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| 1 | Therapeutic targeting of epidermal growth factor receptor in human cancer: successes and limitations显示文摘Epidermal growth fac tor receptor (EGFR) is one of the most commonly altered genes in human cancer by way of over-expression, amplification, and mutation. Targeted inhibition of EGFR activity suppresses signal transduction pathways which control tumor cell growth, proliferation, and resistance to apoptosis. Small molecule tyrosine kinase inhibitors and monoclonal antibodies are among the most common EGFR-targeting agents and have been used clinically for treating various malignancies. This review discusses the successes and challenges of targeting EGFR in human cancer. The genetic alterations of EGFR tend to occur more often in some solid tumors than others, as do the mechanisms of resistance to targeted inhibition. The clinical and basic science experiences with these agents thus far have important implications for the future of therapeutic targeting of EGFR. | Jill Wykosky Tim Fenton Frank Furnari Webster K. Cavenee | 2011 | Chinese Journal of Cancer2011，30，1： | 24 |
| 2 | Esophageal testing: What we have so far显示文摘Gastroesophageal reflux disease(GERD) is a common disorder of the gastrointestinal tract. In the last few decades, new technologies have evolved and have been applied to the functional study of the esophagus, allowing for the improvement of our knowledge of the pathophysiology of GERD. High-resolution manometry(HRM) permits greater understanding of the function of the esophagogastric junction and the risks associated with hiatal hernia. Moreover, HRM has been found to be more reproducible and sensitive than conventional water-perfused manometry to detect the presence of transient lower esophageal sphincter relaxation. Esophageal 24-h p H-metry with or without combined impedance is usually performed in patients with negative endoscopy and reflux symptoms who have a poor response to anti-reflux medical therapy to assess esophageal acid exposure and symptom-reflux correlations. In particular, esophageal 24-h impedance and p H monitoring can detect acid and non-acid reflux events. Endo FLIP is a recent technique poorly applied in clinical practice, although it provides a large amount of information about the esophagogastric junction. In the coming years, laryngopharyngeal symptoms could be evaluated with up and coming non-invasive or minimally invasive techniques, such as pepsin detection in saliva or pharyngeal p H-metry. Future studies are required of these techniques to evaluate their diagnostic accuracy and usefulness, although the available data are promising. | Nicola de Bortoli Irene Martinucci Lorenzo Bertani Salvatore Russo Riccardo Franchi Manuele Furnari Salvatore Tolone Giorgia Bodini Valeria Bolognesi Massimo Bellini Vincenzo Savarino Santino Marchi Edoardo Vincenzo Savarino | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，1： | 8 |
| 3 | Pre-operative clinical and instrumental factors as antireflux surgery outcome predictors显示文摘Gastroesophageal reflux disease(GERD) is nowadays a highly prevalent, chronic condition, with 10% to 30% of Western populations affected by weekly symptoms. Many patients with mild reflux symptoms are treated adequately with lifestyle modifications, dietary changes, and low-dose proton pump inhibitors(PPIs). For those with refractory GERD poorly controlled with daily PPIs, numerous treatment options exist. Fundoplication is currently the most commonly performed antireflux operation for management of GERD. Outcomes described in current literature following laparoscopic fundoplication indicate that it is highly effective for treatment of GERD; early clinical studies demonstrate relief of symptoms in approximately 85%-90% of patients. However it is still unclear which factors, clinical or instrumental, are