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| 1 | Transarterial chemoembolization using degradable starch microspheres and iodized oil in the treatment of advanced hepatocellular carcinoma: evaluation of tumor response, toxicity, and survival显示文摘BACKGROUND: In a multidisciplinary conference patients with advanced non-resectable hepatocellular carcinoma (HCC) were stratified according to their clinical status and tumor extent to different regional modalities or to best supportive care. The present study evaluated all patients who were stratified to repeated transarterial chemoembolization (TACE) from 1999 until 2003 in terms of tumor response, toxicity, and survival. A moderate embolizing approach was chosen using a combination of degradable starch microspheres (DSM) and iodized oil (Lipiodol) in order to combine anti-tumoral efficiency and low toxicity. METHODS: Fourty-seven patients were followed up prospectively. TACE treatment consisted of cisplatin (50 mg/m2), doxorubicin (50 mg/m2), 450-900 mg DSM, and 5-30 ml Lipiodol. DSM and Lipiodol were administered according to tumor vascularization. Patient characteristics,toxicity, and complications were outlined. In multivariate regression analyses of pre-treatment variables from a prospective database, predictors for tumor response and survival after TACE were determined. RESULTS: 112 TACE courses were performed (2.4±1.5 courses per patient). Mean maximum tumor size was 75 (± 43) mm, in 68% there was bilobar disease. Best response to TACE treatment was: progressive disease (PD) 9%, stable disease (SD) 55%, partial remission (PR) 36%, and complete remission (CR) 0%. Multivariate regression analyses identified tumor size ≤75 mm, tumor number ≤5, and tumor hypervascularization as predictors for PR. The overall 1-, 2-, and 3-year-survival rates were 75%, 59%, and 41%, respectively, and the median survival was 26 months. Low α-fetoprotein levels (<400 ng/ml) (Odds ratio=3.3) and PR as best response to TACE (Odds ratio=6.7) were significantly associated with long term survival (>30 months, R2=36%). Grade 3 toxicity occurred in 7.1% (n=8), and grade 4 toxicity in 3.6% (n=4) of all courses in terms of reversible leukopenia and thrombocytopenia. The incidence of major complications was 5.4% (n=6). All complications were managed conservatively. The mortality within 6 weeks after TACE was 2.1% (one patient). CONCLUSIONS: DSM and Lipiodol were combined successfully in the palliative TACE treatment of advanced HCC resulting in high rates of tumor response and survival at limited toxicity. Favourable tumor response was associated with tumor extent and vascularization. TACE using DSM and Lipiodol can be considered a suitable palliative measure in patients who might not tolerate long acting embolizing agents. | Timm D Kirchhoff Joerg S Bleck Arne Dettmer Ajay Chavan Herbert Rosenthal Sonja Merkesdal Bernd Frericks Lars Zender Nisar P Malek Tim F Greten Stefan Kubicka Michael P Manns Michael Galanski | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，3： | 15 |
