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| 1 | Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases显示文摘在各种各样的纸巾的 microRNAs (miRNAs ) 的 Dysregulated 表示与许多疾病被联系了,包括癌症。这里,我们证明 miRNAs 在象老鼠,老鼠,牛的胎儿,小牛,和马那样的人和另外的动物的浆液和血浆是在场的。在浆液的 miRNAs 的层次在一样的种类的个人之中稳定、可再现、一致。采用 Solexa,我们定序健康中国题目的所有浆液 miRNAs 并且分别地在男、女的题目发现超过 100 和 91 浆液 miRNAs。我们也为肺癌症, colorectal 癌症,和糖尿病识别了浆液 miRNAs 的特定的表示模式,提供证据那浆液 miRNAs 为各种各样的疾病包含指纹。癌症特定的浆液 miRNAs 由 Solexa 获得了的二个非小的房间肺进一步在 75 个健康施主和 152 个癌症病人的独立审判被验证,用量的反向的抄写聚合酶链反应试金。通过这些分析,我们断定浆液 miRNAs 能为各种各样的癌症和另外的疾病的察觉用作潜在的 biomarkers。 | Xi Chen Yi Ba Lijia Ma Xing Cai Yuan Yin Kehui Wang Jig ang Guo Yujing Zhang Jiangning Chen Xing Guo Qibin Li Xiaoying Li Wenjing Wang Yan Zhang Jin Wang Xueyuan Jiang Yang Xiang Chen Xu Pingping Zheng Juanbin Zhang Ruiqiang Li Hongjie Zhang Xiaobin Shang Ting Gong Guang Ning Jun Wang Ke Zen Junfeng Zhang Chen-Yu Zhang | 2008 | Cell Research2008，18，10： | 975 |
| 2 | Triptolide induces Sertoli cell apoptosis in mice via ROS/JNK-dependent activation of the mitochondrial pathway and inhibition of Nrf2-mediated antioxidant response显示文摘Triptolide (TP ) ,氧化 diterpene,举办许多有益的 pharmacodynamic 活动但是它的临床的应用程序由于严重阴囊的损害被限制。这研究试图描出在 vitro 并且在 vivo 的导致 TP 的阴囊的损害的分子的机制。TP (5-50000 nmol/L ) dose-dependently 减少了有在 24 h 的 669.5-269.45 nmol/L 的 IC 50 价值的 TM4 Sertoli 房间的生存能力。TP (125, 250,和 500 nmol/L ) dose-dependently 在 TM4 房间增加了 ROS, JNK 的 phosphorylation, mitochondrial 机能障碍和内在的 apoptosis 小径的激活的累积。这些过程被合作处理与抗氧化剂 N 乙酰半胱氨酸稀释(NAC, 1 mmol/L ) 。而且, TP 处理从细胞质禁止了 Nrf2 的 translocation 进原子核以及下游的基因 NAD (P) H quinone 的表示 oxidoreductase1 (NQO1 ) ,过氧化氢酶(猫) 和 hemeoxygenase 1 (HO-1 ) ,因此对氧化应力废除调停 Nrf2 的防卫机制。而且, Nrf2 击倒的 siRNA 显著地加强了 TM4 房间的导致 TP 的 apoptosis。从在 vitro 实验的上述结果进一步在 TP 的口头的管理以后在雄的老鼠被验证(30, 60,和 120 mg 吗? | Yu WANG Su-han GUO Xue-jun SHANG Li-sha YU Jian-wei ZHU Ang ZHAO Yan-fen ZHOU Guo-hua AN Qi ZHANG BO MA | 2018 | Acta Pharmacologica Sinica2018，39，2： | 22 |
| 3 | ALDH2 protects against stroke by clearing 4-HNE显示文摘(ALDH2 ) 醛脱氢酶 2 是使象 4-hydroxy-2-nonenal (4-HNE ) 那样的乙醇和有毒的醛产生代射变化的 mitochondrial 酶。用不偏的 proteomic 搜索,我们作为与自发地高血压的老鼠(SHR ) 相比在击容易的自发地高血压的老鼠(SHR-SP ) 识别了 ALDH2 缺乏。我们作为 overexpression 在 neuronal 损害结束了 ALDH2 缺乏的原因的角色或 ALDH2 的激活由清除 4-HNE 在授与 neuroprotection 在 vitro 研究。进一步, ALDH2 击倒的老鼠揭示了 PKCε 的 neuroprotective 效果的缺席;。被知道对击施加保护的中等乙醇管理被显示提高 4-HNE 的 detoxification,并且免于 ischemic 通过 PKCε 的服的损害; -ALDH2 小径。在 SHR-SP,浆液 4-HNE 水平固执地与 lifespan 相反地被提高并且相关。在在人的击的 4-HNE 的角色被它的血浆层次的坚持的举起也在击以后建议至少 6 个月。最后,我们观察到发展了的跟随 8 年的 1 242 个题目中的 21 个比没得中风的那些摸有的更高起始的血浆 4-HNE 层次。这些调查结果建议 ALDH2 小径的激活可以在击容易的题目的鉴定用作一个有用索引,并且 ALDH2 小径可以是在击的治疗学的干预的一个潜在的目标。 | Jin-Min Guo Ai-Jun Liu Pu Zang Wen-Zhe Dong Li Ying Wei W ang Pu Xu Xu-Rui Song Jun Cai She-Qing Zhang Jun-Li Duan Jawahar L Mehta Ding-Feng Su | 2013 | Cell Research2013，23，7： | 19 |
| 4 | Association between Ambient Air Pollution and Outpatient Visits for Acute Bronchitis in a Chinese City显示文摘Objective To investigate the short-term association between outdoor air pollution and outpatient visits for acute bronchitis,which is a rare subject of research in the mainland of China.Methods A time-series analysis was conducted to examine the association of outdoor air pollutants with hospital outpatient visits in Shanghai by using two-year daily data(2010-2011).Results Outdoor air pollution was found to be associated with an increased risk of outpatient visits for acute bronchitis in Shanghai.The effect estimates of air pollutants