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| 1 | Standardized Operational Protocol for Human Brain Banking in China显示文摘With the progress of society, there is an increasing need to tackle disorders of the central nervous system. Human brain tissue, unlike animal tissues, is an irreplaceable resource for the study of neurological diseases (1)Aimed at scientific research and education, the roles of human brain tissue repositories are to acquire brain tissue from donors, prepare, process, and preserve collected samples,provide tissue to specific eligible facilities, and determine the characteristics of each tissue sample. | Wenying Qiu Hanlin Zhang Aimin Bao Keqing Zhu Yue Huang Xiaoxin Yan Jing Zhang Chunjiu Zhong Yong Shen Jiangning Zhou Xiaoying Zheng Liwei Zhang Yousheng Shu Beisha Tang Zhenxin Zhang Gang Wang Ren Zhou Bing Sun Changlin Gong Shumin Duan Chao Ma | 2019 | Neuroscience Bulletin2019，35，2： | 6 |
| 2 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 3 | Defensive deception framework against reconnaissance attacks in the cloud with deep reinforcement learning显示文摘Implementing defensive deception in the cloud is promising to proactively counter reconnaissance attack. This technique presents decoys to camouflage cloud assets and distracts attack resource. However,the major challenge is to develop an effective deception strategy to orchestrate digital decoys. To address this issue, we propose a deep reinforcement learning(DRL)-based defensive deception framework. First,we formulate a utility function, which mathematically models underlying threats associated with common vulnerabilities among virtual machines in the cloud. Then, we customize training interfaces and the neural networks for a DRL agent. The reward function reflects the effectiveness of asset concealment and the waste of attack resources, referring to a comprehensive defense goal. Finally, the well-trained DRL agent generates the optimal defense strategy. It specifies a more granular deception strategy than existing proposals. Simulation results show that the proposed framework leads to a 7.87% average advantage in realizing the comprehensive defense goal. Moreover, it can stably improve the concealment degree of cloud assets up to 20.58%, and increase the attack cost up to 40.40%. This study shows that it is promising to improve cloud security with deception defense and artificial intelligence techniques. | Huanruo LI Yunfei GUO Shumin HUO Hongchao HU Penghao SUN | 2022 | Science China(Information Sciences)2022，65，7： | 3 |
| 4 | Imine-Linked Covalent Organic Framework on Surface for Biosensor显示文摘Imine-linked covalent organic framework on amino functionalized silicon substrate was constructed via a step-wise reaction between 1,3,5-benzenetricarboxaldehyde and 1,4-diaminobenzene.The obtained material was used as biosensor for bovine serum albumin(BSA)adsorption and probe DNA immobilization,which extended the application of covalent organic frameworks(COFs)to a new field. | Peiyuan Wang Mengmeng Kang Shumin Sun Qiang Liu Zhihong Zhang Shaoming Fang | 2014 | Chinese Journal of Chemistry2014，32，9： | 3 |
| 5 | Loss of MeCP2 in cholinergic neurons causes part of RTT- like phenotypes via α7 receptor in hippocampus显示文摘 | Ying Zhang Shu-Xia Cao Peng Sun Hai-Yang He Ci-Hang Yang Xiao-Juan Chen Chen-Jie Shen Xiao-Dong Wang Zhong Chen Darwin K Berg Shumin Duan Xiao-Ming Li | 2016 | Cell Research2016，26，6： | 3 |
| 6 | SRSF1 plays a critical role in invariant natural killer T cell development and function显示文摘Invariant natural killer T(iNKT)cells are highly conserved innate-like T lymphocytes that originate from CD4^(+)CD8^(+)double-positive(DP)thymocytes.Here,we report that serine/arginine splicing factor 1(SRSF1)intrinsically regulates iNKT cell development by directly targeting Myb and balancing the abundance of short and long isoforms.Conditional ablation of SRSF1 in DP cells led to a substantially diminished iNKT cell pool due to defects in proliferation,survival,and TCRαrearrangement.The transition from stage 0 to stage 1 of iNKT cells was substantially blocked,and the iNKT2 subset was notably diminished in SRSF1-deficient mice.SRSF1 deficiency resulted in aberrant expression of a series of regulators that are tightly correlated with iNKT cell development and iNKT2 differentiation,including Myb,PLZF,Gata3,ICOS,and CD5.In particular,we found that SRSF1 directly binds and regulates pre-mRNA alternative splicing of Myb and that