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| 1 | Protein tyrosine phosphatase non-receptor type 2 andinflammatory bowel disease显示文摘Genome wide association studies have associated single nucleotide polymorphisms within the gene locus encoding protein tyrosine phosphatase non-receptor type 2(PTPN2) with the onset of inflammatory bowel disease(IBD) and other inflammatory disorders. Expression of PTPN2 is enhanced in actively inflamed intestinal tissue featuring a marked up-regulation in intestinal epithelial cells. PTPN2 deficient mice suffer from severe intestinal and systemic inflammation and display aberrant innate and adaptive immune responses. In particular, PTPN2 is involved in the regulation of inflammatory signalling cascades, and critical for protecting intestinal epithelial barrier function, regulating innate and adaptive immune responses, and finally for maintaining intestinal homeostasis. On one hand, dysfunction of PTPN2 has drastic effects on innate host defence mechanisms, including increased secretion of pro-inflammatory cytokines, limited autophagosome formation in response to invading pathogens, and disruption of the intestinal epithelial barrier. On the other hand, PTPN2 function is crucial for controlling adaptive immune functions, by regulating T cell proliferation and differentiation as well as maintaining T cell tolerance. In this way, dysfunction of PTPN2 contributes to the manifestation of IBD. The aim of this review is to present an overview of recent findings on the role of PTPN2 in intestinal homeostasis and the impact of dysfunctional PTPN2 on intestinal inflammation. | Marianne R Spalinger Declan F McCole Gerhard Rogler Michael Scharl | 2016 | World Journal of Gastroenterology2016，22，3： | 4 |
| 2 | Chemistry,occurrence,and biosynthesis of C-glycosyl compounds in plants 显示文摘 | Gerhard F Michael G | 1983 | Planta Med1983，47，3： | 3 |
| 3 | Acellular Muscle with Schwann-Cell Implantation: An Alternative Biologic Nerve Conduit显示文摘 | Hisham Fansa Gerburg Keilhoff Gerhard F?rster Bertolt Seidel Gerald Wolf Wolfgang Schneider | 1999 | J reconstr Microsurg1999，，07： | 2 |
| 4 | The digital front-end of software radio terminals 显示文摘 | Tim H Matthias H Gerhard F | 1999 | IEEE Personal Communications1999，6，8： | 1 |
| 5 | Localization of a unique gene by direct hybridization in situ 显示文摘 | GERHARD D S KAWASAKI E S BANCROFT F C | 1981 | Proc Natl Acad Sci USA1981，78，6： | 1 |
| 6 | Optimization and application of ICPMS with dynamic reaction cell for precise determination of 4*Ca / 4Ca isotope ratios 显示文摘 | Sergei F Boulyga Urs Klol tzli Gerhard Stingeder | 2007 | Anal Chem2007，79，： | 1 |
| 7 | New self-assembled structural motifs in coordination chemistry显示文摘 | Tshepo J Malefetes | 2000 | Chem Rev2000，100，： | 1 |
| 8 | Significance of Morphological Abnormalities Detected by MRI in Patients Undergoing Successful Ablation of Right Ventricular Outflow Tract Tachycardia 显示文摘 | Sebastian G Gerhard K Herbert F | 1997 | Circulation1997，96，3： | 1 |
| 9 | Excretion of matrix metalloproteinases 2 and 9 in urine is associated with a high stage and grade of bladder carcinoma 显示文摘 | Gerhards S lung K Koenig F | 2001 | Urology2001，57，4： | 1 |
| 10 | Conceptual modeling for configuration of mass-customizable products 显示文摘 | Alexander F Gerhard F Dietmar J | 2001 | Artificial Intelligence in Engineering2001，15，2： | 1 |
| 11 | Conceptual modeling for configuration of mass-customizable products 显示文摘 | ALEXANDER F GERHARD F DIETMAR J | 2001 | Artificial Intelligence in Engineering2001，15，2： | 1 |
| 12 | Knowledge management:Problems,promises,realities,and challenges显示文摘 | Gerhard F Jonathan O | 2001 | IEEE Intelligent Systems2001，16，1： | 1 |
| 13 | Conceptual modeling for configure of mass-customization products显示文摘 | Alexander F Gerhard F Dietmar J | 2001 | Artificial Inz telligence in Engineering2001，15，2： | 1 |
| 14 | Insights into structure-activity relationship of GABAA receptor modulating coumarins and furanocoumarins显示文摘 | Judith Singhuber Igor Baburin Gerhard F Ecker | 2011 | Eur J Pharmacol2011，668，12： | 1 |
| 15 | Breast cancer stem eell mark- ers CD44, CD24 and ALDH1 :expression distribution within intrinsic molecular subtype显示文摘 | Ricardo S Vieira A F Gerhard R | 2011 | J Clin Pathol2011，64，11： | 1 |
| 16 | Radiosurgery as alternative treatment for skull base meningiomas显示文摘 | Gerhard P Eustrachio S Vager F | 2001 | Jourmal of clinical Niuroscience2001，8，： | 1 |
| 17 | Methyl bromide adsorption on activated carbon to control emissions from commodity fumigations显示文摘 | James G Leesch Gerhard F Knapp Bruce E Mackey | 1999 | Journal of Stored Products Research1999，，： | 1 |
| 18 | Study of intermittency in electron-positron annihilation into hadrons显示文摘 | Braunschweig W Gerhards R Kirschfink F J | 1989 | Phys Lett1989，231，4： | 1 |
| 19 | A report on experiences using Goldberg's GHQ(General Health Questionmare)显示文摘 | Hobi V Gerhard U Gutzwilleb F | 1989 | Schweiz Rundsch Med Prax(S1013--2058)1989，78，9： | 1 |
| 20 | The digital front-end of software radio terminals显示文摘 | Tim H Matthias H Gerhard F | 1999 | IEEE Personal Communications1999，，8： | 1 |
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