varied with the lag structures of the concentrations of the pollutants.For lag06,a 10 μg/m3 increase in the concentrations of PM10,SO2,and NO2 corresponded to 0.94%(95% CI:0.83%,1.05%),11.12%(95% CI:10.76%,11.48%),and 4.84%(95% CI:4.49%,5.18%) increases in hospital visits for acute bronchitis,respectively.These associations appeared to be stronger in females(P<0.05).Between-age differences were significant for SO2(P<0.05),and between-season differences were also significant for SO2(P<0.05).Conclusion Our analyses have provided the first evidence that the current air pollution level in China has an effect on acute bronchitis and that the rationale for further limiting air pollution levels in Shanghai should be strengthened. | GUO Li Juan ZHAO Ang CHEN Ren Jie KAN Hai Dong KUANG Xing Ya | 2014 | Biomedical and Environmental Sciences2014，27，11： | 13 |
| 5 | Phase-field-lattice Boltzmann study for lamellar eutectic growth in a natural convection melt显示文摘In the present study, the influence of natural convection on the lamellar eutectic growth is determined by a phase-field-lattice Boltzmann study for Al-Cu eutectic alloy. The mass difference resulting from concentration difference led to the fluid flow, and a robust parallel and adaptive mesh refinement algorithm was employed to improve the computational efficiency without any compromising accuracy. Results show that the existence of natural convection would affect the growth undercooling and thus control the interface shape by adjusting the lamellar width. In particular, by alternating the magnitude of the solute expansion coefficient, the strength of the natural convection is changed. Corresponding microstructure patterns are discussed and compared with those under no-convection conditions. | Ang Zhang Zhi-peng Guo Shou-mei Xiong | 2017 | China Foundry2017，14，5： | 6 |
| 6 | Clinical information and management status of de novo stage IV breast cancer patients: a Chinese multicenter investigation (CSBrS-002)显示文摘Background:Although de novo stage IV breast cancer is so far incurable,it has entered an era of individualized treatment and chronic disease management.Based on systemic treatment,whether the surgical resection of primary or metastatic foci of de novo stage IV breast cancer can bring survival benefits is currently controversial.We aimed to explore the clinicopathological factors and current status of the management of de novo stage IV breast cancer in China to provide a reference for clinical decisions.Methods:Based on the assistance of Chinese Society of Breast Surgery,a retrospective study was conducted to analyze the clinical data of patients with de novo stage IV breast cancer in 33 centers from January 2017 to December 2018.The relationship between basic characteristic(age,menstrual status,family history,reproductive history,pathological type,estrogen receptor[ER]status,progesterone receptor[PR]status,human epidermal growth factor receptor 2[HER2]status,Ki-67 percentage,and molecular subtype),and metastasis sites(lung metastasis,liver metastasis,and bone metastasis)was examined by Pearson Chi-square tests.Results:A total of 468 patients with de novo stage IV breast cancer were enrolled.The median age of the enrolled patients was 51.5 years.The most common pathological type of primary lesion was invasive carcinoma(97.1%).Luminal A,luminal B,HER2 overexpressing,and triple-negative subtypes accounted for 14.3%,51.8%,22.1%,and 