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| 1 | 儿童扩张型心肌病的发病率、病因及预后显示文摘背景:扩张型心肌病(dilated cardiomyopathy,DCM)是儿童心肌病最常见的类型,也是小儿心脏移植最常见的原因。但是,目前尚不清楚儿童DCM的流行病学特点和临床过程。
目的:详细描述儿童DCM的发病率、病因、预后及相关危险因素。
设计及地点:本项以人群为基础的前瞻性纵向队列研究入选1996年1月至2003年2月在89个儿科心脏中心诊断为DCM的儿童以及1990年1月至1995年12月在北美大型三级治疗中心诊断的患儿。
参试者:共入选1426例来自美国和加拿大的18岁以下DCM患儿。通过严格的超声心动图和/或病理学标准来诊断原发性DCM。因内分泌、免疫、药物中毒及其他原因患病者除外。
主要观测指标:每年每10万儿童的发病率、死亡率和心脏移植率。
结果:18岁以下儿童DCM每年的总发病率为0.57/10万,男孩的年发病率高于女孩(分别为0.66/10万和0.47/10万;P〈0.001),黑人的年发病率高于白人(分别为0.98/10万和0.46/10万;P〈0.001),婴儿(〈1岁)的年发病率高于儿童(分别为4.40/10万和0.34/10万;P〈0.001)。绝大部分属特发性,最常见的病因为心肌炎(46%)和神经肌肉性疾病(26%)。1年和5年死亡/移植率分别为31%和46%。死亡/移植的独立危险因素包括患儿诊断DCM时年龄较大、伴有充血性心力衰竭、左室收缩期Z评分较低以及DCM的病因(P均〈0.001)。
结论:儿童DCM有其多样性。患儿预后主要取决于病因、年龄和心力衰竭状况。人种、性别和年龄对发病率有一定影响。大部分患儿无明确病因,限制了特异性治疗。 | Jeffrey A. Towbin April M. Lowe Steven D. Colan Lynn A. Sleeper E. John Orav Sarah Clunie Jane Messere Gerald F. Cox Paul R. Lurie Daphne Hsu Charles Canter James D. Wilkinson Steven E. Lipshultz 康俊萍(译) 马长生(校) | 2007 | 美国医学会杂志(中文版)2007，26，4： | 3 |
| 2 | Left Ventricular Contractility and Function in Kawasaki Syndrome: Effect of Intravenous γ-Globulin显示文摘 | Jane W. Newburger Stephen P. Sanders Jane C. Burns Ira A. Parness Alexa S. Beiser Steven D. Colan | 1989 | Circulation1989，，6： | 1 |
| 3 | Epidemiology and Cause-Specific Outcome of Hypertrophic Cardiomyopathy in Children: Findings From the Pediatric Cardiomyopathy Registry显示文摘 | Steven D. Colan Steven E. Lipshultz April M. Lowe Lynn A. Sleeper Jane Messere Gerald F. Cox Paul R. Lurie E John Orav Jeffrey A. Towbin | 2007 | Circulation2007，，6： | 1 |
| 4 | Comparison of Echocardiographic and Cardiac Magnetic Resonance Imaging in Hypertrophic Cardiomyopathy Sarcomere Mutation Carriers Without Left Ventricular Hypertrophy显示文摘 | Anne Marie Valente Neal K. Lakdawala Andrew J. Powell Sarah P. Evans Allison L. Cirino E. John. Orav Calum A. MacRae Steven D. Colan Carolyn Y. Ho | 2013 | Circulation: Cardiovascular Genetics2013，，3： | 1 |
| 5 | Recommendations for Quantification Methods During the Performance of a Pediatric Echocardiogram: A Report From the Pediatric Measurements Writing Group of the American Society of Echocardiography Pediatric and Congenital Heart Disease Council显示文摘 | Leo Lopez Steven D. Colan Peter C. Frommelt Gregory J. Ensing Kathleen Kendall Adel K. Younoszai Wyman W. Lai Tal Geva | 2010 | Journal of the American Society of Echocardiography2010，，5： | 1 |
| 6 | Regional and global left ventricular function in infants with anomalous origin of the left coronary artery from the pulmonary trunk: preoperative and postoperative assessment显示文摘 | AZARIA J. J. T. REIN STEVEN D. COLAN IRA A PARNESS STEPHEN P SANDERS | 1987 | Circulation1987，，1： | 1 |
