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| 1 | Transarterial chemoembolization using degradable starch microspheres and iodized oil in the treatment of advanced hepatocellular carcinoma: evaluation of tumor response, toxicity, and survival显示文摘BACKGROUND: In a multidisciplinary conference patients with advanced non-resectable hepatocellular carcinoma (HCC) were stratified according to their clinical status and tumor extent to different regional modalities or to best supportive care. The present study evaluated all patients who were stratified to repeated transarterial chemoembolization (TACE) from 1999 until 2003 in terms of tumor response, toxicity, and survival. A moderate embolizing approach was chosen using a combination of degradable starch microspheres (DSM) and iodized oil (Lipiodol) in order to combine anti-tumoral efficiency and low toxicity. METHODS: Fourty-seven patients were followed up prospectively. TACE treatment consisted of cisplatin (50 mg/m2), doxorubicin (50 mg/m2), 450-900 mg DSM, and 5-30 ml Lipiodol. DSM and Lipiodol were administered according to tumor vascularization. Patient characteristics,toxicity, and complications were outlined. In multivariate regression analyses of pre-treatment variables from a prospective database, predictors for tumor response and survival after TACE were determined. RESULTS: 112 TACE courses were performed (2.4±1.5 courses per patient). Mean maximum tumor size was 75 (± 43) mm, in 68% there was bilobar disease. Best response to TACE treatment was: progressive disease (PD) 9%, stable disease (SD) 55%, partial remission (PR) 36%, and complete remission (CR) 0%. Multivariate regression analyses identified tumor size ≤75 mm, tumor number ≤5, and tumor hypervascularization as predictors for PR. The overall 1-, 2-, and 3-year-survival rates were 75%, 59%, and 41%, respectively, and the median survival was 26 months. Low α-fetoprotein levels (<400 ng/ml) (Odds ratio=3.3) and PR as best response to TACE (Odds ratio=6.7) were significantly associated with long term survival (>30 months, R2=36%). Grade 3 toxicity occurred in 7.1% (n=8), and grade 4 toxicity in 3.6% (n=4) of all courses in terms of reversible leukopenia and thrombocytopenia. The incidence of major complications was 5.4% (n=6). All complications were managed conservatively. The mortality within 6 weeks after TACE was 2.1% (one patient). CONCLUSIONS: DSM and Lipiodol were combined successfully in the palliative TACE treatment of advanced HCC resulting in high rates of tumor response and survival at limited toxicity. Favourable tumor response was associated with tumor extent and vascularization. TACE using DSM and Lipiodol can be considered a suitable palliative measure in patients who might not tolerate long acting embolizing agents. | Timm D Kirchhoff Joerg S Bleck Arne Dettmer Ajay Chavan Herbert Rosenthal Sonja Merkesdal Bernd Frericks Lars Zender Nisar P Malek Tim F Greten Stefan Kubicka Michael P Manns Michael Galanski | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，3： | 15 |
| 2 | Direct ex vivo analysis of dendritic cells in patients with hepatocellular carcinoma显示文摘瞄准:与肝细胞癌(HCC ) 从病人分析树枝状的房间(DC ) 的显型和功能以便在这疾病理解他们的角色。方法:骨髓的的树枝状的房间在 HCC 病人的外部血被枚举。从外部血的天真、刺激的骨髓的的树枝状的房间上的 CD80, CD83, CD86 和 HLA 医生表示被分析。骨髓的的树枝状的房间从外部血被孤立,他们的功能被测试。吞噬作用用 FITC 葡聚糖祷告被分析,肽特殊刺激,在多形核白细胞 dI:dC 之上刺激 allogeneic T 房间和 cytokines 的分泌物的能力被测试。结果:骨髓的的树枝状的房间与 HCC 在病人被减少。在 CD80, CD83, CD86 和 HLA 医生表示的差别都没从 HCC 病人和健康控制在天真、刺激的骨髓的的树枝状的房间上被发现。肽 specific T 房间的正常吞噬作用或刺激与一个损害 allo-stimulatory 能力和减少的 IL-12 分泌物相对照被观察。结论:在病人的 mDCs 的损害 IL-12 生产能导致建议指导治疗可以提高的那 IL-12 的天真的 T 房间的一个损害 stimulatory 能力在 HCC 病人的肿瘤 specific 免疫者回答。 | Lars A Ormandy Anatol Frber Tobias Cantz Susanne Petrykowska Heiner Wedemeyer Monique Hrning Frank Lehner Michael P Manns Firouzeh Korangy Tim F Greten | 2006 | World Journal of Gastroenterology2006，12，20： | 12 |
