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| 1 | The relation between HLA-DQA1 genes and genetic susceptibility to duodenal ulcer in Wuhan Hans显示文摘AIM To study the genetic susceptibility of HLA-DQA1 alleles to duodenal ulcer in Wuhan Hans.METHODS Seventy patients with duodenalulcer and fifty healthy controls were examinedfor HLA-DQA1 genotypes.HLA-DQA1 typing wascarried out by digesting the locus specificpolymerase chain reaction amplified productswith alleles specific restriction enzymes(PCR-RFLP),i.e.,Apal Ⅰ,Bsaj Ⅰ,Hph Ⅰ,Fok Ⅰ,Mbo Ⅱ and Mnl Ⅰ.RESULTS The allele frequencies of DQA1 * 0301and DQA1 * 0102 in patients with duodenal ulcerwere significantly higher and lower respectivelythan those in healthy controls(0.40 vs 0.20,P = 0.003,mcorret = 0.024)and(0.05 vs 0.14,P = 0.012,but Pcorret>0.05),respectively.CONCLUSION DQA1 * 0301 is a susceptiblegene for duodenal ulcer in Wuhan Hans,andthere are immunogenetic differences in HLA-DQA1 locus between duodenal ulcer patients andhealthy controls. | Du YP Deng CS Lu DY Huang MF Guo SF Hou W | 2000 | World Journal of Gastroenterology2000，6，1： | 37 |
| 2 | Multilineage potential of adult human mesenchymal stem cells显示文摘 | Pittenger MF Mackay AM Beck SC | | 0，，： | 18 |
| 3 | 肝硬化和不可控制的静脉曲张出血患者死亡率的决定因素显示文摘【据Journal of Hepatology 2021年1月报道】肝硬化和不可控制的静脉曲张出血患者死亡率的决定因素(作者Kumar R等)不可控制的食管胃底静脉曲张出血(OGVB)和慢加急性肝衰竭(ACLF)均为肝硬化的重要预后因素。 | KUMAR R KERBERT AJC SHEIKH MF 王妍 金清龙 | 2021 | 临床肝胆病杂志2021，37，2： | 17 |
| 4 | Epidermal growth factor receptor and K-Ras in non-small cell lung cancer-molecular pathways involved and targeted therapies显示文摘Lung cancer is currently the leading cause of cancer death in Western nations.Non-small cell lung cancer(NSCLC)represents 80%of all lung cancers,and adenocarcinoma is the predominant histological type.Despite the intensive research carried out on this field and therapeutic advances,the overall prognosis of these patients remains unsatisfactory,with a 5-year overall survival rate of less than 15%.Nowadays,pharmacogenetics and pharmacogenomics represent the key to successful treatment.Recent studies suggest the existence of two distinct molecular pathways in the carcinogenesis of lung adenocarcinoma:one associated with smoking and activation of the K-Ras oncogene and the other not associated with smoking and activation of the epidermal growth factor receptor(EGFR).The K-ras mutation is mainly responsible for primary resistance to new molecules which inhibit tyrosine kinase EGFR(erlotinib and gefitinib)and most of the EGFR mutations are responsible for increased tumor sensitivity to these drugs.This article aims to conduct a systematic review of the literature regarding the molecular pathways involving the EGFR,K-Ras and EGFR targeted therapies in NSCLC tumor behavior. | Ramon Andrade de Mello Dania Sofia Marques Rui Medeiros António MF Araújo | 2011 | World Journal of Clinical Oncology2011，2，11： | 16 |
