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| 1 | A User-Centric Data Secure Creation Scheme in Cloud Computing显示文摘Due to the use of the cloud computing technology,the ownership is separated from the administration of the data in cloud and the shared data might be migrated between different clouds,which would bring new challenges to data secure creation,especially for the data privacy protection.We propose a User-centric data secure creation scheme(UCDSC) for the security requirements of resource owners in cloud.In this scheme,a data owner first divides the users into different domains.The data owner encrypts data and defines different secure managing policies for the data according to domains.To encrypt the data in UCDSC,we present an algorithm based on Access control conditions proxy re-encryption(ACC-PRE),which is proved to be master secret secure and Chosen-ciphertext attack(CCA) secure in random oracle model.We give the application protocols and make the comparisons between some existing approaches and UCDSC. | SU Mang LI Fenghua SHI Guozhen GENG Kui XIONG Jinbo | 2016 | Chinese Journal of Electronics2016，25，4： | 7 |
| 2 | Rapid isolation and immune profiling of SARS-CoV-2 specific memory B cell in convalescent COVID-19 patients via LIBRA-seq显示文摘B cell response plays a critical role against SARS-CoV-2 infection.However,little is known about the diversity and frequency of the paired SARS-CoV-2 antigen-specific BCR repertoire after SARS-CoV-2 infection.Here,we performed single-cell RNA sequencing and VDJ sequencing using the memory and plasma B cells isolated from five convalescent COVID-19 patients,and analyzed the spectrum and transcriptional heterogeneity of antibody immune responses.Via linking BCR to antigen specificity through sequencing(LIBRA-seq),we identified a distinct activated memory B cell subgroup(CD11c^(high) CD95^(high))had a higher proportion of SARS-CoV-2 antigen-labeled cells compared with memory B cells.Our results revealed the diversity of paired BCR repertoire and the non-stochastic pairing of SARS-CoV-2 antigen-specific immunoglobulin heavy and light chains after SARS-CoV-2 infection.The public antibody clonotypes were shared by distinct convalescent individuals.Moreover,several antibodies isolated by LIBRA-seq showed high binding affinity against SARS-CoV-2 receptor-binding domain(RBD)or nucleoprotein(NP)via ELISA assay.Two RBD-reactive antibodies C14646P3S and C2767P3S isolated by LIBRA-seq exhibited high neutralizing activities against both pseudotyped and authentic SARS-CoV-2 viruses in vitro.Our study provides fundamental insights into B cell response following SARS-CoV-2 infection at the single-cell level. | Bing He Shuning Liu Yuanyuan Wang Mengxin Xu Wei Cai Jia Liu Wendi Bai Shupei Ye Yong Ma Hengrui Hu Huicui Meng Tao Sun Yanling Li Huanle Luo Mang Shi Xiangjun Du Wenjing Zhao Shoudeng Chen Jingyi Yang Haipeng Zhu Yusheng Jie Yuedong Yang Deyin Guo Qiao Wang Yuwen Liu Huimin Yan Manli Wang Yao-Qing Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 3 | A Convenient and Biosafe Replicon with Accessory Genes of SARS-CoV-2 and Its Potential Application in Antiviral Drug Discovery显示文摘SARS-CoV-2 causes the pandemic of COVID-19 and no effective drugs for this disease are available thus far.Due to the high infectivity and pathogenicity of this virus,all studies on the live virus are strictly confined in the biosafety level 3(BSL3)laboratory but this would hinder the basic research and antiviral drug development of SARS-CoV-2 because the BSL3 facility is not commonly available and the work in the containment is costly and laborious.In this study,we constructed a reverse genetics system of SARS-CoV-2 by assembling the viral cDNA in a bacterial artificial chromosome(BAC)vector with deletion of the spike(S)gene.Transfection of the cDNA into cells results in the production of an RNA replicon that keeps the capability of genome or subgenome replication but is deficient in virion assembly and infection due to the absence of S protein.Therefore,such a replicon system is not infectious and can be used in ordinary biological laboratories.We confirmed the efficient replication of the replicon by demonstrating the expression of the subgenomic RNAs which have similar profiles to the wild-type virus.By mutational analysis of nsp12 and nsp14,we showed that the RNA polymerase,exonuclease,and cap N7 methyltransferase play essential roles in genome replication and sgRNA production.We also created a SARS-CoV-2 replicon carrying a luciferase reporter gene and this system was validated by the inhibition assays with known anti-SARS-CoV-2 inhibitors.Thus,such a one-plasmid system is biosafe and convenient to use,which will benefit both fundamental research and development of antiviral drugs. | Yun-Yun Jin Hanwen Lin Liu Cao Wei-Chen Wu Yanxi Ji Liubing Du Yiling Jiang Yanchun Xie Kuijie Tong Fan Xing Fuxiang Zheng Mang Shi Ji-An Pan Xiaoxue Peng Deyin Guo | 2021 | Virologica Sinica2021，36，5： | 2 |
