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| 1 | Reduced striatal volumes in Parkinson’s disease:a magnetic resonance imaging study显示文摘Background:The presence and extent of structural changes in the brain as a consequence of Parkinson’s disease(PD)is still poorly understood.Methods:High-resolution 3-tesla T1-weighted structural magnetic resonance images in sixty-five PD and 27 age-matched healthy control participants were examined.Putamen,caudate,and intracranial volumes were manually traced in the axial plane of 3D reconstructed images.Striatal nuclei volumes were normalized to intracranial volume for statistical comparison.Disease status was assessed using the Unified Parkinson’s Disease Rating Scale and Hoehn and Yahr scale.Cognitive status was assessed using global status tests and detailed neuropsychological testing.Results:Both caudate and putamen volumes were smaller in PD brains compared to controls after adjusting for age and gender.Caudate volumes were reduced by 11%(p=0.001)and putamen volumes by 8.1%(p=0.025).PD striatal volumes were not found to be significantly correlated with cognitive or motor decline.Conclusion:Small,but significant reductions in the volume of both the caudate and putamen occur in PD brains.These reductions are independent of the effects of age and gender,however the relation of these reductions to the functional loss of dopamine,which is characteristic of PD,remains unclear. | Toni L Pitcher Tracy R Melzer Michael R MacAskill Charlotte F Graham Leslie Livingston Ross J Keenan Richard Watts John C Dalrymple-Alford Tim J Anderson | 2012 | Translational Neurodegeneration2012，1，1： | 2 |
| 2 | Quantifying elemental sulfur ( SO ), bisulfide ( HS^- ) and polysulfides (Sx^2- ) using a voltammetric method 显示文摘 | Tim F R Theberge S M George Luther Ⅲ | 2000 | Analytica Chimica Acta2000，415，12： | 1 |
| 3 | Formaldehyde promotes and inhibits the proliferation of cultured turnour and endothelial cells显示文摘 | Tyihák E Bocsi J Timár F | 2001 | Cell Prolif2001，34，： | 1 |
| 4 | Stat3 and NF-κB activationprevents apoptosis in pancreatic carcinogensis显示文摘 | Florion R Christoph K Tim F | 2002 | Gastroenterology2002，123，6： | 1 |
| 5 | User-Level Network Interface Protocols 显示文摘 | R A F Bhoedjang Tim Ruhl Henri E Bal | 1998 | IEEE Computer1998，31，11： | 1 |
| 6 | User-Level Network Interface Protocols显示文摘 | Raoul A F Bhoedjang Tim Rühl Henri E Bal | 1998 | IEEE Computer1998，11，： | 1 |
| 7 | Intercomparision of DPASV and ISE for the Measurement of Cu Complexation Characteristics of NOM in Freshwater显示文摘 | TIM F R GABOURY B | 1999 | Environmental Science and Technology1999，33，： | 1 |
| 8 | Engle:Common persistence in conditional variance显示文摘 | Bollerslev Tim R F | | 0，，01： | 1 |
| 9 | Recovery of Escherichia coli O157:H7 from fiber optic waveguides used for rapid biosensor detection 显示文摘 | Kramer M F Tims T B DeMarco D R | 2002 | Journal of Rapid Methods Automatic Microbiology2002，10，： | 1 |
| 10 | A simple spreadsheet-based,MIAME-supportive format for microarray data:MAGE-TAB显示文摘 | Tim F R Philippe R S Paul T S | 2006 | BMC Bioinformatics2006，7，： | 1 |
| 11 | Evidence for iron, copper and zinc complexation as muhinuclear sulphide clusters in oxic rivers显示文摘 | TIM F R MICHAEL E LASSMAN D P | 2000 | Nature2000，406，： | 1 |
| 12 | Estimating Land Surface Evaporation:A Review of Methods Using Remotely Sensed Surface Temperature Data显示文摘 | Jetse D Kalma Tim R McVicar Matthew F McCabe | 2008 | Surv Geophys2008，29，： | 1 |
| 13 | An Exploratory Examination of Voice Behavior from an Impression Management Perspective显示文摘 | B F Jerry B Tim H C R Kim | | 0，，： | 1 |
| 14 | Antifouling paint booster biocides in the UK coastal evironment and potential risks of biological effects显示文摘 | Kevin V T Tim W F James W R | 2001 | Marine Pollution Bulletin2001，42，8： | 1 |
| 15 | Impact of Dnmtl deficiency, with and without low folate diets, on tumor numbers and DNA methylation in Min mice显示文摘 | Trasler J Deng L Melnyk S Pogribny I Hiou - Tim F Sibani S Oakes C Li E James SJ Rozen R | 2003 | Carcinogenesis2003，24，： | 1 |
| 16 | ^210 Pb and ^137 Cs Dating Methods in Lakes: A Retrospective Study显示文摘 | Gaboury B Tim F R | 2001 | Journal of Pale- olimnology2001，24，： | 1 |
| 17 | Rapid method for the confirmatory analysis of chrysoidine in aquaculture products by ultra-performance liquid chromatography- tandem mass spectrometry显示文摘 | Tim R Stephanie F Desire L | 2010 | Biomedical Chromatography2010，24，9： | 1 |
| 18 | Inracoronary thrombin injection using a microcatheter to treat guidewire-induced coronary artery perforation显示文摘 | TIM A F SOUNDOS K M SANTHOSH R M | 2011 | Cardiovasc Revasc Med2011，12，： | 1 |
| 19 | Quantifying elemental sulfur (SO), bisulfide (HS-) and polysulfides (S-) using a vohammetric method 显示文摘 | Tim F R Theberge S M Luther G E 11I | 2000 | Anal Chim Acta2000，415，1： | 1 |
| 20 | MLC1在调节星形胶质细胞-突触相互作用中的新角色显示文摘星形胶质细胞膜蛋白MLC1的功能丧失是伴皮质下囊肿的巨脑性白质脑病(MLC)的主要遗传原因,这一罕见病的特征是脑内离子和水稳态失衡。MLC1蛋白主要分布于大脑中的液体屏障周围,例如在星形胶质细胞接触血管的终足和接触脑膜的突起中。该蛋白是否在其他星形胶质细胞结构域中发挥作用尚不清楚。本研究表明MLC1存在于星形胶质细胞远端突起中,也称为突触周围星形胶质细胞突起(PAP)或星形胶质细胞小叶;在海马CA1区域它们与兴奋性突触密切相互作用。我们发现在Mlc1缺失小鼠中,向兴奋性突触延伸的PAP末端缩短。这一改变会影响谷氨酸能突触传递,导致自发释放事件的速率降低,并在具有挑战性的条件下减慢谷氨酸的再摄取。此外,虽然野生型小鼠中的PAP在恐惧调节过程从突触回缩,但我们发现在Mlc1缺失小鼠中,这种结构可塑性在本已更短的PAP出现障碍。最后,Mlc1缺失小鼠显示情境恐惧记忆减少。总之,本研究揭示了星形胶质细胞蛋白MLC1在调节PAP结构方面的意想不到的作用。MLC1的缺失会改变兴奋性突触传递,阻止恐惧调节诱导的正常PAP重塑,并破坏情境恐惧记忆表达。因此,MLC1是调节星形胶质细胞-突触相互作用的新参与者。 | Mandy S J Kater Katharina F Baumgart Aina Badia-Soteras Tim S Heistek Karen E Carney A Jacob Timmerman Jan R T vanWeering August B Smit Marjo S van der Knaap Huibert D Mansvelder Mark H G Verheijen Rogier Min | 2023 | 神经损伤与功能重建2023，18，5： | 0 |
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