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| 1 | ALDH2 protects against stroke by clearing 4-HNE显示文摘(ALDH2 ) 醛脱氢酶 2 是使象 4-hydroxy-2-nonenal (4-HNE ) 那样的乙醇和有毒的醛产生代射变化的 mitochondrial 酶。用不偏的 proteomic 搜索,我们作为与自发地高血压的老鼠(SHR ) 相比在击容易的自发地高血压的老鼠(SHR-SP ) 识别了 ALDH2 缺乏。我们作为 overexpression 在 neuronal 损害结束了 ALDH2 缺乏的原因的角色或 ALDH2 的激活由清除 4-HNE 在授与 neuroprotection 在 vitro 研究。进一步, ALDH2 击倒的老鼠揭示了 PKCε 的 neuroprotective 效果的缺席;。被知道对击施加保护的中等乙醇管理被显示提高 4-HNE 的 detoxification,并且免于 ischemic 通过 PKCε 的服的损害; -ALDH2 小径。在 SHR-SP,浆液 4-HNE 水平固执地与 lifespan 相反地被提高并且相关。在在人的击的 4-HNE 的角色被它的血浆层次的坚持的举起也在击以后建议至少 6 个月。最后,我们观察到发展了的跟随 8 年的 1 242 个题目中的 21 个比没得中风的那些摸有的更高起始的血浆 4-HNE 层次。这些调查结果建议 ALDH2 小径的激活可以在击容易的题目的鉴定用作一个有用索引,并且 ALDH2 小径可以是在击的治疗学的干预的一个潜在的目标。 | Jin-Min Guo Ai-Jun Liu Pu Zang Wen-Zhe Dong Li Ying Wei W ang Pu Xu Xu-Rui Song Jun Cai She-Qing Zhang Jun-Li Duan Jawahar L Mehta Ding-Feng Su | 2013 | Cell Research2013，23，7： | 19 |
| 2 | Efficacy of small-volume simethicone given at least 30 min before gastroscopy显示文摘AIM To evaluate the efficacy of 5 m L simethicone solution in decreasing gastric foam if given at least 30 min before gastroscopy.METHODS This was a randomized, placebo controlled, endoscopist blinded study performed at Changi General Hospital. Patients were at least 21 years old, had no prior sur-gical resection of the upper gastrointestinal tract, and scheduled for elective diagnostic gastroscopies. The primary outcome was the total mucosal visibility score(TMVS) which was evaluated using Mc Nally score. The sample size was calculated to be 24 per group(SD 2.4, 80% power, P < 0.05, 2-sample t test). RESULTS Fifty-four patients were randomised to receive either simethicone [1 m L liquid simethicone(100 mg) in 5 m L of water] or placebo(5 m L of water) at least 30 min before their gastroscopy. Six accredited consultants conductedthe gastroscopy, and the interobserver agreement of scoring TMVS was good with a Kappa statistic of 0.73. The simethicone group had significantly better mean TMVS compared to placebo(5.78 ± SD 1.65 vs 8.89 ± SD 1.97, P < 0.001). The improvement was statistically significant for the duodenum and the gastric antrum, angularis, body, and fundus. Percent 51.9 of patients in the simethicone group had a TMVS of 4(no bubbles at all) to 5(only 1 area with minimal bubbles), while in the placebo group 3.7% of patients had TMVS of 4 or 5. The number needed to treat was 2.1 to avoid a TMVS of 6 and more. The simethicone group also had a significantly shorter procedure time with less volume of additional flushes required during gastroscopy to clear away obscuring gastric foam.CONCLUSION With a premedication time of at least 30 min, 5 m L simethicone can significantly decrease gastric foam, decrease the volume of additional flushes, and shorten gastroscopy time. | Mingjun Song Andrew Boon Eu Kwek Ngai Moh Law Jeannie Peng Lan Ong Jessica Yi-Lyn Tan Prem Harichander Thurairajah Daphne Shih Wen Ang Tiing Leong Ang | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，4： | 10 |
| 3 | Effect of ZrO_2 Content on the Properties of Diamond Grinding Wheel Vitrified Bond显示文摘The effect of ZrO2 content on the performance of vitrified bond was discussed. The results showed that when the ZrO2 content was less than 2 mol%, Zr4+ could enter into the glassy network as mending nets and agglomeration composition. In this case, with the increasing of ZrO2, the vitrified bond's bending strength increased and the expansion coefficient decreased. It was also found that the wetting angle between the vitrified bond and diamond got small because Zr4+ was enriched on diamond surface. When ZrO2 content was more than 2 mol%, a part of ZrO2 existing in vitrified bond as ZrO2 particles played the role in nucleating agents and promoting the separation of spodumene. When ZrO2 content was 3 mol%, the bending strength of the vitrified bond reached its maximum of 128 MPa and the wetting angle with the diamond reached its minimum of 37.6°. | 刘小磐 QIAO Ang WAN Long HU Weida SONG Dongdong LI Zheng YIN Zhongjie 潘瑞琨 | 2014 | Journal of Wuhan University of Technology(Materials Science)2014，29，1： | 7 |
