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| 1 | Expression of COX-2, PCNA, Ki-67 and p53 in gastrointestinal stromal tumors and its relationship with histopathological parameters显示文摘AIM: To investigate the expression of Cyclooxygenase-2 (COX-2), proliferating cell nuclear antigen (PCNA), Ki-67 and p53 in gastrointestinal stromal tumors (GISTs) and its relationship with histopathological parameters. METHODS: Twenty-five GISTs were examined by light microscopy and immunohistochemistry. c-kit, CD34, SMA, S-100 protein, COX-2, PCNA, Ki-67 and p53 were detected immunohistochemically and the relationship was evaluated among histopathologic parameters such as mitotic index (MI), tumor grade, tumor size, COX-2, PCNA, Ki-67 and p53. RESULTS: COX-2 protein expression was found in 19 of 25 (76%) of the tumors, and expression was noted in the cytoplasm of the tumor cells. p53 was significantly related to MI and tumor grade but no relationship was found between COX-2, proliferation markers and MI, tumor grade and tumor size. CONCLUSION: COX-2 is expressed in most GISTs and it may play an important role in the proliferation and progression of these tumors or a useful marker to identify GIST. Although immunohistochemical assessment of p53 can be used for distinguishing the risk groups of GISTs, tumor size and mitotic rate should be considered at the same time. | Derya Gumurdulu Seyda Erdogan Fazilet Kayaselcuk Gulsah Seydaoglu Cem K Parsak Orhan Demircan Ilhan Tuncer | 2007 | World Journal of Gastroenterology2007，13，3： | 21 |
| 2 | Comparison of corneal endothelial changes following phacoemulsification with transversal and torsional phacoemulsification machines显示文摘AIM:To compare and evaluate the phacoemulsification parameters and postoperative endothelial cell changes of two different phacoemulsification machines, each with different modes, but also to assess the relationship between postoperative endothelial cell loss and the phacoemulsification parameters, as well as the other factors in both groups.METHODS:This prospective observational study was comprised of consecutive eligible cataract patients operated with phacoemulsification technique performed by the same surgeon using either a WHITESTAR Signature Ellips FX(transversal, group 1) or Infiniti OZil IP(torsional, group 2) machine.RESULTS:The study included 86 patients. Baseline characteristics in the groups were similar. The median nuclear sclerosis grade was 3(2-4) in the first group and2(2-4) in the second group(P =0.265). Both groups had similar phacoemulsification needle times(group 1: 60.63±36 s; group 2: 55.98±30 s; P =0.789). The percentage of endothelial cell loss 30 d after surgery ranged from 3% to15% with a median of 7% in group 1, and from 2% to13% with a median of 6% in group 2; however, there was no statistically significant difference between the groups(P =0.407). Hexagonality(P =0.794) and the coefficient of variation(CV; P =0.142) did not differ significantly between the groups before and 30 d after surgery. Asignificant positive correlation was found between the endothelial cell loss and nuclear sclerosis grade(group1: P <0.001; group 2: P <0.001) and between the endothelial cell loss and average phacoemulsification power(group 1: P =0.007; group 2: P =0.008).CONCLUSION:Both of these machines were efficient,with similar endothelial cell loss. This endothelial cell loss was related to the increased nuclear sclerosis grade and increased phacoemulsification power. | Mustafa Atas Süleyman Demircan Arzu Seyhan Karatepe Hashas Ahmet Gülhan Gkmen Zararsιz | 2014 | International Journal of Ophthalmology(English edition)2014，7，5： | 7 |