11.8% of all cases,respectively.Age,PR status,and HER2 status were correlated with lung metastasis(χ^(2)=6.576,4.117,and 8.643 and P=0.037,0.043,and 0.003,respectively).Pathological type,ER status,PR status,and molecular subtype were correlated with bone metastasis(χ^(2)=5.117,37.511,5.224,and 11.603 and P=0.024,<0.001,0.022,and 0.009,respectively).Age,PR status,HER2 status,Ki-67 percentage,and molecular subtype were correlated with liver metastasis(χ^(2)=11.153,13.378,10.692,21.206,and 17.684 and P=0.004,<0.001,0.001,<0.001,and 0.001,respectively).Combined treatment with paclitaxel and anthracycline was the most common first-line chemotherapy regimen for patients with de novo stage IV breast cancer(51.7%).Overall,91.5% of patients used paclitaxel-containing regimens.Moreover,59.3% of hormone receptor-positive patients underwent endocrine therapy.Conclusions:In 2018,1.07% of patients from all studied centers were diagnosed with de novo stage IV breast cancer.This study indicated that 95.1% of patients received systemic therapy and 54.2% of patients underwent surgical removal of the primary lesion in China. | Ang Zheng Bao-Liang Guo Jian-Guo Zhang Feng Jin Chinese Society of Breast Surgery | 2021 | Chinese Medical Journal2021，，13： | 5 |
| 7 | Parametric 3D Modeling of Worm and Worm Gear Based on AutoCAD显示文摘Worm and worm gear are modeled under development environment in AutoCAD based on the principle of ordinary cylindrical worm drive. The drawing commands available in AutoCAD are used to develop worm blank and cutter models. The solid models of worm and worm gear are obtained through the use of the commands, move, rotate and subtract, to simulate the generating cutting movement on the gear cutting machine. Autolisp language is utilized in programming for parametric modeling of worm and worm gear. The developed program can automatically draw worm and worm gear when users load the wlwg program, input the modulus and the number of threads, handedness, and other parameters. The operation is simple and accurate, providing potentials to speed up product design process and improve efficiency. | ANG Xue-ye GUO Yong-kun | 2010 | Computer Aided Drafting,Design and Manufacturing2010，20，1： | 3 |
| 8 | Identification of Oblate Band in Odd-odd ^(184)Au显示文摘The high-spin states in 184Au were populated by using the 159Tb( 29Si, 4ng) 184Au reaction at a bombarding energy of 140 MeV. The 29Si beam of 8 pnA was provided by the accelerator complex of the Tandem-XTU and ALPI at the Laroratori Nazionale di Legnero, Italy, and focussed onto a natural metallic 159Tb foil | Zhang Yuhu Wang Hualei G. de Angelis N. Maiginean A. Gadea D. R. Napoli M. Axiotis C. R.usu T. Martinez Zhou Xiaohong Fang Yongde Guo Wentao Liu Minliang Lei Xiangguo Guo Yingxiang | 2004 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2004，，1： | 2 |
| 9 | Sildenafil ameliorates left ventricular T-tubule remodeling in a pressure overload-induced murine heart failure model显示文摘瞄准:Sildenafil, phosphodiesterase 5 (PDE5 ) 禁止者,被显示了在心失败施加有益的效果。这研究的目的是测试 sildenafil 是否压制了横向小管的(T 小管) 在左改变室(LV ) 失败并且从而提供治疗学的 benefits.Methods:一个压力导致超载的鼠科的心失败模型被胸的大动脉的 banding (标签) 在老鼠建立。在标签以后的一天,鼠标收到了 sildenafil (100 mg· kg −1·d−1, sc ) 或为 5 个星期盐。在处理的结束, echocardiography 被用来检验 LV 功能。然后,未经触动的心外面被把并且把房间放在 Langendorff 灌注为在 situ 从 epicardial myocytes.Results 的 T 小管超微结构的共焦的成像:标签外科导致了改变的显著 T 小管伴随的心失败。Sildenafil 处理显著地稀释了导致标签的心脏的肥大和充血的心失败,改进了 LV 可收缩的功能,并且保存了在 LV cardiomyocytes 的 T 小管正直。但是 sildenafil 处理显著地没影响房间膨胀。LV T 小管结构的完整与心脏的肥大被相关(R 2=0.74, P< 0.01 ) 并且全球 LV 功能(R 2=0.47, P< 0.01 ).Conclusion:Sildenafil 有效地改善在标签老鼠改变的 LV T 小管,揭示在心失败位于 sildenafil 的治疗学的好处下面的新奇机制。 | Chun-kai HUANG Bi-yi CHEN Ang GUO Rong CHEN Yan-qi ZHU William KUTSCH KE Jiang HONG Long-sheng SONG | 2016 | Acta Pharmacologica Sinica2016，37，4： | 2 |