| 4 | Second and third line treatment options for Helicobacter pylori eradication显示文摘Helicobacter pylori is a highly successful bacterium with a high global prevalence and the infection carries significant disease burden. It is also becoming increasingly difficult to eradicate and the main reason for this is growing primary antibiotic resistance rates in a world where antibiotics are frequently prescribed and readily available. Despite knowing much more about the bacterium since its discovery, such as its genomic makeup and pathogenesis, we have seen declining treatment success. Therefore, clinicians today must be prepared to face one, two or even multiple treatment failures, and should be equipped with sufficient knowledge to decide on the appropriate salvage therapy when this happens. This article discusses the factors contributing to treatment failure and reviews the second and thirdline treatment strategies that have been investigated. Established empiric second line treatment options include both bismuth based quadruple therapy and levofloxacin based triple therapy. Antibiotic testing is recommended prior to initiating third line treatment. In the event that antibiotic susceptibility testing is unavailable, third line treatment options include rifabutin, rifaximin and sitafloxacin based therapies. | Mingjun Song Tiing Leong Ang | 2014 | World Journal of Gastroenterology2014，20，6： | 7 |
| 5 | Study of Failure Diagnostic Methods and Intelligent Diagnostic System for Reciprocating Compressors显示文摘Three categories of failure diagnostic methods for reciprocating compressors are classified according to the signals adopted by the diagnosis. They are parameter method, vibration method, and oil analysis method. In this paper, the applicable range and operational difficulties of these methods are discussed on the basis of analysis and induction upon normal failure. It is proposed that a compressor’s normal failure can be divided into thermodynamical property failure and mechanical function failure. As to the former, the parameter method that takes a cylinder pressure signal as the main diagnostic signal may be applied; and as to the latter, the vibration signal frequency spectrum can be used to diagnose. At the same time, the structure of an intelligent diagnostic system based on neural networks is introduced, and its schematic is given. | LIU Wei hua, ANG Hai song Nanjing University of Aeronautics and Astronautics, Nanjing 210016, P.R.China | 2002 | International Journal of Plant Engineering and Management2002，7，3： | 5 |
| 6 | Pump scheme optimization of an incoherently pumped high-power random fiber laser显示文摘Optical signal-to-noise ratio(OSNR) is one of the most significant parameters for the performance characterization of random fiber lasers(RFLs) and their application potentiality in sensing and telecommunication. An effective way to improve the OSNR of RFLs is pump scheme optimization, for example, employing a temporally stable source as the pump. In this paper, the output performance of an incoherently pumped RFL dependence on the pump bandwidth has been investigated both in experiment and theory. It is found that a high-OSNR RFL can be achieved with broadband amplified spontaneous emission(ASE) source pumping, and a relatively broad pump bandwidth can also help suppress the spectral broadening while maintaining an ultra-high spectral purity.By optimizing the pump bandwidth to ~10 nm, maximum OSNR of ~39 dB(corresponding to a spectral purity of ~99.96%) with more than 99 W output power can be obtained. Moreover, for the pump bandwidth of 0.6–40 nm, the spectral purity can reach as high as >99% with the pump power ranging from ~85 to ~117 W.In addition, with the aid of theoretical simulation based on a modified power balance model, we find that the increment of pump bandwidth can decrease the effective Raman gain coefficient, further influencing the gain characteristics, nonlinear effects, and eventually the output performance. This work provides new insight into the influence of the pump characteristics on the output performance of incoherently pumped RFLs. | JUN YE JIANGMING XU JIAXIN SONG ANG ZHANG HANWEI ZHANG HU XIAO JINYONG LENG PU ZHOU | 2019 | Photonics Research2019，7，9： | 4 |