| 5 | 肥胖患者的冠状动脉微血管功能障碍和心血管病风险显示文摘全世界有〉5亿的肥胖人群,其心血管病风险增加的病理生理机制是复杂的,并且可能涉及脂肪细胞相关因子的过量分泌,导致血管氧化应激增加,神经激素活性上调,以及低度全身炎症,可能导致交感神经系统激活增加,血管张力改变,冠状动脉微血管功能障碍(coronary microvascular dysfunction, CMD) 。 | Bajaj NS Osborne MT Gupta A Tavakkoli A Bravo PE Vita T Bibbo CF Hainer J Dorbala S Blankstein R Bhatt DL Di Carli MF Taqueti VR 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，9： | 11 |
| 6 | 阻塞性睡眠呼吸暂停儿童内皮功能障碍与血浆脂蛋白相关磷脂酶A2活性升高相关显示文摘阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)是高度流行的病症,特别是在肥胖儿童中。与作为动脉粥样硬化前期表现的内皮功能障碍和血脂异常的风险增加有关。脂蛋白相关磷脂酶A2(lipoprotein-associated phospholipase A2,Lp-PLA2)被认为是心血管病风险和动脉粥样硬化斑块活动的独立危险因素。 | 刘莉 叶鹏 Kheirandish-Gozal L Philby MF Qiao Z Khalyfa A Gozal D | 2017 | 中华高血压杂志2017，25，2： | 7 |
| 7 | Antioxidant and anti-glycation activities correlates with phenolic composition of tropical medicinal herbs显示文摘To determine the contribution of total phenolic content(TPC) in glycation inhibitory activity of common tropical medicinal food and spices with potential antioxidative properties. Methods:In vitro glucose-bovine serum albumin(BSA) assay was used.Ethanolic extracts of ten common household condiments/herbs(Allium sativum.Zingiber officinale.Thymus rulgaris, Petroselinum crispum,Murraya koenigii Spreng,Mentha piperita L.,Curcuma longa L.,Allium cepa L.,Allium fistulosum and Coriandrum sativum L.) were evaluated for antinxidative activity by 2,2-diphenyl-2-picrylhydrazyl(DPPH),and ferric reducing antioxidant power(FRAP) and the TPC.flavonoid and tannins content were determined.Results:Findings showed good correlation between TPC/DPPH(r= 0.8).TPC/FRAP(r= 0.8).TPC/Anti-glycation(r=0.9).DPPH/Anti-glycation (r= 0.6),FRAP/Anti-glycation(r = 0.9),Flavonoid/Anti-glycation(r=0.7) and Tannina/Antiglycation (r = 0.8) and relatively fair correlation for TPC/Flavonoids(r = 0.5) and TPC/Tannina(r = 0.5).Results imply that these plants are potential sources of natural antioxidants which have free radical scavenging activity and might be used for reducing oxidative stress.Conclusions:The positive glycation inhibitory and antioxidative activities of these tropical herbs suggest a possible role in targeting ageing,diabetic complications and oxidative stress related diseases. | JS Ramkissoon MF Mahomoodally N Ahmed AH Subratty | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，7： | 6 |
| 8 | 糖尿病患者服用β受体阻滞剂的心血管事件风险显示文摘β受体阻滞剂可能有助于获得强化血糖控制的最大效果,但也存在发生严重低血糖的潜在风险。该研究旨在评估糖尿病患者服用β受体阻滞剂是否有效及其应用是否与严重低血糖有关。 | Tsujimoto T Sugiyama T Shapiro MF Noda M Kajio H 赵狄 练桂丽 | 2017 | 中华高血压杂志2017，25，6： | 6 |
| 9 | 不同电刺激参数对外周和中枢神经再生的不同效应显示文摘 | Eana.,MF 赵飞跃 | 1992 | 国外医学(中医中药分册)1992，14，1： | 5 |
