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| 1 | Genetic diversity of rice cultivars (Oryza sativa L.) in China and the temporal trends in recent fifty years显示文摘To understand geographical distribution of the genetic diversity of rice cultivars {Oryza sativa L.) and its trends in recent fifty years in China, 453 ’ accessions were analyzed by 36 microsatellites loci and 42 phenotypic traits. Results revealed that the genetic diversity by SSRs is highly consistent with that by phenotypic traits and the genetic diversity of indica cultivars was higher than that of japonica cultivars; the genetic diversity of cultivars declined from 1950s to 1980s and then increased greatly; among the six rice ecological zones (REZs), genetic diversity of REZTl was the highest and those of REZV and REZVT were the lowest at both DNA and phenotypic level. Jiangsu and Jiangxi provinces in the middle and lower reaches of Yangtze River and Sichuan province in southwest of China were the areas with the highest genetic diversity. Breeders in REZV which is an important japonica rice area but with very low genetic diversity should explore more gene resources to widen the genetic backgrounds of cultivars. | QI Yonawen ZHANG Dongling ZHANG Hongliang WANG Meixing SUN Junli WEI Xinghua QIU Zongen TANG Shengxiang CAO Yongsheng WANG Xiangkun LI Zichao | 2006 | Chinese Science Bulletin2006，51，6： | 27 |
| 2 | Glacier changes during the last forty years in the Tarim Interior River basin,northwest China显示文摘By comparing digitized glacier outlines from the Chinese Glacier Inventory (CGI) during the 1960s-1970s and Landsat Enhance Thematic Mapper (ETM+) images from 1999 to 2001, we investigated changes for about 7665 alpine glaciers among 11665 glaciers in seven sub-basins of the Tarim Interior River basin (TIRB). The results showed that the total glacier area was reduced by 3.3% from the 1960s/ 1970s to 1999/2001 and area losses for 1-5 km2 glaciers accounted for 48.3% of the total glacier area loss in the TIRB. However, the glacier area reductions varied from 0.7% to 7.9% among the seven sub-basins of the TIRB during the study period. The glacier area changing with altitude showed that the maximum contribution of area shrinkage occurred at 4900-5400 m. Data from 25 meteorological stations in the TIRB showed increases in both the annual mean air temperature and annual precipitation during 1960-2000. This indicates that the glacier shrinkage in the TIRB over the last 40 years was largely due to regional climate warming that enhanced glacier ablation and overcame the effects of increased precipitation on the glacier mass balance. | Donghui Shangguan Shiyin Liu Yongjian Ding Lianfu Ding Junli Xu Li Jing | 2009 | Progress in Natural Science:Materials International2009，19，6： | 26 |
| 3 | MiR-122 in hepatic function and liver diseases显示文摘As the most abundant liver-specific microRNA,mi-croRNA-122(miR-122)is involved in various physio-logical processes in hepatic function as well as in liver pathology.There is now compelling evidence that miR-122,as a regulator of gene networks and pathways in hepatocytes,plays a central role in diverse aspects of hepatic function and in the progress of liver diseases.This liver-enriched transcription factors-regulated miRNA promotes differentiation of hepatocytes and regulates lipid metabolism.With regard to liver diseases,miR-122 was shown to stimulate hepatitis C virus(HCV)replication through a unique and unusual interaction with