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| 1 | The program structure designing and optimizing tests of GRAPES physics显示文摘According to the modularization and standardization of program structure in Global/Regional Assimilation and Prediction System (GRAPES), the plug-compatible and transplantable regional meso-scale and global middle-range physics software package is established. The package's component integrality is comparative with the other advanced models physics. A three-level structure of connecting GRAPES physics and dynamic frame has been constructed. The friendly interface is designed for users to plug in their own physics packages. Phenomenon of grid-point storm rainfall in numerical prediction is analyzed with the numerical tests. The scheme of air vertical velocity calculation is improved. Optimizing tests of physics schemes are performed with the correlative parameters adjusting. The results show that the false grid-point storm rainfall is removed by precipitation scheme improving. Then the score of precipitation forecast is enhanced. | XU GuoQiang CHEN DeHui XUE JiShan SUN Jian SHEN XueShun SHEN YuanFang HUANG LiPing WU XiangJun ZHANG HongLiang WANG ShiYu | 2008 | Chinese Science Bulletin2008，53，22： | 11 |
| 2 | Clp Protease and OR Directly Control the Proteostasis of Phytoene Synthase, the Crucial Enzyme for Carotenoid Biosynthesis in Arabidopsis显示文摘Phytoene synthase (PSY ) 是在类胡萝卜素 biosynthetic 小径的关键 plastidial 酶。然而,它的 translational 以后规定留下逃犯。同样, Clp 朊酶组成质体朊酶网络的中央部分,但是它为降级的底层不是众所周知的。在这研究,我们报导 PSY 是 Clp 朊酶的底层。PSY 被揭开身体上与各种各样的 Clp 朊酶子单元交往(即, ClpS1, ClpC1,和 ClpD ) 。在 clpc1, clpp4,和 clpr1-2 异种的 PSY 和几另外的 carotenogenic 酶蛋白质 overaccumulate 高级。overaccumulated PSY 被发现部分酶地活跃。在 clpc1 的 Clp 活动的缺陷导致 PSY 蛋白质周转的减少的率,进一步在降级的 PSY 支持 Clp 朊酶的角色蛋白质。在另一方面, ORANGE (或) 蛋白质,有 holdase 女伴活动的 PSY 的一个主要 translational 以后管理者,提高 PSY 蛋白质稳定性并且在 clpc1 增加 PSY 的酶地活跃的比例, counterbalancing 在维持 PSY 蛋白质动态平衡的调停 Clp 的解朊作用。一起,这些调查结果提供新奇卓见进质体局部性的蛋白质的质量控制并且建立迄今未辩别出的 translational 以后在在植物的 modulating 类胡萝卜素生合成的 carotenogenic 酶的规章的机制。 | Ralf Welsch Xiangjun Zhou Hui Yuan Daniel Alvarez Tianhu Sun Dennis Schlossarek Yong Yang Guoxin Shen Hong Zhang Manuel Rodriguez-Concepcion Theodore W. Thannhauser Li Li | 2018 | Molecular Plant2018，11，1： | 10 |
| 3 | Palaeoenvironmental changes from pollen record in deep sea core PC-1 from northern Okinawa Trough,East China Sea during the past 24 ka显示文摘A pollen record of core PC-1 from the northern Okinawa Trough,East China Sea(ECS),provides information on vegetation and climate changes since 24 cal.kaBP.A total of 103 samples were palynologically analyzed at 8 cm intervals with a time resolution of 230 a.Four pollen zones are recognized:zone I(812―715 cm,24.2―21.1 cal.kaBP),zone II(715―451 cm,21.1―15.2 cal.kaBP),zone III(451―251 cm,15.2―10.8 cal.kaBP),zone IV(251―0 cm,10.8―0.3 cal.kaBP),corresponding to Late MIS 3,Last Glacial Maximum(LGM),deglaciation and Holocene,respectively.The LGM is characterized by the dominance of herbs,mainly Artemisia,and high pollen influx,implying an open vegetation on the exposed continental shelf and a cool and dry climate.The deglaciation is a climate warming stage with Pinus percentage increased and Artemisia percentage decreased and a rapid sealevel rise.The Holo-cene is characterized by predominance of tree pollen with rapid increase in Castanea-Castanopsis in-dicating the development of mixed evergreen and deciduous broad-leaved forest and a warm,humid climate.Low pollen influx during the Holocene probably implies submergence of the continental shelf and retreat of the pollen source area.The vegetation indicated by pollen assemblage found in this upper zone is consistent with the present vegetation found in Kyushu,Japan.Originating from the humid mountain area of North Luzon of the Philippines,Tasmania and New Zealand,Phyllocladus with sporadic occurrence throughout PC-1 core probably suggests the influence of Palaeo-Kuroshio Current or intense summer monsoon.The observed changes in Pinus and Herbs percentage indicate fluctuations of the sea level,and high Pinus percentage corresponds to high sea level.Spectrum analysis of the pollen percentage record reveals many millennial-scale periodicities,such as periodicities of 6.8,3.8,2.2,1.6 ka. | XU HongYan CHANG FengMing LUO YunLi SUN XiangJun | 2009 | Chinese Science Bulletin2009，54，20： | 9 |
