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614篇 您的检索式:作者名="LEWIS F L"
    题名 作者 年代 出处 被引量
1PrP^C-related signal transduction is influenced by copper, membrane integrity and the alpha cleavage site显示文摘铜绑定,抛锚膜的、细胞的 prion 蛋白质(PrPC ) 有二个组成的劈开地点生产不同 N 终端和 C 终端碎片(N1/C1 和 N2/C2 ) 。用表示也人的 PrPC,鼠标 PrPC 或鼠标 PrPC 的 RK13 房间带 3F4 epitope,这研究在 endoproteolytic 劈开和一个通常认为的 PrPC 函数上探索了 PrPC 主要顺序的影响,地图 kinase 信号 transduction,响应外长的铜与或没有使不安的膜环境。PrPC 主要顺序,特别在 N1/C1 劈开地点附近,看起来在这个地点和细胞外的调整信号的 kinase 1/2 (ERK1/2 ) phosphorylation 影响解朊作用的基础层次,与处理激活增加与基础 ERK1/2 表明一种反的关系。人的 PrPC 独自响应铜显示出增加的 N1/C1 劈开,由特定的 p38 和 JNK/SAPK phosphorylation 伴随了。到加扣押胆固醇的抗菌素 filipin 的铜的联合暴露导致了一只老鼠信号蛋白质 phosphorylation 的 PrPC 特定的实质的增加,由 N1/C1 劈开的增加伴随了。怀有人的 N1/C1 劈开地点的老鼠 PrPC 基础地并且响应铜假定更似人类的侧面并且改变了膜环境。我们的结果证明在 N1/C1 劈开地点附近的 PrPC 主要顺序影响在这个地点处理的 endoproteolytic,它显得连接了基础地并且响应铜印射 kinase 信号 transduction。进一步,主要顺序看起来响应外长的刺激在 PrPC 相关的信号 transduction 的忠实上授与 N1/C1 劈开和膜完整的相互的依赖。Cathryn L Haigh 2009Cell Research2009,19,9:4
2Adaptive fuzzy logic control of discrete-time dynamical systems 显示文摘Jagannathan A Vandegrift M W Lewis F L 2000Automatica2000,36,2:2
3Robust Adaptive Control of Induction Motors Without Flux Measurment显示文摘Kwan C M Lewis F L Yeung K S 1995ACC1995,32,6:1
4Feedback linearization using neural networks显示文摘Yesildirec A Lewis F L 1995Automatica1995,31,11:1
5Neural network output feedback control of robot manipulators 显示文摘KIM Y H LEWIS F L 1999IEEE Trans on Robotics and Automation1999,15,2:1
6Discrete-time non- linear HJB solution using approximate dynamic programming: Convergence proof显示文摘Al-Tamimi A Lewis F L Abu-Khalaf M 2008IEEE Transactions on Systems Man and Cybernetics Part B: Cybernetics2008,38,4:1
7Finite-time distributed con- sensus via binary control protocols 显示文摘Chen G Lewis F L Xie L H 2011Automatica2011,47,9:1
8A survey of linear singular systems显示文摘Lewis F L 1986Circuits Systems and Signal Processing1986,5,1:1
9Chained aggregation of singular system显示文摘 Christodoulou M A Mertzios B G 1989IEEE Trans on Automatic and Control1989,34,9:1
10Dynamic analysis and control of a Stewart platform manipulator 显示文摘Lbret G Liu K Lewis F L 1993Journal of Robotic Systems1993,10,5:1
11Policy iterations on theHamilton-Jacobi-Isaacs equation for state feedback control withinput saturation 显示文摘Abu-Khalaf M Lewis F L Huang J 2006IEEE Transactions on AutomaticControl2006,51,12:1
12The Arabidopsis phenylalanine ammonia lyase gene family:kinetic characterization of the four PAL isoforms显示文摘Cochrane F C Davin L B Lewis N G 0,,11:1
13Evaluating the Stewart platform for manufacturing显示文摘Fitzgerald J M Lewis F L 1993Robotics Today1993,6,1:1
14Current issues of sustainable pro -duction, eco-supply chains and eco-logistics for sustainable develop -ment 显示文摘Koh S C L Birkin F Lewis L 2005International Journal of Global Environmental Issues2005,7,1:1
15Robust practical point stabilization of a nonholonomic mobile robot using neural networks 显示文摘 Lewis F L 1997Journal of Intelligent and Robotic Systems1997,20,:1
16A survey of linear singular systems 显示文摘Lewis F L 1986Circuits Systems and Singular Processing1986,5,1:1
17Disturbance and friction compensations in hard disk drives using neural networks显示文摘Lai C Y Lewis F L Venkataramanan V 2010IEEE Transactions on Industrial Electronics2010,57,2:1
18FDA's pediatric device consortia:National program fosters pediatric medical device development显示文摘Ulrich L C Joseph F D Lewis D Y 2013Pediatrics2013,131,5:1
19Deadzone compensation in discrete time using adaptive fuzzy logic显示文摘CAMPOS J LEWIS F L 1999IEEE Transactions on Fuzzy Systems1999,7,6:1
20Control of a nonholonomic mobile robot: backstepping kinematics into dynamics 显示文摘 Lewis F L 1997Journal of Robotic Systems1997,14,3:1
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