| 3 | Reduced striatal volumes in Parkinson’s disease:a magnetic resonance imaging study显示文摘Background:The presence and extent of structural changes in the brain as a consequence of Parkinson’s disease(PD)is still poorly understood.Methods:High-resolution 3-tesla T1-weighted structural magnetic resonance images in sixty-five PD and 27 age-matched healthy control participants were examined.Putamen,caudate,and intracranial volumes were manually traced in the axial plane of 3D reconstructed images.Striatal nuclei volumes were normalized to intracranial volume for statistical comparison.Disease status was assessed using the Unified Parkinson’s Disease Rating Scale and Hoehn and Yahr scale.Cognitive status was assessed using global status tests and detailed neuropsychological testing.Results:Both caudate and putamen volumes were smaller in PD brains compared to controls after adjusting for age and gender.Caudate volumes were reduced by 11%(p=0.001)and putamen volumes by 8.1%(p=0.025).PD striatal volumes were not found to be significantly correlated with cognitive or motor decline.Conclusion:Small,but significant reductions in the volume of both the caudate and putamen occur in PD brains.These reductions are independent of the effects of age and gender,however the relation of these reductions to the functional loss of dopamine,which is characteristic of PD,remains unclear. | Toni L Pitcher Tracy R Melzer Michael R MacAskill Charlotte F Graham Leslie Livingston Ross J Keenan Richard Watts John C Dalrymple-Alford Tim J Anderson | 2012 | Translational Neurodegeneration2012，1，1： | 2 |
| 4 | The digital front-end of software radio terminals 显示文摘 | Tim H Matthias H Gerhard F | 1999 | IEEE Personal Communications1999，6，8： | 1 |
| 5 | Modelling the Persistence of Conditional Variances 显示文摘 | Robert F Engle Tim Bollerslev | 1986 | Econometric Reviews1986，5，1： | 1 |
| 6 | Source-control stormwater manage- ment for mitigating the impacts of urbanisation on baseflow: A review 显示文摘 | Perrine H Edoardo D Tim D F | 2013 | J Hydrol2013，485，： | 1 |
| 7 | Roughing It Up: Including Jump Components in the Measurement, Modeling, and Forecasting of Return Volatility显示文摘 | Andersen T G Tim Bollerslev F X Diebod | 2007 | The Review of Economics and Statistics2007，89，4： | 1 |
| 8 | Candidate High Spectral Resolution Infrared Indices for Crop Cover 显示文摘 | Tim J M Bruno A Mark D F | 1993 | Remote Sens Environ1993，46，1： | 1 |
| 9 | Analysis of the technical efficiency of state rubber farms in Vietnam显示文摘 | Tran V H Son Tim C Euan F | 1993 | Agricultural Economics1993，，9： | 1 |
| 10 | The digital front-end of software radio terminals显示文摘 | Tim H Matthias H Gerhard F | 1999 | IEEE Personal Communications1999，，8： | 1 |
| 11 | Chromosomal abnormalities in frozen shoulder显示文摘 | Adam F David D Tim B | 2009 | Shoulder Elbow2009，1，8： | 1 |
| 12 | Quantifying elemental sulfur ( SO ), bisulfide ( HS^- ) and polysulfides (Sx^2- ) using a voltammetric method 显示文摘 | Tim F R Theberge S M George Luther Ⅲ | 2000 | Analytica Chimica Acta2000，415，12： | 1 |
| 13 | Recent studies of particle packing in organic coatings显示文摘 | Gordon B F Tim S | 1999 | Progress in Organic Coatings1999，35，14： | 1 |
| 14 | Effect of hydrogen on the strength and superplastic deformation of beta-titanium alloys 显示文摘 | Zhang H Tim F L Xu J L | 1996 | Journal of Materials Science1996，31，： | 1 |
| 15 | Dead-zone compensation in motion control systems using adaptive fuzzy logic control 显示文摘 | LEWIS F L TIM W K WANG L Z | 1999 | IEEE Transactions on Control System Technology1999，7，6： | 1 |
| 16 | Rep and Rep' protein of porcine circovirus type 1 bind to the origin of replication in vitro显示文摘 | TOBIAS S TIM F ANNETI'E M | 2001 | Virol2001，291，1： | 1 |
| 17 | Plant sterols:Friend or foe in CNS disorders? 显示文摘 | Tim V Jeroen F J Jo M | 2015 | Progress Lipid Research2015，58，： | 1 |
| 18 | Quantltative fault seal prediction显示文摘 | Graham Y Brett F Tim N | 1997 | AAPG Bulletin1997，81，： | 1 |
| 19 | Heavy use of equations impedes commu-nication among biologists 显示文摘 | Tim W F Andrew D | 2012 | PNAS2012，109，11： | 1 |
| 20 | Extracellular superoxide dismutase in biology and medicine显示文摘 | Cheryl L F Lisa MS Tim DO | 2003 | Free Rad Biol Med2003，35，3： | 1 |
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