two binding sites in the 5′-UTR of HCV genome to mediate the stability of the viral RNA,whereas inhibit the expression and replication of hepatitis B virus(HBV)by a miR-122-cylin G1/p53-HBV enhancer regulatory pathway.In addition,miR-122 acts as a suppressor of cell prolif-eration and malignant transformation of hepatocytes with remarkable tumor inhibition activity.Notably,a clinical trial targeting miR-122 with the anti-miR-122 oli-gonucleotides miravirsen,the first miRNA targeted drug,has been initiated for treatment of HCV infection.With further understanding of the comprehensive roles of miR-122 in hepatic functions and the mechanisms in-volved in miR-122 down-regulation in chronic hepatitis or hepatocellular carcinoma,miR-122 appears to be a promising candidate for effective therapeutic ap-proaches against tumor and infectious diseases. | Jun Hu Yaxing Xu Junli Hao Saifeng Wang Changfei Li Songdong Meng | 2012 | Protein & Cell2012，3，5： | 22 |
| 4 | Natural Variation in CCD4 Promoter Underpins Species-Specific Evolution of Red Coloration in Citrus Peel显示文摘Carotenoids and apocarotenoids act as phytohormones and volatile precursors that influence plant development and confer aesthetic and nutritional value critical to consumer preference.Citrus fruits display considerable natural variation in carotenoid and apocarotenoid pigments.In this study,using an integrated genetic approach we revealed that a 5;c/s-regulatory change at CCD4b encoding CAROTENOID CLEAVAGE DIOXYGENASE 4b is a major genetic determinant of natural variation in C3 0 apocarotenoids responsible for red coloration of citrus peel.Functional analyses demonstrated that in addition the known role in synthesizing 3-citraurin,CCD4b is also responsible for the production of another important C3 0 apocarotenoid pigment,p-citraurinene.Furthermore,analyses of the CCD4b promoter and transcripts from various citrus germplasm accessions established a tight correlation between the presence of a putative 5'c/s-regulatory enhancer within an MITE transposon and the enhanced allelic expression of CCD4b in C3 0 apocarotenoid-rich red-peeled accessions.Phylogenetic analysis provided further evidence that functional diversification of CCD4b and naturally occurring variation of the CCD4b promoter resulted in the stepwise evolution of red peels in mandarins and their hybrids.Taken together,our findings provide new insights into the genetic and evolutionary basis of apocarotenoid diversity in plants,and would facilitate breeding efforts that aim to improve the nutritional and aesthetic value of citrus and perhaps other fruit crops. | Xiongjie Zheng Kaijie Zhu Quan Sun Weiyi Zhang Xia Wang Hongbo Cao Meilian Tan Zongzhou Xie Yunliu Zeng Junli Ye Lijun Chai Qiang Xu Zhiyong Pan Shunyuan Xiao Paul D.Fraser Xiuxin Deng | 2019 | Molecular Plant2019，12，9： | 18 |
| 5 | Characteristics of acoustic emission signals in damp cracking coal rocks显示文摘A uniaxial load experiment on coal rocks at different stress rates was carried out, based on the characteristics of acoustic emission (AE) signals in cracking coal rocks, decomposition, de-noising and reconstruction for the AE signals through wavelet packet transform for solving the current problems created by the presence of noise in AE signals and the existing problems in AE signal processing. The results show that the various characteristics of AE signals in coal rocks cracking under different situations can be clearly reflected, after the AE signals