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| 1 | Diagnostic yield of EUS-FNA of small(≤15 mm) solid pancreatic lesions using a 25-gauge needle显示文摘Background: Early detection of small solid pancreatic lesions is increasingly common. To date, few and contradictory data have been published about the relationship between lesion size and endoscopic ultrasound-guided fine needle aspiration(EUS-FNA) diagnostic yield. The aim of this study was to assess the relation between the size of solid pancreatic lesions and the diagnostic yield of EUS-FNA using a 25-gauge needle in a center without available rapid on-site evaluation.Methods: In the retrospective cohort study, we selected patients who underwent EUS-FNA for solid pancreatic lesions with a 25-gauge needle from October 2014 to October 2015. Patients were divided into three groups(≤15 mm, 16–25 mm and >25 mm), and the outcomes were compared.Results: We analyzed 163 patients. Overall adequacy, sensitivity, specificity and accuracy were 85.2%,81.8%, 93.7%, and 80.4%, respectively. When stratified by size, the sensitivity and accuracy correlated with size(P = 0.016 and P = 0.042, respectively). Multivariate analysis showed that lesion size was the only independent factor(P = 0.019, OR = 4.76) affecting accuracy. The role of size as an independent factor affecting accuracy was confirmed in a separate multivariate analysis, where size was included in the model as a covariate(P = 0.018, OR = 1.08).Conclusion: Our study demonstrates that, in the absence of rapid on-site evaluation, mass size affects the accuracy of EUS-FNA of solid pancreatic lesions. | Stefano Francesco Crinò Maria Cristina Conti Bellocchi Laura Bernardoni Erminia Manfrin Alice Parisi Antonio Amodio Nicolò De Pretis Luca Frulloni Armando Gabbrielli | 2018 | Hepatobiliary & Pancreatic Diseases International2018，17，1： | 4 |
| 2 | Endoscopic ultrasound diagnostic gain over computed tomography and magnetic resonance cholang-iopancreatography in defining etiology of idiopathic acute pancreatitis显示文摘BACKGROUND About 10%-30%of acute pancreatitis remain idiopathic(IAP)even after clinical and imaging tests,including abdominal ultrasound(US),contrast-enhanced computed tomography(CECT)and magnetic resonance cholangiopancreatography(MRCP).This is a relevant issue,as up to 20%of patients with IAP have recurrent episodes and 26%of them develop chronic pancreatitis.Few data are available on the role of EUS in clarifying the etiology of IAP after failure of one or more cross-sectional techniques.AIM To evaluate the diagnostic gain after failure of one or more previous crosssectional exams.METHODS We retrospectively collected data about consecutive patients with AP and at least one negative test between US,CECT and MRCP,who underwent linear EUS between January 2017 and December 2020.We investigated the EUS diagnostic yield and the EUS diagnostic gain over different combinations of these crosssectional imaging techniques for the etiologic diagnosis of AP.Types and frequency of EUS diagnosis were also analyzed,and EUS diagnosis was compared with the clinical parameters.After EUS,patients were followed-up for a median of 31.5 mo to detect cases of pancreatitis recurrence.RESULTS We enrolled 81 patients(63%males,mean age 61±18,23%with previous cholecystectomy,17%with recurrent pancreatitis).Overall EUS diagnostic yield for AP etiological diagnosis was 79%(20%lithiasis,31%acute on chronic pancreatitis,14%pancreatic solid or cystic lesions,5%pancreas divisum,5%autoimmune pancreatitis,5%ductal abnormalities),while 21%remained idiopathic.US,CECT and MRCP,taken alone or in combination,led to AP etiological diagnosis in 16(20%)patients;among the remaining 65 patients,49(75%)obtained a diagnosis at EUS,with an overall EUS diagnostic gain of 61%.Sixty-eight patients had negative US;among them,EUS allowed etiological diagnosis in 59(87%).Sixty-three patients had a negative CECT;among them,47(74%)obtained diagnosis with EUS.Twenty-four had a negative MRCP;among them,20(83%)had EUS diagnosis.Twenty-one had negative CT+MRCP,of which 17(81%)had EUS diagnosis,with a EUS diagnostic gain of 63%.Patients with biliary etiology and without previous cholecystectomy had higher median values of alanine aminotransferase(154 vs 25,P=0.010),aspartate aminotransferase(95 vs 29,P=0.018),direct bilirubin(1.2 vs 0.6,P=0.015),gammaglutamyl transpeptidase(180 vs 48,P=0.006)and alkaline phosphatase(150 vs 72,P=0.015)Chronic pancreatitis diagnosis was more frequent in patients with recurrent pancreatitis at baseline(82%vs 21%,P<0.001).During the follow-up,AP recurred in 3 patients,one of which remained idiopathic.CONCLUSION EUS is a good test to define AP etiology.It showed a 63%diagnostic gain over CECT+MRCP.In suitable patients,EUS should always be performed in cases of IAP.Further prospective studies are needed. | Stefano Mazza Biagio Elvo Clara Benedetta Conti Andrea Drago Maria Chiara Verga Sara Soro Annalisa De Silvestri Fabrizio Cereatti Roberto Grassia | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，6： | 3 |
