece for experiments.The interrelationship between feed rate and depth of cut was discussed.By measuring the surface roughness of workpiece,the overall efficacy of utilizing RUM for milling was evaluated and presented.Ultrasonic assisted milling results in the reduction of milling resistance,which leads to a greater process rate. | KUO Kei-lin TSAO Chung-chen | 2012 | 中国有色金属学会会刊:英文版2012，22，S3： | 6 |
| 9 | High Prevalence of Antibiotic-Resistant Bacterial Infections Among Patients With Cirrhosis at a US Liver Center显示文摘 | Puneeta Tandon Angela DeLisle Jeffrey E. Topal Guadalupe Garcia–Tsao | 2012 | Clinical Gastroenterology and Hepatology2012，，11： | 5 |
| 10 | 新型他汀类药物——ZD4522对ApoE基因敲除小鼠血管内皮粘附功能的影响显示文摘目的 :观察他汀类新药ZD45 2 2对ApoE基因敲除小鼠主动脉内皮粘附单核细胞的抑制效应。 方法 :40只高胆固醇血症动物模型 ApoE基因敲除小鼠随机均分为A ,B ,C ,D ,E 5组 ,各组ZD45 2 2的皮下注射剂量分别为 0 ,1,5 ,2 0和 2 0mg·kg-1,qd ,E组给药 6周 ,其余 4组均给药 2周。 2或 6周后测定小鼠血浆胆固醇水平和主动脉内皮对单核细胞的粘附率。结果 :5组ApoE基因敲除小鼠血浆胆固醇水平均比正常小鼠显著升高 (P <0 .0 1) ,与A组比较 ,E组血浆胆固醇水平明显降低 (P <0 .0 1)。 5组ApoE基因敲除小鼠的主动脉内皮单核细胞粘附率均高于正常组 ,与A组比较 ,C ,D ,E组的单核细胞粘附率均显著降低 (P <0 .0 5 ,P <0 .0 1,P <0 .0 1)。结论 :他汀类新药ZD45 2 2对ApoE基因敲除小鼠血管内皮粘附单核细胞有明显的抑制作用 。 | 黄海英 周广耀 Phillip S Tsao | 2001 | 中国新药杂志2001，10，12： | 5 |
| 11 | 高血压病并胰岛素抵抗患者单核细胞粘附功能的变化显示文摘观察高血压、胰岛素抵抗对单核细胞—血管内皮粘附功能的影响 ,采用改良的胰岛素抑制试验和单核细胞—血管内皮细胞粘附试验检测 33例高血压病患者和 32例正常对照者的胰岛素敏感性和单核细胞—血管内皮粘附功能。结果发现 ,高血压病患者单核细胞对内皮的粘附性显著高于正常对照者 (P <0 .0 1) ,且高血压患者稳态血糖浓度与单核细胞粘附数显著正相关 (r=0 .6 1,P <0 .0 0 1) ,正常对照者稳态血糖浓度与单核细胞粘附数也显著正相关 (r=0 .71,P <0 .0 0 1) ,而平均动脉压只有在两组合并分析时与单核细胞粘附数存在显著正相关关系 (r=0 .4 3,P <0 .0 0 1)。经多元回归分析发现 ,稳态血糖浓度及胰岛素浓度与单核细胞粘附数有独立的相关关系。结果提示 ,高血压、胰岛素抵抗使单核细胞对血管内皮的粘附性增强 ,这可能是高血压、胰岛素抵抗等代谢异常易发生动脉粥样硬化的机制之一。 | 李伟 吴智勇 Gerald M Reaven Philip S Tsao | 2002 | 中国动脉硬化杂志2002，10，2： | 4 |
| 12 | Computational neuroscience:a frontier of the 21^st century显示文摘THEORY IN NEUROSCIENCE The human brain is a biological organ,weighing about three pounds or 1.4 kg,that determines our behaviors,thoughts,emotions and consciousness.Although comprising only 2%of the total body weight,the brain consumes about 20%of the oxygen entering the body.With the expensive energy demand,the brain enables us to perceive and act upon the external world,as well as reflect on our internal thoughts and feelings. | Xiao-Jing Wang Hailan Hu Chengcheng Huang Henry Kennedy Chengyu Tony Li Nikos Logothetis Zhong-Lin Lu Qingming Luo Mu-ming Poo Doris Tsao Si Wu Zhaohui Wu Xu Zhang Douglas Zhou | 2020 | National Science Review2020，7，9： | 4 |
| 13 | Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma according to baseline status: Subset analyses of the phase III Sorafenib Asia–Pacific trial显示文摘 | Ann-Lii Cheng Zhongzhen Guan Zhendong Chen Chao-Jung Tsao Shukui Qin Jun Suk Kim Tsai-Sheng Yang Won Young Tak Hongming Pan Shiying Yu Jianming Xu Fang Fang Jessie Zou Giuseppe Lentini Dimitris Voliotis Yoon-Koo Kang | 2011 | European Journal of Cancer2011，，10： | 4 |
| 14 | Rotablation in the treatment of high-risk patients with heavily calcified left-main coronary lesions显示文摘Objective Heavily calcified left-main coronary diseases (LMCA) remain a formidable challenge for percutaneous interventions (PCI). This study was to investigate the safety and efficacy of using rotational atherectomy (RA) in treating such lesions in actual practice. Methods From February 2004 to March 2012, all consecutive patients who received RA for heavily-calcified LMCA lesions in our cath lab were en-rolled. The relevant clinical and angiographic characteristics at the time of index PCI, as well as the clinical follow-up outcomes, were re-trieved and analyzed. Results A total of 34 consecutive patients were recruited with a mean age 77.2 ± 10.2 years. There were 82.4%pre-sented with acute coronary syndrome and 11.8%with cardiogenic shock. Chronic renal disease and diabetes were seen in 64.7%and 52.9%, respectively. Triple-vessel