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| 1 | Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy显示文摘BACKGROUND Intraductal papillary mucinous neoplasms(IPMNs)are non-invasive pancreatic precursor lesions that can potentially develop into invasive pancreatic ductal adenocarcinoma.Currently,the International Consensus Guidelines(ICG)for IPMNs provides the basis for evaluating suspected IPMNs on computed tomography(CT)imaging.Despite using the ICG,it remains challenging to accurately predict whether IPMNs harbor high grade or invasive disease which would warrant surgical resection.A supplementary quantitative radiological tool,radiomics,may improve diagnostic accuracy of radiological evaluation of IPMNs.We hypothesized that using CT whole lesion radiomics features in conjunction with the ICG could improve the diagnostic accuracy of predicting IPMN histology.AIM To evaluate whole lesion CT radiomic analysis of IPMNs for predicting malignant histology compared to International Consensus Guidelines.METHODS Fifty-one subjects who had pancreatic surgical resection at our institution with histology demonstrating IPMN and available preoperative CT imaging were included in this retrospective cohort.Whole lesion semi-automated segmentation was performed on each preoperative CT using Healthmyne software(Healthmyne,Madison,WI).Thirty-nine relevant radiomic features were extracted from each lesion on each available contrast phase.Univariate analysis of the 39 radiomics features was performed for each contrast phase and values were compared between malignant and benign IPMN groups using logistic regression.Conventional quantitative and qualitative CT measurements were also compared between groups,viaχ2(categorical)and Mann Whitney U(continuous)variables.RESULTS Twenty-nine subjects(15 males,age 71±9 years)with high grade or invasive tumor histology comprised the'malignant'cohort,while 22 subjects(11 males,age 70±7 years)with low grade tumor histology were included in the'benign'cohort.Radiomic analysis showed 18/39 precontrast,19/39 arterial phase,and 21/39 venous phase features differentiated malignant from benign IPMNs(P<0.05).Multivariate analysis including only ICG criteria yielded two significant variables:thickened and enhancing cyst wall and enhancing mural nodule<5 mm with an AUC(95%CI)of 0.817(0.709-0.926).Multivariable post contrast radiomics achieved an AUC(95%CI)of 0.87(0.767-0.974)for a model including arterial phase radiomics features and 0.834(0.716-0.953)for a model including venous phase radiomics features.Combined multivariable model including conventional variables and arterial phase radiomics features achieved an AUC(95%CI)of 0.93(0.85-1.0)with a 5-fold cross validation AUC of 0.90.CONCLUSION Multi-phase CT radiomics evaluation could play a role in improving predictive capability in diagnosing malignancy in IPMNs.Future larger studies may help determine the clinical significance of our findings. | Stuart L Polk Jung W Choi Melissa J McGettigan Trevor Rose Abraham Ahmed Jongphil Kim Kun Jiang Yoganand Balagurunathan Jin Qi Paola T Farah Alisha Rathi Jennifer B Permuth Daniel Jeong | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 2 | Transgenic zebrafish as sentinels for aquatic pollution显示文摘 | Carvan M J Dalton T P Stuart G W | 2000 | Ann N Y Acad Sci2000，919，： | 1 |
| 3 | Emerging ap- plications of stimuli-response polymer materials 显示文摘 | Stuart M A C Huck W T S Genzer J | 2010 | Nat Mater2010，9，： | 1 |
| 4 | Inducer-stimulated Fas targets activated endothelium for destruction by anti-angiogenic thrombospondin-1 and pigment epithelium-derived factor 显示文摘 | Volpert OV Zalchuk T Zhou W Reiher F Ferguson TA Stuart PM | 2002 | Nat Med2002，8，4： | 1 |
| 5 | When Do Scientists Become Entrepreneurs? The Social Structural Antecedents of Commercial Activity in the Academic Life Sciences 显示文摘 | DING W STUART T | 2006 | American Journal of Sociology2006，112，1： | 1 |
| 6 | Emerging applications of stimuli-responsive polymer materials显示文摘 | Stuart M A C Huck W T S Genzer J | 2010 | Nature Materials2010，9，： | 1 |
| 7 | When do scientists become entrepreneurs? The social structural antecedents of commercial activity in the academic life sciences显示文摘 | Stuart T E Ding W W | | 0，，01： | 1 |
| 8 | Bioeompatibility of methyleellulose-based constructs designed for intracerebral gelation following experimental traumatic brain injury 显示文摘 | Matthew C T Deborah A S Stuart W H | 2001 | Biomaterials2001，22，： | 1 |
| 9 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 10 | Femtosecond pulsed laser ablation of metal alloy and semiconductor largets显示文摘 | TRELENBERG T W DINH L N STUART B C | 2004 | Applied Surjace Science2004，229，： | 1 |
| 11 | Subfascial endoscopic perforator surgery is associated with significantly less morbidity and shorter hospital stay than open operation (Linton's procedure)显示文摘 | Adam D T Bradburg A W | 1997 | Br J Surg1997，84，10： | 1 |
| 12 | The Social structural antecedents of commercial activity in the academic life science 显示文摘 | STUART T E DING W W | 2006 | American Journal of Sociology2006，12，1： | 1 |
| 13 | Modularized battery management for large lithium ion cells显示文摘 | STUART T A ZHU W | 2011 | Journal of Power Sources2011，11，： | 1 |
| 14 | Enhancment of ovulation rate in gilts by increasing diatary engry and administering insulin during follicular growth 显示文摘 | Cox N M Stuart T G Althen W A | 1987 | Anim Sci1987，64，： | 1 |
| 15 | Fast equalization for large lithium ion ba- tteries 显示文摘 | STUART T A ZHU W | 2000 | Aerospace and Electronic Systems Magazine (IEEE)2000，24，7： | 1 |
| 16 | The determinants of faculty patenting behavior: demographics or opportuni- ties显示文摘 | AZOULAY P DING W STUART T | 2007 | Journal of Economic Behavior & Organization2007，63，4： | 1 |
| 17 | Transgenic zebra fish as sentinels for aquatic pollution显示文摘 | Carvan M J Dalton T P Stuart G W | 2000 | Ann NY Acad Sci2000，919，： | 1 |
| 18 | A Program of Classical Condi-tioning Experiments Testing Variations in the Conditioned Stimulusand Context显示文摘 | Shimp T A Stuart E W Engle R W | 1991 | Journal of Consumer Research1991，18，1： | 1 |
| 19 | Effects of participation in a martial arts-based antibullying program in elementary schools 显示文摘 | Stuart W T Bridget K B Timothy D N Eric M V Peter F Stephen W T | 2008 | Psychology in the School2008，45，10： | 1 |
| 20 | Fast equalization for large lithim bat- teries 显示文摘 | STUART T A ZHU W | 2000 | Aerospace and Electronic Systems Magazine E)2000，24，7： | 1 |
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