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| 1 | The heterodimeric structure of heterogeneous nuclear ribonucleoprotein C1/C2 dictates 1,25-dihydroxyvitamin D-directed transcriptional events in osteoblasts显示文摘Heterogeneous nuclear ribonucleoprotein(hnRNP) C plays a key role in RNA processing but also exerts a dominant negative effect on responses to 1,25-dihydroxyvitamin D(1,25(OH)2D) by functioning as a vitamin D response element-binding protein(VDRE-BP). hnRNPC acts a tetramer of hnRNPC1(huC1) and hnRNPC2(huC2), and organization of these subunits is critical to in vivo nucleic acid-binding. Overexpression of either huC1 or huC2 in human osteoblasts is sufficient to confer VDRE-BP suppression of 1,25(OH)2D-mediated transcription. However, huC1 or huC2 alone did not suppress 1,25(OH)2D-induced transcription in mouse osteoblastic cells. By contrast, overexpression of huC1 and huC2 in combination or transfection with a bone-specific polycistronic vector using a ‘‘self-cleaving'' 2A peptide to co-express huC1/C2 suppressed1,25D-mediated induction of osteoblast target gene expression. Structural diversity of hnRNPC between human/NWPs and mouse/rat/rabbit/dog was investigated by analysis of sequence variations within the hnRNP CLZ domain. The predicted loss of distal helical function in hnRNPC from lower species provides an explanation for the altered interaction between huC1/C2 and their mouse counterparts. These data provide new evidence of a role for hnRNPC1/C2 in 1,25(OH)2D-driven gene expression, and further suggest that species-specific tetramerization is a crucial determinant of its actions as a regulator of VDR-directed transactivation. | Thomas S Lisse Kanagasabai Vadivel S Paul Bajaj Rui Zhou Rene F Chun Martin Hewison John S Adams | 2014 | Bone Research2014，2，2： | 2 |
| 2 | Vitamin D metabolism and innate immunity 显示文摘 | Lagishetty V Nancy QL Hewison M | 2011 | Mol Cell Endocrinol2011，347，12： | 1 |
| 3 | Tuberculosis treatment in a refugee and migrant population: 20years of experience on the Thai-Burmese border显示文摘 | Minetti A Camelique O Hsa Thaw K Thi S Swaddiw-udhipong W Hewison C Pinoges L Bonnet M Guerin PJ | 2010 | Int J Tu- berc Lung Dis2010，14，12： | 1 |
| 4 | 11betaHydroxysteroid dehydrogenase expression and glucocorticoid synthesis are directed by a molecular switch during osteoblast differentiation显示文摘 | Eijken M Hewison M Cooper MS | 2005 | Mol Endocrinol2005，19，3： | 1 |
| 5 | A switch in dehydrogenase to reductase activity of 11 betahydroxysteroid dehydrogenase type 1 upon differentiation of human omental adipose stromal cells显示文摘 | Bujalska IJ Walker EA Hewison M | 2002 | J Clin Endocrinol Metab2002，87，3： | 1 |
| 6 | Update in vitaminD显示文摘 | AdatnsJS Hewison M | 2010 | J Clin Endocrinol Metab2010，95，3： | 1 |
| 7 | Differentiation of adipose stromal cells:the roles of glucocorticoids and 11beta-hydroxysteroid dehydrogenase显示文摘 | Bujalska IJ Kumar S Hewison M | 1999 | Endocrinology1999，140，7： | 1 |
| 8 | New types of CO-releasing molecules (CO-RMs), based on iron dithiocarbamate complexes and 显示文摘 | Hewison L Crook SH Mann BE | 2012 | Organometallics2012，31，： | 1 |
| 9 | Field evaluation of a simple fluorescence method for detection of viable Mycobacterium tuberculosis in sputum specimens during treatment follow-up显示文摘 | Schramm B Hewison C Bonte L | | 0，，8： | 1 |
| 10 | An update on vitamitl D amJ human immunity 显示文摘 | Hewison M | 2012 | Clin Endocrinol (Oxf)2012，76，3： | 1 |
| 11 | Vitamin D and the immune system: new perspectives on an old theme显示文摘 | Hewison M | 2012 | Rheum Dis Clin North Am2012，38，1： | 1 |
| 12 | The radiometric characterization of AMSU-B 显示文摘 | Saunders R W Hewison T J | 1995 | IEEE Transaction on Microwave Theory and Tech- niques1995，43，4： | 1 |
| 13 | Prenatal screening for Down's syndrome: some psychosocial implications of a 'screening for all' policy显示文摘 | Bryant LD Green JM Hewison J | 2001 | Public Heahh2001，115，5： | 1 |
| 14 | Update in vitamin D显示文摘 | Adams JS Hewison M | | 0，，02： | 1 |
| 15 | Unexpected actions of vitamin D:new perspectives on the regulation of innate and adaptive immunity显示文摘 | Adams JS Hewison M | 2008 | Nat Clin Pract Endocrinol Metab2008，4，2： | 1 |
| 16 | Vitamin D as a cytokine and hematopoetic factor显示文摘 | Hewison M Gacad MA Lemire J | 2001 | Rev Endocr Metab Disord2001，2，2： | 1 |
| 17 | Vitamin D : beyond bone显示文摘 | Christakos S Hewison M Gardner DG | 2013 | Ann N Y Acad Sci2013，1287，1： | 1 |
| 18 | Power of language in a ward for the care of older people显示文摘 | | 1995 | Nursing Times1995，91，21： | 1 |
| 19 | Toll-like receptor triggering of a vitamin D-media- ted human antimicrobial response 显示文摘 | Liu PT Stenger S Li H Wenzel L Tan BH Krutzik SR Ochoa MT Schauber J Wu K Meinken C Kamen DL Wagner M Bals R Steinmeyer A Ztigel U Gallo RL Eis- enberg D Hewison M Hollis BW Adams JS Bloom BR Modlin RL | 2006 | Science2006，311，： | 1 |
| 20 | Vitamin D and immune function:an overview显示文摘 | Hewison M | 2012 | Proc Nut Soc2012，71，： | 1 |
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