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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | DEDD regulates degradation of intermediate filaments during apoptosis 显示文摘 | Lee J C Schickling O Stegh A H | 2002 | J Cell Biol2002，158，6： | 1 |
| 3 | The Role of Bcl-2 Family Proteins in Therapy Responses of Malignant Astr- ocytic Gliomas : Bcl2L12 and beyond 显示文摘 | Kouri M Jensen S A Stegh A H | 2012 | Scientific World Journal2012，2012，83： | 1 |
| 4 | Targeting the p53 signaling pathway in cancer therapy the promises, challenges and perils 显示文摘 | Stegh AH | 2012 | Expert Opin TherTargets2012，16，1： | 1 |
| 5 | Bcl2L12- mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma显示文摘 | Stegh AH Kesari S Mahoney JE et 01 | 2008 | Proc Natl Acad Sci USA2008，105，10： | 1 |
| 6 | Incentive Effects in Asym- metric Tournaments-Empirical Evidence from the Ger- man Hockey League 显示文摘 | Petra Nieken Michael Stegh | 2010 | Discussion Paper Bonn2010，，： | 1 |
| 7 | Malignant astrocytic glioma:genetics,biology,and paths to treatment显示文摘 | Furnari FB Fenton T Bachoo RM Mukasa A Stommel JM Stegh A Hahn WC Ligon KL Louis DN Brennan C Chin L DePinho RA Cavenee WK | | 0，，21： | 1 |
| 8 | Targeting the p53 signaling pathway in cancer therapy-the promises,challenges and perils显示文摘 | Stegh AH | | 0，，01： | 1 |
| 9 | Targeting the p53 signaling pathway in cancer therapy - the promises, challenges and perils显示文摘 | Stegh AH | 2012 | Expert Opin Ther Targets2012，16，1： | 1 |
| 10 | Bcl2L12-mediated inhi- bition of effector Caspase-3 and Caspase-7 via distinct mecha- nisms in glioblastoma 显示文摘 | Stegh AH Kesari S Mahoney JE | 2008 | Proc Natl Acad Sci USA2008，105，10： | 1 |
| 11 | Glioma oncoprotein BcI2L12 inhibits the p53 tumor suppressor显示文摘 | Stegh AH Breunan C Maho hey JA | 2010 | Genes Dev2010，124，19： | 1 |
| 12 | Nuclear localization of DEDD leads to caspase-6 activation through its death effector domain and inhibition of RNA polymerase I dependent transcription 显示文摘 | Schickling O Stegh AH Byrd J | 2001 | Cell Death Differ2001，8，： | 1 |
| 13 | Gliomaoncoprotein Bcl2L12 inhibits the p53 tumor suppressor显示文摘 | Stegh AH Brennan C Mahoney JA | 2010 | Genes Dev2010，24，19： | 1 |
| 14 | DEDD regulates degradation of intermediate filaments during apoptosis 显示文摘 | Lee JC Schickling O Stegh AH | 2002 | J Cell Biol2002，158，： | 1 |
| 15 | Targeting the p53 signaling pathway in cancer therapy the promises, challenges and perils 显示文摘 | Stegh AH | 2012 | Expert Opin Ther Targets2012，16，1： | 1 |
| 16 | Targeting the p53 signaling pathway in cancer therapy-the promises,challenges and perils显示文摘 | Stegh A H | | 0，，01： | 1 |
| 17 | Targeting the p53 signaling pathway in cancer therapy - the promises, challenges and perils 显示文摘 | Stegh AH | 2012 | Expert Opin Ther Targets2012，16，1： | 1 |
| 18 | DEDD regulates degradation of intermediate filaments during apoptosis 显示文摘 | Lee JC Schickling O Stegh AH | 2002 | J Cell Biol2002，158，6： | 1 |
| 19 | Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma显示文摘 | Stegh AH Kesari S Mahoney JE | 2008 | Proc Natl Acad Sci USA2008，105，10： | 1 |
| 20 | Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma显示文摘 | STEGH A H KESARI S MAHONEY J E | 2008 | Proc Natl Acad Sci USA2008，105，10： | 1 |
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