| 10 | 血液透析患者血压水平的地域和季节性差异显示文摘季节和气候对一般人群以及血液透析患者的血压调节有影响。目前这个现象在世界各地是否有所不同尚不清楚。研究者对来自7个欧洲国家(西班牙、意大利、法国、比利时、德国、英国和瑞典)2005-2011年间参加国际透析预后与实践模式研究(dialysis outcomes and practice patterns study,DOPPS)的患者进行了研究,目的是探究来自不同地理位置的血液透析患者的血压季节差异。 | 刘青 叶鹏 Duranton F Kramer A Szwarc I Bieber B Gayrard N Jover B Vetromile F Massy ZA Combe C Tentori F Jager KJ Servel MF Argilés | 2018 | 中华高血压杂志2018，26，1： | 5 |
| 11 | 咽鼓管功能障碍定义、类型、临床表现及诊断的共识声明显示文摘1引言 英国NIHR卫生技术评估(HTA)计划发表的咽鼓管功能障碍治疗的系统回顾性研究指出,目前缺乏咽鼓管功能障碍统一的定义和诊断标准,推进这一领域研究进展的关键是针对咽鼓管功能障碍的诊断标准和重要临床结果达成共识。因此,2014年06月21日在荷兰阿姆斯特丹召开了由咽鼓管功能障碍领域的医学专家和科学家们参加的研讨会,旨在针对咽鼓管功能障碍的定义、临床表现、诊断及未来研究领域等方面达成共识。本文针对本次会议讨论结果总结如下。 | Schilder AG Bhutta MF Butler CC Holy C Levine LH Kvaerner KJ Norman G Pennings RJ Poe D Silvola JT Sudhoff H Lund VJ 翻曲腾飞 龚树生 | 2015 | 中国医学文摘(耳鼻咽喉科学)2015，30，6： | 5 |
| 12 | Two New Isopimarane Diterpenes from theRoots of Acorus Tatarinowii Schott显示文摘Two new isopimarane diterpenes, tatarol (1) and tataroside (2) were isolated from the roots of Acorus tatarinowii Schott. Their structurs were identified ty Spectral methods. | Wang, MF Lao, AN Wang, HC | 1997 | Chinese Chemical Letters1997，8，1： | 5 |
| 13 | 巨大的火成区显示文摘 | Coff.,MF 肖波 | 1994 | 科学(中文版)1994，，2： | 5 |
| 14 | 同种主动脉瓣临床应用的初步报告显示文摘本文报告5例应用同种主动脉瓣手术治疗的初步经验,并将同种瓣的收集、保存、修剪和缝合方法以及同种瓣的优缺点作了简要的介绍。 | 萧明第 O'Brien MF 朱晓东 郭加强 刘迎龙 漆志涛 李晓东 | 1989 | 中国循环杂志1989，4，1： | 5 |
| 15 | 正相-反相两步高效液相色谱法制备毫克量级维生素D_3异构体显示文摘利用正相半制备柱和反相分析柱的两步高效液相色谱法,在实验室规模制备了毫克是级维生素D_3的三个重要异构体——维生素D_3前体、光甾醇_3和速甾醇_3·维生素D_3原体,7-去氢胆固醇的光照是在一个装有UVB荧光灯的光治疗室中进行。采用紫外分光光度法和高效液相色谱法对制得的三个异构体进行了定性定量分析。在这三个异构体检测极限下,除了维生素D_3前体中有不超过0.25%的维生素D_3杂质外,三个产品中均没有发现任何除它本身之外的其他异构体杂质。 | 陆志仁 TC Chen MF Holick | 1992 | 药学学报1992，27，5： | 5 |
| 16 | Hepatocellular carcinoma in Egypt: A single center study over a decade显示文摘AIM: To identify the trend, possible risk factors and any pattern change of hepatocellular carcinoma (HCC) in Egyptover a decade.METHODS: All HCC patients attending Cairo Liver Center between January 1993 and December 2002, were enrolledin the study. Diagnosis of HCC was based on histopath ological examination and/or detection of hepatic focal lesions by two imaging techniques plus α-fetoprotein level above 200 ng/mL. The duration of the study was divided into two periods of 5 years each; period Ⅰ (1993-1997) and period Ⅱ (1998-2002). Trend, demographic features of patients (age, gender, and residence), risk factors (HBsAg,HCV-Ab, schistosomiasis and others) and pattern of the focal lesions were compared between the two periods.Logistic regression model was fitted to calculate the adjusted odds ratios for the potential risk factors. The population attributable risk percentage was calculated to estimate the proportion of HCC attributed to hepatitis B and C viral infections.RESULTS: Over a decade, 1 328 HCC patients out of 22 450 chronic liver