| 3 | Comorbidity, Hospitalization, and Mortality in COPD: Results from a Longitudinal Study显示文摘 | Claudio Terzano Vittoria Conti Fabio Di Stefano Angelo Petroianni Daniela Ceccarelli Elda Graziani Salvatore Mariotta Alberto Ricci Antonio Vitarelli Giovanni Puglisi Corrado De Vito Paolo Villari Luigi Allegra | 2010 | Lung2010，，4： | 2 |
| 4 | Cooling performance of earth-to-air heat exchangers applied to a poultry barn in semi-desert areas of south Iraq显示文摘Earth-to-air heat exchangers(EAHE)can reduce the energy consumption required for heating and cooling of buildings.The composition and the thermal characteristics of the soil influence the heat exchange capacity,and the soil moisture can furthermore affect thermal performance of EAHE.The aim of this study was to compare the thermal performance of EAHE in dry and artificially wetted soil.Tests were carried out in the Basra Province(Iraq),in a semi-desert area.Two experimental EAHE were built in a poultry barn and tested from June 2013 to September 2013.The pipe exchangers were buried at 2 m deep.One heat exchanger operated in dry soil(DE),while the other one operated in artificially wetted soil(WE).In the WE system,a drip tubing placed 10 cm above the air pipe wetted the soil around the exchanger.Air temperatures at the inlet and at the outlet of both the exchangers as well as soil temperature at 2 m deep were continuously monitored.The experimental results confirmed that wetting the soil around EAHE improves the general heat exchange efficiency.The coefficient of cooling performance(COP)of the earth-to-air heat exchangers system was evaluated on the basis of the ratio between the heat removed from the air or added to the air and the energy input.During the day,with an average COP of 6.41,the WE system cooled the air more than the DE system,which reported a value of 5.07.On average,in the hottest hours of the day,the outlet temperature of the WE was 37.35℃ while in the DE it was 38.91℃.Moreover,during the nighttime,the WE system warmed the air more than the DE system. | Wasseem Morshed Lorenzo Leso Leonardo Conti Giuseppe Rossi Stefano Simonini Matteo Barbari | 2018 | International Journal of Agricultural and Biological Engineering2018，11，3： | 2 |
| 5 | Risk of gastrointestinal events with sorafenib, sunitinib and pazopanib in patients with solid tumors: A systematic review and meta‐analysis of clinical trials显示文摘 | Matteo Santoni Alessandro Conti Ugo De Giorgi Roberto Iacovelli Francesco Pantano Luciano Burattini Giovanni Muzzonigro Rossana Berardi Daniele Santini Stefano Cascinu | 2014 | Int. J. Cancer2014，，： | 2 |
| 6 | CXC and CC Chemokines as Angiogenic Modulators in Nonhaematological Tumors显示文摘 | Matteo Santoni Sergio Bracarda Massimo Nabissi Francesco Massari Alessandro Conti Emilio Bria Giampaolo Tortora Giorgio Santoni Stefano Cascinu Yi-Fang Ping | 2014 | BioMed Research International2014，，： | 1 |
| 7 | Mixed acidbase disorders,hydroelectrolyte imbalance and lactate production in hypercapnic respiratory failure:the role of noninvasive ventilation显示文摘 | Terzano C Di Stefano F Conti V | 2012 | PLoS One2012，7，35： | 1 |
| 8 | Comorbidity, hospitalization and mortality in COPD: results from a longitudinal study 显示文摘 | Terzano C Conti V Di Stefano F | 2010 | Lung2010，188，4： | 1 |
| 9 | Gastric per-oral endoscopic myotomy:Indications,technique,results and comparison with surgical approach显示文摘Gastroparesis is a chronic disease of the stomach that causes a delayed gastric emptying,without the presence of a stenosis.For 30 years the authors identified pylorospasm as one of the most important pathophysiological mechanisms determining gastroparesis.Studies with EndoFLIP,a device that assesses pyloric distensibility,increased the knowledge about pylorospasm.Based on this data,several pyloric-targeted therapies were developed to treat refractory gastroparesis:Surgical pyloroplasty and endoscopic approach,such as pyloric injection of botulinum and pyloric stenting.Notwithstanding,the success of most of these techniques is still not complete.In 2013,the first human gastric per-oral endoscopic myotomy(GPOEM)was performed.It was inspired by the POEM technique,with a similar dissection method,that allows pyloromyotomy.Therapeutical results of GPOEM are similar to surgical approach in term of clinical success,adverse events and post-surgical pain.In the last 8 years GPOEM has gained the attention of the scientific community,as a minimally invasive technique with high rate of clinical success,quickly prevailing as a promising therapy for gastroparesis.Not surprisingly,in referral centers,its technical success rate is 100%.One of the main goals of recent studies is to identify those patients that will respond better to the therapies targeted on pylorus and to choose the better approach for each patient. | Maria Chiara Verga Stefano Mazza Francesco Azzolini Fabrizio Cereatti Clara Benedetta Conti Andrea Drago Sara Soro Biagio Elvo Roberto Grassia | 2022 | World Journal of Gastrointestinal Surgery2022，14，1： | 1 |