are de-noised by the wavelet packet. Compared to dry coal rocks, the number of AE occurrences in damp coal rocks was significantly reduced, as well as the average amplitude. The number of AE occurrences in damp and dry coal rocks clearly increased with increases in the loading rate, but the largest amplitude of the AE signals in damp coal rocks has been reduced. There is no clear evidence of change in dry coal rocks. | TANG Shoufeng, TONG Minming, HU Junli, HE Xinmin School of Information and Electrical Engineering, China University of Mining & Technology, Xuzhou 221008, China | 2010 | Mining Science and Technology2010，20，1： | 17 |
| 6 | Transcriptomics-based identification of WRKY genes and characterization of a salt and hormone-responsive PgWRKY1 gene in Panax ginseng显示文摘WRKY 蛋白质属于一个抄写因素(TF ) 家庭和戏在许多植物过程,对不能生活、关於生命的压力的包括的植物回答,以及第二等的新陈代谢的动态角色。然而,在人参属人参 C ·迈耶的 WRKY 基因都没迄今为止被报导。在这研究,从甲基 jasmonate (MeJA ) 的很多 WRKY unigenes 对待偶然这种的根 transcriptome 用下一代的定序被识别技术。编码 WRKY 蛋白质的 48 有希望的 WRKY unigenes 的一个总数被消除冤屈和不完全的开的读物框架(ORF ) 获得。种系发生的分析揭示 48 WRKY TF,包括 11 组我, 36 组 II,和 1 组 III。而且,指定为 PgWRKY1 的一 MeJA 应答的 unigene 被克隆并且描绘。它包含 1077 bp 的全部 ORF 并且编码 358 氨基酸残余的多肽。PgWRKY1 蛋白质包含由保存氨基酸顺序主题 WRKYGQK 和 C 2 H 2-type 锌手指主题属于 WRKY 亚群 II-d。在洋葱和烟草外皮房间的 PgWRKY1-GFP 熔化蛋白质的 Subcellular 本地化表明 PgWRKY1 在原子核是只在场的。量的即时聚合酶链反应分析证明 PgWRKY1 的表示与叶子,茎,和种子相比在根和侧面的根是相对更高的。重要地, PgWRKY1 表示被水杨酸显著地导致酸, abscisic 酸,和 NaCl,而是由 MeJA 处理的 downregulated。这些结果建议 PgWRKY1 可能是对荷尔蒙和盐压力作出回应的多重压力可诱导的基因。 | Mohammed Nuruzzaman Hongzhe Cao Hao Xiu Tiao Luo Jijia Li Xianghui Chen Junli Luo Zhiyong Luo | 2016 | Acta Biochimica et Biophysica Sinica2016，48，2： | 12 |
| 7 | Regulation of polyphenols accumulation by combined overexpression/silencing key enzymes of phyenylpropanoid pathway显示文摘对有象 chlorogenic 酸(CGA ) 和卢丁那样的增加的理想的多酚的植物的新陈代谢的工程有成长兴趣。在这研究,两本氨基丙酸氨 lyase (AtPAL2 ) 的 overexpression 的效果, phenylpropanoid 小径的第一酶,和 hydroxycinnamoyl-CoA, quinate:hydroxycinnamoyl transferase (NtHQT ) , CGA 生合成的最后酶,和和 NtHQT 的 silencing 的 AtPAL2 的 overexpression 在烟草被调查。转基因的烟草植物 overexpressing AtPAL2 证明二和五预定 CGA 和卢丁层次的增加比野类型(WT ) 分别地种。NtHQT 的 Overexpression 进一步比 WT 水平的在 AtPAL2 植物增加 CGA 的累积到大约三次,当在 AtPAL2 的 NtHQT 的 silencing 比 WT 植物的在卢丁水平的 12 次增加种结果时。本氨基丙酸氨 lyase (PAL ) 和 overexpression/silencing HQT 的同时的 overexpression 能与增加的多酚被用于功能的食物的生产。 | Junli Chang Jie Luo Guangyuan He | 2009 | Acta Biochimica et Biophysica Sinica2009，41，2： | 12 |
| 8 | Development of an activity-directed selection system enabled significant improvement of the carboxylation efficiency of Rubisco显示文摘光合的公司 < 潜水艇 class= “ a-plus-plus ” > 2 固定是在地球上的器官的碳的最终的来源并且因此为庄稼生产和碳隐遁是必要的。Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco ) 催化光合的公司的第一步 < 潜水艇 class= “ a-plus-plus ” > 2 固定。然而, Rubisco 的极端低 carboxylation 效率为改进光合的效率使它成为最吸引人的目标。广泛的研究集中了于重新设计更有效的酶,而是努力被它的结构功能关系的有限理解和一个有效选择系统的缺乏向它的活动阻碍了。探讨 Rubisco 的失败的分子的工程,我们开发了在那里完全连接宿主房间的生长到 Rubisco 活动的一个 Escherichia 基于 coli 的指导活动的选择系统。Synechococcus sp。与在小子单元的 E49V 和 D82G 替换变异的 PCC7002 Rubisco 被一个轮进化从 15,000 异种的一个总数选择。这异种证明 85% 向公司在催化效率在特定的 carboxylation 活动和 45% 改进增加 < 潜水艇 class= “ a-plus-plus ” > 2 。小子单元的 E49V 变化被推测通过和大子单元的 Q225 的相互作用影响 holoenzyme 催化作用。这个相互作用从更高的植物和 Chlamydomonas reinhardtii 在各种各样的 Rubisco 之中被保存。这些的知识可能为从更高的植物设计 Rubisco 提供线索,与增加庄稼收益的潜力。 | Zhen Cai Guoxia Liu Junli Zhang Yin Li | 2014 | Protein & Cell2014，5，7： | 12 |
