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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Impact of antiretroviral therapy on lipid metabolism of human immunodeficiency virus-infected patients: Old and new drugs显示文摘For human immunodeficiency virus(HIV)-infected patients, the 1990s were marked by the introduction of highly active antiretroviral therapy(HAART) representing a new perspective of life for these patients. The use of HAART was shown to effectively suppress the replication of HIV-1 and dramatically reduce mortality and morbidity, which led to a better and longer quality of life for HIV-1-infected patients. Apart from the substantial benefits that result from the use of various HAART regimens, laboratory and clinical experience has shown that HAART can induce severe and considerable adverse effects related to metabolic complications of lipid metabolism, characterized by signs of lipodystrophy, insulin resistance, central adiposity, dyslipidemia, increased risk of cardiovascular disease and even an increased risk of atherosclerosis. New drugs are being studied, new therapeutic strategies are being implemented, and the use of statins, fibrates, and inhibitors of intestinal cholesterol absorption have been effective alternatives. Changes in diet and lifestyle have also shown satisfactory results. | Joel da Cunha Luciana Morganti Ferreira Maselli Ana Carolina Bassi Stern Celso Spada Sérgio Paulo Bydlowski | 2015 | World Journal of Virology2015，4，2： | 9 |
| 3 | Botulinum injection therapy for blepharospasm a review and report of 75 patients显示文摘 | Cohen DA Sarino P Stern MB | 1986 | Clin Neuropharmacol1986，9，3： | 1 |
| 4 | Th1/Th2 patterns and balance in cytokine production in the parents and infants of a large birth cohort显示文摘 | Halonen M Lohman IC Stern DA | 2009 | J Immunol2009，182，5： | 1 |
| 5 | Intramedul ary fixation of humeral shaft fractures显示文摘 | Stern PJ Mattingly DA Pomeroy DL | | 0，，05： | 1 |
| 6 | Cryopreservation of human ovarian tissue显示文摘 | Gook DA Edgar DH Stern C | 2004 | Eur J Obstet Gynecol Reprod Biol2004，1131，： | 1 |
| 7 | Botulinum injection therapyfor a review and report of 75 patients显示文摘 | Cohen DA Savino P Stern MB | 1986 | Clin Neuropharmaco l1986，9，： | 1 |
| 8 | Botulinum injection therapy for blepharospasm:A review and report of 75 patients显示文摘 | Cohen DA Savino P Stern MB | 1986 | Clin Neurophar- marol1986，9，： | 1 |
| 9 | Botulinum injection therapy for blepharo spasm: a review and report of 75 patients 显示文摘 | COHEN DA SAVINO P STERN MB | 1986 | Clim Neurop Harmacol1986，9，5： | 1 |
| 10 | Effect of cooling rate and dehydration regimen on the histological appearance of human ovarian cortex following cryopreservation in 1, 2 - propanediol 显示文摘 | Gook DA Edgar DH Stern C | 1999 | Hum Reprod1999，14，： | 1 |
| 11 | Botulinum injection therapy for blepharospasn; a review and report of 75 patients显示文摘 | 1,Cohen DA Savino P Stern MB | 1986 | Clin1986，1986，9： | 1 |
| 12 | Relationship between infantile colic and Asthma/ atopy:A prospective study in an unselected population显示文摘 | Castro-Rodriguez JA Stern DA Halonen M | 2001 | Pediatrics2001，108，4： | 1 |
| 13 | The effects of cryopreservation regimens on the morphology of human ovarian tissue显示文摘 | Gook DA Edgar DH Stern C | 2000 | Mol Cell Endocrinol2000，169，12： | 1 |
| 14 | XPD codon 751 polymorphism, metabolism genes, smoking, and bladder cancer risk显示文摘 | Stern MC Johnson LR Bell DA | 2002 | Cancer Epidemiol Biomarkers Prev2002，11，101： | 1 |
| 15 | Effect of cooling rate and dehydration regimen on the histological appearance of human ovarian cortex following cryopreservation in 1,2-propanediol显示文摘 | Gook DA Edgar DH Stern C | 1999 | Hum Reprod1999，14，8： | 1 |
| 16 | The effects of cryopreservation regimens on the morphology of human ovarian tissue显示文摘 | Gook DA Edgar DH Stern C | 2000 | Mol Cell Endocrinol2000，169，12： | 1 |
| 17 | Asthma-associated differences in microbial composition of induced sputum 显示文摘 | Marri PR Stern DA Wright AL | 2013 | J Allergy Clin Immunol2013，131，2： | 1 |
| 18 | Botulinum injection therapy for blepharospasm: a review and report of 75 patients显示文摘 | Cohen DA Savino P Stern MB | 1986 | Chin Neuropharmacol1986，9，： | 1 |
| 19 | Botulinum injection therapy for blepharospasm:a review and report of 75 patients显示文摘 | Cohen DA Savino PJ Stern MB | 1986 | Clin Neuropharmacol1986，9，： | 1 |
| 20 | Asthma-associated differences in microbial composition of induced sputum 显示文摘 | Marri PR Stern DA Wright AL | 2013 | J Allergy Clin Immunol2013，151，2： | 1 |
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