| 3 | Evaluation of early results of quick-chop phacoemulsification in the patients with high myopic cataract显示文摘AIM:To assess the early surgical outcomes of quickchop phacoemulsification technique in patients with high myopia.METHODS:The data of patients with high myopia who underwent quick-chop phacoemulsification were reviewed retrospectively. There were 42 eyes of 31 patients. The axial length was more than 26 mm in all eyes. All eyes underwent quick-chop phacoemulsification surgery with the placement of an intraocular lens(IOL) in the capsular bag. Postoperative visits were performed at 1, 3d; 2wk,1mo. Early postoperative best corrected visual acuity(BCVA), preoperative and postoperative corneal endothelial cell density(ECD), central corneal thickness(CCT) and postoperative complications were assessed.Paired sample t-test or Wilcoxon tests were used to compare data between preoperative and postoperative data.· RESULTS:There was no statistically significant difference between preoperative and postoperative ECD and CCT. Retinal detachment was developed in one eye at postoperative first day. There was an iris prolapsus from side port insicion.· CONCLUSION:Quick-chop phacoemulsification technique is a safe surgical technique. However we can encounter some complications in high myopic eyes due to histopathological differences. Both side port and clear corneal tunnel insicion size is crucial for preventing postoperative complications. If any persistent leakage is noticed, suture should be placed. | Ali Akal Tugba Goncu Sevin Soker Cakmak Isa Yuvaci Mustafa Atas Süleyman Demircan Omer Faruk Yilmaz | 2014 | International Journal of Ophthalmology(English edition)2014，7，5： | 4 |
| 4 | Comparison of 45- degree Kelman and 45- degree balanced phaco tip designs in torsional microcoaxial phacoemulsification显示文摘AIM: To compare the intraoperative performance and postoperative outcome after microcoaxial torsional phacoemulsification using either a Kelman or balanced phaco tip.· METHODS: Cataracts were treated using 2.2 mm microcoaxial torsional phacoemulsification using either a45-degree mini-flared Kelman or a 45-degree IntrepidBalanced phaco tip. Intraoperative measurements included total ultrasound(US) time, cumulative dissipated energy(CDE), torsional US time, and balanced salt solution(BSS) use. The central endothelial cell density(ECD) and central corneal thickness(CCT) were evaluated preoperatively and postoperatively 1, 7, and30 d after surgery using noncontact specular microscopy.·RESULTS: The 116 enrolled eyes(116 patients) were divided equally between the Kelman and balanced tip groups. Intraoperative measurements showed significantly less total US time, torsional US time, CDE, and BSS use in the balanced group than in Kelman group(P <0.05).The total US time, torsional US time, CDE, and BSS use were 17.45 ±14.53 s, 16.63 ±13.97 s, 6.38 ±5.26, and 48.21 ±17.21 m L in the Kelman group and 11.39 ±9.60 s, 10.90 ±9.25 s, 4.04 ±3.42, and 41.36 ±12.70 m L in the balanced group, respectively.·CONCLUSION: Torsional phacoemulsification performed with a balanced tip provided more effective lens removal with less total US time, torsional time, CDE, and BSS use, as well as similar changes in ECD with a Kelman tip in all cataract grades. This special designed phaco tip for torsional phacoemulsification provides an alternative phaco tip for many surgeons' preference with straight phaco tip. | Süleyman Demircan Mustafa Atas Emre Goktas Burhan Baskan | 2015 | International Journal of Ophthalmology(English edition)2015，8，6： | 3 |
