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| 1 | The Arabidopsis catalase triple mutant reveals important roles of catalases and peroxisome-derived signaling in plant development显示文摘Hydrogen peroxide(H_2O_2)is generated in many metabolic processes.As a signaling molecule,H_2O_2plays important roles in plant growth and development,as well as environmental stress response.In Arabidopsis,there are three catalase genes,CAT1,CAT2,and CAT3.The encoded catalases are predominately peroxisomal proteins and are critical for scavenging H_2O_2.Since CAT1 and CAT3 are linked on chromosome 1,it has been almost impossible to generate cat1/3 and cat1/2/3 mutants by traditional genetic tools.In this study,we constructed cat1/3 double mutants and cat1/2/3 triple mutants by CRISPR/Cas9 to investigate the role of catalases.The cat1/2/3 triple mutants displayed severe redox disturbance and growth defects under physiological conditions compared with wild-type and the cat2/3 double mutants.Transcriptome analysis showed a more profound transcriptional response in the cat1/2/3 triple mutants compared to the cat2/3 mutants.These differentially expressed genes are involved in plant growth regulation as well as abiotic and biotic stress responses.In addition,expression of OXI1(OXIDATIVE SIGNAL INDUCIBLE 1)and several MAPK cascade genes were changed dramatically in the catalase triple mutant,suggesting that H_2O_2produced in peroxisomes could serve as a peroxisomal retrograde signal. | Tong Su Pingping Wang Huijuan Li Yiwu Zhao Yao Lu Peng Dai Tianqi Ren Xiaofeng Wang Xuezhi Li Qun Shao Dazhong Zhao Yanxiu Zhao Changle Ma | 2018 | Journal of Integrative Plant Biology2018，60，7： | 3 |
| 2 | Clinical significance of extended high-risk human papillomavirus genotyping and viral load in cervical cancer and precancerous lesions显示文摘Persistent infections with specific high-risk human papillomavirus(HR-HPV)strains are the leading cause of cervical cancer and precancerous lesions.HPV-16 and HPV-18 are associated with more than 70%of cervical cancer.However,with recent widespread vaccination efforts against cervical cancer,the infection rates of HPV-16 and HPV-18 have decreased across all age groups,while the infection rates of other HR-HPV strains have increased.The non-16/18 HR-HPV strains play an important role in cervical lesions.These strains can be identified with extended genotyping,and the 2019 American Society for Colposcopy and Cervical Pathology(ASCCP)guidelines recommended an HPV-based testing to assess the risk of cervical disease in patients.We reviewed and analyzed the clinical benefits of applying extended HR-HPV genotyping,which was published by the International Agency for Research on Cancer(HPV-16,18,31,33,35,39,45,51,52,56,58,59,66,and 68),to cervical cancer screening.This review concluded that cervical cancer screening needs to include extended HR-HPV genotyping.The examination of extended HR-HPV genotyping in cervical intraepithelial lesions and cervical cancers can help guide clinical practices. | Pingping Su Jincheng Ma Lirui Yu Shuting Tang Pengming Sun | 2023 | Gynecology and Obstetrics Clinical Medicine2023，3，1： | 2 |
| 3 | An efficient screening system to identify protein-protein or protein-DNA interaction partners of rice transcription factors显示文摘Plant transcription factors(TFs)are key molecular components in the regulation of plant growth,development,and environmental adaptability.Generally,TFs need to form complexes with other interactors to control gene transcription.For example,Heading date 1(Hd1),Grain number,plant height and heading-date(Ghd)7,or Ghd7.1 interacts with Ghd8 and NF-YCs to form a trimeric complex,respectively. | Qingmei Su Fang Zhang Yunping Xiao Pingping Zhang Hefei Xing Fan Chen | 2022 | Journal of Genetics and Genomics2022，49，10： | 1 |
