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| 1 | A rationale for the development of thermally stable nanostructured CeO_2-ZrO_2-containing mixed oxides显示文摘CeO2-ZeO2 solid solutions are extensively used as oxygen storage promoters in the current automotive three-way catalysts. High thermal stability of the textural properties is one of the most important requirements for practical application since temperatures up to 1273 K are easily experienced by these materials under real working conditions. In the present paper, we investigated how hydrothermal treatments applied to cakes of doped and undoped ZrO2-rich CeO2-ZrO2 precursors might improve the thermal stability of the final CeO2-ZrO2 solid so- lution. A rationale was developed that allowed to correlate the morphology of the hydrothermally treated cake with the thermal stability at 1273 K of the final product, which did not depend on the composition of the mixed oxides. | Roberta Di Monte Jan Kapar Heather Bradshaw Colin Norman | 2008 | Journal of Rare Earths2008，26，2： | 10 |
| 2 | Gut barrier failure biomarkers are associated with poor disease outcome in patients with primary sclerosing cholangitis显示文摘AIM To assess the prevalence of a panel of serologic markers that reflect gut barrier dysfunction in a mixed cohort of pediatric and adult primary sclerosing cholangitis(PSC) patients.METHODS Sera of 67 PSC patients [median age(range): 32(5-79) years, concomitant IBD: 67% and cirrhosis: 20%] were assayed for the presence of antibodies against to F-actin(AAA Ig A/Ig G) and gliadin(AGA Ig A/Ig G)] and for serum level of intestinal fatty acid-binding protein(I-FABP) by ELISA. Markers of lipopolysaccharide(LPS) exposure [LPS binding protein(LBP)] and various antimicrobial antibodies [anti-OMP Plus Ig A and endotoxin core Ig A antibody(Endo CAb)] were also determined. Poor disease outcome was defined as orthotopic liver transplantation and/or liver-related death during the follow-up [median: 99(14-106) mo]. One hundred and fifty-three healthy subjects(HCONT) and 172 ulcerative colitis(UC) patients were the controls. RESULTS A total of 28.4%, 28.0%, 9% and 20.9% of PSC patients were positive for AAA Ig A, AAA Ig G, AGA Ig A and AGA Ig G, respectively. Frequencies of AAA Ig A and AAA Ig G(P < 0.001, for both) and AGA Ig G(P = 0.01, for both) but not AGA Ig A were significantly higher compared to both of the HCONT and the UC groups. In survival analysis, AAA Ig A-positivity was revealed as an independent predictor of poor disease outcome after adjusting either for the presence of cirrhosis [HR = 5.15(1.27-20.86), P = 0.022 or for the Mayo risk score(HR = 4.24(0.99-18.21), P = 0.052]. AAA Ig A-positivity was significantly associated with higher frequency of antimicrobial antibodies(P < 0.001 for Endo Cab Ig A and P = 0.012 for anti-OMP Plus Ig A) and higher level of the enterocyte damage marker(median I-FABP_(AAA Ig A pos vs neg): 365 vs 166 pg/m L, P = 0.011), but not with serum LBP level. CONCLUSION Presence of Ig A type AAA identified PSC patients with progressive disease. Moreover, it is associated with enhanced mucosal immune response to various microbial antigens and enterocyte damage further highlighting the importance of the gut-liver interaction in PSC. | Tamas Tornai Eszter Palyu Zsuzsanna Vitalis Istvan Tornai David Tornai Peter Antal-Szalmas Gary L Norman Zakera Shums Gabor Veres Antal Dezsofi Gabriella Par Alajos Par Peter Orosz Ferenc Szalay Peter Laszlo Lakatos Maria Papp | 2017 | World Journal of Gastroenterology2017，23，29： | 5 |
| 3 | Immunological changes in different patient populations with chronic hepatitis C virus infection显示文摘AIM: To investigate killer inhibitory and activating receptor expression by natural killer(NK), natural killer T-like(NKT-like) and CD8+ T lymphocytes in patients with chronic hepatitis C virus(HCV) infection with elevated and with persistently normal alanine aminotransferase(PNALT).METHODS: The percentage of peripheral blood Treg cells, KIR2DL3, ILT-2, KIR3DL1, CD160, NKG2 D, NKG2 C expressing NK, T and NKT-like cells, cytokine production and NK cytotoxicity were determined by flow cytometry. Twenty-one patients with chronic HCV infection with elevated alanine aminotransferase, 11 HCV carriers with persistently normal alanine aminotransferase and 15 healthy volunteers were enrolled. RESULTS: No significant differences were observed in the percentage of total T, NK or NKT-like cells between study groups. Comparing the activating and inhibitoryreceptor expression by NK cells obtained from HCV carriers with PNALT and chronic