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| 1 | Evaluation of latent links between irritable bowel syndrome and sleep quality显示文摘AIM:To examine the links between quality of sleep and the severity of intestinal symptoms in irritable bow-el syndrome(IBS).METHODS:One hundred and forty-two outpatients(110female,32 male)who met the Rome Ⅲ criteria for IBS with no psychiatric comorbidity were consecutively en-rolled in this study.Data on age,body mass index(BMI),and a set of life-habit variables were recorded,and IBS symptoms and sleep quality were evaluated using the questionnaires IBS Symptom Severity Score(IBS-SSS)and Pittsburgh Sleep Quality Index(PSQI).The associa-tion between severity of IBS and sleep disturbances was evaluated by comparing the global IBS-SSS and PSQI score(Pearson's correlation and Fisher's exact test)and then analyzing the individual items of the IBS-SSS and PSQI questionnaires by a unitary bowel-sleep model based on item response theory(IRT).RESULTS:IBS-SSS ranged from mild to severe(120-470).The global PSQI score ranged from 1 to 17(median 5),and 60 patients were found to be poor sleepers(PSQI>5).The correlation between the global IBS-SSS and PSQI score indicated a weak association(r=0.2 and 95% CI:-0.03 to 0.35,P<0.05),which becomes stronger using our unitary model.Indeed,the IBS and sleep disturbances severities,estimated as latent variables,resulted significantly high intra-subject cor-relation(posterior mean of r=0.45 and 95% CI:0.17 to 0.70,P<0.05).Moreover,the correlations between patient features(age,sex,BMI,daily coffee and alcohol intake)and IBS and sleep disturbances were also ana-lyzed through our unitary model.Age was a signif icant regressor,with patients≤50 years old showing more severe bowel disturbances(posterior mean=-0.38,P<0.05)and less severe sleep disturbances(posterior mean=0.49,P<0.05)than older patients.Higher daily coffee intake was correlated with a lower sever-ity of bowel disturbances(posterior mean=-0.31,P<0.05).Sex(female)and daily alcohol intake(modest)were correlated with less severe sleep disturbances.CONCLUSION:The unitary bowel-sleep model based on IRT revealed a strong positive correlation between the severity of IBS symptoms and sleep disturbances. | Massimo Bellini Angelo Gemignani Dario Gambaccini Simona Toti Danilo Menicucci Cristina Stasi Francesco Costa Maria Gloria Mumolo Angelo Ricchiuti Remo Bedini Nicola de Bortoli Santino Marchi | 2011 | World Journal of Gastroenterology2011，17，46： | 17 |
| 2 | Analysis of promoter regions regulating basal and interleukin-4-inducible expression of the human CB1 receptor gene in T lymphocytes 显示文摘 | Borner C Bedini A Holh V | 2008 | Mol Pharmacol2008，73，3： | 1 |
| 3 | Effects of long-term land use on arbuseular mycorrhizal fungi and glomalin related soil protein 显示文摘 | Bedini S Avio L Argese E | 2007 | Agriculture Ecosystems & Environment2007，120，24： | 1 |
| 4 | Uric acid concentration in subjects at risk of type 2 diabetes mellitus : relationship to components of the metabolic syndrome显示文摘 | Costa A Iguala I Bedini J | 2002 | Metabolism2002，51，3： | 1 |
| 5 | Uric acid concentration in subjects at risk of type 2 diabetes mellitus: Relationship to components of the metabolic syndrome显示文摘 | A. Costa I. Igual J. Bedini L. Quint I. Conget | 2002 | Metabolism2002，，3： | 1 |
| 6 | Women with physical disabilities and the negotiation of leisure con straints显示文摘 | HENDERSON K A BEDINI L A HCCHT L | 1995 | Leisure Stud1995，14，1： | 1 |
| 7 | Molecular characterization and glomalin production of arbuscular mycorrhizal fungi colo nizing a heavy metal polluted ash disposal island, downtown Venice 显示文摘 | Bedini S Turrini A Rigo C | 2010 | Soil Biology & Biochemistry2010，42，5： | 1 |
| 8 | CELIAS - Charge, Element and Isotope Analysis System for SOHO显示文摘 | D. Hovestadt M. Hilchenbach A. Bürgi B. Klecker P. Laeverenz M. Scholer H. Grünwaldt W. I. Axford S. Livi E. Marsch B. Wilken H. P. Winterhoff F. M. Ipavich P. Bedini M. A. Coplan A. B. Galvin G. Gloeckler P. Bochsler H. Balsiger J. Fischer J. Geiss R. Ka | 1995 | Solar Physics (-)1995，，1： | 1 |
| 9 | Effects of cryopreservationwith a newly-developed magnetic field programmed freezer on periodontalligament cells and pulp tis su e s 显示文摘 | A bedini S Kaku M Kawata T | | C ry o b io lo g y0，62，3： | 1 |
| 10 | Effects of globulin therapy in severely epilepsia children显示文摘 | Bedini R | | 0，，： | 1 |
| 11 | Adhesion to hyphal matrix and antifungal activity of Pseudomonas strains isolated from Tuber borchii ascocarps显示文摘 | Sbrana C Bagnoli G Bedini S | | 0，，： | 1 |
| 12 | High bilirubinlevels interfere with serum tartrate-resistant acid phosphatase determination: relevance as a marker of bone resorption in jaundiced patients 显示文摘 | Alvarez L Peris P Bedini JL | 1999 | Calcif Tissue Int1999，64，： | 1 |
| 13 | Mediation analysis of leis- ure,perceived stress, and quality of life in informal caregivers 显示文摘 | Bedini LA Gladwell NJ Dudley WN | 2011 | J Leisure Res2011，43，2： | 1 |
| 14 | Flexural properties of endodontic posts and human root dentin显示文摘 | Plotino G Grande NM Bedini R | 2007 | Dent Mater2007，23，9： | 1 |
| 15 | Uric acid concentration in subjects at risk of type 2 diabetes mellitus relationship to components of the metabolie syndrome显示文摘 | Costa A Igualal L Bedini J | 2002 | Metabolism2002，51，3： | 1 |
| 16 | Towards the optimization of a parallel streaming engine for telco applications显示文摘 | Theeten B Bedini I Cogan P | 2014 | Bell Labs Technical Journal2014，18，4： | 1 |
| 17 | Platinum-group elements and melt percolation processes in Sidamo spinel peridotite xenoliths, Ethiopia, East African Rift显示文摘 | Lorand J Reisberg L Bedini R M | 2003 | Chemical Geology2003，196，1： | 1 |
| 18 | A GNC algorithm forcon- strained image reconstruction with continuons-value line pro- cess显示文摘 | L Bedini I Gerace A Tonazzini | 1994 | Pattern Recognition Letters1994，15，9： | 1 |
| 19 | Epidemiology of candidemia and antifungat susceptibility patients in an Italian tertiary-care hospital显示文摘 | Bedini A Venturelli C Mussini C | 2006 | Clin Microbiol Infect2006，12，1： | 1 |
| 20 | Young age is not an ominous prognostic factor in breast cancer patients 显示文摘 | Muscolino G Villani C Bedini AV | 1987 | Tumori1987，73，3： | 1 |
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