| 4 | Crystal Growth and Characterization of Fluorinated Perylene Diimides显示文摘 | HUANG Jiachi LI Hanying MO Xiong SHI Minmin WANG Mang CHEN Hongzheng | 2014 | Chemical Research in Chinese Universities2014，30，1： | 1 |
| 5 | Wildlife-borne microorganisms and strategies to prevent and control emerging infectious diseases显示文摘China is one of the countries with the richest wildlife population.The large variety of widely distributed species act as natural or susceptible hosts for numerous infectious diseases.It is estimated that there are more than 1.2 million unknown virus species in China,and there might be 10,000–30,000 unknown bacteria in wild mammals on the Qinghai-Tibet Plateau alone.There are no less than 600,000 species of animal-borne parasites and approximately 2 million species of fungi worldwide.With rapid economic growth and globalization,humans and wildlife interact more frequently,which enhances the probability of wildlife-borne pathogens infecting humans.The occurrence of animal-borne infectious diseases will become the“new normal”we have to face in the future.Therefore,research should be carried out on wildlife-borne microorganisms and the prevention and control of emerging infectious diseases to establish an analytical framework and an evaluation technology system for risk assessment and early warning of potential animal-borne emerging infectious diseases.This will not only improve our understanding of wildlife-borne microbial communities but also enable in-depth analysis,discovery,early warning,and even prediction of major animal-borne emerging infectious diseases that might occur in the future.Furthermore,this research will reduce response times,minimize the social and economic impact and losses,enable interventions related to the emergence or spread of the disease as early as possible,and comprehensively improve our management of infectious disease outbreaks. | Tian Qin Xiangdong Ruan Zhaojun Duan Jianping Cao Junrong Liang Jing Yang Yan Jiang Mang Shi Jianguo Xu | 2021 | Journal of Biosafety and Biosecurity2021，3，2： | 1 |
| 6 | Tribological performance of TiAl matrix self-lubricating composites containing Ag, Ti 3 SiC 2 and BaF 2 /CaF 2 tested from room temperature to 600°C显示文摘 | Xiaoliang Shi Jie Yao Zengshi Xu Wenzheng Zhai Siyuan Song Mang Wang Qiaoxin Zhang | 2013 | Materials and Design2013，，： | 1 |
| 7 | Tribological behavior of TiAl matrix self-lubricating composites containing silver from 25 to 800<ce:hsp sp='0.25'/>°C显示文摘 | Xiaoliang Shi Zengshi Xu Mang Wang Wenzheng Zhai Jie Yao Siyuan Song Abid Qamar ud Din Qiaoxin Zhang | 2013 | Wear (-)2013，，1： | 1 |
| 8 | Effect of the Double Frequency of Trap Field in a Paul Trap显示文摘The effect of double frequency oftrap field φ = U - V1 cos Ωt - V2 cos 2Ωt in a Paul trap can be described exactly by using a function series expansion to solve the corresponding Mathieu equation.The stability regions of a trapped ion are plotted and some meaningful physical results are shown. | NIE Zong-Xiu FENG Mang LI Jiao-Mei SHI Lei ZHU Xi-Wen GAO Ke-Lin | 2001 | Communications in Theoretical Physics2001，，11： | 1 |
| 9 | Recombination is associated with an outbreak of novel highly pathogenic porcine reproductive and respiratory syndrome viruses in China 显示文摘 | Shi Mang Holmes E C Brar M S | 2013 | J Virol2013，87，10： | 1 |
| 10 | Recent development of organic electron transport materials显示文摘This article reviews the recent development of organic electron transport materials applied in the fields of organic photoconductors, light-emitting diodes, field-effect transistors and solar cells. Several technologies for charge carrier mobility measurement are summarized and compared, and a series of basic principles for designing high-performance organic electron transport materials are suggested as well. | YE Jian, CHEN Hongzheng, SHI Minmin and WANG Mang(Department of Polymer Science & Engineering, State Key Laboratory of Silicon Materials, Zhejiang University, Hangzhou 310027, China) | 2003 | Progress in Natural Science:Materials International2003，13，2： | 1 |