able to predict a good outcome after surgery. Virtually all demographic, esophagogastric junction anatomic conditions, as well as instrumental(such as presence of esophagitis at endoscopy, or motility patterns determined by esophageal high resolution manometry or reflux patterns determined by means of pH /impedance-pH monitoring) and clinical features(such as typical or atypical symptoms presence) of patients undergoing laparoscopic fundoplication for GERD can be factors associated with symptomatic relief. With this in mind, we sought to review studies that identified the factors that predict outcome after laparoscopic total fundoplication. | Salvatore Tolone Giorgia Gualtieri Edoardo Savarino Marzio Frazzoni Nicola de Bortoli Manuele Furnari Giuseppina Casalino Simona Parisi Vincenzo Savarino Ludovico Docimo | 2016 | World Journal of Gastrointestinal Surgery2016，8，11： | 3 |
| 4 | Genetics and malignant progression of human brain tumours显示文摘 | Furnari F B Huang H J Cavenee W K | 1995 | Cancer Surv1995，25，： | 1 |
| 5 | Replacement of the p16/CDKNN2 gene suppresses human glioma cell growth 显示文摘 | Arap W Nishikawa R Furnari FB | 1995 | Cancer Res1995，55，6： | 1 |
| 6 | Demonstration of developmental anomalies in mouse fetuses by transfer of murine cytomegalovirus DNA injected eggs to surrogate mothers显示文摘 | BASKAR J F FURNARI B HUANG E S | 1993 | J Infect Dis1993，167，6： | 1 |
| 7 | PHLPP: a phosphataset hat directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth 显示文摘 | GAO T FURNARI F NEWTON A C | 2005 | Mol Cell2005，18，1： | 1 |
| 8 | Continuous insulin infusion reduces mortality in patients with diabetes undergoing coronary artery bypass grafting 显示文摘 | Furnary AP Gao G Grunkemeier GL | 2003 | J Thorae Cardiovase Surg2003，125，5： | 1 |
| 9 | Malignant glioma: genetics and biology of a grave matter显示文摘 | Maher EA Furnari FB Bachoo RM | 2001 | Genes Dev2001，15，11： | 1 |
| 10 | Continuous insulin infusion reduces mortality in patients with diabetes undergoing coronary artery bypass grafting显示文摘 | Furnary Anthony P MD Gao Guangqiang MD | 2003 | Journal of Thoracic & Cardiovascular Surgery2003，125，5： | 1 |
| 11 | Malignant glioma:genetics and biology of a grave matter显示文摘 | Maher EA Furnari FB Bachoo RM | 2001 | Genes Dev2001，15，11： | 1 |
| 12 | Malignant astrocytic glioma:genetics,biology,and paths to treatment显示文摘 | Furnari FB Fenton T Bachoo RM | | 0，，21： | 1 |
| 13 | Optimal management of constipation associated with irritable bowel syndrome显示文摘 | Furnari M de Bortoli N Martinueci I | 2015 | Ther Clin Risk Manag2015，11，： | 1 |
| 14 | Application of robot- ic-assisted techniques to the surgical evaluation and treat- ment of the anterior mediastinum 显示文摘 | Savitt MA Gao G Furnary AP | 2005 | Ann Thorac Surg2005，79，2： | 1 |
| 15 | Replacement of the p 16/CDKN2 gene suppresses human glioma cell growh 显示文摘 | ARAP W NISHKAWA R FURNARI F B | 1995 | Cancer Res1995，55，6： | 1 |
| 16 | Growth suppression of glioma cells by PTEN requires a functiona;phosphatase catalytic domain显示文摘 | Furnari FB Lin H Huang HS | 1997 | Proc Natl Acad Sci USA1997，94，12： | 1 |
| 17 | Effects of outcome on in-hospital transition from intravenous insulin infusion to subcutaneous therapy显示文摘 | Anthony P Furnary M D | 2006 | Am J Cardiol2006，98，4： | 1 |
| 18 | Loss of P16INK4expressio is frequent in high grade gliomas显示文摘 | Nishikawa R Furnari FB Lin H | 1995 | Cancer Res1995，5，9： | 1 |
| 19 | PHLPP: a phosphatase that directly dephosphorylates akt, promotes apoptosis, and suppresses tumor growth显示文摘 | Gao T Furnari F Newton AC | 2005 | Mol Cell2005，18，1： | 1 |
| 20 | Continuous intravenous insulin infusion reduces the incidence of deep sternal wound infection in diabetic patients after cardiac surgical procedures显示文摘 | Furnary AP Zerr KJ Grunkemeier GL | 1999 | Ann Thorac Surg1999，67，2： | 1 |
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