| 10 | Parallel implementation of w-projection wide-field imaging显示文摘w-Projection is a wide-field imaging technique that is widely used in radio synthesis arrays. Processing the wide-field big data generated by the future Square Kilometre Array(SKA) will require significant updates to current methods to significantly reduce the time consumed on data processing. Data loading and gridding are found to be two major time-consuming tasks in w-projection. In this paper, we investigate two parallel methods of accelerating w-projection processing on multiple nodes: the hybrid Message Passing Interface(MPI) and Open Multi-Processing(OpenMP) method based on multicore Central Processing Units(CPUs) and the hybrid MPI and Compute Unified Device Architecture(CUDA)method based on Graphics Processing Units(GPUs). Both methods are successfully employed and operated in various computational environments, confirming their robustness. The experimental results show that the total runtime of both MPI + OpenMP and MPI + CUDA methods is significantly shorter than that of single-thread processing. MPI + CUDA generally shows faster performance when running on multiple nodes than MPI + OpenMP, especially on large numbers of nodes. The single-precision GPU-based processing yields faster computation than the double-precision processing; while the single-and doubleprecision CPU-based processing shows consistent computational performance. The gridding time remarkably increases when the support size of the convolution kernel is larger than 8 and the image size is larger than 2,048 pixels. The present research offers useful guidance for developing SKA imaging pipelines. | Baoqiang Lao Tao An Ang Yu Wenhui Zhang Junyi Wang Quan Guo Shaoguang Guo Xiaocong Wu | 2019 | Science Bulletin2019，64，9： | 2 |
| 11 | Ecdysone receptor isoforms play distinct roles in larval–pupal–adult transition in Leptinotarsa decemlineata显示文摘A heterodimer of two nuclear receptors,ecdysone receptor(EcR)and ultraspiracle,mediates 20‐hydroxyecdysone(20E)signaling to modulate many aspects in insect life,such as molting and metamorphosis,reproduction,diapause and innate immunity.In the present paper,we intended to determine the isoform‐specific roles of EcR during larval–pupal–adult transition in the Colorado potato beetle.Double‐stranded RNAs(dsRNAs)were prepared using the common(dsEcR)or isoform‐specific(dsEcRA,dsEcRB1)regions of EcR as templates.Ingestion of either dsEcR or dsEcRA,rather than dsEcRB1,by the penultimate(3rd)and final(4th)instar larvae caused failure of larval–pupal and pupal–adult ecdysis.The RNA interference(RNAi)larvae remained as prepupae,or became deformed pupae and adults.Determination of messenger RNA(mRNA)levels of EcR isoforms found that LdEcRA regulates the expression of LdEcRB1.Moreover,silencing the two EcR transcripts,LdEcRA or LdEcRB1 reduced the mRNA levels of Ldspo and Ldsad,and lowered 20E titer.In contrast,the expression levels of HR3,HR4,E74 and E75 were significantly decreased in the LdEcR or LdEcRA RNAi larvae,but not in LdEcRB1 depleted specimens.Dietary supplement with 20E did not restore the expression of five 20E signaling genes(USP,HR3,HR4,E74 and E75),and only partially alleviated the pupation defects in dsEcR‐or dsEcRA‐fed beetles.These data suggest that EcR plays isoform‐specific roles in the regulation of ecdysteroidogenesis and the transduction of 20E signal in L.decemlineata. | Qing-Yu Xu Pan Deng Qiong Zhang Ang Li Kai-Yun Fu Wen-Chao Guo Guo-Qing Li | 2020 | Insect Science2020，27，3： | 2 |