the expression of the short isoform of Myb is substantially reduced in SRSF1-deficient DP and iNKT cells.Strikingly,ectopic expression of the Myb short isoform partially rectified the defects caused by ablation of SRSF1.Furthermore,we confirmed that the SRSF1-deficient mice exhibited resistance to acute liver injury uponα-GalCer and Con A induction.Our findings thus uncovered a previously unknown role of SRSF1 as an essential post-transcriptional regulator in iNKT cell development and functional differentiation,providing new clinical insights into iNKT-correlated disease. | Jingjing Liu Menghao You Yingpeng Yao Ce Ji Zhao Wang Fang Wang Di Wang Zhihong Qi Guotao Yu Zhen Sun Wenhui Guo Juanjuan Liu Shumin Li Yipeng Jin Tianyan Zhao Hai-Hui Xue Yuanchao Xue Shuyang Yu | 2021 | Cellular & Molecular Immunology2021，18，11： | 3 |
| 7 | Characterization of DNA damage response deficiency in pancreatic cancer patients from China显示文摘To the editor,Pancreatic ductal adenocarcinoma(PDAC)has the worst prognosis among all common malignant solid tumors,with a 5-year overall survival(OS)rate of less than 10%[1].Few effective targets for anticancer ther-apy have been confirmed in pancreatic cancer.Recently,it was substantiated that pancreatic cancer patients carry-ing deleterious mutations of the DNA damage response(DDR)genes are more likely to benefit from platinum-based chemotherapy[2]and poly(adenosine diphosphate-ribose)polymerase(PARP)inhibitor[3]. | Xiaofei Zhang Tiebo Mao Bei Zhang Haiyan Xu Jiujie Cui Feng Jiao Dongqin Chen Yu Wang Jiong Hu Qing Xia Shumin Li Ming Yue Jingyu Ma Jiayu Yao Yongchao Wang Xiao Zhang Shiqing Chen Yuezong Bai Yuexiang Wang Xuebin Zhang Qiang Liu Yongwei Sun Deliang Fu Yingbin Liu Lei Xiong Liwei Wang | 2022 | Cancer Communications2022，42，1： | 2 |
| 8 | Antimicrobial effect and membrane-active mechanism of tea polyphenols against Serratia marcescens显示文摘 | Shumin Yi Wei Wang Fengling Bai Junli Zhu Jianrong Li Xuepeng Li Yongxia Xu Tong Sun Yutang He | 2014 | World Journal of Microbiology and Biotechnology2014，，2： | 2 |
| 9 | Multi-element analysis for determining the geographical origin of mutton from different regions of China显示文摘 | Shumin Sun Boli Guo Yimin Wei Mingtao Fan | 2010 | Food Chemistry2010，，3： | 2 |
| 10 | Rapidly developable therapeutic-grade equine immunoglobulin against the SARS-CoV-2 infection in rhesus macaques显示文摘Dear Editor,The unprecedented COVID-19 pandemic caused by SARS-CoV-2 remains ongoing,but there is a lack of fully effective treatments.Convalescent plasma-derived hyperimmune globulins have been a safe and effective treatment but restricted by the difficulties in obtaining sufficient plasma with high antibody titers from a large number of recovered patients.Heterologous antibodies,particularly equine antibodies,have been widely used for decades as the therapeutics against some viral infections or as antivenoms.1 Equine antibodies could be rapidly developed and manufactured into therapeutic antibodies in large quantities under WHO standardized guidelines.Here we explored the development of equine antibody-derived F(ab′)2 as an option to treat COVID-19 by targeting the receptor-binding domain(RBD)of the viral spike protein that is essential for the viral entry into the host cells.2 We observed excellent neutralization titers of the F(ab′)2 in vitro and high potency against SARS-CoV-2 infection in the nonhuman primate rhesus macaques. | Xiaolei Liu Yi Liu Xuemin Jin Zhanlong He Zhen Huang Shumin Sun Yuwei Gao Jingyu Li Qin Ning Zhongping Xie Ningyi Jin Mingyuan Liu | 2022 | Signal Transduction and Targeted Therapy2022，7，8： | 2 |
| 11 | Multi-element analysis for determining the geographical origin of mutton from different regions of China显示文摘 | SUN Shumin GUO Boli WEI Yimin | | 0，，03： | 1 |
| 12 | A composite control scheme for 6DOF spacecraft formation control显示文摘 | Haibin Sun Shihua Li Shumin Fei | 2011 | Acta Astronautica2011，69，78： | 1 |
