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| 1 | Transarterial chemoembolization using degradable starch microspheres and iodized oil in the treatment of advanced hepatocellular carcinoma: evaluation of tumor response, toxicity, and survival显示文摘BACKGROUND: In a multidisciplinary conference patients with advanced non-resectable hepatocellular carcinoma (HCC) were stratified according to their clinical status and tumor extent to different regional modalities or to best supportive care. The present study evaluated all patients who were stratified to repeated transarterial chemoembolization (TACE) from 1999 until 2003 in terms of tumor response, toxicity, and survival. A moderate embolizing approach was chosen using a combination of degradable starch microspheres (DSM) and iodized oil (Lipiodol) in order to combine anti-tumoral efficiency and low toxicity. METHODS: Fourty-seven patients were followed up prospectively. TACE treatment consisted of cisplatin (50 mg/m2), doxorubicin (50 mg/m2), 450-900 mg DSM, and 5-30 ml Lipiodol. DSM and Lipiodol were administered according to tumor vascularization. Patient characteristics,toxicity, and complications were outlined. In multivariate regression analyses of pre-treatment variables from a prospective database, predictors for tumor response and survival after TACE were determined. RESULTS: 112 TACE courses were performed (2.4±1.5 courses per patient). Mean maximum tumor size was 75 (± 43) mm, in 68% there was bilobar disease. Best response to TACE treatment was: progressive disease (PD) 9%, stable disease (SD) 55%, partial remission (PR) 36%, and complete remission (CR) 0%. Multivariate regression analyses identified tumor size ≤75 mm, tumor number ≤5, and tumor hypervascularization as predictors for PR. The overall 1-, 2-, and 3-year-survival rates were 75%, 59%, and 41%, respectively, and the median survival was 26 months. Low α-fetoprotein levels (<400 ng/ml) (Odds ratio=3.3) and PR as best response to TACE (Odds ratio=6.7) were significantly associated with long term survival (>30 months, R2=36%). Grade 3 toxicity occurred in 7.1% (n=8), and grade 4 toxicity in 3.6% (n=4) of all courses in terms of reversible leukopenia and thrombocytopenia. The incidence of major complications was 5.4% (n=6). All complications were managed conservatively. The mortality within 6 weeks after TACE was 2.1% (one patient). CONCLUSIONS: DSM and Lipiodol were combined successfully in the palliative TACE treatment of advanced HCC resulting in high rates of tumor response and survival at limited toxicity. Favourable tumor response was associated with tumor extent and vascularization. TACE using DSM and Lipiodol can be considered a suitable palliative measure in patients who might not tolerate long acting embolizing agents. | Timm D Kirchhoff Joerg S Bleck Arne Dettmer Ajay Chavan Herbert Rosenthal Sonja Merkesdal Bernd Frericks Lars Zender Nisar P Malek Tim F Greten Stefan Kubicka Michael P Manns Michael Galanski | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，3： | 15 |
| 2 | Direct ex vivo analysis of dendritic cells in patients with hepatocellular carcinoma显示文摘瞄准:与肝细胞癌(HCC ) 从病人分析树枝状的房间(DC ) 的显型和功能以便在这疾病理解他们的角色。方法:骨髓的的树枝状的房间在 HCC 病人的外部血被枚举。从外部血的天真、刺激的骨髓的的树枝状的房间上的 CD80, CD83, CD86 和 HLA 医生表示被分析。骨髓的的树枝状的房间从外部血被孤立,他们的功能被测试。吞噬作用用 FITC 葡聚糖祷告被分析,肽特殊刺激,在多形核白细胞 dI:dC 之上刺激 allogeneic T 房间和 cytokines 的分泌物的能力被测试。结果:骨髓的的树枝状的房间与 HCC 在病人被减少。在 CD80, CD83, CD86 和 HLA 医生表示的差别都没从 HCC 病人和健康控制在天真、刺激的骨髓的的树枝状的房间上被发现。肽 specific T 房间的正常吞噬作用或刺激与一个损害 allo-stimulatory 能力和减少的 IL-12 分泌物相对照被观察。结论:在病人的 mDCs 的损害 IL-12 生产能导致建议指导治疗可以提高的那 IL-12 的天真的 T 房间的一个损害 stimulatory 能力在 HCC 病人的肿瘤 specific 免疫者回答。 | Lars A Ormandy Anatol Frber Tobias Cantz Susanne Petrykowska Heiner Wedemeyer Monique Hrning Frank Lehner Michael P Manns Firouzeh Korangy Tim F Greten | 2006 | World Journal of Gastroenterology2006，12，20： | 12 |