coronary disease was found in 76.5%of them. The mean SYNTAX score was 50 ± 15 and EuroSCORE II scale 5.6 ± 4.8. The angiographic success rate was 100%with a procedural success rate of 91.2%. The mean number of burrs per patient was 1.7 ± 0.5. Crossing-over stenting was used in 64.7%. Most stents were drug-eluting (67.6%). Intra-aortic ballon pump was used in 20.6%of the procedures. Three patients died during hospitalization, all due to presenting cardiogenic shock. No major complication occurred. Among 31 hospital survivors, the major adverse cardiac events (MACE) rate was 16.1%, all due to target lesion revascularization or target vessel revas-cularization. Conclusions In high-surgical-risk elderly patients, plaque modification with RA in PCI of heavily-calcified LMCA could be safely accomplished with a minimal complication rate and low out-of-hospital MACE. | Meng-Hsiu Chiang Hung-Tao Yi Cheng-Rong Tsao Wei-Chun Chang Chieh-Shou Su Tsun-Jui Liu Kae-Woei Liang Chih-Tai Ting Wen-Lieng Lee | 2013 | Journal of Geriatric Cardiology2013，10，3： | 4 |
| 15 | 加拿大产藜麦可溶性酚类物质组成及抗氧化活性显示文摘藜麦(Chenopodium quinoa willd.)的营养价值和潜在的健康功效日益引起人们重视,文中借助HPLC/LC-MS等技术方法对不同品种加拿大产藜麦的酚类物质组成及抗氧化能力进行比较研究。鉴定的23种游离态酚类和19种结合态酚类中主要成分是酚酸,如香草酸、阿魏酸及其衍生物,也有部分黄酮类化合物存在。其中红色品种藜麦的总酚和总黄酮含量及其抗氧化活性显著高于白色品种。 | 高凯 张文涛 汤尧 李喜宏 RONG Tsao | 2016 | 食品与发酵工业2016，42，7： | 4 |
| 16 | Bank Reforms, Competition and Efficiency in China's Banking System: Are Small City Bank Entrants More Efficient?显示文摘这篇论文象 pre-WTO 和 post-WTO 就职时期一样由大银行和小城市银行在中国的银行系统分析技术效率。为 63 使用失衡的面板数据集存超过 1997 2006 并且采用随机的边疆函数途径,实验结果表明新进入者,小城市银行,平均比义不容辞的大银行经历了一个稍微更高的效率分数。与 pre-WTO 就职时期相比,效率分数被发现由于比赛效果在入口以后显著地改善了进 WTO。这比赛效果为小城市银行是特别地相关的。最后, X 无效的决定因素被检验。 | Hui-Lin Lin Chia-Chi Tsao Chih-Hai Yang | 2009 | China & World Economy2009，17，5： | 4 |
| 17 | 最初的格拉斯哥昏迷量表得分可预测后循环卒中溶栓治疗的效果 | Tsao J.W. Hemphill III J.C. Johnston S.C. 郭俊 | 2005 | 世界核心医学期刊文摘(神经病学分册)2005，0，11： | 3 |
| 18 | Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial显示文摘 | Ann-Lii Cheng Yoon-Koo Kang Zhendong Chen Chao-Jung Tsao Shukui Qin Jun Suk Kim Rongcheng Luo Jifeng Feng Shenglong Ye Tsai-Sheng Yang Jianming Xu Yan Sun Houjie Liang Jiwei Liu Jiejun Wang Won Young Tak Hongming Pan Karin Burock Jessie Zou Dimitris Volio | 2009 | Lancet Oncology2009，，1： | 3 |
| 19 | A Randomized, Prospective, Double-Blind, Placebo-Controlled Trial of Terlipressin for Type 1 Hepatorenal Syndrome显示文摘 | Arun J. Sanyal Thomas Boyer Guadalupe Garcia–Tsao Frederick Regenstein Lorenzo Rossaro Beate Appenrodt Andres Blei Veit Gülberg Samuel Sigal Peter Teuber | 2008 | Gastroenterology2008，，5： | 3 |
| 20 | Mechanism and management of burr entrapment:A nightmare of interven-tional cardiologists显示文摘Entrapment of the burr within calcified lesion is an uncommon, but serious complication during rotational atherectomy and usually needs surgical retrieval. We report a case series of this complication and also review the possible mechanisms, such as kokesi phenomenon or insufficient pecking motion with decreased rotational speed. We also review the potential techniques ever proposed to rescue this complica-tion percutaneously, including simple manual traction, balloon dilation to release the trap, snaring the burr as distal as possible for forceful local traction and wedging the burr with a child catheter to facilitate retrieval. Gentle pecking motion of the burr for sufficient ablation and shortening the run less than 15 s may avoid such complications. Interventional cardiologists using the rotablator should be familiar with the tips and tricks to avoid and rescue this complication. | Chia-Pin Lin Ji-Hung Wang Wen-Ling Lee Po-Ming Ku Wei-Hsian Yin Ten-Ping Tsao Chi-Jen Chang | 2013 | Journal of Geriatric Cardiology2013，10，3： | 3 |
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