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| 1 | Managements of recurrent hepatocellular carcinoma after liver transplantation: A systematic review显示文摘AIM: To investigate the efficacy(survival) and safety of treatments for recurrent hepatocellular carcinoma(HCC) in liver transplantation(LT) patients.METHODS: Literature search was performed on available online databases without a time limit until January 2015. Clinical studies describing survival after HCC recurrence in LT patients were retrieved for a fulltext evaluation. A total of 61 studies were selected: 13 case reports, 41 retrospective case series, and 7 retrospective comparative studies.RESULTS: Based on all included studies, the mean HCC recurrence rate was 16% of all LTs for HCC. A total of 1021 LT patients experienced HCC recurrence. The median time from LT to HCC recurrence was 13 mo(range 2-132 mo). The majority of patients(67%) presented with HCC extra-hepatic recurrences, involving lung, bone, adrenal gland, peritoneal lymph nodes, and rarely the brain. Overall survival after HCC recurrence was 12.97 mo. Surgical resection of localized HCC recurrence and Sorafenib for controlling systemic spread of HCC recurrence were associated with the higher survival rates(42 and 18 mo, res-pectively). However, Sorafenib, especially when combined with m TOR, was frequently associated with severe side effects that required dose reduction or discontinuation CONCLUSION: Management of recurrent HCC in LT patients is challenging and associated with poor prognosis independently of the type of treatment. | Nicola de'Angelis Filippo Landi Maria Clotilde Carra Daniel Azoulay | 2015 | World Journal of Gastroenterology2015，21，39： | 42 |
| 2 | Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer显示文摘Inflammatory bowel diseases are characterised by inflammation that compromises the integrity of the epithelial barrier. The intestinal epithelium is not only a static barrier but has evolved complex mechanisms to control and regulate bacterial interactions with the mucosal surface. Apical tight junction proteins are critical in the maintenance of epithelial barrier function and control of paracellular permeability. The characterisation of alterations in tight junction proteins as key players in epithelial barrier function in inflammatory bowel diseases is rapidly enhancing our understanding of critical mechanisms in disease pathogenesis as well as novel therapeutic opportunities. Here we give an overview of recent literature focusing on the role of tight junction proteins, in particular claudins, in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer. | Jonathan Landy Emma Ronde Nick English Sue K Clark Ailsa L Hart Stella C Knight Paul J Ciclitira Hafid Omar Al-Hassi | 2016 | World Journal of Gastroenterology2016，22，11： | 39 |
| 3 | 贵阳市大气颗粒物(PM_(2.5))污染特征及气象参数的影响显示文摘运用连续颗粒物采样仪(URG Model 2000-01J)对贵阳市城区大气颗粒物PM2.5进行了连续3个月(9-11月)的采集与分析,探讨了PM2.5的浓度分布特征、气象条件的影响。结果显示,贵阳市大气颗粒物PM2.5的平均质量浓度为53±27μg/m^3,变化范围为3.7-186μg/m^3;初步推断大气颗粒物PM2.5的污染来源主要是燃料燃烧、生物质燃烧、汽车尾气等人为源;相对湿度、风速、风向、温度等气象条件是影响大气颗粒物浓度及分布的重要因素。 | 刘娜 冯新斌 Landis Matthew 陈卓 仇广乐 | 2014 | 地球与环境2014，42，3： | 29 |
| 4 | Sarcopenia in heart failure: mechanisms and therapeutic strategies显示文摘长期的心失败(CHF ) 是一个高度流行的条件在之中老并且与可观的病态, institutionalization 和死亡被联系。在它的先进阶段, CHF 被肌肉质量和力量的损失经常伴随。Sarcopenia 是活跃地与大量不利健康结果由于它的协会在最近的年里被学习了的衰老老人症候群。这评论的目标是讨论在 CHF 和 sarcopenia 之间的关系,与分享的 pathophysiological 小径和处理的一个焦点。营养不良,全身的发炎,内分泌的不平衡,和氧化应力看起来连接 sarcopenia 和 CHF。在肌肉发达的水平, ubiquitin proteasome 系统,发信号的 myostatin,和 apoptosis 的改变在 sarcopenia 和 CHF 被描述了并且能在肌肉质量和功能的损失起一个作用。阻碍肌肉在 CHF 病人浪费的前进的可能的治疗学的策略包括变换血管收缩素的酶禁止者和 β 的蛋白质和维生素 D 补充,结构化的物理锻练,和管理; -blockers。有生长荷尔蒙,睾丸激素,和 ghrelin 的神经质的补充也作为潜在的治疗被讨论。 | Agnese Collamati Emanuele Marzetti Riccardo Calvani Matteo Tosato Emanuela D'Angelo Alex N Sisto Francesco Landi | 2016 | Journal of Geriatric Cardiology2016，13，7： | 25 |