| 11 | SUPERPLASTICITY OF A RAPIDLY SOLIDIFIED AI-Li ALLOY显示文摘A rapidly solidified microcrystalline Al-Li-Cu-Mg-Zr alloy and its superplasicity have beeninvestigated.An optimum tensile elongation of 585% was obtained at 540℃ and strain rate1.67×10-2s-1.The superplastic Al-Li alloy is manufaetured using thermomechanical pro-cessing:solution,overaging,warm rolling and recrystallization.Microstructural changes inthermomechanical processing and cavitation occurred during superplastic deformation havebeen observed.The superplastic failure of alloy may be caused mainly by nucleation andgrowth of cavities as well as the linkage around grains. | MANG Weishi WANG Guozhi ZHANG Yongchang HU Zhuangqi SHI Changxu Institute of Metal Research,Academia Sinica,Shenyang,China Yongchang Associate Professor,Institute of Metal Research,Academia Sinica,Shenyang 110015,China | 1990 | Acta Metallurgica Sinica(English Letters)1990，3，4： | 1 |
| 12 | A distinct lineage of influenza A virus from bats 显示文摘 | Suxiang Tong Yah Li Pierre Rivailler Christina Con- rardy Danilo A Alvarez Castillo Li-Mei Chen Sergio Recuenco James A Ellison Charles T Davis Ian A York Amy S Turmelle David Moran Shannon Rog- ers Mang Shi Ying Tao Michael R Weil Kevin Tang Lori A Rowe Scott Sammons Xiyan Xu Mi- chael Frace Kim A Lindblade Nancy J Cox Larry J Anderson Charles E Rupprecht Ruben O Donis | 2012 | PANS U S A2012，109，11： | 1 |
| 13 | Tribological Properties of TiAl-Ti_3SiC_2 Composites显示文摘The tribological properties of TiAl-Ti3SiC2 composites(TMC) against Si3N4 ceramic ball pair at room temperature were investigated through the determination of friction coefficients and wear rates, and the morphologies and compositions of wear debris, worn surfaces of TMC and Si3N4 ceramic ball were analyzed. The experimental results showed that TMC with 15wt% Ti3SiC2 exhibited relatively excellent tribological properties. The solid-phase self-lubricating tribo-layers formed on the worn surfaces of both TMC with 15wt% Ti3SiC2 and Si3N4 ceramic ball, which was beneficial to the lower friction coefficient and wear rate. | 薛冰 XU Zengshi ZHANG Qiaoxin SHI Xiaoliang WANG Mang ZHAI Wenzheng YAO Jie SONG Siyuan | 2014 | Journal of Wuhan University of Technology(Materials Science)2014，29，2： | 0 |
| 14 | Association between the nasopharyngeal microbiome and metabolome in patients with COVID-19显示文摘SARS-CoV-2,the causative agent for COVID-19,infect human mainly via respiratory tract,which is heavily inhabited by local microbiota.However,the interaction between SARS-CoV-2 and nasopharyngeal microbiota,and the association with metabolome has not been well characterized.Here,metabolomic analysis of blood,urine,and nasopharyngeal swabs from a group of COVID-19 and non-COVID-19 patients,and metagenomic analysis of pharyngeal samples were used to identify the key features of COVID-19.Results showed lactic acid,L-proline,and chlorogenic acid methyl ester(CME)were significantly reduced in the sera of COVID-19 patients compared with non-COVID-19 ones.Nasopharyngeal commensal bacteria including Gemella morbillorum,Gemella haemolysans and Leptotrichia hofstadii were notably depleted in the pharynges of COVID-19 patients,while Prevotella histicola,Streptococcus sanguinis,and Veillonella dispar were relatively increased.The abundance of G.haemolysans and L.hofstadii were significantly positively associated with serum CME,which might be an anti-SARS-CoV-2 bacterial metabolite.This study provides important information to explore the linkage between nasopharyngeal microbiota and disease susceptibility.The findings were based on a very limited number of patients enrolled in this study;a larger size of cohort will be appreciated for further investigation. | Jing Liu Sheng Liu Zhao Zhang Xuejun Lee Wenxuan Wu Zhanlian Huang Ziying Lei Wenxiong Xu Dabiao Chen Xing Wu Yang Guo Liang Peng Bingliang Lin Yutian Chong Xiangyu Mou Mang Shi Ping Lan Tao Chen Wenjing Zhao Zhiliang Gao | 2021 | Synthetic and Systems Biotechnology2021，6，3： | 0 |