| 4 | U-Pb ages and Hf-O isotopes of zircons from Late Paleozoic mafic ultramafic units in the southern Central Asian Orogenic Belt:Tectonic implications and evidence for an Early-Permian mantle plume显示文摘 | Su Benxun Qin Kezhang Sakyi P A Li Xianhua Yang Yueheng Sun He Tang Dongmei Liu Pingping Xiao Qinghua Malaviarachchi S P K | | 0，，： | 1 |
| 5 | Stereocontrol during photo-initiated controlled/living radical polymerization of acrylamide in the presence of Lewis acids显示文摘 | Xiaoli Su Zhengguo Zhao Hui Li Xinxin Li Pingping Wu Zhewen Han | 2008 | European Polymer Journal2008，，6： | 1 |
| 6 | Copolymer-controlled homogeneous precipitation for the synthesis of porous microfibers of alumina 显示文摘 | BAI Peng SU Fabing WU Pingping | 2007 | Langmuir2007，23，8： | 1 |
| 7 | Direct electron transfer of horseradish peroxidase and its eleetrocatalysis based on carbon nanotube/thionine/gold composites 显示文摘 | Wang Zhijuan Li Meiye Su Pingping | 2008 | Electrochemistry Communications2008，10，2： | 1 |
| 8 | Crosstalk between IL-15Rα^(+)tumor-associated macrophages and breast cancer cells reduces CD8+T cell recruitment显示文摘Background:Interleukin-15(IL-15)is a promising immunotherapeutic agent owing to its powerful immune-activating effects.However,the clinical benefits of these treatments are limited.Crosstalk between tumor cells and immune cells plays an important role in immune escape and immunotherapy drug resistance.Herein,this study aimed to obtain in-depth understanding of crosstalk in the tumor microenvironment for providing potential therapeutic strategies to prevent tumor progression.Methods:T-cell killing assays and co-culture models were developed to determine the role of crosstalk between macrophages and tumor cells in breast cancer resistant to IL-15.Western blotting,histological analysis,CRISPR-Cas9 knockout,multi-parameter flow cytometry,and tumor cell-macrophage co-injection mouse models were developed to examine the mechanism by which IL-15Rα^(+)tumor-associated macrophages(TAMs)regulate breast cancer cell resistance to IL-15.Results:We found thatmacrophages contributed to the resistance of tumor cells to IL-15,and tumor cells induced macrophages to express high levels of theαsubunit of the IL-15 receptor(IL-15Rα).Further investigation showed that IL-15Rα^(+)TAMs reduced the protein levels of chemokine CX3C chemokine ligand 1(CX3CL1)in tumor cells to inhibit the recruitment of CD8^(+)T cells by releasing the IL-15/IL-15Rαcomplex(IL-15Rc).Administration of an IL-15Rc blocking peptide markedly suppressed breast tumor growth and overcame the resistance of cancer cells to anti-programmed cell death protein 1(PD-1)antibody immunotherapy.Interestingly,Granulocyte-macrophage colony-stimulating factor(GMCSF)inducedγchain(γc)expression to promote tumor cell-macrophage crosstalk,which facilitated tumor resistance to IL-15.Additionally,we observed that the non-transcriptional regulatory function of hypoxia inducible factor-1alpha(HIF-1α)was essential for IL-15Rc to regulateCX3CL1 expression in tumor cells.Conclusions:The IL-15Rc-HIF-1α-CX3CL1 signaling pathway serves as a crosstalk between macrophages and tumor cells in the tumormicroenvironment of breast cancer.Targeting this pathway may provide a potential therapeutic strategy for enhancing the efficacy of cancer immunotherapy. | Wenlong Zhang Qing Zhang Nanfei Yang Qian Shi Huifang Su Tingsheng Lin Zhonglei He Wenxin Wang Hongqian Guo Pingping Shen | 2022 | Cancer Communications2022，42，6： | 0 |
