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| 1 | Estimation and Projection of the HIV Epidemic Trend among the Migrant Population in China显示文摘Objective The migrant population is a vulnerable group for HIV infection in China.Understanding potential epidemic trends among migrants is critical for developing HIV preventative measures in this population.Methods The Estimation and Projection Package (EPP) model was used to process prefecture and county-level surveillance data to generate HIV prevalence and epidemic trends for migrant populations in China.Results The prevalence of HIV among migrants in 2009 was estimated at 0.075% (95% CI:0.042%,0.108%) in China.The HIV epidemic among migrants is likely to increase over the next 5 years,with the prevalence expected to reach 0.110% (95% CI:0.070%,0.150%) by 2015.Conclusion Although the 2009 estimates for the HIV/AIDS epidemic in China indicate a slower rate of increase compared with the national HIV/AIDS epidemic,it is estimated to persistently increase among migrants over the next 5 years.Migrants will have a strong impact on the overall future of the HIV epidemic trend in China and evidence-based prevention and monitoring efforts should be expanded for this vulnerable population. | MENGXiaoJun WANG Lu Susan CHAN Kathleen Heather REILLY PENG ZhiHang GUO Wei DING GuoWei DING ZhengWei QIN QianQian | 2011 | Biomedical and Environmental Sciences2011，24，4： | 8 |
| 2 | Ikaros in B cell development and function显示文摘The zinc finger transcription factor,Ikaros,is a central regulator of hematopoiesis.It is required for the development of the earliest B cell progenitors and at later stages for VDJ recombination and B cell receptor expression.Mature B cells rely on Ikaros to set the activation threshold for various stimuli,and to choose the correct antibody isotype during class switch recombination.Thus,Ikaros contributes to nearly every level of B cell differentiation and function. | MacLean Sellars Philippe Kastner Susan Chan | 2011 | World Journal of Biological Chemistry2011，2，6： | 3 |
| 3 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 4 | Role of Ikaros in T-cell acute lymphoblastic leukemia显示文摘Ikaros is a zinc finger transcriptional regulator encoded by the Ikzf1 gene.Ikaros displays crucial functions in the hematopoietic system and its loss of function has been linked to the development of lymphoid leukemia.In particular,Ikaros has been found in recent years to be a major tumor suppressor involved in human B-cell acute lymphoblastic leukemia.Its role in T-cell leukemia,however,has been more controversial.While Ikaros deficiency appears to be very frequent in murine T-cell leukemias,loss of Ikaros appears to be rare in human T-cell acute lymphoblastic leukemia (T-ALL).We review here the evidence linking Ikaros to T-ALL in mouse and human systems. | Philippe Kastner Susan Chan | 2011 | World Journal of Biological Chemistry2011，2，6： | 2 |
| 5 | Community nursing services for postdischarge chronically ill patients显示文摘 | Susan KY Chow Frances KY Wong Tony MF Chan Loretta YF Chung Katherine KP Chang Rance PL Lee | 2008 | Journal of Clinical Nursing2008，，7： | 1 |
| 6 | Biomedical research: increasing value, reducing waste显示文摘 | Malcolm R Macleod Susan Michie Ian Roberts Ulrich Dirnagl Iain Chalmers John P A Ioannidis Rustam Al-Shahi Salman An-Wen Chan Paul Glasziou | 2014 | The Lancet . 2014 (9912)2014，，9912： | 1 |
| 7 | Comparison of Pyrosequencing, Sanger Sequencing, and Melting Curve Analysis for Detection of Low-Frequency Macrolide-Resistant Mycoplasma pneumoniae Quasispecies in Respiratory Specimens显示文摘 | Kwok-Hung Chan Kelvin K. W. To Betsy W. K. Chan Clara P. Y. Li Susan S. Chiu Kwok-Yung Yuen Pak-Leung Ho | 2013 | Journal of Clinical Microbiology2013，，8： | 1 |