| 15 | Self-assembled helical nanostructures from an asymmetrical perylene diimide显示文摘不均匀的 perylene diimide 3, N-(4-methoxyphenyl )-N 鈥 ?(4-nitrophenyl)-perylene-3,4,9,10-tetracarboxylic diimide,被综合,并且它的自己组装并且在氯仿的分离行为被紫外鈥搗i s 和荧光光谱学详细学习。结果从 3 的唯一的螺旋状的 nanostructures 被建议经由蟺鈥撓€叠,位的阻碍者和 electrophile 鈥搉u cleophile 类型配对的合作行动自我装配。 | Lan Ying Yang Min Min Shi Mang Wang Hong Zheng Chen | 2008 | Chinese Chemical Letters2008，19，10： | 0 |
| 16 | 北美洲型猪蓝耳病病毒高频重组热点的分布显示文摘猪蓝耳病,即猪繁殖与呼吸综合征(Porcine reproductive and respiratory syndrome, PRRS),是由猪繁殖与呼吸综合征病毒(PRRS virus,PRRSV)引起的一种重要传染病,临床上主要表现为妊娠母猪的繁殖障碍、各种年龄阶段猪的呼吸道症状和死亡。该病在世界各养猪国家流行,给养猪业造成了巨大的经济损失。PRRSV可分为两个基因型,即欧洲型PRRSV和北美洲型PRRSV,又称为PRRSV-1和PRRSV-2,二者基因组的核苷酸同源性约为60%。PRRSV-2流行区主要为北美洲和亚洲,GenBank中超过80%的PRRSV-2基因组序列来自中国和美国。 | Yu Fang Yan Yi Shi Mang | 2020 | 中国预防兽医学报2020，42，2： | 0 |
| 17 | Novel pegiviruses infecting wild birds and rodents显示文摘Pegivirus(family Flaviviridae)is a genus of small enveloped RNA viruses that mainly causes blood infections in various mammals including human.Herein,we carried out an extensive survey of pegiviruses from a wide range of wild animals mainly sampled in the Qinghai-Tibet Plateau of China.Three novel pegiviruses,namely Passer montanus pegivirus,Leucosticte brandti pegivirus and Montifringilla taczanowskii pegivirus,were identified from different wild birds,and one new rodent pegivirus,namely Phaiomys leucurus pegivirus,was identified from Blyth's vole.Interestingly,the pegiviruses of non-mammalian origin discovered in this study substantially broaden the host range of Pegivirus to avian species.Co-evolutionary analysis showed virus-host co-divergence over long evolutionary timescales,and indicated that pegiviruses largely followed a virus-host co-divergence relationship.Overall,this work extends the biodiversity of the Pegivirus genus to those infecting wild birds and hence revises the host range and evolutionary history of genus Pegivirus. | Wentao Zhu Jing Yang Shan Lu Yuyuan Huang Dong Jin Ji Pua Liyun Liu Zhenjun Li Mang Shi Jianguo Xu | 2022 | Virologica Sinica2022，37，2： | 0 |
| 18 | Virome in healthy pangolins reveals compatibility with multiple potentially zoonotic viruses显示文摘Previous studies have identified multiple viruses in dead or severely diseased pangolins,but descriptions of the virome in healthy pangolins are lacking.This poses a greater risk of cross-species transmission due to poor preventive awareness and frequent interactions with breeders.In this study,we investigated the viral composition of 34 pangolins with no signs of disease at the time of sampling and characterized a large number of arthropodassociated viruses belonging to 11 families and vertebrate viruses belonging to eight families,including those with pathogenic potential in humans and animals.Several important vertebrate viruses were identified in the pangolins,including parvovirus,pestivirus,and picobirnavirus.The picobirnavirus was clustered with human and grey teal picobirnaviruses.Viruses with cross-species transmission ability were also identified,including circovirus,rotavirus,and astrovirus.Our study revealed that pangolins are frequently exposed to arthropod-associated viruses in the wild and can carry many vertebrate viruses under natural conditions.This study provides important insights into the virome of pangolins,underscoring the importance of monitoring potential pathogens in healthy pangolins to prevent outbreaks of infectious diseases in domesticated animals and humans. | Feng-Juan Tian Jing Li Wen-Li Liu Yu-Jie Liu Yun-Jia Hu Qi-Hang Tu Yang Li Yu Bai Mang Shi Teng-Cheng Que Yan-Ling Hu Yi-Gang Tong | 2022 | Zoological Research2022，43，6： | 0 |
| 19 | PHOTOCONDUCTIVITY STUDY OF NEW POLYACETYLENE DERIVATIVES WITH DIFFERENT SUBSTITUENTS显示文摘The photoconductivities of a series of novel polyacetylene derivatives (PAs) serving as charge generation materials in the single-layered photoreceptors were investigated using photoinduced xerographic discharge technique. It was found that the substitution can improve the photosensitivity of PAs by increasing the conjugation of π electrons. When the substituent is itself photoconductive, the photoconductivity becomes even higher. It can be concluded from cyclic voltammetry that when the HOMO level of the polymer is closer to that of the charge transport material, the photoconduction performance will be better. | Hai-peng Xu Min-min Shi Hong-zheng Chen Mang Wang Ben-zhong Tang | 2005 | Chinese Journal of Polymer Science2005，23，6： | 0 |
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