| 9 | Isolation of Swine Corynebacteria and Analysis of 16S rDNA Gene显示文摘A strain of gram-positive bacillus was isolated from suppurative lung organs of nursery pigs in a pig farm,which was further characterized by morphological observation,cultivation test,biochemical test,drug sensitivity test,pathogenicity test and 16 S rDNA gene cloning and sequence analysis. The results showed that the isolate grew well in rabbit blood agar plate and horse serum tryptone soybean agar( TSA) plate under aerobic condition,which could lead to mortality of mice and were susceptible to cephalosporin antibiotics and fluoroquinolone antibiotics. Phylogenetic analysis showed that the isolate had close genetic evolutionary relationships with Corynebacterium bacteria,and the sequence of 16 S rRNA gene shared the homology of 91. 7%-98. 3% with the representative strain of corynebacteria,indicating the isolated strain was corynebacterium. | Qin Yibin He Pingping Lu Bingxia He Ying Li Bin Liang Jiaxing Duan Qunpeng Chen Zhongwei Bi Bingfen Zhou Yingning Su Qianlian Jiang Dongfu Li Keyu Lu Jingzhuan Zhao Wu | 2016 | Animal Husbandry and Feed Science2016，8，6： | 0 |
| 10 | Exploration of sea anemone-inspired high-performance biomaterials with enhanced antioxidant activity显示文摘Antioxidant biomaterials have attracted much attention in various biomedical fields because of their effective inhibition and elimination of reactive oxygen species(ROS)in pathological tissues.However,the difficulty in ensuring biocompatibility,biodegradability and bioavailability of antioxidant materials has limited their further development.Novel bioavailable antioxidant materials that are derived from natural resources are urgently needed.Here,an integrated multi-omics method was applied to fabricate antioxidant biomaterials.A key cysteine-rich thrombospondin-1 type Ⅰ repeat-like(TSRL)protein was efficiently discovered from among 1262 adhesive components and then used to create a recombinant protein with a yield of 500 mg L^(-1).The biocompatible TSRL protein was able to self-assemble into either a water-resistant coating through Ca^(2+)-mediated coordination or redox-responsive hydrogels with tunable physical properties.The TSRL-based hydrogels showed stronger 1,1-diphenyl-2-picrylhydrazyl(DPPH)radical scavenging rates than glutathione(GSH)and ascorbic acid(Aa)and protected cells against external oxidative stress significantly more effectively.When topically applied to mice skin,TSRL alleviated epidermal hyperplasia and suppressed the degradation of collagen and elastic fibers caused by ultraviolet radiation B(UVB)irradiation,confirming that it enhanced antioxidant activity in vivo.This is the first study to successfully characterize natural antioxidant biomaterials created from marine invertebrate adhesives,and the findings indicate the excellent prospects of these biomaterials for great applications in tissue regeneration and cosmeceuticals. | Lulu Wang Xiaokang Zhang Pingping Xu Jicheng Yan Yuzhong Zhang Hainan Su Chengjun Sun Qiang Lu Weizhi Liu | 2022 | Bioactive Materials2022，7，4： | 0 |