| 7 | Diagnostic Utility of Diffusion-weighted Magnetic Resonance Imaging in Differentiating Small Solid Renal Tumors (≤4 cm) at 3.0T Magnetic Resonance Imaging显示文摘 | Han-Mei Zhang Ying-Hua Wu Qi Gan Xiao Lyu Xiang-Lan Zhu Min Kuang Rong-Bo Liu Zi-Xing Huang ang Yuan Xi-Jiao Liu Bin Song | 2015 | Chinese Medical Journal2015，，11： | 4 |
| 8 | ASAF: altered spontaneous activity fingerprinting in Alzheimer’s disease based on multisite fMRI显示文摘Several monocentric studies have noted alterations in spontaneous brain activity in Alzheimer's disease (AD), although there is no consensus on the altered amplitude of low-frequency fluctuations in AD patients. The main aim of the present study was to identify a reliable and reproducible abnormal brain activity pattern in AD. The amplitude of local brain activity (AM), which can provide fast mapping of spontaneous brain activity across the whole brain, was evaluated based on multisite rs-fMRI data for 688 subjects (215 normal controls (NCs), 221 amnestic mild cognitive impairment (aMCI) 252 AD). Two-sample t-tests were used to detect group differences between AD patients and NCs from the same site. Differences in the AM maps were statistically analyzed via the Stouffer's meta-analysis. Consistent regions of lower spontaneous brain activity in the default mode network and increased activity in the bilateral hippocampus/parahippocampus, thalamus, caudate nucleus, orbital part of the middle frontal gyrus and left fusiform were observed in the AD patients compared with those in NCs. Significant correlations (P? | Jiachen Li Dan Jin Ang Li Bing Liu Chengyuan Song Pan Wang Dawei Wang Kaibin Xu Hongwei Yang Hongxiang Yao Bo Zhou Alexandre Bejanin Gael Chetelat Tong Han Jie Lu Qing Wang Chunshui Yu Xinqing Zhang Yuying Zhou Xi Zhang Tianzi Jiang Yong Liu Ying Han | 2019 | Science Bulletin2019，64，14： | 3 |
| 9 | A Dose-response Meta-analysis of Egg Intake and Breast Cancer Risk显示文摘Aim Eggs are one of the most nutritious foods in nature,but there is no unified conclusion about the association between egg intake and breast cancer risk.Methods The PubMed and Web of Science databases for the literature on egg intake and breast cancer risk were searched for papers published during the last 10 years.These were then filtered according to the inclusion and exclusion criteria.Stata16.0 software was applied to perform a meta-analysis,the generalized least squares method and constrained cubic spline model were used to assess the dose-response trends between egg intake and breast cancer risk.Results A total of 9 articles were included:6 case control studies and 3 cohort studies.The Newcastle-Ottawa scale(NOS)values of the included articles were all≥6 points.The pooled relative risks(RR)of egg intake and breast cancer risk was 0.91(95%CI:0.69-1.19).The dose-response analysis showed a linear trend for egg intake and breast cancer risk(P=0.689).With every 10 g/day increase in egg intake,the incidence of breast cancer increased by 2%(RR=1.02,95%CI:0.99-1.05).However,these results were not statistically significant.Conclusion This meta-analysis found no significant association between egg intake and breast cancer. | Peng Wei Ma Fei Fei Feng Zi Ang Shi Ke Di Xu Yuan Lin Zou Yan Li Wang Si Qi Ning Chun Hua Song | 2021 | Journal of Nutritional Oncology2021，6，2： | 3 |
| 10 | Sildenafil ameliorates left ventricular T-tubule remodeling in a pressure overload-induced murine heart failure model显示文摘瞄准:Sildenafil, phosphodiesterase 5 (PDE5 ) 禁止者,被显示了在心失败施加有益的效果。这研究的目的是测试 sildenafil 是否压制了横向小管的(T 小管) 在左改变室(LV ) 失败并且从而提供治疗学的 benefits.Methods:一个压力导致超载的鼠科的心失败模型被胸的大动脉的 banding (标签) 在老鼠建立。在标签以后的一天,鼠标收到了 sildenafil (100 mg· kg −1·d−1, sc ) 或为 5 个星期盐。在处理的结束, echocardiography 被用来检验 LV 功能。然后,未经触动的心外面被把并且把房间放在 Langendorff 灌注为在 situ 从 epicardial myocytes.Results 的 T 小管超微结构的共焦的成像:标签外科导致了改变的显著 T 小管伴随的心失败。Sildenafil 处理显著地稀释了导致标签的心脏的肥大和充血的心失败,改进了 LV 可收缩的功能,并且保存了在 LV cardiomyocytes 的 T 小管正直。但是 sildenafil 处理显著地没影响房间膨胀。LV T 小管结构的完整与心脏的肥大被相关(R 2=0.74, P< 0.01 ) 并且全球 LV 功能(R 2=0.47, P< 0.01 ).Conclusion:Sildenafil 有效地改善在标签老鼠改变的 LV T 小管,揭示在心失败位于 sildenafil 的治疗学的好处下面的新奇机制。 | Chun-kai HUANG Bi-yi CHEN Ang GUO Rong CHEN Yan-qi ZHU William KUTSCH KE Jiang HONG Long-sheng SONG | 2016 | Acta Pharmacologica Sinica2016，37，4： | 2 |