| 9 | Nidus vespae protein inhibiting proliferation of HepG2 hepatoma cells through extracellular signal-regulated kinase signaling pathways and inducing G1 cell cycle arrest显示文摘蛋白质说出 NVP (1 ) 从巢 vespae 被孤立。T 他现在的学习的目的是阐明 NVP (1 ) 是否并且怎么调制 HepG2 房间的增长。在 6.6 μg/ml 的集中的 NVP (1 ) 能在阶段 G 1 逮捕房间周期并且禁止 cyclinB, cyclinD1 和 cyclinE 的 mRNA 表示。NVP (1 ) 压制了 cdk2 蛋白质表示,但是增加了 p27 和 p21 蛋白质表示。然而, NVP (1 ) 没改变 p16 蛋白质表示层次。NVP (1 ) 在由原子染色质冷凝作用显示了的 HepG2 房间支持了 apoptosis,并且另外,表明小径的细胞外的调整信号的 kinase (英皇家空军之阶级最低之兵) 被激活。而且,当 HepG2 房间是有英皇家空军之阶级最低之兵禁止者 PD98059 的 pretreated 时,津贴蛋白质表示水平被稀释。这些结果证明 NVP (1 ) 通过表明小径的英皇家空军之阶级最低之兵禁止 HepG2 的增长。NVP (1 ) 能是为肝癌症的潜在的药。 | Changdong Wang Peng Chen Hongjuan Jin Xu Yan Lu Gan Yi Li Shiyi Zhou Junli Chang Yuesheng Wang Guangxiao Yang Guangyuan He | 2008 | Acta Biochimica et Biophysica Sinica2008，40，11： | 11 |
| 10 | Propofol differentially induces unconsciousness and respiratory depression through distinct interactions between GABAa receptor and GABAergic neuron in corresponding nuclei显示文摘Propofol is the most commonly used intravenous anesthetic worldwide.It can induce loss of consciousness prior to the occurrence of severe respiratory suppression,which is also a pharmacodynamic feature of all general anesthetics.However,the neural mechanisms underlying this natural phenomenon are controversial and highly related to patient safety.In the present study,we demonstrated that the pharmacodynamic effects of propofol(50 and 100 μM)on suppression of consciousness-related excitatory postsynaptic currents in the medial prefrontal cortex(mPFC)and centromedian nucleus of the thalamus(CMT)were lower than those in the kernel respiratory rhythmogenesis nucleus pre-Botzinger complex(PrBo).Furthermore,we unexpectedly found that the GABAa receptor β3 subunit is the key target for propofol's action and that it is mutually and exclusively expressed in GABAergic neurons.It is also more abundant in the mPFC and CMT,but mainly co-localized with GABAergic neurons in the PrBo.As a result,the differentiated expression pattern should mediate more neuron suppression through the activation of GABAergic neurons in the mPFC and CMT at low doses of propofol(50 μM).However,PrBo GABAergic neurons were only activated by propofol at a high dose(100 μM).These results highlight the detailed pharmacodynamic effects of propofol on consciousness-related and respiration-related nuclei and provide the distinct interaction mechanism between the β3 subunit and GABAergic neurons in mediating the suppression of consciousness compared to the inhibition of respiration. | Junli Jiang Yingfu Jiao Po Gao Wen Yin Wei Zhou Yunchun Zhang Yanjun Liu Daxiang Wen Yuan Wang Liang Zhou Tian Yu Weifeng Yu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，8： | 11 |
| 11 | Mechanistic and therapeutic advances in non-alcoholic fatty liver disease by targeting the gut microbiota显示文摘Non-alcoholic fatty liver disease (NAFLD)is one of the most common metabolic diseases currently in the context of obesity worldwide,which contains a spectrum of chronic liver diseases,including hepatic steatosis, non-alcoholic steatohepatitis and hepatic carcinoma.In addition to the classical 'Two-hit'theory,NAFLD has been recognized as a typical gut microbiota-related disease because of the intricate role of gut microbiota in maintaining human health and disease formation.Moreover,gut microbiota is even regarded as a 'metabolic organ'that play complementary roles to that of liver in many aspects.The mechanisms underlying gut microbiota-mediated development of NAFLD include modulation of host energy metabolism,insulin sensitivity, and bile acid and choline metabolism.As a result,gut microbiota have been emerging as a novel therapeutic target for NAFLD by manipulating it in various ways,including probiotics,prebiotics,synbiotics,antibiotics,fecal microbiota transplantation,and herbal components.In this review,we summarized the most recent advances in gut microbiota-mediated mechanisms,as well as gut microbiota-targeted therapies on NAFLD. | Ruiting Han Junli Ma Houkai Li | 2018 | Frontiers of Medicine2018，12，6： | 11 |