| 12 | A software reliability time series growth model with Kalman filter 显示文摘 | Guo J Liu H ang X | 2006 | WSEAS Transactions on Computers2006，5，1： | 1 |
| 13 | Calculation of dielectric constant and loss of two-phase composites 显示文摘 | Ang C Yu Z Guo R | 2003 | Journal of Applied Physics2003，93，6： | 1 |
| 14 | Compact Internal Multiband Antennas for Mobile Handsets 显示文摘 | Yong-Xin Guo Irene Ang M Y W Chia | 2003 | IEEE Antennas and Wireless Propagation Letters2003，，2： | 1 |
| 15 | Piezoelectric and strainproperties of Ba(Ti1-xZrx)O3 ceramics 显示文摘 | YU Z ANG C GUO R BHALLA A S | 2002 | J Appl Phys2002，92，3： | 1 |
| 16 | Phase-field modeling of dendritic growth of magnesium alloys with a parallel-adaptive mesh refinement algorithm显示文摘A two-dimensional phase field(PF)model was developed to simulate the dendritic solidification in magnesium alloy with hcp crystal structure.By applying a parallel-adaptive mesh refinement(Para-AMR)algorithm,the computational efficiency of the numerical model was greatly improved.Based on the PF model,a series of simulation cases were conducted and the results showed that the anisotropy coefficient and coupling coefficient had a great influence on the dendritic morphology of magnesium alloy.The dendritic growth kinetics was determined by the undercooling and equilibrium solute partition coefficient.A significant finding is acquired that with a large undercooling,the maximum solute concentration is located on both sides of the dendrite tip in the liquid,whereas the maximum solute concentration gradient is located right ahead of the dendrite tip in the liquid.The dendrite tip growth velocity decreases with the increase of the equilibrium solute partition coefficient,while the variation trend of the dendrite tip radius is the opposite.Quantitative analysis was carried out relating to the dendritic morphology and growth kinetics,and the simulated results are consistent with the theoretical models proposed in the previously published works. | Bing-hui Tian Meng-wu Wu Ang Zhang Zhi-peng Guo Shou-mei Xiong | 2021 | China Foundry2021，18，6： | 1 |
| 17 | The diagnostic criteria for primary osteoporosis and the incidence of osteoporosis in China显示文摘 | Zhonghou Liu Junhong Piao Lianping Pang Xiang Qing Su Nan Zi’ang Pan Yichao Guo Xiaohong Wang Fangfang Li Jingping Liu Xiaoguang Cheng | 2002 | Journal of Bone and Mineral Metabolism2002，，4： | 1 |
| 18 | Piezoelectric and strain properties of Ba (Ti1-xZrx)O3 ceramics显示文摘 | YU Z ANG C GUO R | | 0，，03： | 1 |
| 19 | The diagnostic criteria for primary osteoporosis and the incidence of osteoporosis in China显示文摘 | Zhonghou Liu Junhong Piao Lianping Pang Xiang Qing Su Nan Zi’ang Pan Yichao Guo Xiaohong Wang Fangfang Li Jingping Liu Xiaoguang Cheng | 2002 | Journal of Bone and Mineral Metabolism2002，，4： | 1 |
| 20 | Piezoelectric and strain properties of Ba(Ti1-xZrx) O3 ceramics显示文摘 | Yu Z Ang C Guo R | 2002 | J Appl Phys2002，92，3： | 1 |
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