| 2 | Source-control stormwater manage- ment for mitigating the impacts of urbanisation on baseflow: A review 显示文摘 | Perrine H Edoardo D Tim D F | 2013 | J Hydrol2013，485，： | 1 |
| 3 | Candidate High Spectral Resolution Infrared Indices for Crop Cover 显示文摘 | Tim J M Bruno A Mark D F | 1993 | Remote Sens Environ1993，46，1： | 1 |
| 4 | Chromosomal abnormalities in frozen shoulder显示文摘 | Adam F David D Tim B | 2009 | Shoulder Elbow2009，1，8： | 1 |
| 5 | Heavy use of equations impedes commu-nication among biologists 显示文摘 | Tim W F Andrew D | 2012 | PNAS2012，109，11： | 1 |
| 6 | Chromosomal abnormalities in frozen shoulder显示文摘 | Adam F David D Tim B | 2009 | Shoulder Elbow2009，1，： | 1 |
| 7 | Extracellular superoxide dismutase in biology and medicine 显示文摘 | Cheryl L F Lisa M S Tim D O | 2003 | Free Rad Biol Med2003，35，3： | 1 |
| 8 | Insecticidal toxin complex proteins from Xenorhabdus nematophilus:Structure and pore fromation显示文摘 | Joel J S Tim D H Kristin J F | | 0，，： | 1 |
| 9 | Recovery of Escherichia coli O157:H7 from fiber optic waveguides used for rapid biosensor detection 显示文摘 | Kramer M F Tims T B DeMarco D R | 2002 | Journal of Rapid Methods Automatic Microbiology2002，10，： | 1 |
| 10 | Modelling heterogeneity in manpower planning:dividing the personnel system into more homogeneous subgroups显示文摘 | Tim D F | | 0，，3： | 1 |
| 11 | Evidence for iron, copper and zinc complexation as muhinuclear sulphide clusters in oxic rivers显示文摘 | TIM F R MICHAEL E LASSMAN D P | 2000 | Nature2000，406，： | 1 |
| 12 | Estimating Land Surface Evaporation:A Review of Methods Using Remotely Sensed Surface Temperature Data显示文摘 | Jetse D Kalma Tim R McVicar Matthew F McCabe | 2008 | Surv Geophys2008，29，： | 1 |
| 13 | Isolating Bone Marrow Stem Cells Using Sieve Technology显示文摘 | Wei T Leong D Tim F | 2004 | Stem Cells2004，22，6： | 1 |
| 14 | Extracellular superoxide dismutase in biology and medicine显示文摘 | CHERYL L F LISA M S TIM D 0 | 2003 | Free Rad Biol Med2003，35，3： | 1 |
| 15 | Pay-fbr-performance programs in family practices in the United Kingdom显示文摘 | Tim D Catherine F Hugh G | 2006 | The New England Journal of Medicine2006，355，： | 1 |
| 16 | Resolving coastal conflicts using marine spatial planning 显示文摘 | Arthur O Tuda Tim F Stevens Lynda D Rodwell | 2014 | Journal of En- vironmental Management2014，133，： | 1 |
| 17 | MLC1在调节星形胶质细胞-突触相互作用中的新角色显示文摘星形胶质细胞膜蛋白MLC1的功能丧失是伴皮质下囊肿的巨脑性白质脑病(MLC)的主要遗传原因,这一罕见病的特征是脑内离子和水稳态失衡。MLC1蛋白主要分布于大脑中的液体屏障周围,例如在星形胶质细胞接触血管的终足和接触脑膜的突起中。该蛋白是否在其他星形胶质细胞结构域中发挥作用尚不清楚。本研究表明MLC1存在于星形胶质细胞远端突起中,也称为突触周围星形胶质细胞突起(PAP)或星形胶质细胞小叶;在海马CA1区域它们与兴奋性突触密切相互作用。我们发现在Mlc1缺失小鼠中,向兴奋性突触延伸的PAP末端缩短。这一改变会影响谷氨酸能突触传递,导致自发释放事件的速率降低,并在具有挑战性的条件下减慢谷氨酸的再摄取。此外,虽然野生型小鼠中的PAP在恐惧调节过程从突触回缩,但我们发现在Mlc1缺失小鼠中,这种结构可塑性在本已更短的PAP出现障碍。最后,Mlc1缺失小鼠显示情境恐惧记忆减少。总之,本研究揭示了星形胶质细胞蛋白MLC1在调节PAP结构方面的意想不到的作用。MLC1的缺失会改变兴奋性突触传递,阻止恐惧调节诱导的正常PAP重塑,并破坏情境恐惧记忆表达。因此,MLC1是调节星形胶质细胞-突触相互作用的新参与者。 | Mandy S J Kater Katharina F Baumgart Aina Badia-Soteras Tim S Heistek Karen E Carney A Jacob Timmerman Jan R T vanWeering August B Smit Marjo S van der Knaap Huibert D Mansvelder Mark H G Verheijen Rogier Min | 2023 | 神经损伤与功能重建2023，18，5： | 0 |
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