| 12 | Inactivation of Cryptosporidium by ozone and cell ultrastructures显示文摘The fluorescence staining method and scanning electron microscopy (SEM) were used to study the effect of ozone (O3) inactivating Cryptosporidium in water and cell ultrastructures variation to shed light on the mechanism of inactivation preliminarily.Results indicated that O3 had a stronger inactivating capability.When the concentration of O3 was above 3.0 mg/L and the contact time was up to 7 min,a significant inactivating effect could be achieved.The turbidity on inactivation effects was also found to be statistically significant in artificial water.With increases in turbidity,the inactivating effect decreased.Inactivation rate improved with a temperature increase from 5 to 25°C,but decreased beyond this.The inactivating capability of O3 was found to be stronger under acidic than that under alkalic conditions.When the concentration of organic matter in the reaction system was increased,the competition between Cryptosporidium and organics with O3 probably took place,thereby reducing the inactivation rate.In addition,the cellular morphology of Cryptosporidium varied with different contact times.At zero contact time,cells were rotundity and sphericity,at 60 sec they became folded,underwent emboly,and burst at 480 sec,the cell membrane of Cryptosporidium shrinked and collapsed completely. | Zhilin Ran Shaofeng Li Junli Huang Yixing Yuan Chongwei Cui Craig Denver Williams | 2010 | Journal of Environmental Sciences2010，22，12： | 11 |
| 13 | TiO_2-loaded activated carbon fiber:Hydrothermal synthesis,adsorption properties and photo catalytic activity under visible light irradiation显示文摘TiO_2-loaded activated carbon fibers(ACF) were prepared by a hydrothermal method.The samples were characterized by scanning electron microscopy(SEM),X-ray diffraction(XRD),Fourier transform infrared(FT1R) spectrometry and UV-vis diffuse reflectance spectra(DRS).SEM images showed that the TiO_2nanoparticles were deposited on the surface of ACF,and the particle size and loading amount of TiO_2were varied by changing the initial concentration of tetrabutyl titanate(TBOT).The results of an ash experiment showed that the loading amounts of TiO_2 were 18.4%,43.3%,52.5%,75.1%,and 91.1%for initial concentrations of TBOT of 0.07,014,0.21,0.28,and 0.35 mol/L,respectively.Physical interactions played an important role in the formation of TiO_2/ACF composite fibers that absorb UV and visible light.Compared with those of ACF,improved adsorption and photocatalytic activity toward Rhodamine B(RhB)were observed for TiO_2/ACF composite fiber.The Rhodamine B could be removed efficiently by TiO_2/ACF composite fibers,and the TiO_2 loading amount had a significant effect on the photocatalytic activity of TiO_2/ACF composite fibers. | Hao Meng Wei Hou Xinxin Xu Junli Xu Xia Zhang | 2014 | Particuology2014，12，3： | 10 |