| 13 | Anchoring polysulfide with artificial solid electrolyte interphase for dendrite-free and low N/P ratio Li-S batteries显示文摘Lithium sulfur batteries are regarded as a promising candidate for high-energy-density energy storage devices.However,the lithium metal anode in lithium-sulfur batteries encounters the problem of lithium dendrites and lithium metal consumption caused by polysulfide corrosion.Herein we design a dualfunction PMMA/PPC/LiNO3composite as an artificial solid electrolyte interphase(PMCN-SEI)to protect Li metal anode.This SEI offers multiple sites of C=O for polysulfide anchoring to constrain corrosion of Li metal anode.The lithiated polymer group and Li3N in PMCN-SEI can homogenize lithium-ion deposition behavior to achieve a dendrite-free anode.As a result,the PMCN-SEI protected Li metal anode enables the Li||Li symmetric batteries to maintain over 300 cycles(1300 h)at a capacity of 5 m Ah cm^(-2),corresponding to a cumulative capacity of 3.25 Ah cm^(-2).Moreover,Li-S batteries assembled with 20μm of Li metal anode(N/P=1.67)still deliver an initial capacity of 1166 m A h g-1at 0.5C.Hence,introducing polycarbonate polymer/inorganic composite SEI on Li provides a new solution for achieving the high energy density of Li-S batteries. | Wei Lu Zhao Wang Guiru Sun Shumin Zhang Lina Cong Lin Lin Siru Chen Jia Liu Haiming Xie Yulong Liu | 2023 | Journal of Energy Chemistry2023，，5： | 1 |
| 14 | In-plane heterostructured Ag_(2)S-In_(2)S_(3) atomic layers enabling boosted CO_(2) photoreduction into CH_(4)显示文摘Sluggish separation and migration kinetics of the photogenerated carriers account for the low-efficiency of CO_(2) photoreduction into CH_(4). Design and construction two-dimensional (2D) in-plane heterostructures demonstrate to be an appealing approach to address above obstacles. Herein, we fabricate 2D in-plane heterostructured Ag_(2)S-In_(2)S_(3) atomic layers via an ion-exchange strategy. Photoluminescence spectra, time-resolved photoluminescence spectra, and photoelectrochemical measurements firmly affirm the optimized carrier dynamics of the In_(2)S_(3) atomic layers after the introduction of in-plane heterostructure. In-situ Fourier transform infrared spectroscopy spectra and density functional theory (DFT) calculations disclose the in-plane heterostructure contributes to CO_(2) activation and modulates the adsorption strength of CO* intermediates to facilitate the formation of CHO* intermediates, which are further protonated to CH4. In consequence, the in-plane heterostructure achieves the CH_(4) evolution rate of 20 µmol·g^(−1)·h^(−1), about 16.7 times higher than that of the In2S3 atomic layers. In short, this work proves construction of in-plane heterostructures as a promising method for obtaining high-efficiency CO_(2)-to-CH_(4) photoconversion properties. | Weiwei Shao Shumin Wang Juncheng Zhu Xiaodong Li Xingchen Jiao Yang Pan Yongfu Sun Yi Xie | 2021 | Nano Research2021，14，12： | 1 |
| 15 | Discussion on a new paradigm of endogenous security towards 6G networks显示文摘The sixth-generation mobile communication(6G)networks will face more complex endogenous security problems,and it is urgent to propose new universal security theories and establish new practice norms to deal with theªunknown unknownºsecurity threats in cyberspace.This paper first expounds the new paradigm of cyberspace endogenous security and introduces the vision of 6G cyberspace security.Then,it analyzes the security problems faced by the 6G core network,wireless access network,and emerging associated technologies in detail,as well as the corresponding security technology development status and the integrated development of endogenous security and traditional security.Furthermore,this paper describes the relevant security theories and technical concepts under the guidance of the new paradigm of endogenous security. | Xinsheng JI Jiangxing WU Liang JIN Kaizhi HUANG Yajun CHEN Xiaoli SUN Wei YOU Shumin HUO Jing YANG | 2022 | Frontiers of Information Technology & Electronic Engineering2022，23，10： | 1 |
| 16 | Numerical study of the optimum counter-flow mode of air jets in a large utility furnace显示文摘 | HE Boshu CHEN Meiqian YU Qiumei LIU Shumin FAN Lijuan SUN Shouguang XU Jinyuan PAN Wei-Ping | | 0，，： | 1 |
| 17 | A closed-loop detection and open-loop control strategy for booms of truck-mounted concrete pump显示文摘 | Xiaojie Sun Hua Ye Shumin Fei | 2012 | Automation in Construction2012，，： | 1 |
| 18 | A closed-loop de tection and open-loop control strategy for booms of truck-mounted concrete pump显示文摘 | Sun Xiaojie Ye Hua Fei Shumin | 2013 | Automation in Con- struction2013，31，5： | 1 |
| 19 | Feedback control and adaptive control of the energy resource chaotic system显示文摘 | Mei Sun Lixin Tian Shumin Jiang | 2007 | Chaos Solitons & Fractals2007，32，5： | 1 |
| 20 | New concept on airseparation显示文摘 | Zhu Xuefeng Sun Shumin He Yufeng | 2008 | Journal of Membrane Science2008，323，： | 1 |
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