| 11 | 中国北京地区部分医院患者疼痛现状调查(英文)显示文摘Objective:This study aimed to survey the characteristics and treatments of cancer pain in Beijing hospitals,China.Methods:At 20:00 on December 22,2009,there conducted a questionnaire survey in 2238 patients with malignant tumors of 26 hospitals in Beijing,and the survey results were statistically analyzed.Results:The 531 cases in 2238 patients had pained and 121 cases (22.79%) had outbreak pain with one week.At 20:00 on December 22,2009,199 cases (38%) in the above-mentioned 531 pain patients suffered the moderate to severe pain (pain scores ≥ 4).The number of pain (pain scores ≥ 4) patients in the consecutive three days from December 20 to December 22 were 150.Conclusion:In the 531 cancer pain patients of the surveyed hospitals,38% of the patients were not satisfied with the pain control.Doctors believed that the main reason for pain not controlled was the non-standard treatment,but patients considered to be afraid of addiction. | Shikai Wu Fang Li Pingping Li Jian Luo Xiaoming Wu Heling Shi Xiaohong Ning Yufei Yang Huangying Tan Ping Yang Guangqing Zhu Jianhua Zhu Guoqing Liao Huoming Chen Dapeng Lv Ye Fang Hong Dai Xiaoming Xi Xiuhua Li Yuan Qin Li Feng Su Wang Xiaoyan Chen Hongyong Wang Hongyan Li Duanqi Liu | 2012 | The Chinese-German Journal of Clinical Oncology2012，11，6： | 0 |
| 12 | Isolation and Growth Characteristics of SARS-CoV-2 in Vero Cell显示文摘Dear Editors,The coronavirus disease 2019(COVID-19),caused by SARS-CoV-2,broke out in early December 2019 has escalated into a global pandemic(Lai et al.2020).Till the May 20 th 2020,more than 4,700,000 people were infected and the number is still increasing especially in Europe,North America and Asia(http://gffzze7c39cdc9e894ca6spqfwow0uocv06ofq.ffgz.tsg.suse.edu.cn/). | Pingping Yao Yachun Zhang Yisheng Sun Yulin Gu Fang Xu Bo Su Chen Chen Hangjing Lu Dehui Wang Zhangnv Yang Biao Niu Jiancai Chen Lixia Xie Lei Chen Yajing Zhang Hui Wang Yuying Zhao Yue Guo Juncheng Ruan Zhiyong Zhu Zhenfang Fu Dayong Tian Qi An Jianmin Jiang Hanping Zhu | 2020 | Virologica Sinica2020，35，3： | 0 |
| 13 | 领进高度有竞争力的环境: 在中国的追随者承诺上的行政主管充满信心的领导的效果显示文摘作为一个特点,领导人信心在主要领导理论被检验了,例如 transformational/charismatic,皮格马利翁,和授权的领导。然而,信心怎么影响领导有效性,仍然是一个实验问题。在二封行为的 approachesdemonstrating 自信(DC 自我) 的 Conceptualizing 领导信心和独立人士在追随者承诺上与坚挺的环境二 DC 行为以及他们的交互效果完成的在这研究测试的追随者(DC 追随者) 的示威信心。线性建模分析的 Hierarchal 的结果建议两 DC 行为在追随者承诺上有重要影响,他们的效果稀释对方。结果也表明 DC 自我与坚挺的环境交往影响追随者承诺。追随者承诺上的 DC 自我的效果在更有竞争力的环境是更强壮的。为领导研究和实践的那些调查结果和他们的含意被讨论。 | Pingping Fu Jun Liu Xiaoli Ji Su Zhong Guangtao Yu | 2016 | Frontiers of Business Research in China2016，10，2： | 0 |
| 14 | 卵巢癌术前腹腔化疗的临床应用及其评价(英文)显示文摘Objective:To investigate the clinical efficacy of intraperitoneal chemotherapy before surgery for ovarian cancer.Methods:60 patients with stages II-IV of ovarian cancer were treated with intraperitoneal chemotherapy of CAP or TP regimen followed by a surgery treatment and another chemotherapy for 6 cycles.And then the efficiency of the therapy was evaluated by analyzing the changes of ascites, the serum CA-125 and CA-19-9 levels and the findings in the operation, and investigating the recurrence of cancer and the survival.Results:After 1-3 cycles of intraperitoneal chemotherapy, serum levels of CA-125 and CA-19-9 and carcinous ascites significantly reduced in all patients, ascites reduce was over 50% in 98.3% cases;all cases were successfully treated with cytoreduction and it was found during the operation that bulky tumor was reduced and looser so as to be easily isolated and removed;PFS of the patients was prolonged, while the toxicity and side-effects were not so serious as beyond the patient toleration.Conclusion:Intraperitoneal chemotherapy before surgery for ovarian cancer has an active efficacy in clinic, being able to improve conditions of surgery and increase the opportunity of maximal cytoreduction, and prolong survival of the patients, and should be a good selection for the treatment of advanced ovarian cancer. | Dianyun Shi Mei Xiao Saiying Chen Bin Yang Qijiang Zhu Pingping Xu Chenfang Su | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，5： | 0 |
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