| 14 | Pharmacokinetics and tissue distribution of 5-fluorouracil encapsulated by galactosylceramide liposomes in mice显示文摘Aim: To study the pharmacokinetics and tissue distribution of 5-fluorouracil encapsulated by galactosylceramide liposomes (5-Fu-GCL) in mice. Methods: The concentration of 5-fluorouracil (5-Fu) in serum was detected by high performance liquid chromatography after 5-Fu-GCL (80, 40, 20 mg/kg) and free 5-Fu (40 mg/kg) were injected intravenously into mice. The tissue distribution of 5-Fu-GCL (40 mg/kg) and free 5-Fu (40 mg/kg) was investigated, and concentration-time profile of the two preparations in the liver were studied. Data were analyzed by 3p97 program. Results: Serum concentration-time curves of 5-Fu-GCL and free 5-Fu conformed to one compartment model of first order absorption. 5-Fu-GCL at 80, 40, and 20 mg/kg had T1/2Ke of 25.8±4.2, 27.3±4.4, and 28.2±5.6 min; C0 of 24.9±4.9, 17.7±3.6, and 11.5±2.7 mg/L; and AUC of 990.0±45.2, 622.5±38.3, and 340.4±25.6 mg.min-L^-4, respectively. In contrast free 5-Fu at 40 kg/mg had T1/2ke of 15.8±2.2 min, C0 of 35.8±6.2 mg/L, AUC of 639.0±35.9 mg-min.L^-1. The tissue distribution of 5-Fu-GCL in the liver and immune organs was significantly increased, while in heart and kidney it was remarkably decreased. The AUC of 5-Fu-GCL in the liver was 3 times higher than that of free 5-Fu. Conclusion: The pharmacokinetics and tissue distribution of 5-Fu-GCL appears to be linear-related and dose-dependent, and exhibits sustained-release and hepatic target characteristics. | YongJIN JunLI Long-fuRONG Xiong-wenLü YanHUANG Shu-yunXU | 2005 | Acta Pharmacologica Sinica2005，26，2： | 10 |
| 15 | The role of RIP3 in cardiomyocyte necrosis induced by mitochondrial damage of myocardial ischemia-reperfusion显示文摘Myocardial damage caused by myocardial ischemia-reperfusion injury (MIRI)is difficult to be alleviated because cardiomyocyte necrosis is an irreversible and unregulated death form.Recently, necroptosis,a necrosis form caused by tumor necrosis factor-α (TNF-α)and Fas ligand (FasL),was found to be regulated by receptor interacting protein 3 (RIP3)and RIP3-receptor interacting protein 1 (RIP1)-mixed lineage kinase domain like protein (MLKL)pathway.But it is unclear whether they also play a regulatory role in MIRI-induced necroptosis.Our previous results showed that in rat MIRI,RIP3 could translocate and express highly in mitochondria.Therefore,it is important to explore proteins that interact with RIP3 which was translocated to mitochondria.The aim of this study was to explore the role of RIP3 in cardiomyocyte necrosis induced by mitochondrial damage of hypoxia/reoxygenation (H/R).Our results showed that H/R could cause RIP3-depended mitochondrial fragmentation and necrosis-based death;and RIP3-promoted H/R-induced necroptosis in H9c2 cells through increasing lactate dehydrogenase release and inhibiting cell viability.This process did not require RIP1 or MLKL but dynamin-related protein 1 (Drp1),which was related to Drpl activation,reactive oxygen species elevation,and △Ψm decline.This study provides novel insights into the role of RIP3 in cardiomyocyte injury during H/R.RIP3 may serve as a potential target for the treatment of MIRI. | Huifang Hou Yongling Wang Qiong Li Zaibing Li Yan Teng Jingyu Li Xiaoying Wang Junli Chen Ning Huang | 2018 | Acta Biochimica et Biophysica Sinica2018，50，11： | 10 |