| 10 | Usefulness of Bedside Testing for Brain Natriuretic Peptide to Identify Right Ventricular Dysfunction and Outcome in Normotensive Patients With Acute Pulmonary Embolism显示文摘 | Filippo Pieralli Iacopo Olivotto Simone Vanni Alberto Conti Alberto Camaiti Giacomo Targioni Stefano Grifoni Giancarlo Berni | 2006 | The American Journal of Cardiology2006，，9： | 1 |
| 11 | Comorbidity,hospitalization,and mortality in COPD:results from a longitudinal study显示文摘 | Terzano C Conti V Di Stefano F | 2010 | Lung2010，188，： | 1 |
| 12 | Treatment‐related fatigue with sorafenib, sunitinib and pazopanib in patients with advanced solid tumors: An up‐to‐date review and meta‐analysis of clinical trials显示文摘 | Matteo Santoni Alessandro Conti Francesco Massari Giorgio Arnaldi Roberto Iacovelli Mimma Rizzo Ugo Giorgi Laura Trementino Giuseppe Procopio Giampaolo Tortora Stefano Cascinu | 2015 | Int. J. Cancer2015，，： | 1 |
| 13 | Comorbidity,hospitalization,and mortality in COPD:results from a longitudinal study显示文摘 | Terzano C Conti V Stefano F | 2010 | Lung2010，188，4： | 1 |
| 14 | Toll like receptors and pancreatic diseases: From a pathogenetic mechanism to a therapeutic target显示文摘 | Matteo Santoni Kalliopi Andrikou Valeria Sotte Alessandro Bittoni Andrea Lanese Chiara Pellei Francesco Piva Alessandro Conti Massimo Nabissi Giorgio Santoni Stefano Cascinu | 2015 | Cancer Treatment Reviews2015，，7： | 1 |
| 15 | Larvicidal and ovideterrent properties of neem oil and fractions against the filariasis vector Aedes albopictus (Diptera: Culicidae): a bioactivity survey across production sites显示文摘 | Giovanni Benelli Stefano Bedini Francesca Cosci Chiara Toniolo Barbara Conti Marcello Nicoletti | 2015 | Parasitology Research2015，，1： | 1 |
| 16 | Air pollution ultrafine particles: toxicity beyond the lung显示文摘 | Terzano C Di Stefano F Conti V | 2010 | Eur Rev Med Pharmacol Sci2010，14，10： | 1 |
| 17 | Short-Term Clinical Outcome of Patients With Acute Pulmonary Embolism, Normal Blood Pressure, and Echocardiographic Right Ventricular Dysfunction显示文摘 | Stefano Grifoni Iacopo Olivotto Paolo Cecchini Filippo Pieralli Alberto Camaiti Gennaro Santoro Alberto Conti Giancarlo Agnelli Giancarlo Berni | 2000 | Circulation: Journal of the American Heart Association2000，，24： | 1 |
| 18 | Mixed acid-base disor- ders, hydroelectrolyte imbalance and lactate production in hyper- capnic respiratory failure: the role of noninvasive ventilation显示文摘 | Terzano C Di Stefano F Conti V | 2012 | PLoS One2012，7，35： | 1 |
| 19 | Noninvasive versus conventional ventilation to treat hypercapnic encephalopathy in chronic obstructive pulmonary disease显示文摘 | Raffaele Scala Stefano Nava Giorgio Conti Massimo Antonelli Mario Naldi Ivano Archinucci Giovanni Coniglio Nicholas S. Hill | 2007 | Intensive Care Medicine2007，，12： | 1 |
| 20 | A multidisciplinary approach in recognizing seep-carbonates:A case study from the Loiano Formation(late Eocene)in the northern Apennines(Italy)显示文摘Carbonate deposits related to active seeps are documented along most continental margins and are characterized by peculiar seep-related facies and by chemical(isotope signature),paleontological and mineralogical markers.Their fossil analogues are recognized all over the world by the same features and occurred since the beginning of Phanerozoic.In this paper,we present a new seep outcrop(Castagneto village,Reggio Emilia,northern Italy)belonging to the late Eocene Loiano Formation which,to our knowledge,is in Italy the most ancient seep deposit with not-reworked chemosymbiotic fauna.The outcrop can be roughly divided into two portions,a northern part showing abundant presence of macrofossils in silty carbonate matrix and subhorizontal subdivisions,and a southern part,where macrofossils are almost absent,characterized by sub-vertical internal subdivisions and a clear vertical structure consisting of the rhythmic alternation of light and dark mineralization.Detailed analysis of samples from the southern portion showed the occurrence of authigenic calcite and pyrite,the latter with a peculiar framboidal texture.This feature,together with the occurrence of chemosymbiotic species and~(13)C isotope depletion,suggests possible hydrocarbon-rich fluid-related genesis and provides useful criteria for identifying hydrocarbon-rich fluid-related deposits in geologic units. | Stefano CONTI Filippo PANINI Pietro PATTERI Riccardo RONDELLI Daniele MALFERRARI | 2023 | Science China Earth Sciences2023，66，11： | 0 |
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