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| 1 | 三结构域蛋白27通过降解转化生长因β活化激酶1结合蛋白2/3减轻肝缺血再灌注损伤显示文摘【据Hepatology 2021年2月报道】题:三结构域蛋白27通过降解转化生长因β活化激酶1结合蛋白2/3减轻肝缺血再灌注损伤(作者Chen SY等)肝缺血再灌注(IR)损伤是肝移植术后器官功能障碍的主要原因,其主要涉及炎症反应和细胞凋亡等过程。作为调控多种细胞炎症和凋亡的关键介质,三结构域蛋白27(TRIM27)在肝IR损伤中的作用值得研究。 | CHEN SY ZHANG HP LI J 陈三洋 | 2021 | 临床肝胆病杂志2021，37，6： | 11 |
| 2 | Intravenous vitamin C as adjunctive therapy for enterovirus/rhinovirus induced acute respiratory distress syndrome显示文摘We report a case of virus-induced acute respiratory distress syndrome(ARDS) treated with parenteral vitamin C in a patient testing positive for enterovirus/rhinovirus on viral screening. This report outlines the first use of high dose intravenous vitamin C as an interventional therapy for ARDS, resulting from enterovirus/rhinovirus respiratory infection. From very significant preclinical research performed at Virginia Commonwealth Universitywith vitamin C and with the very positive results of a previously performed phase Ⅰ safety trial infusing high dose vitamin C intravenously into patients with severe sepsis, we reasoned that infusing identical dosing to a patient with ARDS from viral infection would be therapeutic. We report here the case of a 20-year-old, previously healthy, female who contracted respiratory enterovirus/rhinovirus infection that led to acute lung injury and rapidly to ARDS. She contracted the infection in central Italy while on an 8-d spring break from college. During a return flight to the United States, she developed increasing dyspnea and hypoxemia that rapidly developed into acute lung injury that led to ARDS. When support with mechanical ventilation failed, extracorporeal membrane oxygenation(ECMO) was initiated. Twelve hours following ECMO initiation, high dose intravenous vitamin C was begun. The patient's recovery was rapid. ECMO and mechanical ventilation were discontinued by day-7 and the patient recovered with no long-term ARDS sequelae. Infusing high dose intravenous vitamin C into this patient with virus-induced ARDS was associated with rapid resolution of lung injury with no evidence of post-ARDS fibroproliferative sequelae. Intravenous vitamin C as a treatment for ARDS may open a new era of therapy for ARDS from many causes. | Alpha A Fowler Ⅲ Christin Kim Lawrence Lepler Rajiv Malhotra Orlando Debesa Ramesh Natarajan Bernard J Fisher Aamer Syed Christine DeWilde Anna Priday Vigneshwar Kasirajan | 2017 | World Journal of Critical Care Medicine2017，6，1： | 9 |
| 3 | A promising diagnostic method:Terahertz pulsed imaging and spectroscopy显示文摘The terahertz band lies between the microwave and infrared regions of the electromagnetic spectrum.This radiation has very low photon energy and thus it does not pose any ionization hazard for biological tissues.It is strongly attenuated by water and very sensitive to water content.Unique absorption spectra due to intermolecular vibrations in this region have been found in different biological materials.These unique features make tera-hertz imaging very attractive for medical applications in order to provide complimentary information to existing imaging techniques.There has been an increasing interest in terahertz imaging and spectroscopy of biologically related applications within the last few years and more and more terahertz spectra are being reported.This paper introduces terahertz technology and provides a short review of recent advances in terahertz imaging and spectroscopy techniques,and a number of applications such as molecular spectroscopy,tissue characterization and skin imaging are discussed. | Ming Yiu Sy Yi-Xiang J Wang Anil T Ahuja Emma Pickwell-MacPherson | 2011 | World Journal of Radiology2011，3，3： | 7 |