| 11 | Intense single-band red upconversion emission in BiOCl:Er3+ layered semiconductor via co-doping Ho3+显示文摘Exploring a new tuning way to facilely realize single-band red emission in trivalent rare-earth ions(RE3+) doped upconversion(UC) materials is still desirable.In this work,the intense single-band red emission is achieved by co-doping only Ho3+in the BiOCl:Er3+ under 1550 nm excitation.In the BiOCl layered host,co-doping Ho3+can further enhance the red emission and simultaneously suppress the green emission of Er3+,and thus obviously improve the red-to-green(R/G) ratio.It is found that Ho3+does not se rve as ene rgy trapping through the 5 I6 state as in traditional UC materials but acts as ET bridge(4 S3/2,2 H11/2(Er3+)→5 F4,5 S2(Ho3+)→4 F9/2(Er3+)).The tuning mechanism of Ho3+is discussed in detail and further confirms through a comparative experiment.Our research gives an unusual perspective to tune the UC behavior of Er3+through co-doping Ho3+,which might be inspiring for achievement of single-band red UC emission. | Yuehong Peng Jincai Peng Jiajun Han Tianhui Wang Zhaoyi Yin Jianbei Qiu Qi W ang Zhengwen Yang Zhiguo Song | 2020 | Journal of Rare Earths2020，38，6： | 2 |
| 12 | Modulation of the cutoff wavelength in the spectra for solar selective absorbing coating based on high-entropy films显示文摘This paper demonstrates an intrinsic modulation of the cutoff wavelength in the spectra for solar selective absorbing coating based on high-entropy films.The(NiCuCrFeSi)N((NCCFS)N)films were deposited by a magnetron sputtering system.Rutherford backscattering spectroscopy analysis confirms the uniform composition and good homogeneity of these high-entropy films.The real and imaginary parts of the permittivity for the(NCCFS)N material are calculated on the basis of the reflectance spectral fitting results.A redshift cutoff wavelength of the reflectance spectrum with increasing nitrogen gas flow rate exists because of the different levels of dispersion when changing nitrogen content.To realize significant solar absorption,the film surface was reconstituted to match its impedance with air by designing a pyramid nanostructure metasurface.Compared with the absorptance of the as-deposited films,the designed metasurface obtains a significant improvement in solar absorption with the absorptance increasing from 0.74 to 0.99.The metasurfaces also show low mid-infrared emissions with thermal emittance that can be as low as 0.06.These results demonstrate a new idea in the design of solar selective absorbing surface with controllable absorptance and low infrared emission for high-efficiency photo-thermal conversion. | Ping Song Cong Wang Jie Ren Ying Sun Yong Zhang Angélique Bousquet Thierry Sauvage Eric Tomasella | 2020 | International Journal of Minerals,Metallurgy and Materials2020，27，10： | 2 |
| 13 | Fixing, preventing, and recovering from concurrency bugs显示文摘Concurrency bugs are becoming widespread with the emerging ubiquity of multicore processors and multithreaded software. They manifest during production runs and lead to severe losses. Many effective concurrency-bug detection tools have been built. However, the dependability of multi-threaded software does not improve until these bugs are handled statically or dynamically. This article discusses our recent progresses on fixing, preventing, and recovering from concurrency bugs. | DENG DongDong JIN GuoLiang de KRUIJF Marc LI Ang LIBLIT Ben LU Shan QI ShanXiang REN JingLei SANKARALINGAM Karthikeyan SONG LinHai WU YongWei ZHANG MingXing ZHANG Wei ZHENG WeiMin | 2015 | Science China(Information Sciences)2015，58，5： | 2 |