| 4 | Paleoenvironmental information recorded by pollen in B-3GC gravity core in Okinawa Trough显示文摘Based on pollen records in B-3GC gravity core, environmental change since 9500 aBP of Okinawa Trough and its adjacent islands was derived. The result showed that the most time during this period was in a warm temperate climate except in middle Holocene (6800-4400 aBP) that was under subtropical climate control. During 9500-8300 aBP and 3100-2000 aBP periods, it appeared colder and drier than the rest time. The original area of pollen sources surrounding Okinawa Trough was covered by evergreen and deciduous broadleaf forest alternatively with mixed broad-leaf-conifer forest distributed in high mountainous areas. Usually, these three kinds of forests existed at the same time with difference in altitude. Pollen from subtropical and tropical plants increased obviously in about 5000-6000 aBP, reflecting a great lifting of vegetation zone and expansion of evergreen broad-leaf forest in the study area. However, there was a slight descending of plant zone and shrinking of evergreen broadleaf forest during | SONG Changqing, SUN Xiangjun & Yoshiki SaitoNational Natural Science Foundation of China, Beijing 100085, China Open Lab of Marine Geology, Tongji University, Shanghai 200039, China Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China Geological Survey of Japan, Higashi 1-1-3, Tsukuba, Ibaraki, 305-8567,Japan | 2001 | Chinese Science Bulletin2001，46，11： | 7 |
| 5 | Vegetation evolution and its response to climatic change during 3.15-0.67 Ma in deep-sea pollen record from northern South China Sea显示文摘In order to study vegetation evolution and environmental change during 3.15-0.67 Ma,a total of 608 pollen samples with an average time resolution of 4 ka has been analyzed from ODP Site 1145(water depth 3175 m),northern South China Sea.The deep-sea sediments(213.62-91.9 m) cover from 3.15 to 0.67 Ma based on micropaleonotological stratigraphy.The characteristic features of the pollen diagram include that,pollen influx rises twice obviously around 2.58 Ma and during 2.0-1.8 Ma,in response to global climatic cooling and winter monsoon enhancement.Before 2.58 Ma,tropical and subtropical vegetation,mainly evergreen Quercus(E) and Altingia,predominated around northern SCS with much more tropical montane conifers and ferns relatively.From 2.58 Ma,temperate vegetation increased obviously,implying climatic cooling and winter monsoon enhancement.Spectral analysis shows that percentage variation in tropical and subtropical taxa has a strong 20 ka procession cycle probably due to the summer monsoon;while pollen influx has 100,41 and 19 ka cycles,indicating the sea level and winter monsoon change response to the ice-sheet variations. | LUO YunLi SUN XiangJun | 2013 | Chinese Science Bulletin2013，58，3： | 4 |
| 6 | Separation and simultaneous quantitation of PGF2α and its epimer 8-iso-PGF2α using modifier-assisted differential mobility spectrometry tandem mass spectrometry显示文摘Because many therapeutic agents are contaminated by epimeric impurities or form epimers as a result of metabolism, analytical tools capable of determining epimers are increasingly in demand. This article is a proof-of-principle report of a novel DMS–MS/MS method to separate and simultaneously quantify epimers, taking PGF2α and its 8-epimer, 8-iso-PGF2α, as an example. Good accuracy and precision were achieved in the range of 10–500 ng/m L with a run time of only 1.5 min. Isopropanol as organic modifier facilitated a good combination of sensitivity and separation. The method is the first example of the quantitation of epimers without chromatographic separation. | Chunsu Liang Hui Sun Xiangjun Meng Lei Yina J.Paul Fawcett Huaidong Yu Ting Liu Jingkai Gu | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 3 |