HCV hepatitis patients with elevated alanine aminotransferase, NKG2 D activating receptor expression was the only receptor showing a significant difference. NKG2 D expression of NK cells was significantly lower in patients with elevated alanine aminotransferase. The expression of CD160, NKG2 D and NKG2 C activating receptor by CD8+ T cells were significantly lower in patients with chronic HCV hepatitis than in healthy controls and in HCV carriers with PNALT. Plasma TGF-β1 levels inversely correlated with NKG2 D expression by NK cells. In vitro TGF-β1 treatment inhibited NK cells cytotoxic activity and downregulated NKG2 D expression. CD8+ T cells from HCV carriers with PNALT showed significantly elevated expression of CD160, NKG2 D and NKG2 C activating receptors compared to chronic HCV patients with elevated alanine aminotransferase. Enhanced expression of inhibitory KIR2DL3 receptor, and decreased ILT-2 expression on NK cells were also found in chronic hepatitis C patients compared to healthy controls.CONCLUSION: Our study demonstrated a complex dysregulation of activating and inhibitory receptor expression, such as decreased NKG2 D and CD160 activating receptor expression and increased KIR2DL3 inhibitory receptor expression by NK and cytotoxic T cells and may provide further mechanism contributing to defective cellular immune functions in chronic hepatitis C. Increased NKG2 D receptor expression in HCV patients with persistently normal ALT suggests an important pathway for sustaining NK and CD8 T cell function and a protective role against disease progression. | Laszlo Szereday Matyas Meggyes Melinda Halasz Julia Szekeres-Bartho Alajos Par Gabriella Par | 2016 | World Journal of Gastroenterology2016，22，20： | 5 |
| 4 | 消化道微生态学显示文摘一般来讲,人类或动物在出生时都是不污染有细菌的。然而,这种无菌状态仅维持短暂时间,因为在出生后几个小时,微生物群体就开始在消化道中出现并定植。人类及所有恒温动物的生长、发育和死亡都是在消化道中存在着大量活细菌细胞的情况下进行的:一个成年人的消化道中蕴藏有约1014个活细菌,即1百万亿个细菌细胞;而人体也不过仅由1013个动物细胞所组成。 | Par R Ducluzeau 苏文金 | 1991 | 中国微生态学杂志1991，3，2： | 3 |
| 5 | Microstructural evolution and grain growth mechanism of pre-twinned magnesium alloy during annealing显示文摘The microstructural evolution and underlying grain growth mechanism of a{1012}-twin-containing Mg alloy during annealing are investigated through quasi in situ electron backscatter diffraction measurements of a rolled AZ31 alloy subjected to precompression along the rolling direction(RD).The precompressed material shows a partially twinned structure consisting of a twinned region and a residual matrix region,and this structure changes to an almost twin-free structure consisting of grown grains with serrated grain boundaries in twinand matrix-originated regions after annealing at 250℃ for 1 h.In addition,the average grain size almost doubles and the internal strain energy decreases significantly after annealing.These microstructural variations are induced mainly by grain growth through the strain-induced migration of high-angle grain boundaries without the movement of twin boundaries.The twinned region of the precompressed material has higher stored strain energy than the residual matrix region because the crystallographic orientation of the former region is favorable for basal slip and because of the occurrence of the dislocation transmutation reaction in the twins.For reducing the total strain energy accumulated in the precompressed material,the residual matrix region—having lower stored strain energy—preferentially grows while consuming the twinned regions formed in the surrounding grains during annealing.As a result,the area fraction of grains with a matrix texture increases whereas that of grains with a twin texture decreases after annealing.The twin texture intensity increases significantly and this texture becomes more concentrated along the RD because the highly RD oriented twins tend to grow during annealing on account of their fairly low stored strain energy. | Ye Jin Kim Jong Un Lee Young Min Kim Sung Hyuk Par | 2021 | Journal of Magnesium and Alloys2021，9，4： | 3 |
| 6 | Health-related quality of life, work productivity, and health care resource utilization of subjects with irritable bowel syndrome: Baseline results from logic (longitudinal outcomes study of gastrointestinal symptoms in Canada), a naturalistic study显示文摘 | Pierre Paré James Gray Sy Lam Robert Balshaw Shideh Khorasheh Martin Barbeau Suzanne Kelly Christopher R. McBurney | 2006 | Clinical Therapeutics2006，，10： | 2 |
| 7 | Excellent long-term survival in patients with primary biliary cirrhosis and biochemical response to ursodeoxycholic acid显示文摘 | Parés A Caballeria L Rodés J | | Gastroenterology0，，： | 2 |