| 8 | Evaluation of a nurse-led disease management programme for chronic kidney disease: A randomized controlled trial 显示文摘 | Frances Kam Yuet Wong Susan Ka Yee Chow Tony Moon Fai Chan | 2009 | International Journal of Nursing Studies2009，12，3： | 1 |
| 9 | The Value of Value - based Pur- chasing显示文摘 | Alan Channing Susan D De Vore | 2009 | Healthcare Financial Management2009，63，10： | 1 |
| 10 | Occurrence of gross motor behaviors and attainment of motor objectives in children with cerebral palsy participating in conductive education显示文摘 | Susan K Effgen Laurie Chan | 2010 | Physiotherapy Theory and Practice2010，，1： | 1 |
| 11 | Adenovirus respiratory infection in hospitalized children in Hong Kong: serotype–clinical syndrome association and risk factors for lower respiratory tract infection显示文摘 | Shuk-Kuen Chau So-lun Lee Malik J. S. Peiris Kwok-Hung Chan Eunice Chan Wilfred Wong Susan S. Chiu | 2014 | European Journal of Pediatrics2014，，3： | 1 |
| 12 | Percutaneous ethanol injection as a possible curative treatment for malignant portal vein thrombosis in hepatocellular carcinoma显示文摘 | Man-kwong Chan Philip Chong-hei Kwok Susan Chi-hum Chan Ting-wa Lam Ki-kam Lo Chun-lit Lam | 1999 | CardioVascular and Interventional Radiology1999，，4： | 1 |
| 13 | β-Catenin activation synergizes with Pten loss and Myc overexpression in Notch-independent T-ALL显示文摘 | Deepika Kaveri Philippe Kastner Doulaye Dembélé Claus Nerlov Susan Chan Peggy Kirstetter | 2013 | Blood2013，，5： | 1 |
| 14 | Electronic Messages Increase Hepatitis B Screening in At-Risk Asian American Patients: A Randomized, Controlled Trial显示文摘 | Leeyen Hsu Christopher L. Bowlus Susan L. Stewart Tram Thanh Nguyen Julie Dang Brian Chan Moon S. Chen | 2013 | Digestive Diseases and Sciences2013，，3： | 1 |
| 15 | Percutaneous ethanol injection as a possible curative treatment for malignant portal vein thrombosis in hepatocellular carcinoma显示文摘 | Man-kwong Chan Philip Chong-hei Kwok Susan Chi-hum Chan Ting-wa Lam Ki-kam Lo Chun-lit Lam | 1999 | CardioVascular and Interventional Radiology1999，，4： | 1 |
| 16 | Evaluation of a nurse-led disease management program for chronic kid- ney disease: A randomized controlled trial显示文摘 | Frances Kam Yuet Wang Susan Ka Yee Chow Tony Moon Fai Chan | 2010 | International Journal of Nursing Studies2010，，47： | 1 |
| 17 | Effect of 20-Hydroxyecdysone injection and eyestalk ablation on the molting cycle of the shrimp Penaeus vannamei 显示文摘 | Chan Siu-Ming Susan M Rankin Larry LKeeley | 1990 | Comp Biolchem Physiol1990，96，1： | 1 |
| 18 | 降脂药物治疗病人需住院肌溶解症的发生率显示文摘背景:在美国降脂药物已获广泛应用。但是对各种降脂药物发生肌溶解症的危险性目前尚缺乏可靠的估计。
目的:对门诊情况下,不同他汀及贝特类药物(单用或联用)治疗病人肌溶解症的发生率进行估计。
设计、地点及病人:根据全美11个卫生保健计划申报数据建立不同他汀和贝特类用药起始队列。人选本队列的病例为1998年1月1H至2001年6月30日人组保健计划前至少用药180天的病人。人-时间按照单药治疗或他汀-贝特类联合治疗分类。
主要结局指标:每治疗10000人一年肌溶解症的发生率、所需治疗例数以及发生肌溶解症的相对危险性。
结果:在252460例采用降脂药物治疗的病人中,24例于治疗期间发生住院的肌溶解症。采用阿托伐他汀、普伐他汀或辛伐他汀单药治疗平均每10000人一年肌溶解症的发生率为0.44(95%可信区间[confidence interval,CI],0.20~0.84);西立伐汀为5.34(95%CI,1.46~13.68);贝特类为2.82(95%CI,0.58—8.24;P=0.056)。未用药者(unexposed person—time)肌溶解症的发生率为0(95%CI,0—0.48,P=0.56)。阿托伐他汀、普伐他汀与一种贝特联川肌溶解症的发生率增至5.98(95%CI,0.72~216.0),西立伐他汀与叭特类联用增至1035(95%CI,389—2117)。每治疗1年,发现1例肌溶解症的所需治疗例数他汀单药治疗为2272例,采用他汀和贝特类联合治疗的年龄较大的糖尿病人为484例,采用西立伐他汀加贝特类治疗的病人为9.7到12.7例。
结论:采用阿托伐他汀、普伐他汀及辛伐他汀单药治疗发生肌溶解症的危险相似而且很低;联合使用他汀及贝特类者危险增加,特别是在老年糖尿病病人。西立伐他汀联合贝特类每年治疗10例即可能有1例发生肌溶解症。 | David J, Graham Judy A , Staffa Deborah shatin Susan E. Andrade Stephanie D, Schech Lois La Grenade Jerry H. Gurwitz K. Arnold Chan Michael .J. Goodman Richard Platt 徐成斌(译) | 2006 | 美国医学会杂志(中文版)2006，25，1： | 0 |
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