| 7 | Characteristics and outcomes of cardiomyopathy in children with Duchenne or Becker muscular dystrophy: A comparative study from the Pediatric Cardiomyopathy Registry显示文摘 | David M. Connuck Lynn A. Sleeper Steven D. Colan Gerald F. Cox Jeffrey A. Towbin April M. Lowe James D. Wilkinson E. John Orav Leigha Cuniberti Bonnie A. Salbert Steven E. Lipshultz | 2008 | American Heart Journal2008，，： | 1 |
| 8 | The Pediatric Cardiomyopathy Registry and Heart Failure: Key Results from the First 15 Years显示文摘 | James D. Wilkinson David C. Landy Steven D. Colan Jeffrey A. Towbin Lynn A. Sleeper E. John Orav Gerald F. Cox Charles E. Canter Daphne T. Hsu Steven A. Webber Steven E. Lipshultz | 2010 | Heart Failure Clinics2010，，4： | 1 |
| 9 | Outcomes in children with Noonan syndrome and hypertrophic cardiomyopathy: A study from the Pediatric Cardiomyopathy Registry显示文摘 | James D. Wilkinson April M. Lowe Bonnie A. Salbert Lynn A. Sleeper Steven D. Colan Gerald F. Cox Jeffrey A. Towbin David M. Connuck Jane E. Messere Steven E. Lipshultz | 2012 | American Heart Journal2012，，3： | 1 |
| 10 | Outcomes of Restrictive Cardiomyopathy in Childhood and the Influence of Phenotype显示文摘 | Steven A. Webber Steven E. Lipshultz Lynn A. Sleeper Minmin Lu James D. Wilkinson Linda J. Addonizio Charles E. Canter Steven D. Colan Melanie D. Everitt John Lynn Jefferies Paul F. Kantor Jacqueline M. Lamour Renee Margossian Elfriede Pahl Paolo G. Rusco | 2012 | Circulation2012，，10： | 1 |
| 11 | Incidence of and Risk Factors for Sudden Cardiac Death in Children With Dilated Cardiomyopathy显示文摘 | Elfriede Pahl Lynn A. Sleeper Charles E. Canter Daphne T. Hsu Minmin Lu Steven A. Webber Steven D. Colan Paul F. Kantor Melanie D. Everitt Jeffrey A. Towbin John L. Jefferies Beth D. Kaufman James D. Wilkinson Steven E. Lipshultz | 2012 | Journal of the American College of Cardiology2012，，6： | 1 |
| 12 | Balloon Dilation of Severe Aortic Stenosis in the Fetus: Potential for Prevention of Hypoplastic Left Heart Syndrome: Candidate Selection, Technique, and Results of Successful Intervention显示文摘 | Wayne Tworetzky Louise Wilkins-Haug Russell W. Jennings Mary E. van der Velde Audrey C. Marshall Gerald R. Marx Steven D. Colan Carol B. Benson James E. Lock Stanton B. Perry | 2004 | Circulation2004，，15： | 1 |
| 13 | Left Heart Obstructive Lesions and Left Ventricular Growth in the Midtrimester Fetus: A Longitudinal Study显示文摘 | Lisa K. Hornberger Stephen P. Sanders Azaria J.J.T. Rein Philip J. Spevak Ira A. Parness Steven D. Colan | 1995 | Circulation1995，，6： | 1 |
| 14 | Electrocardiographic Features of Sarcomere Mutation Carriers With and Without Clinically Overt Hypertrophic Cardiomyopathy显示文摘 | Neal K. Lakdawala Jens Jakob Thune Barry J. Maron Allison L. Cirino Ole Havndrup Henning Bundgaard Michael Christiansen Christian M. Carlsen Jean-Fran?ois Dorval Raymond Y. Kwong Steven D. Colan Lars V. K?ber Carolyn Y. Ho | 2011 | The American Journal of Cardiology2011，，11： | 1 |
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