| 8 | Genetic Determinants of Dabigatran Plasma Levels and Their Relation to Bleeding显示文摘 | Guillaume Paré Niclas Eriksson Thorsten Lehr Stuart Connolly John Eikelboom Michael D. Ezekowitz Tomas Axelsson Sebastian Haertter Jonas Oldgren Paul Reilly Agneta Siegbahn Ann-Christine Syvanen Claes Wadelius Mia Wadelius Heike Zimdahl-Gelling Salim Yusu | 2013 | Circulation2013，，13： | 2 |
| 9 | Serially concatenated continuous phase modulation with iterative decoding显示文摘 | Par Moqvist Aulin Tor M | 2001 | IEEE Transaction on Communications2001，49，11： | 2 |
| 10 | Alcohol dehydrogenase from human stomach: variability in normal mucosa and effect of age, gender, ADH3 phenotype and gastric region显示文摘 | Moreno A Parés A Ortiz J Enriquez J Parés X | 1994 | Alcohol Alcohol1994，29，6： | 2 |
| 11 | 炉底电磁搅拌对电炉冶炼不锈钢工艺的影响显示文摘安装在电炉炉底下方的电磁搅拌器(ArcSave~)能使整个熔池的钢液产生有效的混合,从而加速熔炼过程中钢液温度和化学成分的均匀化。研究了电磁搅拌对瑞典Outokumpu不锈钢厂的90t电炉冶炼不锈钢工艺的影响。热测试结果显示,ArcSave能加速废钢和铬铁合金的熔化,精确控制出钢量;熔池的温度也更加均匀,出钢温度能得到准确的控制;稳定的电炉出钢质量和出钢温度的控制有利于后续AOD的顺利操作。通过对钢液的搅拌能减少熔池液面的过热度并提高熔池内的热传导,使得炉壁和炉盖的热损失减少,因此降低了耗电量和电极消耗量,总能耗能降低3%~4%。同时,搅拌也能强化钢-渣间的界面反应,降低渣中Cr_2O_3的含量,提高合金收得率和降低FeSi的消耗量。还能缩短冶炼周期,并且连续稳定的冶炼操作能提高电炉冶炼的产量约6%~8%。电磁搅拌技术是提高电炉冶炼不锈钢工艺水平的一种安全、可靠而有效的解决方案。 | 滕立东 LJUNGQVIST Par 钟云涛 ANDERSSON Joakim | 2017 | 炼钢2017，33，2： | 2 |
| 12 | Hepatotoxicity associated with glucosamine and chondroitin sulfate in patients with chronic liver disease显示文摘Glucosamine and chondroitin sulfate are molecules involved in the formation of articular cartilage and are frequently used for symptom relief in patients with arthrosis.These molecules are well tolerated with scarce secondary effects.Very few cases of possible hepatotoxicity due to these substances have been described.The aim of this paper is to report the frequency of presumed glucosamine hepatotoxicity in patients with liver disease.A questionnaire was given to 151 consecutive patients with chronic liver disease of different etiology(mean age 59 years,56.9%women)attended in an outpatient clinic with the aim of evaluating the frequency of consumption of these drugs and determine whether their use coincided with a worsening in liver function test results.Twenty-three patients(15.2%)recognized having taken products containing glucosamine or chondroitin sulfate previously or at the time of the questionnaire.Review of the clinical records and liver function tests identified 2 patients presenting an elevation in aminotransferase values temporarily associated with glucosamine treatment;one of the cases simultaneously presented a skin rash attributed to the drug.Review of these two patients and the cases described in the literature suggest toxicity of glucosamine and chondroitin sulfate.The clinical spectrum is variable,and the mechanism of toxicity is not clear but may involve reactions of hypersensitivity.The consumption of products containing glucosamine and/or chondroitin sulfate is frequent among patients with chronic liver diseases and should be taken into account on the appearance of alterations in liver function tests not explained by the underlying disease. | Cristian Cerda Miguel Bruguera Albert Parés | 2013 | World Journal of Gastroenterology2013，19，32： | 2 |
| 13 | Progest erond and non-specific immunologic mechanism in pregnancy 显示文摘 | Par G Szereday L | 1997 | Am J Reprod Imm unol1997，38，3： | 1 |
| 14 | A ge,gender,race,and associa-tions with kidney failure following living kidney donation显示文摘 | Gibney EM Par ikh CR Garg AX | 2008 | Trans-plant Proc2008，40，5： | 1 |
| 15 | Effect of Talc content on the cell- population density of extruded PP foams显示文摘 | C B Par L S Cheung | 1996 | Cellular and Microcellular Materials ASME1996，76，： | 1 |
| 16 | Treatment results for gastric cancer:12 year's experience at a single institute in Korea显示文摘 | Par CH Song KY Kim SN | 2008 | Eur J Surg Oncol2008，34，1： | 1 |
| 17 | Parametric coding of stereo audio 显示文摘 | BREEBAART J PAR S KOHLRAUSCH A | 2005 | EURASfP Journal on Applied Signal Processing2005，，9： | 1 |
| 18 | Automotive catalytic converters:current status and some perspectives显示文摘 | J.Ka?par P.Fornasiero N.Hickey | | 0，，： | 1 |
| 19 | Validation of subareo-lar and periareolar injection techniques for breast sentinel lymphnode biopsy显示文摘 | CKa^par A Martin RC 3rd Chao C | 2004 | Arch Surg2004，139，6： | 1 |
| 20 | miR-193b Regulates Mcl-1 in Melanoma显示文摘 | Jiamin Chen Xiao Zhang Cindy Lentz Marie Abi-Daoud Geneviève C. Paré Xiaolong Yang Harriet E. Feilotter Victor A. Tron | 2011 | The American Journal of Pathology2011，，5： | 1 |
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