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| 1 | Virological course of hepatitis A virus as determined by real time RT-PCR: Correlation with biochemical, immunological and genotypic profiles显示文摘瞄准:承担肝炎 A 的分析,并且相关病毒的负担,丙氨酸 aminotransferase (中高音) ,和有病毒血的持续时间的病毒的遗传型有控制调停房间的免疫的 CD4 (+)/ CD8 (+) 淋巴细胞人口的这些参数。方法:房间计数用用荧光在乙二胺四乙酸小瓶收集的新鲜全血被执行激活的房间 sorter。肝炎 A 病毒(HAV ) RNA 从血浆液被提取,抄录进 cDNA 并且由实时聚合酶链反应确定了并且是 genotyped 的颠倒。结果:在 11 个病人之中, 10 能完全被分析。这些, 3 有严重尖锐肝炎(s -- 啊) 并且剩余物有自我限制尖锐肝炎 A (啊哈) ,在第 4 d 上与有暴发性的疾病(脑病等级 IV ) 的一个病人一起死。中高音水平在啊哈两个都是显著地更高的(1070.9 +/- 894.3;P = 0.0014 ) 并且 s -- 啊(1713.9 +/- 886.3;P = 0.001 ) 与正常控制相比(23.6 +/- 7.2 ) 。在 s 的前凝血酶时间 -- 啊病人(21.0 +/- 2.0;P = 0.02 ) 比在啊哈显著地高(14.3 +/- 1.1;P = 0.44 ) 。在啊哈病人的 CD4 (+)/CD8 (+) 比率(1.17 +/- 0.11;P = 0.22 ) 并且 s -- 啊(0.83 +/- 0.12;P = 0.0002 ) 比在正常健康控制(1.52 ) 看低。有的自我限制盒子达到顶点在分析的开始的病毒的负担当时在 s -- 啊病人这发生在第 15 或第 30 d。在敏锐、严格的组,一耐心的各个属于遗传型 IA,与仍然是 8 个盒子属于遗传型 IIIA。唯一的暴发性的肝的失败大小写属于遗传型 IA。在自我限制感染的全部功课期间收集的 HAV 病毒的负担和中高音价值直接为 s 被相关,但是这不是事实 -- 啊病人。结论:基于小规模的研究, s 的固执地更高的病毒的负担 -- 啊可能由于减少的细胞免疫和溶血。病毒血的持续时间依赖于主人,当病毒的遗传型没在 AVH 和 s 的临床的结果有明显的角色 -- 啊盒子。 | Zahid Hussain Bhudev C Das Syed A Husain Sunil K Polipalli Tanzeel Ahmed Nargis Begum Subhash Medhi Alice Verghese Mohammad Raish Apiradee Theamboonlers Yong Poovorawan Premashis Kar | 2006 | World Journal of Gastroenterology2006，12，29： | 10 |
| 2 | Antihyperglycemic and antioxidant effects of Solanum xanthocarpum leaves(field grown & in vitro raised) extracts on alloxan induced diabetic rats显示文摘Objective:To investigate antidiabetic efficacy of the extract of field grown and in vitro raised leaves of Solanum xanthocarpum(S.xanthocarpum) against alloxan induced diabetic rats. Methods:The antidiabetic activity of the crude methanol extracts of the field grown and in vitro raised leaves of S.xanthocarpum at different concentrations(100-200 mg/kg bw) was tested against alloxan induced diabetic rats.The antidiabetic efficacy was validated through various biochemical parameters and the antioxidant effect was also determined.The phytochemical analyses of field grown S.xanthocarpum and in vitro rasied 5.xanthocarpum leaves were done by estimating their chlorophyll,carotenoids,total sugar,protein,amino acid and minerals contents. Results:The results revealed that the methanol extracts of both the leaves(field grown and in vitro raised) of S.xanthocarpum was efficient anti hyperglycemic agents at a concentration of 200 mg/kg bw and posses potent antioxidant activity.However,the extracts of in vitro rasied S.xanthocarpum raised leaves exhibit higher efficacy than the field grown leaves in all tested concentrations.Proximal composition and mineral analysis of S.xanthocarpum revealed higher concentration of contents in in vitro rasied S.xanthocarpum than field grown S.xanthocarpum. Conclusions:From the results it can be concluded that the leaves extracts of S.xanthocarpum can be a potential candidate in treating the hyperglycemic conditions and suits to be an agent to reduce oxidative stress. | K Poongothai P Ponmurugan K Syed Zameer Ahmed B Senthil Kumar SA Sheriff | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，10： | 9 |
| 3 | Stereotactic body radiation therapy for management of spinal metastases in patients without spinal cord compression: a phase 1–2 trial显示文摘 | Xin Shelley Wang Laurence D Rhines Almon S Shiu James N Yang Ugur Selek Ibrahima Gning Ping Liu Pamela K Allen Syed S Azeem Paul D Brown Hadley J Sharp David C Weksberg Charles S Cleeland Eric L Chang | 2012 | Lancet Oncology2012，，4： | 2 |
| 4 | A Study on the Reaction Mechanism of Bromocresol Green with Bovine Serum Albumin显示文摘AStudyontheReactionMechanismofBromocresolGreenwithBovineSerumAlbuminKenZhu;KeAnLI;ShenYangTONG(ChemistryDepartment,PekingUniv... | Zhu, K Li, KA Tong, SY | 1996 | Chinese Chemical Letters1996，7，11： | 2 |