| 5 | 贵阳市大气黑碳污染特征显示文摘利用连续颗粒物采样仪(URG Model 2000-01 J)和黑碳仪(Aethalometer)对贵阳市城区2008年9—11月大气黑碳浓度进行了连续观测,结果表明,贵阳市城区秋冬季大气24h黑碳浓度变化范围为1.6~12μg.m-3,平均值为4.1μg.m-3;12 h黑碳浓度观测值主要分布在2~5μg.m-3,白昼黑碳浓度变化范围介于1.9~9.2μg.m-3,平均值3.9μg.m-3,夜间黑碳浓度变化范围0.48~15μg.m-3,平均值4.3μg.m-3;黑碳浓度与大气PM2.5浓度变化一致,呈正相关关系(r=0.84,P〈0.0001,n=178),大气黑碳浓度的变化趋势还明显受相对湿度、温度和风速的影响。 | 仇广乐 刘娜 冯新斌 LANDIS Matthew 商立海 付学吾 | 2011 | 生态学杂志2011，30，5： | 9 |
| 6 | Spatial Properties of Mismatch Negativity in Patients with Disorders of Consciousness显示文摘In recent decades, event-related potentials have been used for the clinical electrophysiological assessment of patients with disorders of consciousness(DOCs). In this paper, an oddball paradigm with two types of frequencydeviant stimulus(standard stimuli were pure tones of 1000 Hz; small deviant stimuli were pure tones of 1050 Hz; large deviant stimuli were pure tones of 1200 Hz) was applied to elicit mismatch negativity(MMN) in 30 patients with DOCs diagnosed using the JFK Coma Recovery ScaleRevised(CRS-R). The results showed that the peak amplitudes of MMN elicited by both large and small deviant stimuli were significantly different from baseline.In terms of the spatial properties of MMN, a significant interaction effect between conditions(small and large deviant stimuli) and electrode nodes was centered at the frontocentral area. Furthermore, correlation coefficients were calculated between MMN amplitudes and CRS-R scores for each electrode among all participants to generate topographic maps. Meanwhile, a significant negative correlation between the MMN amplitudes elicited by large deviant stimuli and the CRS-R scores was also found at the frontocentral area. In consequence, our results combine the above spatial properties of MMN in patients with DOCs,and provide a more precise location(frontocentral area) at which to evaluate the correlation between clinical electrophysiological assessment and the level of consciousness. | Xiaoyu Wang Rao Fu Xiaoyu Xia Xueling Chen Han Wu Nicole LANDi Ken Pugh Jianghong He Fengyu Cong | 2018 | Neuroscience Bulletin2018，34，4： | 9 |
| 7 | Neoadjuvant sorafenib combined with gemcitabine plus oxaliplatin in advanced hepatocellular carcinoma显示文摘This paper reports the first case of a patient with hepatocellular carcinoma with lymph node metastasis treated by sorafenib combined with gemcitabine plus oxaliplatin,with a partial response and normalization of α fetoprotein,which allowed curative surgery.The potential synergy between these three drugs needs to be confirmed,and is currently being investigated in a randomized phase Ⅱ trial. | Nicolas Williet Olivier Dubreuil Tarek Boussaha Isabelle Trouilloud Bruno Landi Martin Housset Muriel Botti Philippe Rougier Jacques Belghiti Julien Taieb | 2011 | World Journal of Gastroenterology2011，17，17： | 8 |
| 8 | Effect of vernalization on tuberization and flowering in the Tibetan turnip is associated with changes in the expression of FLC homologues显示文摘The turnip(Brassica rapa var. rapa) is a biennial crop that is planted in late summer/early fall and forms fleshy tubers for food in temperate regions. The harvested tubers then overwinter and are planted again the next spring for flowering and seeds. FLOWERING LOCUS C(FLC) is a MADS-box transcription factor that acts as a major repressor of floral transition by suppressing the flowering promoters FT and SOC1. Here we show that vernalization effectively represses tuber formation and promotes flowering in Tibetan turnip. We functionally characterized four FLC homologues(BrrFLC1,FLC2, FLC3, and FLC5), and found that BrrFLC2 and BrrFLC1 play a major role in repressing flowering in turnip and in transgenic Arabidopsis. In contrast, tuber formation was correlated with BrrFLC1 expression in the hypocotyl and was repressed under cold treatment following the quantitative downregulation of BrrFLC1. Grafting experiments of non-vernalized and vernalized turnips revealed that vernalization independently suppressed tuberization in the tuber or hypocotyl of the rootstock or scion, which occurred in parallel with the reduction in BrrFLC1 activity. Together, our results demonstrate that the Tibetan turnip is highly responsive to cold exposure, which is associated with the expression levels of BrrFLC genes. | Yan Zheng Landi Luo Yuanyuan Liu Yunqiang Yang Chuntao Wang Xiangxiang Kong Yongping Yang | 2018 | Plant Diversity2018，40，2： | 7 |