| 14 | Radiation-hardened property of single-walled carbon nanotube film-based field-effect transistors under low-energy proton irradiation显示文摘Strong C-C bonds,nanoscale cross-section and low atomic number make single-walled carbon nanotubes(SWCNTs)a potential candidate material for integrated circuits(ICs)applied in outer space.However,very little work combines the simulation calculations with the electrical measurements of SWCNT field-effect transistors(FETs),which limits further understanding on the mechanisms of radiation effects.Here,SWCNT film-based FETs were fabricated to explore the total ionizing dose(TID)and displacement damage effect on the electrical performance under low-energy proton irradiation with different fluences up to 1×1015 p/cm2.Large negative shift of the threshold voltage and obvious decrease of the on-state current verified the TID effect caused in the oxide layer.The stability of the subthreshold swing and the off-state current reveals that the displacement damage caused in the CNT layer is not serious,which proves that the CNT film is radiation-hardened.Specially,according to the simulation,we found the displacement damage caused by protons is different in the source/drain contact area and channel area,leading to varying degrees of change for the contact resistance and sheet resistance.Having analyzed the simulation results and electrical measurements,we explained the low-energy proton irradiation mechanism of the CNT FETs,which is essential for the construction of radiation-hardened CNT film-based ICs for aircrafts. | Xiaorui Zhang Huiping Zhu Song’ang Peng Guodong Xiong Chaoyi Zhu Xinnan Huang Shurui Cao Junjun Zhang Yunpeng Yan Yao Yao Dayong Zhang Jingyuan Shi Lei Wang Bo Li Zhi Jin | 2021 | Journal of Semiconductors2021，42，11： | 2 |
| 15 | Ten‐day triple therapy versus sequential therapy versus concomitant therapy as first‐line treatment for H elicobacter pylori infection显示文摘 | Tiing Leong Ang Kwong Ming Fock Mingjun Song Daphne Ang Andrew Boon Eu Kwek Jeannie Ong Jessica Tan Eng Kiong Teo Subbiah Dhamodaran | 2015 | J Gastroenterol Hepatol2015，，7： | 2 |
| 16 | The effect of continuous Ni(Ⅱ) exposure on the organic degradation and soluble microbial product(SMP) formation in two-phase anaerobic reactor显示文摘A two-phase anaerobic reactor fed with glucose substrate(3 g chemical oxygen demand(COD)/L) was used to investigate the effects of toxic metals on the degradation of organics and the soluble microbial product(SMP) formation. Low concentrations of Ni(II)(5 and10 mg/L) promoted the acid phase, whereas high concentrations(15, 20, and 25 mg/L)exhibited an inhibitory effect on, but did not alter the fermentative method, which mainly involved the fermentation of propionic acid. The methanogenic microorganism exhibited a strong capability adapting constantly increased Ni(II) levels. The acid phase was an accumulation stage of SMP. In the absence of Ni(II), the high-molecular-weight material in the effluent SMP mainly contained polysaccharide, tryptophan, and casein. Methanogens metabolized most of the polysaccharide, the whole tryptophan content, and part of the casein, leading to the presence of humic acid and protein in effluent. After Ni(II) dosage, the protein and polysaccharide of the acid phase increased, and tryptophan changed, while casein remained stable. More protein than polysaccharide was produced, suggesting the prominent function of protein when addressing the negative effect of toxic metals. The analysis of DNA confirmed the change of bacterial activity. | Wei Wu Tengteng Duan Hailiang Song Yan Li Ang Yu Long Zhang Aimin Li | 2015 | Journal of Environmental Sciences2015，27，7： | 2 |
| 17 | Adenovirus expressing IFN-k (Ad/hIFN-k) produced anti-tumor effects through inducing apop- tosis in human tongue squamous cell carcinoma cell显示文摘 | Song B ang Wang YL | 2015 | Int J Clin Exp Med2015，8，12： | 1 |
| 18 | A theoretical model for laser removal of particles form solid surfaces显示文摘 | Lu YF Song WD Ang BW | 1997 | Appl Phys A1997，，65： | 1 |
| 19 | Early detection of early gastric cancer using image-enhanced endoscopy:Current trends显示文摘 | Song M Ang T L | 2014 | Gastrointest Interv2014，3，1： | 1 |
| 20 | Direct observation of the transient thermal-lensing effect using the phase-object Z-scan technique 显示文摘 | Y ANG J SONG Y | 2009 | Opt Lett2009，34，2： | 1 |
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