disease (CLD) patients were diagnosed with an overall proportion of 5.9%. The annual proportion of HCC showed a significant rising trend from 4.0% in 1993 to 7.2% in 2002 (P = 0.000). A significant increase in male proportion from 82.5% to 87.6% (P = 0.009); M/F from 5:1 to 7:1 and a slight increase of the predominant age group (40-59 years) from 62.6% to 66.8% (P = 0.387)in periods Ⅰ and Ⅱ respectively, reflecting a shift to younger age group. In the bivariate analysis, HCC was significantly higher in rural residents, patients with history of schistosomiasis and/or blood transfusion. Yet, after adjustment, these variables did not have a significant risk for development of HCC. There was a significant decline of HBsAg from 38.6% to 20.5% (P = 0.000), and a slight increase of HCV-Ab from 85.6% to 87.9% in periods Ⅰ and Ⅱ respectively. HBV conferred a higher risk to develop HCC more than HCV in period Ⅰ (OR 1.9 vs 1.6) and period Ⅱ (OR 2.7 vs 2.0), but the relative contribution of HBV for development of HCC declined in period Ⅱ compared to period Ⅰ (PAR% 4.2%, 21.32%). At presentation,diagnostic α-fetoprotein level (≥200 ng/mL) was demonstrated in 15.6% vs28.9% and small HCC (≤3 cm)represented 14.9% vs 22.7% (P = 0.0002) in periods Ⅰ and Ⅱ respectively.CONCLUSION: Over a decade, there was nearly a twofold increase of the proportion of HCC among CLD patients in Egypt with a significant decline of HBV and slight increase of HCV as risk factors. α-Fetoprotein played a limited role in diagnosis of HCC, compared to imaging techniques.Increased detection of small lesions at presentation reflects increased awareness of the condition. | Adbel-Rahman El-Zayadi Hanaa M Badran Eman MF Barakat Mohy El-Deen Attia Sherine Shawky Mostafa K Mohamed Osaima Selim Ahmed Saeid | 2005 | World Journal of Gastroenterology2005，11，33： | 5 |
| 17 | 数学与计算机革命显示文摘 | Atiy.,MF 陈冬生 | 1991 | 数学译林1991，10，1： | 4 |
| 18 | 妊娠期高血压疾病与后代在儿童中期的心血管代谢健康的关系:Viva项目调查结果显示文摘暴露于先兆子痫或妊娠期高血压疾病与后代收缩压较高有关,但与其他心脏代谢风险标志物的相关性研究较少。该研究收集Viva研究项目中在1999-2002年出生的1097名儿童资料。从产前记录先兆子痫或妊娠期高血压疾病的发生情况,及产前、孕早期、孕中期、孕晚期的平均收缩压水平。 | 刘莉 叶鹏 Tripathi RR Rifas-Shiman SL Hawley N Hivert MF Oken E | 2018 | 中华高血压杂志2018，26，4： | 4 |
| 19 | 急性儿茶酚胺暴露引起可逆的无心脏细胞再生的心肌细胞损伤显示文摘儿茶酚胺增加心脏收缩力,但暴露于高浓度儿茶酚胺或长时间暴露可引起心脏损伤。最近的一项研究表明,小鼠单次皮下注射异丙肾上腺素(isoproterenol,ISO;200 mg/kg)导致急性心肌细胞死亡(8%-10%),但在1个月之内心脏完整修复。心脏再生是通过内源性原癌基因蛋白质cKit+心脏干细胞介导新的心肌细胞形成。 | 刘莉 叶鹏 Wallner M Duran JM Mohsin S Troupes CD Vanhoutte D Borghetti G Vagnozzi RJ Gross P Yu D Trappanese DM Kubo H Toib A Sharp TE Harper SC Volkert MA Starosta T Feldsott EA Berretta RM Wang T Barbe MF Molkentin JD Houser SR | 2016 | 中华高血压杂志2016，24，8： | 4 |
| 20 | 禽病毒活疫苗中污染网状内皮组织增生病毒显示文摘 | Aly,MF 张存帅 | 1998 | 国外兽医学(畜禽传染病)1998，18，2： | 4 |
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