| 9 | Interspinous posterior devices: What is the real surgical indication?显示文摘Interspinous posterior device(IPD) is a term used to identify a relatively recent group of implants used to treat lumbar spinal degenerative disease. This kind of device is classified as part of the group of the dynamic stabilization systems of the spine. The concept of dynamic stabilization has been replaced by that of dynamic neutralization of hypermobility, with the intention of clarifying that the primary aim of this kind of system is not the preservation of the movement, but the dynamic neutralization of the segmental hypermobility which is at the root of the pathological condition. The indications for the implantation of an IPD are spinal stenosis and neurogenic claudication, assuming that its function is the enlargement of the neural foramen and the decompression of the roots forming the cauda equina in the central part of the vertebral canal. In the last 10 years, use of these implants has been very common but to date, no long-term clinical follow-up regarding clinical and radiological aspects are available. The high rate of reoperation, recurrence of symptoms and progression of degenerative changes is evident in the literature. If these devices are effectively a miracle cure for lumbar spinal stenosis, why do the utilization and implantation of IPD remain extremely controversial and should they be investigated further? Excluding theproblems related to the high cost of the device, the main problem remains the pathological substrate on which the device is explicit in its action: the degenerative pathology of the spine. | Alessandro Landi | 2014 | World Journal of Clinical Cases2014，2，9： | 7 |
| 10 | Syringomyelia associated with cervical spondylosis: A rare condition显示文摘Spinal spondylosis is an extremely common condition that has only rarely been described as a cause of syringomyelia. We describe a case of syringomyelia associated with cervical spondylosis admitted at our division and treated by our institute. It is the case of a 66-yearold woman. At our observation she was affected by moderate-severe spastic tetraparesis. T2-weighted magnetic resonance imaging(MRI) showed an hyperintense signal within spinal cord from C3 to T1 with a more sharply defined process in the inferior cervical spinal cord. At the same level bulging discs, facets and ligamenta flava hypertrophy determined a compression towards subarachnoid space and spinal cord. Spinal cord compression was more evident in hyperextension rather than flexion. A 4-level laminectomy and subsequent posterior stabilization with intra-articular screws was executed. At 3-mo follow up there was a regression of tetraparesis but motor deficits of the lower limbs residuated. At the same follow up postoperative MRI was executed. It suggested enlargement of the syrinx. Perhaps hyperintensity within spinal cord appeared 'bounded' from C3 to C7 with clearer margins. At the level of surgical decompression, subarachnoid space and spinal cord enlargement were also evident. A review of the literature was executed using Pub Med database. The objective of the research was to find an etiopathological theory able to relate syringomyelia with cervical spondylosis. Only 6 articles have been found. At the origin of syringomyelia the mechanisms of compression and instability are proposed. Perhaps other studies assert the importance of subarachnoid space regard cerebrospinal fluid(CSF) dynamic. We postulate that cervical spine instability may be the cause of multiple microtrauma towards spinal cord and consequently may damage spinal cord parenchyma generating