| 7 | BTEX anomalies used as indicators of submarine oil and gas reservoirs显示文摘It is a conventional method for petroleum prospecting to generally use paraffin hydrocarbon as basic indexes of oil and gas. This conventional geochemical technology, however, shows some limits in the prospecting as paraffin is vulnerable to influences from human and biologic activities. Consequently, BTEX (short for benzene, toluene, ethyl benzene and xylem, which are direct biomarkers) among aromatic hydrocarbon series has been taken into account for the oil and gas prediction. Domestic and foreign study results demonstrate that BTEX is hardly disturbed and can well indicate oil and gas reservoirs. Based on measured data from a South China Sea area, the present authors have used self-developed visual assessment software for petroleum prospecting has been used to process data, strip background anomalies, and outline significant BTEX anomalies. By comparison with stratigraphic profiles of the target area, it is confirmed that BTEX is a good indication of marine oil and gas during the petroleum prospecting. | ZHANG Yong MENG Xiangjun SUN Ping CHEN Yanli QU Peng | 2009 | Acta Oceanologica Sinica2009，28，4： | 3 |
| 8 | GRACE terrestrial water storage data assimilation based on the ensemble four-dimensional variational method PODEn4DVar:Method and validation显示文摘Seasonal and interannual changes in the Earth's gravity field are mainly due to mass exchange among the atmosphere,ocean,and continental water sources.The terrestrial water storage changes,detected as gravity changes by the Gravity Recovery and Climate Experiment(GRACE) satellites,are mainly caused by precipitation,evapotranspiration,river transportation and downward infiltration processes.In this study,a land data assimilation system LDAS-G was developed to assimilate the GRACE terrestrial water storage(TWS) data into the Community Land Model(CLM3.5) using the POD-based ensemble four-dimensional variational assimilation method PODEn4 DVar,disaggregating the GRACE large-scale terrestrial water storage changes vertically and in time,and placing constraints on the simulation of vertical hydrological variables to improve land surface hydrological simulations.The ideal experiments conducted at a single point and assimilation experiments carried out over China by the LDAS-G data assimilation system showed that the system developed in this study improved the simulation of land surface hydrological variables,indicating the potential of GRACE data assimilation in large-scale land surface hydrological research and applications. | SUN Qin XIE ZhengHui TIAN XiangJun | 2015 | Science China Earth Sciences2015，58，3： | 3 |
| 9 | Rapid isolation and immune profiling of SARS-CoV-2 specific memory B cell in convalescent COVID-19 patients via LIBRA-seq显示文摘B cell response plays a critical role against SARS-CoV-2 infection.However,little is known about the diversity and frequency of the paired SARS-CoV-2 antigen-specific BCR repertoire after SARS-CoV-2 infection.Here,we performed single-cell RNA sequencing and VDJ sequencing using the memory and plasma B cells isolated from five convalescent COVID-19 patients,and analyzed the spectrum and transcriptional heterogeneity of antibody immune responses.Via linking BCR to antigen specificity through sequencing(LIBRA-seq),we identified a distinct activated memory B cell subgroup(CD11c^(high) CD95^(high))had a higher proportion of SARS-CoV-2 antigen-labeled cells compared with memory B cells.Our results revealed the diversity of paired BCR repertoire and the non-stochastic pairing of SARS-CoV-2 antigen-specific immunoglobulin heavy and light chains after SARS-CoV-2 infection.The public antibody clonotypes were shared by distinct convalescent