| 5 | Effect of torsional mode phacoemulsification on cornea in eyes with/without pseudoexfoliation显示文摘AIM: To evaluate the effect of torsional mode phacoemulsification on central corneal thickness, corneal endothelial cell density, and morphology in eyes with/without pseudoexfoliation(PEX) syndrome.METHODS: Fourty-two consecutive patients with and42 patients without PEX as a control group scheduled for cataract surgery was studied. Phacoemulsification, using OZi L IP system, was performed with quick chop technique. Using noncontact specular microscopy, the central endothelial cell density(ECD), coefficient of variation, percentage of hexagonal cells, and the central corneal thickness(CCT) were evaluated preoperatively and postoperatively at 1, 7 and 30 d.RESULTS: The ECD in PEX syndrome was statistically significantly lower than that in the control group preoperatively and postoperatively(P ≤0.001).Percentage change in ECD was statistically significantly higher in PEX than that in control group after surgery follow up(P ≤0.04).There was no statistically significant difference between both groups comparing percentage of hexagonal cells and coefficient of variation in the cell size before and after the surgery. At 1 and 7d after surgery, percentage change in CCT was statistically significantly higher in PEX group than that in the control group(P ≤0.041).CONCLUSION: Although torsional mode phacoemulsification and intraocular lens(IOL) implantation provided a safe and favorable surgical outcome in patients with/without PEX, torsional phacoemulsification led to significantly higher ECD loss in the PEX group than that in the control group during the whole follow up period.In addition, more corneal swelling in the PEX group than that in the control group during the early postoperative period has indicated that the corneal endothelium, in presence of PEX endotheliopathy, seems to be more susceptible to the effects of phacoemulsification surgeryin eyes with PEX. The increased risk of anterior chamber manipulations in patients with PEX should be taken into account for an increased risk of bullous keratopathy. | Süleyman Demircan Mustafa Atas Yusufcan Yurtsever | 2015 | International Journal of Ophthalmology(English edition)2015，8，2： | 3 |
| 6 | Pentacam Scheimpflug成像测量晶状体密度与torsional超声乳化参数间的关系(英文)显示文摘目的:评价运用Pentacam Scheimpflug成像测量晶状体核密度与torsinal超声乳化动力学参数(如:运用于老年核性白内障患者的超声能量水平、液体留存时间及液体量)间的关系。方法:此研究为前瞻性双盲研究。瞳孔扩大后运用Pentacam Scheimpflug 成像进行测量。白内障的等级由pentacam核密度测定法[ pentacam nucleus densitometry, PND;又名Pentacam核分段( Pentacam nucleus staging, PNS)软件]自主分为1到5个等级。超声乳化术后,自动在Infiniti Ozil IP超声乳化系统监视器上计算并显示总超声( U/S)时间、累计耗散能、Torsional U/S时间以及估算液体的使用情况。组间差异运用单因素方差分析( ANOVA )进行评定,多组分析运用Tamhane测试法,PND测量的晶状体密度与torsinal超声乳化动力学参数间的关系运用Spearman相关分析进行评定。界定P〈0.05时具有统计学意义。结果:此项研究包括125例患者(125眼),平均年龄为69.7±9.4岁(范围:48~88岁),其中61例男性、64例女性。 U/S总时间、torsional U/S时间、CDE及估算液体使用情况的范围分别为0.70~158.9s,0.70~158.5s,0.11~42.65和21~98mL. PND组间数据有统计学差异。评估超声乳化动力学参数与PND数据间关系后得出PND数据与总超声时间( r=0.767; P〈0.01)、torsional超声时间(r=0.767;P〈0.01)、CDE(r=0.758; P〈0.01)及液体使用量(r=0.602;P〈0.01)均有显著相关性。结论:白内障手术前运用PND评分法获得核密度的客观程度可为超声乳化术中的参数提供可靠的预见性。因此,对每一位患者进行每一单项超声乳化参数的评估,有助于降低超声乳化能量的使用量,减少内皮细胞丢失和类固醇的使用,加速视力的恢复。 | Suleyman Demircan Mustafa Atas Murat Koksal Emine Pangal Isa Yuvaci Altan Goktas | 2014 | 国际眼科杂志2014，14，10： | 2 |
| 7 | Relationship between myocardial injury and soluble P-selectin in non-ST elevation acute coronary syndromes显示文摘 | Yazici M Demircan S Duma K | 2005 | Circ J2005，69，5： | 1 |
| 8 | Operating system selection using fuzzy replacement analysis and analytic hierarchy process 显示文摘 | Tolga E Demircan M L Kahraman C | 2005 | International Journal of Production Economics2005，97，1： | 1 |
| 9 | Left ventricular diverticulum in two adult patients 显示文摘 | Yazici M Demircan S Duma K | 2005 | Int Heart J2005，46，1： | 1 |
| 10 | Relationship between myocardial injury and soluble P-selection in non-ST elevation acute coronary syndromes显示文摘 | Yazici M Demircan S Durna K | 2005 | Circ J2005，69，53： | 1 |