| 3 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 4 | Liver Transplantation for Nonresectable Liver Metastases From Colorectal Cancer显示文摘 | Morten Hagness Aksel Foss P?l-Dag Line Tim Scholz P?l Foyn J?rgensen Bjarte Fosby Kirsten Muri Boberg ?ystein Mathisen Ivar P. Gladhaug Tor Skatvedt Egge Steinar Solberg John Hausken Svein Dueland | 2013 | Annals of Surgery2013，，5： | 4 |
| 5 | Pathological grading of regression following neoadjuvant chemoradiation therapy: the clinical need is now显示文摘 | Tom P MacGregor Tim S Maughan Ricky A Sharma | 2012 | Journal of Clinical Pathology2012，，10： | 2 |
| 6 | Assessment of erosion haz- ard with the USLE and GIS A ease study of the Upper Ewaso Nglro North basin of Kenya显示文摘 | Bancy M Mati Royston P C Morgan Francis N Gichuki John N Quinton Tim R Brewer Hans P l iniger | 2000 | lnternation Journal of Applied Earth Ob- servation and Geoinformation2000，2，2： | 1 |
| 7 | Alexithymia in diabetes mellitus 显示文摘 | Topsever P Filiz TIM Salman S | 2006 | Scott Med J2006，51，3： | 1 |
| 8 | Creation of viable pulmonary artery autografts through tissue engineering显示文摘 | Shinoka T Tim A D Ma P X | 1998 | J Thorac Cardiovas Surg1998，115，： | 1 |
| 9 | Modeling systems of innovation: a framework for industrial cluster analysis in regions 显示文摘 | TIM P HERVEY G | 1998 | Research Policy1998，，6： | 1 |
| 10 | Statistical process monitoring and Feedback adjustment-a discussion显示文摘 | TIM K | 1992 | Technometrics1992，34，3： | 1 |
| 11 | Structured light scanning for high-resolution documentation of in situ archaeological finds显示文摘 | SHANNON P M TIM G JEAN J H | 2009 | Journal of Archaeological Science2009，36，1： | 1 |
| 12 | Distribution and abundance of Antarctic krill (Euphausia superba) off East Antarctica (80-150E) during the Austral summer of 1995/1996显示文摘 | Tim P Stephen N Ian H | 2000 | Deep-Sea Res I/2000，47，： | 1 |
| 13 | Interannu- al and interdecadal variations of the East Asian sum-mor monsoon and tropical Pacific SSTs, part Ⅰ: roles of the subtropical ridge显示文摘 | CHANG C P ZHANG Yongsheng LI Tim | 2000 | Journal of Climate2000，13，24： | 1 |
| 14 | Towards sustainable tourism planning in New Zealand: Monitoring local government planning under the Resource Management Act显示文摘 | Joanne C Stephen J P Tim B | 2009 | Tourism Management2009，30，6： | 1 |
| 15 | Intcrannu- al and interdecadal variations of the East Asiom sum- mer monsoon and tropical Pacific SSTs, part Ⅱ: merid- ional structure of the monsoon显示文摘 | CHANG C P ZHANG Yongsheng LI Tim | 2000 | Journal of Climate2000，13，24： | 1 |
| 16 | Commentaries on ‘active networking and end-to-end arguments’显示文摘 | Tim S Beverly S | 1998 | IEEE Network1998，12，3： | 1 |
| 17 | Patenting Strategy of Entrepreneurial Oriented Firms in New Zealand 显示文摘 | Jenny Darroch Morgan Miles P Tim Muisson | 2005 | International Entrepreneurship and Management Journal2005，1，1： | 1 |
| 18 | Acute effects of ambient par- ticulate matter on mortality in Europe and North America: Results from the APHENA Study 显示文摘 | Evangelia S Roger P Tim R | 2008 | Environmental Health Perspectives2008，116，11： | 1 |
| 19 | Nature and nurture in the dynamics of C, N and P during litter decomposition in Cana- dian forests显示文摘 | Tim R Moore J A T Cindy E P | 2011 | Plant and Soil2011，339，12： | 1 |
| 20 | Escape of methane gas from the seabed along the West Spitsbergen continental margin显示文摘 | Westbrook Graham K. Thatcher Kate E. Rohling Eelco J. Piotrowski Alexander M. P?like Heiko Osborne Anne H. Nisbet Euan G. Minshull Tim A. Lanoisellé Mathias James Rachael H. Hühnerbach Veit Green Darryl Fisher Rebecca E. Crocker Anya J. Chab | 2009 | Geophysical Research Letters2009，，15： | 1 |
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