| 16 | One-step disposal of Cr (Ⅵ)-bearing wastewater by natural pyrrhotite显示文摘Cr(Ⅵ)-bearing wastewater can be treated by natural pyrrhotite which is used for reductant to reduce Cr(Ⅵ) and precipitant to precipitate Cr(Ⅲ) simultaneously. The disposal products can be divided into three parts in the beakers, namely supernatant in the upper part, the yellowish colloidal precipitates in the middle part and the pyrrhotite in the lower part. The content of total Cr=Cr(Ⅵ)+Cr(Ⅲ) in the supernatant liquid is 0.06 mg/L, which is lower than 1.5 mg/L of the discharge standard of China and near to 0.05 mg/L of the standard of potable water. This one-step disposal composing of both reduction and precipitation which is traditionally divided into two independent steps called reducing technology and precipitating technology respectively. The new method is of obvious economic advantage and favourable to decreasing surplus mud derived from adding Ca(OH)2 to precipitate Cr(Ⅲ) traditionally so as to avoid recontamination. In fact, sodium sulfite (Na2SO3) used in disposal of Cr(Ⅵ) was | LU Anhuai, CHEN Jie, SHI Junxian, LU Xiaoying, TANG Junli & GUO Min1. Departmenl of Geology, Peking University, Beijing 100871, China 2. National Laboratory of Mineral and Rock Materials, China University of Geosciences, Beijing 100083, China (e-mail: luanhuai | 2000 | Chinese Science Bulletin2000，45，17： | 9 |
| 17 | Yangtze Three Gorges Reservoir, China: A holistic assessment of organic pollution, mutagenic effects of sediments and genotoxic impacts on fish显示文摘Besides obvious benefits,the Three Gorges Dam's construction resulted in new pollution scenarios with the potentials to threaten the Three Gorges Reservoir(TGR) ecosystem.In order to record organic contamination,to find links to ecotoxicological impacts and to serve as reference for ensuing monitoring,several sites in the TGR area were screened applying the triad approach with additional lines-of-evidence as a holistic assessment method.Sediments and the benthic fish species Pelteobagrus vachellii were sampled in 2011 and 2012 to determine organic pollution levels,mutagenic potentials and genotoxic impacts.Two regional hot-spots near the cities of Chongqing and Kaixian were identified and further investigated in 2013.Only polycyclic aromatic hydrocarbons(PAHs) could be detected in sediments in 2011(165–1653 ng/g),emphasizing their roles as key pollutants of the area.Their ubiquity was confirmed at Chongqing(150–433 ng/g) and Kaixian(127–590 ng/g) in2013.Concentrations were comparable to other major Chinese and German rivers.However,the immense sediment influx suggested a deposition of 216–636 kg PAH/day(0.2–0.6 mg PAH/(m2·day)),indicating an ecotoxicological risk.PAH source analysis highlighted primary impacts of combustion sources on the more industrialized upper TGR section,whereas petrogenic sources dominated the mid-low section.Furthermore,sediment extracts from several sites exhibited significant activities of frameshift promutagens in the Ames fluctuation assay.Additionally,significant genotoxic impairments in erythrocytes of P.vachellii were detected(Chongqing/Kaixian),demonstrating the relevance of genotoxicity as animportant mode of action in the TGR's fish.PAHs,their derivatives and non-target compounds are considered as main causative agents. | Tilman Floehr Bj?rn Scholz-Starke Hongxia Xiao Josef Koch Lingling Wu Junli Hou Anja Wolf Axel Bergmann Kerstin Bluhm Xingzhong Yuan Martina Ro?-Nickoll Andreas Sch?ffer Henner Hollert | 2015 | Journal of Environmental Sciences2015，27，12： | 9 |
