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| 1 | Protective links between vitamin D,inflammatory boweldisease and colon cancer显示文摘Vitamin D deficiency has been associated with a wide range of diseases and multiple forms of cancer including breast, colon, and prostate cancers. Relatively recent work has demonstrated vitamin D to be critical in immune function and therefore important in inflammatory diseases such as inflammatory bowel disease(IBD). Because vitamin D deficiency or insufficiency is increasingly prevalent around the world, with an estimated 30%-50% of children and adults at risk for vitamin D deficiency worldwide, it could have a significant impact on IBD. Epidemiologic studies suggest that low serum vitamin D levels are a risk factor for IBD and colon cancer, and vitamin D supplementation is associated with decreased colitis disease activity and/or alleviated symptoms. Patients diagnosed with IBD have a higher incidence of colorectal cancer than the general population, which supports the notion that inflammation plays a key role in cancer development and underscores the importance of understanding how vitamin D influences inflammation and its cancer-promoting effects. In addition to human epidemiological data, studies utilizing mouse models of colitis have shown that vitamin D is beneficial in preventing or ameliorating inflammation and clinical disease. The precise role of vitamin D on colitis is unknown; however, vitamin D regulates immune cell trafficking and differentiation, gut barrier function and antimicrobial peptide synthesis, all of which may be protective from IBD and colon cancer. Here we focus on effects of vitamin D on inflammation and inflammation-associated colon cancer and discuss the potential use of vitamin D for protection and treatment of IBD and colon cancer. | Stacey Meeker Audrey Seamons Lillian Maggio-Price Jisun Paik | 2016 | World Journal of Gastroenterology2016，22，3： | 15 |
| 2 | 树突状细胞在溃疡性结肠炎发病中的价值与途径分析显示文摘树突状细胞(dendritic cells,DC)作为目前发现的功能最强的专职抗原提呈细胞,其功能紊乱是溃疡性结肠炎(Ulcerative Colitis,UC)发病的主要原因,其多可从通过共刺激分子的表达参与Th细胞分化参与Th17/Treg细胞间平衡调节肠黏膜免疫状态,通过分泌细胞因子参与Th1/Th2细胞间平衡调节黏膜免疫状态等多个角度参与溃疡性结肠炎的发病,且通过干预树突状细胞功能可以有效治疗溃疡性结肠炎,提示调控树突状细胞活化和功能可能是有效治疗溃疡性结肠炎的有效策略之一。 | 刘端勇 徐荣 黄敏芳 王馨 邹勇 岳海洋 赵海梅 | 2016 | 世界中西医结合杂志2016，11，4： | 10 |
| 3 | 活性维生素D类似物对炎症性肠病的治疗作用显示文摘1971年DeLuca[1]发现1α,25-二羟维生素D3(1α,25-(OH)2-D3,125D)是维生素D中最具有生理活性的代谢产物之后,立刻引起了医学界及化学界的关注。125D通过与维生素D受体(vitamin D receptor,VDR)特异性结合发挥作用,除了能调节体内钙磷平衡之外,还能促进细胞分化、抑制细胞增生,与人体的免疫系统也密切相关[2]。 | 陈涛 刘懿 | 2015 | 中国临床研究2015，28，6： | 2 |
| 4 | 骨化三醇不同口服方法对63例维持性血液透析患者的临床影响探讨显示文摘目的 探讨口服骨化三醇对维持性血液透析患者的矿物质和骨代谢异常的影响.方法 将我院行维持性血液透析治疗6个月以上,且血清全段甲状旁腺激素(IPTH)水平300 ~ 600 pg/mL63例患者,随机分为空白对照组、每日口服组、骨化三醇冲击治疗组.观察8周,比较骨化三醇治疗前后IPTH、血清钙、钙磷乘积、碱性磷酸酶(ALP)、颈动脉内膜厚度等相关因素的变化情况.结果 F检验结果显示,3组患者ALP、颈动脉内膜厚度和IPTH指标不完全一致(P<0.05,拒绝H0假设,接收H1假设),而血清内钙磷含量差异无统计学意义(P>0.05).LSD法两两比较结果显示,ALP含量指标3组患者差异具有统计学意义,并且骨化三醇冲击治疗组<每日口服组<空白对照组;颈动脉内膜厚度和IPTH指标也具有类似规律.结论 口服骨化三醇对治疗维持性血液透析患者矿物质和骨代谢异常治疗有效,尤其是口服冲击治疗取得满意临床效果. | 沈建松 唐炯 宫壮 贾海萍 | 2014 | 黑龙江医学2014，38，4： | 1 |
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