individuals.Moreover,several antibodies isolated by LIBRA-seq showed high binding affinity against SARS-CoV-2 receptor-binding domain(RBD)or nucleoprotein(NP)via ELISA assay.Two RBD-reactive antibodies C14646P3S and C2767P3S isolated by LIBRA-seq exhibited high neutralizing activities against both pseudotyped and authentic SARS-CoV-2 viruses in vitro.Our study provides fundamental insights into B cell response following SARS-CoV-2 infection at the single-cell level. | Bing He Shuning Liu Yuanyuan Wang Mengxin Xu Wei Cai Jia Liu Wendi Bai Shupei Ye Yong Ma Hengrui Hu Huicui Meng Tao Sun Yanling Li Huanle Luo Mang Shi Xiangjun Du Wenjing Zhao Shoudeng Chen Jingyi Yang Haipeng Zhu Yusheng Jie Yuedong Yang Deyin Guo Qiao Wang Yuwen Liu Huimin Yan Manli Wang Yao-Qing Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 10 | The records of coastline changes reflected by mangroves on the Sunda Shelf since the last 40ka显示文摘This paper presents a 40000-year-long high-resolution mangrove record from sediments of Core 18300,18302 and 18323 on the continental shelf of the southern South China Sea and reconstructs the coast-line changes on Sunda Shelf since the last 40000 years. In the period Marine Isotope 3,the old Sunda Shelf had low sea level,and it was partly exposed. Flourishing vegetations grew on the exposed old land. Mangroves developed along the coastline. On the Last Glacial Maximum,the sea level dropped greatly,coastline moved from inner shelf to outer shelf,the Old Sunda Land exposed further,and the lowering sea level induced the gradual disappearing of mangroves from the inner Sunda Shelf to the outer Sunda Shelf. And pioneer vegetation ferns covered the broadly exposed old land immediately. At the time of the last Deglaciation,sea level rose greatly,the coastline moved to the sea and the Sunda Shelf was drown again. Mangroves were emergent again from outer shelf to inner shelf and developed quickly. | WANG XiaoMei SUN XiangJun WANG PinXian Karl Stattegger | 2008 | Chinese Science Bulletin2008，53，13： | 2 |
| 11 | Web-based Product Development and Simulation with Virtual Reality 显示文摘 | Xiangjun ZOU Bangjun GU Jian SUN | 2006 | Journal of Computational Information Systems (S0887-4417)2006，2，2： | 1 |
| 12 | Timing for high lake levels of Qinghai Lake in the Qinghai-Tibetan Plateau since the Last Interglaciation based on quartz OSL dating显示文摘 | XiangJun Liu ZhongPing Lai QiShun Fan Hao Long YongJuan Sun | 2009 | Quaternary Geochronology2009，，2： | 1 |
| 13 | Pollen record of surface sediments from vertical forest zones of changhai mountain northeast China and their relations to the modern vegelation显示文摘 | Sun Xiangjun Luo Yunli Tian Jun el al | 2003 | Aeta Botanica Sinica2003，45，8： | 1 |
| 14 | The natural partial order on the semigroup of all transformations of a set that reflect an equivalence relation显示文摘 | SUN Lei XIN Xiangjun | 2013 | Bulletin of the Australian Mathematical Society2013，88，3： | 1 |
| 15 | Last glacial maximum in China:Comparison between land and sea显示文摘 | Wang Pinxian Sun Xiangjun | 1994 | Catena1994，，23： | 1 |
| 16 | Pollen distribution in hemipelagic surface sediments of the South China Sea and its relation to modem vegetation distribution 显示文摘 | Sun Xiangjun Li Xun Beug H-J | 1999 | Mar Geol1999，156，14： | 1 |
| 17 | Web-based Product Development and Simulation with Virtual Reality显示文摘 | Bangjun Gu Jian Sun Hanwu He | 2006 | Journal of Computational Information (S1553-9105)2006，2，1： | 1 |
| 18 | Last Glacial Maximum in China: comparison between land and sea显示文摘 | Wang Pinxian Sun Xiangjun | 1994 | Catena1994，23，34： | 1 |
| 19 | Last glacial maximum in China:Comparison between land and sea 显示文摘 | Wang Pinxian Sun Xiangjun | 1994 | Catena1994，，23： | 1 |
| 20 | Web-based Product Development and Simulation with Virtual Reality显示文摘 | ZOU Xiangjun GU Bangjun SUN Jian HE Hanwu | 2006 | JOURNAL OF COMPUTATIONAL INFORMATION SYSTEMS2006，2，1： | 1 |
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