| 18 | Crosstalk Complexities between Auxin, Cytokinin, and Ethylene in Arabidopsis Root Development: From Experiments to Systems Modeling, and Back Again显示文摘理解荷尔蒙和基因怎么交往在变化环境协调植物生长是在植物的主要挑战发展生物学。植物生长素,细胞激动素,和乙烯是调整植物开发的许多方面的三重要荷尔蒙。这评论极其在 Arabidopsis 根开发评估在三荷尔蒙之间的串音。我们把许多试验性的数据集成到一个串音网络,它在植物生长素,细胞激动素,和乙烯串音揭示复杂性的多重层。特别地,数据集成揭示在乙烯和细胞激动素小径之间的一个另外的、大部分俯看的连接,它通过 phosphorelay 机制行动。这个建议连接探讨乙烯申请是否支持或禁止乙烯受体的受体 kinase 活动的突出的问题。阐明在植物生长素,细胞激动素,和乙烯串音的复杂性要求一联合试验性并且系统建模途径。我们为证实在植物生长素,细胞激动素,和乙烯之间的串音怎么在根开发调整 patterning 评估重要当模特儿的努力。我们讨论反复地把实验与为分析建模的系统相结合的新奇方法论怎么为阐明是必要的在在根开发的植物生长素,细胞激动素,和乙烯的串音的复杂性。最后,我们讨论未来挑战从一联合试验性、建模的观点。 | Junli Liu Simon Moore Chunli Chen Keith Lindsey | 2017 | Molecular Plant2017，10，12： | 8 |
| 19 | Association of HLA-B Alleles With Human Immunodeficiency Virus Type 1 Infection in the Yi Ethnic Group in Sichuan Province显示文摘Objective To determine the distribution of HLA-B alleles in the Chinese Yi ethnic group and its association with HIV infection. Methods One hundred and six unrelated healthy HIV negative and 73 HIV positive Chinese Yi ethnic individuals were typed by PCR-SSP. Results The frequency of alleles B*07, B*35, and B*46 were increased in HIV-1-positive subjects, whereas the alleles B*55, B*44 and B*78 were absent in the HIV-infected persons studied. The B*46 allele was present in a significantly higher gene frequency among HIV-1-positive individuals (P=0.02, OR=3.32, 95% CI=1.13-9.78) compared with control subjects. Conclusion HLA-B*46 may be associated with its susceptibility to HIV-1 infections. | MING-YANXU KUN-XUEHONG XIAO-LINGDENG JUNLI HONGPENG Yu-HuARUAN GUAN-MINGQIN HUIXING XIAO-HUXU ANDYI-MINGSHAO | 2004 | Biomedical and Environmental Sciences2004，17，2： | 8 |
| 20 | Spatio-temporal pattern and changes of evapotranspiration in arid Central Asia and Xinjiang of China显示文摘Accurate inversion of land surface evapotranspiration (ET) in arid areas is of great significance for understanding global eco-hydrological process and exploring the spatio-temporal variation and ecological response of water resources.It is also important in the functional evaluation of regional water cycle and water balance,as well as the rational allocation and management of water resources.This study,based on model validation analysis at varied scales in five Central Asian countries and China's Xinjiang,developed an appropriate approach for ET inversion in arid lands.The actual ET during growing seasons of the study area was defined,and the changes in water participating in evaporation in regional water cycle were then educed.The results show the simulation error of SEBS (Surface Energy Balance System) model under cloud amount consideration was 1.34% at 30-m spatial scale,2.75% at 1-km spatial scale and 6.37% at 4-km spatial scale.ET inversion for 1980-2007 applying SEBS model in the study area indicates:(1) the evaporation depth (May-September) by land types descends in the order of waters (660.24 mm) > cultivated land (464.66 mm) > woodland (388.44 mm) > urbanized land (168.16 mm) > grassland (160.48 mm) > unused land (83.08 mm);and (2) ET during the 2005 growing season in Xinjiang and Central Asia was 2,168.68×10 8 m 3 (with an evaporation/precipitation ratio of 1.05) and 9,741.03×10 8 m 3 (with an evaporation/precipitation ratio of 1.4),respectively.The results unveiled the spatio-temporal variation rules of ET process in arid areas,providing a reference for further research on the water cycle and water balance in similar arid regions. | Xi CHEN BaiLian LI Qin LI JunLi LI Saparnov ABDULLA | 2012 | Journal of Arid Land2012，4，1： | 8 |
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