myelomalacia and consequently syrinx. Otherwise the hemorrhage within spinal cord central canal can cause an obstruction of CSF outflow, finally generating the syrinx. On the other hand in cervical spondylosis the stenotic elements can affect subarachnoid space. These elements rubbing towards spinal cord during movements of the neck can generate arachnoiditis, subarachnoid hemorrhages and arachnoid adhesions. Analyzing the literature these 'complications' of cervical spondylosis are described at the origin of syringomyelia. So surgical decompression, enlarging medullary canal prevents rubbings and contacts between the bone-ligament structures of the spine towards spinal cord and subarachnoid space therefore syringomyelia. Perhaps stabilization is also necessary to prevent instability of the cervical spine at the base of central cord syndrome or syringomyelia. Finally although patients affected by central cord syndrome are usually managed conservatively we advocate, also for them, surgical treatment in cases affected by advanced state of the symptoms and MRI. | Alessandro Landi Lorenzo Nigro Nicola Marotta Cristina Mancarella Pasquale Donnarumma Roberto Delfini | 2013 | World Journal of Clinical Cases2013，1，3： | 7 |
| 11 | Magnetic resonance diffusion tensor imaging and fibertracking diffusion tensor tractography in the management of spinal astrocytomas显示文摘Some specially imaging of magnetic resonance imaging,the diffusion-weighted imaging(DWI),the diffusion tensor imaging and fractional anisotropy(FA),are useful to described,detect,and map the extent of spinal cord lesions.FA measurements may are used to predicting the outcome of patients who have spinal cord lesions.Fiber tracking enable to visualizing the integrity of white matter tracts surrounding some lesions,and this information could be used to formulating a differential diagnosis and planning biopsies or resection.In this article,we will describe the current uses for DWI and fiber tracking and speculate on others in which we believe these techniques will be useful in the future. | Alessandro Landi Valeria Palmarini Alessandro D'Elia Nicola Marotta Maurizio Salvati Antonio Santoro Roberto Delfini | 2016 | World Journal of Clinical Cases2016，4，1： | 6 |
| 12 | Evaluation of kefir as a potential probiotic on growth performance,serum biochemistry and immune responses in broiler chicks显示文摘This experiment was conducted to evaluate the effect of milk or molasses kefir as a probiotic on growth performance, carcass traits, serum biochemistry and humoral immune responses in broiler chickens. A total of 192 one-d-old as hatched broiler chicks(Ross 308) were randomly allotted to 4 treatments, each with 4 replicate pens of 12 chicks. The following treatments were applied: 1) a basal diet(C) and normal drinking water, 2) 2% milk kefir in drinking water, 3) 2% molasses kefir in drinking water, and 4) the diet C supplemented with commercial probiotic. At d 42, eight birds per treatment were killed for determination of carcass traits. Broilers at 28 days of age were bled for measuring antibody titers against Newcastle disease virus(NDV) and avian influenza virus(AIV), at 30 days of age for antibody titers against sheep red blood cell(SRBC), and at 42 days of age for biochemical analysis. Supplementing 2%milk kefir increased body weight of broilers at 28 and 42 days of age(P < 0.05). Supplementing 2%molasses kefir improved feed conversation ratio(FCR) of broilers during growth period(P < 0.05), but FCR of broilers in other periods was not affected. Daily feed intake, internal organ weights, and carcass traits were not influenced by the treatments except for small intestine and ceca length. Small intestinal length significantly decreased in broilers supplemented with milk and molasses kefir(P < 0.05). Molasses kefir supplementation significantly(P < 0.05) increased antibody titer against SRBC at 31 days of age but other immune related parameters were not statistically