| 11 | Effects of moxifloxacin exposure on the conjunctival flora and antibiotic resistance profile following repeated intravitreal injections显示文摘AIM:To evaluate the effects of moxifloxacin exposure on the conjunctival flora and antibiotic resistance profile following repeated intravitreal injections.METHODS:Seventy-two eyes of 36 patients [36 eyes in control group, 36 eyes in intravitreal injection(IVI) group]were enrolled in the study. All the eyes had at least one IVI and had diabetic macular edema(DME) or age-related macular degeneration(ARMD). Moxifloxacin was prescribed to all the patients four times a day for five days following injection. Conjunctival cultures were obtained from the lower fornix via standardized technique with every possible effort made to minimize contamination from the lids, lashes, or skin. Before the application of any ophthalmic medication, conjunctival cultures were obtained from both eyes using sterile cotton culture. An automated microbiology system was used to identify the growing bacteria and determine antibiotic sensitivity.RESULTS:The bacterial cultures were isolated from 72 eyes of 36 patients, sixteen of whom patients(44.4%)were male and twenty(55.6%) were female. Average age was 68.4 ±9.0(range 50-86). The average number of injections before taking cultures was 3.1+1.0. Forty-eight(66.7%) of 72 eyes had at least one significant organism.There was no bacterial growth in 8(20.5%) of IVI eyes and in 16(44.4%) of control eyes(P =0.03). Of the bacteria isolated from culture, 53.8% of coagulase negative staphylococci(CoNS) in IVI eyes and 47.2%CoNS in control eyes. This difference between IVI eyes and control eyes about bacteria isolated from culture was not statistically significant(P =0.2). Eleven of 25 bacteria(44.0%) isolated from IVI eyes and 11(57.9%) of 19 bacteria isolated from control eyes were resistant to oxacillin. The difference in frequency of moxifloxacine resistance between two groups was not statistically significant(12.0% in IVI eyes and 21.1% in control eyes)(P =0.44). There were no cases of resistance to vancomycin, teicoplanin and linezolid.CONCLUSION:There was no difference in species of bacteria isolated from cultures, or in the frequency of resistance to antibiotics between eyes that had recurrent IVI followed by moxifloxacin exposure compared with control eyes. However, the number of eyes that had bacterial growth was higher in IVI group than in the control group. | Mustafa Atas Burhan Baskan Ayse zkse Fatma Mutlu Sarιgüzel Süleyman Demircan Emine Pangal | 2014 | International Journal of Ophthalmology(English edition)2014，7，5： | 1 |
| 12 | Untreated growing cranial fractures detected in late stage显示文摘 | Kutlay M Demircan N Akin ON | 1998 | Neurosurgery1998，43，： | 1 |
| 13 | Determinations of vitreous interleukin-1 (IL-1) and tumor necrosis factor(TNF) levels in proliferative diabetic retinopathy显示文摘 | DEMIRCAN N SAFRAN B G SOYLU M | 2006 | Eye2006，20，： | 1 |
| 14 | Relationship between myocardial injury and P-selectin in non-ST-elevation acute coronary syndromes 显示文摘 | Yazici M Demircan S Duma K | 2005 | Circ J2005，69，5： | 1 |
| 15 | Effect of hyperthyroidism and propyhhiouracil treatment on liver biochemical tests 显示文摘 | Aydemir S Bayraktaroglu T Demircan N | 2005 | Int J Clin Pract2005，59，： | 1 |
| 16 | Paraoxonase activity in glomerulonephritic patients显示文摘 | Gullulu M Kahvecioglu S Dirican M Akdag I Ocak N Demircan C | 2007 | Ren Fail2007，29，4： | 1 |
| 17 | Supercontinuum generation by the modulation instability显示文摘 | A Demircan U Bandelow | 2005 | Opt Commun2005，，244： | 1 |
| 18 | Vitamin E and L-carnitine, separately or in combination,in the prevention of radiation-in- dueed brain and retinal damages显示文摘 | Sezen O Ertekin MV Demircan B | 2008 | Neurosurg Rev2008，31，2： | 1 |
| 19 | The role of adrenergic activity in slow coronary flow and its relationship to TIMI frame count显示文摘 | Yazici M Demircan S Durna K | 2007 | Angiology2007，58，4： | 1 |
| 20 | Cardiac troponin I and beta 2 microglobulin as risk factors for early-onset atherosclerosis in patients on haemodialysis显示文摘 | Zumrutdal A Sezer S Demircan S | 2005 | Nephrology (Carlton)2005，10，5： | 1 |
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