| 5 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 6 | Association of dilated retinal arteriolar caliber with early age-related macular degeneration:the Handan Eye Study显示文摘 | Yang K Zhan SY Liang YB Duan X Wang F Wong TY | | 0，，5： | 1 |
| 7 | Microflow cytometry utilizing a magnetic bead-based immunoassay for rapid virus detection显示文摘 | Yang SY Lien KY Huang K J | 2008 | Biosen Bioelectron2008，24，4： | 1 |
| 8 | Green tea catechins as a BACE1 (β-secretase) inhibitor显示文摘 | Jeon SY Bae K Seong YH | 2003 | Bioorg Med Chem Lett2003，13，22： | 1 |
| 9 | A new coupled catalytic system for Dihydroxylation of olefins by H2O2 显示文摘 | Bergstad K Jonsson SY Baekvall JE | 1999 | J Am Chem Soc1999，121，10： | 1 |
| 10 | An unusual complication of silastic dural substitute case report显示文摘 | Thomas H K Chan K H Leung SY | 1990 | Neurosurgery1990，27，3： | 1 |
| 11 | TRAF-6 mediated regulation of the PI3kinase (PI3K)-Akt-GSK3beta cascade is required for TNF-induced cell survival 显示文摘 | Yoon K Jung EJ Lee SY | 2008 | Biochem Biophys Res Commun2008，371，1： | 1 |
| 12 | Mierosatellite instability, EMAST, and morphology associations with T cell infiltration in colorectal neoplasia显示文摘 | Lee SY Miyai K Han HS | 2011 | Dig Dis Sci2011，57，1： | 1 |
| 13 | Dysregulation of iron homeostasis in the CNS contributes to disease progression in a mouse model of amyotrophic lateral sclerosis显示文摘 | Jeong SY Rathore KI Schulz K | | 0，，： | 1 |
| 14 | Stereotactic radiotherapy for prostate cancer:A review and future directions显示文摘Prostate cancer affects over 200000 men annually in the United States alone.The role of conventionally fractionated external beam radiation therapy (RT) is well established as a treatment option for eligible prostate cancer patients; however,the use of stereotactic body radiotherapy (SBRT) in this setting is less well defined.Within the past decade,there have been a number of studies investigating the feasibility of SBRT as a potential treatment option for prostate cancer patients.SBRT has been well studied in other disease sites,and the shortened treatment course would allow for greater convenience for patients.There may also be implications for toxicity as well as disease control.In this review we present a number of prospective and retrospective trials of SBRT in the treatment of prostate cancer.We focus on factors such as biochemical progression-free survival,prostate specific antigen (PSA) response,and toxicity in order to compare SBRT to established treatment modalities.We also discuss future steps that the clinical community can take to further explore this new treatment approach.We conclude that initial studies examining the use of SBRT in the treatment of prostate cancer have demonstrated impressive rates of biochemical recurrencefree survival and PSA response,while maintaining a relatively favorable acute toxicity profile,though long-term follow-up is needed. | Yusef A Syed Ami K Patel-Yadav Charlotte Rivers Anurag K Singh | 2017 | World Journal of Clinical Oncology2017，8，5： | 1 |
| 15 | 显示文摘 | Saoulli K Lee SY Cannons JL | 1998 | J Exp Med1998，187，11： | 1 |
| 16 | Gene transfer as a tool to induce therapeuticvascular growth显示文摘 | Herttuala SY Alitalo K | 2003 | Nat Med2003，9，： | 1 |
| 17 | Mitochondria localization and dimerization are required for CIDE-B to induce apoptosis显示文摘 | Chen Z Guo K Toh SY | 2000 | J Biol Chem2000，275，22： | 1 |
| 18 | Traffic noise survey and analysis in Singapore显示文摘 | Sy H K Ong P P Tang S H Tan K L | 1985 | Applied Acoustics1985，，18： | 1 |
| 19 | Identification of ATF-3,caveolin-1,DLC-1,and nm23-H2 as putative antitumorigenic,progesterone-regulated genes for ovarian cancer cells by gene profiling显示文摘 | SYED V MUKHERJEE K LYONS-WWEILER J | 2005 | Oncogene2005，24，10： | 1 |
| 20 | Low expression of Bax predicts poor prognosis in patients with locally advanced esophageal cancer treated with definitive chemoradiotherapy 显示文摘 | Kang SY Han JH Lee K J | 2007 | Clin Cancer Res2007，13，： | 1 |
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