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| 1 | Calcitriol analog ZK191784 ameliorates acute and chronic dextran sodium sulfate-induced colitis by modulation of intestinal dendritic cell numbers and phenotype显示文摘AIM: To investigate the effects of ZK1916784, a low calcemic analog of calcitriol on intestinal inflammation. METHODS: Acute and chronic colitis was induced by dextran sodium sulfate (DSS) according to standard procedures. Mice were treated intraperitoneally with ZK1916784 or placebo and colonic inflammation was evaluated. Cytokine production by mesenterial lymph node (MLN) cells was measured by ELISA. Immunohistochemistry was performed to detect intestinal dendritic cells (DCs) within the colonic tissue, and the effect of the calcitriol analog on DCs was investigated. RESULTS: Treatment with ZK191784 resulted in significant amelioration of disease with a reduced histological score in acute and chronic intestinal inflammation. In animals with acute DSS colitis, down- regulation of colonic inflammation was associated with a dramatic reduction in the secretion of the proinflammatory cytokine interferon (IFN)-γ and a significant increase in intereleukin (IL)-10 by MLN cells. Similarly, in chronic colitis, IL-10 expression in colonic tissue increased 1.4-fold when mice were treated with ZK191784, whereas expression of the Th1-specific transcription factor T-beta decreased by 81.6%. Lower numbers of infiltrating activated CD11c+ DCs were found in the colon in ZK191784-treated mice with acute DSScolitis, and secretion of proinflammatory cytokines by primary mucosal DCs was inhibited in the presence of the calcitriol analog. CONCLUSION: The calcitriol analog ZK191784 demonstrated significant anti-inflammatory properties in experimental colitis that were at least partially mediated by the immunosuppressive effects of the derivate on mucosal DCs. | Ulrike G Strauch Florian Obermeier Nicole Grunwald Nadja Dunger Heiko C Rath Jürgen Schlmerich A Steinmeyer U Zügel HH Herfarth | 2007 | World Journal of Gastroenterology2007，13，48： | 4 |
| 2 | Pharmacological basis for the therapy of pain and inflammation with nonsteroidal anti-inflammatory drugs显示文摘 | Steinmeyer J | 2000 | Arthritis Res2000，2，5： | 1 |
| 3 | Proteoglycan metabolism and viability of artrcular cartrcular cartilage explants as modulated by the frequency of intermittent loading显示文摘 | Saucrland K Raiss Rx Steinmeyer J | 2003 | Osteoarthritis Cartilage2003，11，5： | 1 |
| 4 | Diagnosing schizophrenia in the initial prodromal phase显示文摘 | Klosterkotter J Hellmich M Steinmeyer E | 2001 | Arch Gen Psychiatry2001，58，2： | 1 |
| 5 | The efficacy of auriculotherapy for smoking cessation: A ran- domized, placebo-controlled trial 显示文摘 | Fritz DJ Carney RM Steinmeyer B | 2013 | J Am Board Faro Med2013，26，1： | 1 |
| 6 | MicroRNA- 145 targets the metalloprotease ADAM17 and is suppressed in re- nal cell carcinoma patients 显示文摘 | Doberstein K Steinmeyer N Hartmetz AK | 2013 | Neoplasia2013，15，2： | 1 |
| 7 | Depression and five year survival following acute myocardial infarction: a prospec- tive study 显示文摘 | Carney RM Freedland KE Steinmeyer B | 2008 | J Affect disord2008，109，12： | 1 |
| 8 | Helium Release From Aged Palladium Tritide显示文摘 | Abell GC Matson LK Steinmeyer RH | 1990 | Phys Rev B1990，41，2： | 1 |
| 9 | Saturation of the all-optical Kerr effect显示文摘 | Brée C Demircan A Steinmeyer G | | 0，，18： | 1 |
| 10 | Toll-like receptor triggering of a vitamin D-media- ted human antimicrobial response 显示文摘 | Liu PT Stenger S Li H Wenzel L Tan BH Krutzik SR Ochoa MT Schauber J Wu K Meinken C Kamen DL Wagner M Bals R Steinmeyer A Ztigel U Gallo RL Eis- enberg D Hewison M Hollis BW Adams JS Bloom BR Modlin RL | 2006 | Science2006，311，： | 1 |
| 11 | History of depression and survival after acute myocardial infarction显示文摘 | Carney R M Freedland K F Steinmeyer B | | 0，，03： | 1 |
| 12 | Effects of non-steroidal antiinflammatory drugs and dexamethasone on the activity and expression of matrix metalloproteinase-1,matrix metalloproteinase-3 and tissue inhibitor of metalloproteinases-1 by bovine articular chondrocytes显示文摘 | Sadowski T Steinmeyer J | 2001 | Osteoarthritis Cartilage2001，9，5： | 1 |
| 13 | Diagnosing schizophrenia in the initial prodromal phase显示文摘 | Klosterkfitter J I-Iellmich M Steinmeyer EM | 2001 | Arch Gen Psychiatry2001，58，2： | 1 |
| 14 | Collagen synthesis of articular cartilage explants in response to frequency of cyclic mechanical loading显示文摘 | Wolf A Ackermann B Steinmeyer J | 2007 | Cell Tissue Res2007，327，1： | 1 |
| 15 | Zur wirkung yon antiphlogistika auf die granulozytenenzyme elastase und kathepsin G 显示文摘 | Steinmeyer J Kalbhen DA | 1989 | Arzneim - Forsch/Drug Res1989，39，： | 1 |
| 16 | Effects of non-steroidal antiinflammatory drugs and dexamethasone on the activity and expression of matrix metalloproteinase-1,matrix metalloproteinase-3 and tissue inhibitor of metalloproteinases-1 by bovine articular chondrocytes显示文摘 | Sadowski T Steinmeyer J | 2001 | Osteoarthr Cartil2001，9，5： | 1 |
| 17 | Genomicorganization of the human muscle chloride channel CIC-1 andanalysis of novel mutations leading to Becker-type myotonia显示文摘 | Lorenz C Meyer-Kleine C Steinmeyer K | 1994 | Hum Mol Genet1994，3，： | 1 |
| 18 | Sub-6-fs pulses from a SESAM-assisted Kerr-lens modelocked Ti:sapphire laser: at the frontiers of ultrashort pulse generation显示文摘 | D.H. Sutter L. Gallmann N. Matuschek F. Morier-Genoud V. Scheuer G. Angelow T. Tschudi G. Steinmeyer U. Keller | 2000 | Applied Physics B Lasers and Optics2000，，1： | 1 |
| 19 | Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages显示文摘 | Fabri M Stenger S Shin DM Yuk JM Liu PT Realegeno S Lee HM Krutzik SR Schenk M Sieling PA Teles R Montoya D Iyer SS Bruns H Lewinsohn DM Hollis BW Hewison M Adams JS Steinmeyer A Zügel U Cheng G Jo EK Bloom BR Modlin RL | | 0，，： | 1 |
| 20 | Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response显示文摘 | Liu PT Stenger S Li H Wenzel L Tan BH Krutzik SR Ochoa MT Schauber J Wu K Meinken C Kamen DL Wagner M Bals R Steinmeyer A Zugel U Gallo RL Eisenberg D Hewison M Hollis BW Adams JS Bloom BR Modlin RL | 2006 | Science2006，311，5768： | 1 |
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