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| 1 | Ron receptor-dependent gene regulation in a mouse model of endotoxin-induced acute liver failure显示文摘BACKGROUND:Prior experimentation has shown that loss of the tyrosine kinase(TK) signaling domain of the Ron receptor leads to marked hepatocyte protection in a model of lipopolysaccharideinduced acute liver failure(ALF) in D-galactosamine(GalN)sensitized mice.The aim of this study was to identify the role of Ron in the regulation of hepatic gene expression.METHODS:Microarray analyses were performed on liver RNA isolated sequentially from wild-type(WT) and TK-/mice during the progression of ALF.Gene array data were validated using Western and immunohistochemistry analyses as well as with ex vivo culture systems.RESULTS:At baseline,101 genes were differentially expressed between WT and TK-/-livers,which regulate processes involved in hypoxia,proliferation,apoptosis and metabolism.One hour after ALF induction,WT livers exhibited increased cytokine expression compared to TK-/-livers,and after 4 hours,an induction of suppressor of cytokine signaling(SOCS) genes as well as JAK-STAT pathway activation were prominent in TK-/livers compared to controls.CONCLUSION:Our studies suggest a novel hepato-protective mechanism in Ron TK-/-mice wherein increased and sustained SOCS production and JAK-STAT activation in the hepatocyte may inhibit the destructive proinflammatory milieu and promote survival factors which blunt hepatic death and the ensuing development of ALF. | Rishikesh M Kulkarni Louis W Kutcher William D Stuart Daniel J Carson Mike A Leonis Susan E Waltz | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，4： | 3 |
| 2 | Hepatocellular carcinoma locoregional therapies:Outcomes and future horizons显示文摘Hepatocellular carcinoma(HCC)is the most common primary cancer of the liver and has an overall five-year survival rate of less than twenty percent.For patients with unresectable disease,evolving liver-directed locoregional therapies provide efficacious treatment across the spectrum of disease stages and via a variety of catheter-directed and percutaneous techniques.Goals of locoregional therapies in HCC may include curative intent in early-stage disease,bridging or downstaging to surgical resection or transplantation for early or intermediate-stage disease,and local disease control and palliation in advanced-stage disease.This review explores the outcomes of chemoembolization,bland embolization,radioembolization,and percutaneous ablative therapies.Attention is also given to prognostic factors related to each of the respective techniques,as well as future directions of locoregional therapies for HCC. | Mina S Makary Stuart Ramsell Eric Miller Eliza W Beal Joshua D Dowell | 2021 | World Journal of Gastroenterology2021，27，43： | 2 |
| 3 | PHarmacokinetie Parameters and mechanisms of rat type 1 and 2 steroid 5 alpha-reduce-tases:determinants for differentiin vivo activities of c1198745 and finasfereride in the rat boil显示文摘 | Stuart J D Lee F W Simpson-Noel D | 2001 | Chen2001，162，： | 1 |
| 4 | NEMO Satellite Sensor Imaging Payload 显示文摘 | Myers W A Smith R D Stuart J L | 1998 | Proceeding of SPIE1998，3437，： | 1 |
| 5 | Distributed containment control for multiple autonomous vehicles with double-integrator dynamics : algorithms and experiments显示文摘 | CAO Y C STUART D REN W | 2011 | IEEE Transactions on Control Systems Technology2011，19，4： | 1 |
| 6 | Distributed containment control for multiple autonomous vehicles with double-integrator dynamics:algorithms and experiments显示文摘 | CAO Y STUART D REN W | | 0，，04： | 1 |
| 7 | Knowledge sharing: Context, confusion and controversy 显示文摘 | Scott F Stuart D Stephanie J W | 2003 | International Journal of Project Management2003，21，3： | 1 |
| 8 | T-cell division in human immunodeficiency virus (HIV)-1 infection is mainly due to immune activation:a longitudinal analysis in patients before and during highly active antiretroviral therapy (HAART)显示文摘 | Hazenberg M D Stuart J W Otto S A | 2000 | {H}Blood2000，，01： | 1 |
| 9 | Validation of Asphalt Binder and Mixture Tests that Predict Rutting Susceptibility using FHWA Accelerated Loading Facility显示文摘 | Stuart K D Mogawer W S | 1997 | Journal of the Association of Asphalt Paving Technologists1997，66，： | 1 |
| 10 | Effects of mineral fillers on properties of stone matrix asphalt mixtures 显示文摘 | Mogawer W S Stuart K D | 1996 | TRR1996，，： | 1 |
| 11 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 12 | Subfascial endoscopic perforator surgery is associated with significantly less morbidity and shorter hospital stay than open operation (Linton's procedure)显示文摘 | Adam D T Bradburg A W | 1997 | Br J Surg1997，84，10： | 1 |
| 13 | Distributed containment control for multiple autonomous vehicles with doubleintegrator dynamics: Algorithms and experiments 显示文摘 | Cao Y Stuart D Ren W | 2011 | IEEE Transcations on Control Systems Technology2011，19，4： | 1 |
| 14 | Lack of an effect of collecting duct-specific detetion of adenylyl cyclase 3 on renal Na ^+ and water excretion or arterial pressure 显示文摘 | Kittikulsuth W Stuart D Van Hock AN | 2014 | Am J Physiol Renal Physiol2014，306，6： | 1 |
| 15 | Density- dependent fitness benefits in quorum-sensing bacterial populations 显示文摘 | Sophie E D Stuart A W Klaus W | 2012 | Pans2012，109，22： | 1 |
| 16 | Instability model for recurring large and great earthquakes in Southern California 显示文摘 | Stuart W D | 1985 | Pageoph1985，122，6： | 1 |
| 17 | Effects of participation in a martial arts-based antibullying program in elementary schools 显示文摘 | Stuart W T Bridget K B Timothy D N Eric M V Peter F Stephen W T | 2008 | Psychology in the School2008，45，10： | 1 |
| 18 | Apolipoprotein J: Structure and tissue distribution 显示文摘 | De Silva H V Harmony J A Stuart W D | 1990 | Biochemistry1990，29，22： | 1 |
| 19 | Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection显示文摘 | Hazenberg M D Otto S A Cohen Stuart J W | 2000 | Nat Med2000，6，9： | 1 |
| 20 | A second-generation reactive empirical bond order (RE- BO) potential energy expression for hydrocarbons显示文摘 | Brenner D W Shenderova O A Harrison J A Stuart S J Ni B Sinnott S B | 2002 | Journal of Physics: Condensed Matter2002，14，： | 1 |
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