|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 肌萎缩性侧索硬化蛋白激活小胶质细胞NLRP3炎性小体显示文摘小胶质细胞NLRP3炎性小体激活正在成为神经退行性变过程中神经炎症的关键因素。诸如β-淀粉样蛋白和α-突触核蛋白之类的致病性蛋白质聚集体触发小胶质NLRP3激活,从而导致半胱天冬酶-1激活和IL-1β的分泌。在小鼠肌萎缩性侧索硬化症(ALS)的SOD1G93A模型中,半胱天冬酶-1和IL-1β均促进疾病进展,提示小胶质NLRP3在该进程中发挥作用。然而先前的研究表明,SOD1G93A小鼠小胶质细胞不表达NLRP3,SOD1G93A蛋白在小胶质细胞中产生独立于NLRP3的IL-1β。本研究论证了使用Nlrp3-GFP基因敲入小鼠,在SOD1G93A小鼠中小胶质细胞表达NLRP3。本研究显示聚集和可溶性SOD1G93A均可激活小鼠原代小胶质细胞中的炎性小体,导致半胱天冬酶-1和IL-1β裂解,ASC斑点形成以及呈剂量和时间依赖性的IL-1β分泌。重要的是,SOD1G93A无法从缺乏Nlrp3的小胶质细胞或者用特异性NLRP3抑制剂MCC950预处理的小胶质细胞中诱导IL-1β分泌,从而证实NLRP3是介导SOD1诱导的小胶质细胞IL-1β分泌的关键炎症小体复合物。在TDP-43Q331K ALS小鼠模型中也观察到小胶质NLRP3上调,TDP-43野生型和突变蛋白亦可以NLRP3依赖性的方式激活小胶质炎性小体。从机制上讲,本研究确定了活性氧簇和ATP的生成是SOD1G93A介导的NLRP3激活所需的关键事件。总之,本研究的数据表明ALS小胶质细胞表达NLRP3,而病理ALS蛋白激活小胶质NLRP3炎性小体。因此,NLRP3抑制可能是阻止小胶质细胞神经炎症和ALS疾病进展的潜在治疗方法。 | Vandana Deora John D Lee Eduardo AAlbornoz Luke McAlary Cyril J Jagaraj Avril A B Robertson Julie D Atkin Matthew A Cooper Kate Schroder Justin J Yerbury Richard Gordon Trent MWoodruff 杜一星(编译) | 2020 | 神经损伤与功能重建2020，15，9： | 13 |
| 2 | XIAP regulates akt activity and caspase-3-dependent cleavage during eisplatin-induced apoptosis in human ovarian epithelial cancer eells显示文摘 | Eric A Gordon B M Benjamin K T | 2001 | Cancer Res2001，61，5： | 1 |
| 3 | Submarine thermal springs on the Galapagos Rift 显示文摘 | Corliss J B Dymond J Gordon L I | 1979 | Science1979，203，： | 1 |
| 4 | Forests and climate change: forciags, feedbacks, and the climate benefits of forests 显示文摘 | GORDON B B | 2008 | Science2008，320，5882： | 1 |
| 5 | Earlyonset sepsis in very low birth weight neonates:a report form the National Institute of Child Health and Human Development Neonatal Research Network显示文摘 | Stoll B J Gordon T Korones S B | 1996 | Pediatrics1996，129，1： | 1 |
| 6 | A Study of the Environmental Disclosure Policies of Australian Corporations 显示文摘 | Deegan C Gordon B | 1996 | Accounting and Business Research1996，26，3： | 1 |
| 7 | Differential gene expression in endometrium,endometrial lymphocytes,and trophoblasts during successful and abortive embryo implantation显示文摘 | CHANDRAKANT T GORDON P B YUAN F | 2006 | J Immunol2006，176，： | 1 |
| 8 | The emerging role of lysophosphatidic acid in cancer显示文摘 | GORDON B WOUTER M H MOOLENAAR W H | 2003 | Nature2003，3，8： | 1 |
| 9 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 10 | Optical detection of crack patterns in the opening-mode fracture of marble显示文摘 | NOLEN-HOEKSEMA R C GORDON R B | 1987 | International Journal of Rock Mechanics and Mining Sciences and Geomechanics Abstracts1987，24，4： | 1 |
| 11 | Volatile organiccompounds in exhaled air from patients with lung cancer显示文摘 | Gordon S M Szidon J P Krotoszynski B K | 1985 | ClinChem1985，31，： | 1 |
| 12 | Rules, discretion and reputation in a model of monetary policy 显示文摘 | R-O'BERT J BARRO DAVID B GORDON | 1983 | Journal of Monetary Eeonmics1983，，12： | 1 |
| 13 | In search of the liquidity effect 显示文摘 | LEEPER E M GORDON D B | 1992 | Journal of Monetary Economics1992，29，3： | 1 |
| 14 | Structure-function studies on small heat shock protein oligomeric assembly and interaction with unfoldedpolypeptides显示文摘 | Leroux MR Melki R Gordon B | 1997 | J Biol Chem1997，272，24： | 1 |
| 15 | Far-feild approximation to the Kirchoff-Helmholtz representations of scattered field显示文摘 | Gordon W B | 1975 | IEEE rrans on Antennas and Propagation1975，23，4： | 1 |
| 16 | Role of Spl,C/EBPα, HNF3 and PXR in the basal- and xenobiotic-mediated regulation of the CYP3A4 gene 显示文摘 | Vicent B Kevin T Gordon G | 2004 | Drug Metab Dispos2004，32，： | 1 |
| 17 | Ectopic adrenal myelolipoma presenting as a splenic mass显示文摘 | Cina S J Gordon B M Curry N S | 1995 | Arch Pathol Lab Med1995，119，： | 1 |
| 18 | Volume Electrical Resistivity of Carbon Fiber Cement Composites显示文摘 | Farhad Reza Gordon B Batson Jerry A Yamamuro | 2001 | ACI Materials Journal2001，98，1： | 1 |
| 19 | Tacit,manifest,and intentional reference:How spontaneous trait inferences refer to persons显示文摘 | Uleman James S Moskowitz Gordon B Roman Robert J | 1993 | Social Cognition1993，11，3： | 1 |
| 20 | A role of the ubiquitin-proteasome system in neuropathic pain显示文摘 | ANDREW M GORDON B M EMER M | 2002 | J Neurosci2002，22，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员