different among treatments. Biochemical parameters including serum protein, albumin, and triglyceride concentrations were not statistically(P> 0.05) influenced. Broilers supplemented with molasses kefir, had a significantly lower concentration of serum total cholesterol, low density lipoprotein cholesterol and elevated high density lipoprotein cholesterol at 42 days of age(P < 0.05). In conclusion, the results indicated that inclusion of 2% milk kefir in drinking water would improve growth performance of broiler chickens. | Majid Toghyani Seyed kazem Mosavi Mehrdad Modaresi Nasir Landy | 2015 | Animal Nutrition2015，，4： | 6 |
| 13 | 贵阳市大气降水中汞的分布特征显示文摘于2008年7—9月对贵阳市中心城区采集的21个大气降水进行了总汞、甲基汞及阴、阳离子浓度的测定,分析了大气降水中总汞与阴阳离子间的相互关系。结果表明:大气降水中总汞的平均含量为18 ng.L-1,变化范围为0.4~57.4 ng.L-1;甲基汞的平均含量为0.07 ng.L-1,变化范围为0.02~0.2 ng.L-1。大气降水中的阴离子以SO24-和NO-3为主,其浓度平均值分别为151和145 mo.lL-1;阳离子主要以Ca2+为主,平均浓度达到了123 mo.lL-1,变化范围为3.7~560 mo.lL-1,其次是NH4+和Mg2+,其浓度平均值分别为52.2和20.4 mo.lL-1。通过分析降水中总汞和阴阳离子之间的相互关系,发现总汞和阴离子SO24-具有显著的相关性,与F-有一定的相关性,而与NO-3不具有相关性。由此初步判定,大气降水中的总汞主要来源于燃煤等人为释放源。 | 刘娜 仇广乐 冯新斌 LANDIS Matthew 付学吾 商立海 | 2011 | 生态学杂志2011，30，5： | 5 |
| 14 | Arthropods and biofuel production systems in North America显示文摘 | Douglas A. Landis Benjamin P. Werling | 2010 | Insect Science2010，17，3： | 5 |
| 15 | Trans-sacral screw fixation in the treatment of high dyplastic developmental spondylolisthesis显示文摘We describe the case of a 67-year-old woman with L5-S1 ontogenetic spondylolisthesis treated with pedicle fixation associated with interbody arthrodesis performed with S1-L5 trans-sacral screwing according to the technique of Bartolozzi. The procedure was followed by a wide decompressive laminectomy. The patient had a progressive improvement of the symptoms which gradually disappeared in 12 mo. The radiograph at 6 and 12 mo showed complete fusion system. The choice of treatment in L5-S1 ontogenetic spondylolithesis is related to a correct clinical and diagnostic planning(X-ray, computer tomography magnetic resonance imaging, Measurement). In particular, the severity index and the square of unstable zone, and the standard measurements already described in the literature, are important to understand and to plane the correct surgical strategy, that require, in most of the times, fusion and interbody artrodesis. | Alessandro Landi Nicola Marotta Cristina Mancarella Roberto Tarantino Roberto Delfini | 2013 | World Journal of Clinical Cases2013，1，3： | 4 |
| 16 | 高氨氮低碳废水短程硝化-反硝化脱氮过程研究显示文摘通过间歇曝气的运行方式,对高浓度氨氮低碳废水进行短程硝化-反硝化脱氮过程的研究。在生物驯化过程中考察亚硝酸盐氮的积累,并验证短程硝化即亚硝化的可行性。实验结果表明,短程硝化-反硝化过程满足高氨氮低碳废水的生物脱氮要求,亚硝化率达到98.0%以上。采用16S rRNA基因克隆文库分子生物学分析方法对系统中的硝化菌群进行分析,发现系统中主要存在将氨氧化成亚硝酸根的氨氧化菌(AOB)及亚硝酸盐还原菌。 | Ali Ibrah Landi 蒋明 林大泉 仝明 鲁军 | 2009 | 化工环保2009，29，6： | 4 |
| 17 | A case for systemic environmental analysis of cultured meat显示文摘The environmental implications of cultured meat are profound. An anticipatory life cycle assessment of cultured meat published in 2011 suggested it could have a smaller impact than agricultural meat in all categories except energy consumption. As with most technologies, cultured meat will almost certainly be accompanied by unintended consequences as well as unforeseen costs and benefits that accrue disproportionately to different stakeholders. Uncertainty associated with new engineered products cannot be completely eliminated prior to introduction, but ongoing environmental assessments of the technologies as they advance can serve to reduce unforeseen risks. Given the pace at which tissue engineering is advancing, systemic assessments of the technology will be pivotal in mitigating unintended environmental consequences. | Carolyn S Mattick Amy E Landis Braden R Allenby | 2015 | Journal of Integrative Agriculture2015，14，2： | 4 |