| 4 | Drug eluting biliary stents to decrease stent failure rates:Areview of the literature显示文摘Biliary stenting is clinically effective in relieving both malignant and non-malignant obstructions. However, there are high failure rates associated with tumor ingrowth and epithelial overgrowth as well as internally from biofilm development and subsequent clogging. Within the last decade, the use of prophylactic drug eluting stents as a means to reduce stent failure has been investigated. In this review we provide an overview of the current research on drug eluting biliary stents. While there is limited human trial data regarding the clinical benefit of drug eluting biliary stents in preventing stent obstruction, recent research suggests promise regarding their safety and potential efficacy. | Joseph Shatzel Jisoo Kim Kartik Sampath Sharjeel Syed Jennifer Saad Zilla H Hussain Kabir Mody J Marc Pipas Stuart Gordon Timothy Gardner Richard I Rothstein | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，2： | 6 |
| 5 | Activation of mitochondrial ATP-sensitive potassium channels improves rotenone-related motor and neurochemical alterations in rats显示文摘 | Yang Y Liu X Long Y Wang F Ding JH Liu SY Sun YH Yao HH Wang H Wu J Hu G | 2006 | 中国生物学文摘2006，20，10： | 4 |
| 6 | Effects of systemic administration of iptakalim on extracellular neurotransmitter levels in the striatum of unilateral 6-hydroxydopamine-lesioned rats显示文摘 | Wang S Hu LF Zhang Y Sun T Sun YH Liu SY Ding JH Wu J Hu G | 2006 | 中国生物学文摘2006，20，10： | 3 |
| 7 | Stereotactic body radiation therapy for management of spinal metastases in patients without spinal cord compression: a phase 1–2 trial显示文摘 | Xin Shelley Wang Laurence D Rhines Almon S Shiu James N Yang Ugur Selek Ibrahima Gning Ping Liu Pamela K Allen Syed S Azeem Paul D Brown Hadley J Sharp David C Weksberg Charles S Cleeland Eric L Chang | 2012 | Lancet Oncology2012，，4： | 2 |
| 8 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 9 | Inhibition of HIV-1 Tat-mediated LTR transactiation and HIV-1 infection by anti-Tat single chain intrabodies显示文摘 | Mhashikar AM Bagley J Chen SY | 1995 | EMBO J1995，14，7： | 2 |
| 10 | Case-deletion measures for models with incomplete data显示文摘 | Zhu HT Lee SY Wei BC Zhu J | 2001 | Biometrika2001，88，： | 1 |
| 11 | IgA nephropathy: Long - term prognosis for pediatric patients显示文摘 | Wyatt R J Kritehevsky SB Woodford SY | 1995 | J Pediatr1995，127，91： | 1 |
| 12 | Serun uric acid level as an independent risk factor for all-cause, cardiovascular, and ischemic stroke mortality: a Chinese cohort study 显示文摘 | Chen JH Chuang SY Chen H J | 2009 | Arthritis Rheum2009，61，2： | 1 |
| 13 | MRG15 is a novel PALB2-interaeting :ctor involved in homologous recombin:ion 显示文摘 | Sy S M Huen M S Chen J | 2009 | J Biol Chem2009，284，21： | 1 |
| 14 | Toll-like receptor 9-dependent activation by DNA-containing imm-une complexes is mediated by HMGB1 and RAGE显示文摘 | Tian J Avalos AM Mao SY | 2007 | Nat Immunol2007，8，5： | 1 |
| 15 | Clinical prognostic factors and grading system for rib fracture following stereotactic body radiation therapy (SBRT) in patients with peripheral lung tumors显示文摘 | Kim SS Song SY Kwak J | 2013 | Lung Cancer2013，79，2： | 1 |
| 16 | Preoperative serum CYFRA 21-1 level as a prognostic factor in surgically treatedadenocarcinoma of lung显示文摘 | Park SY Lee JG Kim J | 2013 | Lung Cancer2013，79，2： | 1 |
| 17 | Effects of Methylpredniaolone Pulse Therapy on Refractory Myeoplasma pneumoniae Pneumonia in Children显示文摘 | You SY Jwa H J Yang EA | 2014 | Allergy Asthma Immunol Res2014，6，1： | 1 |
| 18 | Immunomodulatory properties of Grifola frondosa in submerged culture显示文摘 | Wu M J Cheng TL Cheng SY | 2006 | Journal of Agricultural and Food Chemistry2006，54，8： | 1 |
| 19 | Compact optical diagnostic device for isothermal nucleic acids amplifi cation显示文摘 | LEE SY HUANG J G CHUANG T L | | 0，，： | 1 |
| 20 | Bupivacaine induces reactive oxy- gen species production via activation of the AMP-activated pro- tein kinase-dependent pathway显示文摘 | Lu J Xu SY Zhang QO | 2011 | Pharmacology2011，87，34： | 1 |
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