| 18 | The“A”of FAIR-As Open as Possible,as Closed as Necessary显示文摘In order to provide responsible access to health data by reconciling benefits of data sharing with privacy rights and ethical and regulatory requirements,Findable,Accessible,Interoperable and Reusable(FAIR)metadata should be developed.According to the H2020 Program Guidelines on FAIR Data,data should be'as open as possible and as closed as necessary','open'in order to foster the reusability and to accelerate research,but at the same time they should be'closed'to safeguard the privacy of the subjects.Additional provisions on the protection of natural persons with regard to the processing of personal data have been endorsed by the European General Data Protection Regulation(GDPR),Reg(EU)2016/679,that came into force in May 2018.This work aims to solve accessibility problems related to the protection of personal data in the digital era and to achieve a responsible access to and responsible use of health data.We strongly suggest associating each data set with FAIR metadata describing both the type of data collected and the accessibility conditions by considering data protection obligations and ethical and regulatory requirements.Finally,an existing FAIR infrastructure component has been used as an example to explain how FAIR metadata could facilitate data sharing while ensuring protection of individuals. | Annalisa Landi Mark Thompson Viviana Giannuzzi Fedele Bonifazi Ignasi Labastida Luiz Olavo Bonino da Silva Santos Marco Roos | 2020 | Data Intelligence2020，2，1： | 4 |
| 19 | 360° fusion for realignment of high grade cervical kyphosis by one step surgery: Case report显示文摘Surgical treatment for cervical kyphotic deformity is still controversial. Circumferential approach has been well described in the literature but long terms outcomes are not well reported. Important to decide the correct treatment option is the preoperative radiological exams to value the type of deformity(flexible or fixed). We report the case of a 67-year-old woman affected by a severe cervical kyphotic deformity who underwent combined anterior/posterior surgical approach, getting a good reduction of the deformity and an optimal stability in a long term follow up. | Alessandro Landi Nicola Marotta Cristina Mancarella Demo Eugenio Dugoni Roberto Tarantino Roberto Delfini | 2014 | World Journal of Clinical Cases2014，2，7： | 4 |
| 20 | Chemical characterization and sources of PM2.5 at 12-h resolution in Guiyang, China显示文摘The increasing emission of primary and gaseous precursors of secondarily formed atmospheric particulate matter due to continuing industrial development and urbanization are leading to an increased public awareness of environmental issues and human health risks in China.As part of a pilot study, 12-h integrated fine fraction particulate matter(PM_(2.5) filter samples were collected to chemically characterize and investigate the sources of ambient particulate matter in Guiyang City, Guizhou Province, southwestern China. Results showed that the 12-h integrated PM_(2.5) concentrations exhibited a daytime average of 51 ± 22 lg m^(-3)(mean ± standard deviation) with a range of 17–128 lg m^(-3) and a nighttime average of55 ± 32 lg m~(^(-3)) with a range of 4–186 lg m^(-3). The 24-h integrated PM_(2.5) concentrations varied from 15 to157 lg m~(^(-3)), with a mean value of 53 ± 25 lg m^(-3), which exceeded the 24-h PM_(2.5) standard of 35 lg m^(-3) set by USEPA, but was below the standard of 75 lg m^(-3), set by China Ministry of Environmental Protection. Energy-dispersive X-ray fluorescence spectrometry(XRF) was applied to determine PM_(2.5) chemical element concentrations. The order of concentrations of heavy metals in PM_(2.5) were iron(Fe) [ zinc(Zn) [ manganese(Mn) [ lead(Pb) [ arsenic(As) [ chromium(Cr). The total concentration of 18 chemical elements was 13 ± 2 lg m^(-3),accounting for 25% in PM_(2.5), which is comparable to other major cities in China, but much higher than cities outside of China. | Longchao Liang Na Liu Matthew S. Landis Xiaohang Xu Xinbin Feng Zhuo Chen Lihai Shang Guangle Qiu | 2018 | Acta Geochimica2018，37，2： | 4 |
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