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| 1 | ALDH2 protects against stroke by clearing 4-HNE显示文摘(ALDH2 ) 醛脱氢酶 2 是使象 4-hydroxy-2-nonenal (4-HNE ) 那样的乙醇和有毒的醛产生代射变化的 mitochondrial 酶。用不偏的 proteomic 搜索,我们作为与自发地高血压的老鼠(SHR ) 相比在击容易的自发地高血压的老鼠(SHR-SP ) 识别了 ALDH2 缺乏。我们作为 overexpression 在 neuronal 损害结束了 ALDH2 缺乏的原因的角色或 ALDH2 的激活由清除 4-HNE 在授与 neuroprotection 在 vitro 研究。进一步, ALDH2 击倒的老鼠揭示了 PKCε 的 neuroprotective 效果的缺席;。被知道对击施加保护的中等乙醇管理被显示提高 4-HNE 的 detoxification,并且免于 ischemic 通过 PKCε 的服的损害; -ALDH2 小径。在 SHR-SP,浆液 4-HNE 水平固执地与 lifespan 相反地被提高并且相关。在在人的击的 4-HNE 的角色被它的血浆层次的坚持的举起也在击以后建议至少 6 个月。最后,我们观察到发展了的跟随 8 年的 1 242 个题目中的 21 个比没得中风的那些摸有的更高起始的血浆 4-HNE 层次。这些调查结果建议 ALDH2 小径的激活可以在击容易的题目的鉴定用作一个有用索引,并且 ALDH2 小径可以是在击的治疗学的干预的一个潜在的目标。 | Jin-Min Guo Ai-Jun Liu Pu Zang Wen-Zhe Dong Li Ying Wei W ang Pu Xu Xu-Rui Song Jun Cai She-Qing Zhang Jun-Li Duan Jawahar L Mehta Ding-Feng Su | 2013 | Cell Research2013，23，7： | 19 |
| 2 | Angiomyolipoma with minimal fat: differentiation from renal cell carcinoma at helical CT显示文摘Renal cell carcinoma (RCC) accounts for 85%-90% of all kidney tumors.Although the majority of renal tumors in surgical series are malignant,a number of patients do undergo nephrectomy for benign lesions.1 Such minimal fat angiomyolipomas (AML) are visually indistinguishable from RCC and present particular diagnostic difficulties.2,3 In this study,CT number in region of whole mass (ROW) is advocated. | ZHAO Xiao-jun PU Jin-xian PING Ji-gen ZANG Jin LU Yong XI Qi-lin HOU Wen-jie | 2013 | Chinese Medical Journal2013，，5： | 12 |
| 3 | Continuous glucose monitoring defined time-in-range is associated with sudomotor dysfunction in type 2 diabetes显示文摘BACKGROUND Time in range(TIR),as a novel metric for glycemic control,has robust relevance with diabetic complications.Diabetic peripheral neuropathy(DPN)is characterized by sudomotor dysfunction.AIM To explore the relationship between TIR obtained from continuous glucose monitoring(CGM)and sudomotor function detected by SUDOSCAN in subjects with type 2 diabetes.METHODS The research enrolled 466 inpatients with type 2 diabetes.All subjects underwent 3-d CGM and SUDOSCAN.SUDOSCAN was assessed with electrochemical skin conductance in hands(HESC)and feet(FESC).Average feet ESC<60μS was defined as sudomotor dysfunction(+),otherwise it was sudomotor dysfunction(-).TIR refers to the percentage of time when blood glucose is between 3.9-10 mmol/L during 1 d period.RESULTS Among the enrolled subjects,135(28.97%)presented with sudomotor dysfunction.Patients with sudomotor dysfunction(+)showed a decreased level of TIR(P<0.001).Compared to the lowest tertile of TIR,the middle and the highest tertiles of TIR was associated with an obviously lower prevalence of sudomotor dysfunction(20.51%and 21.94%vs 44.52%)(P<0.001).In addition,with the increase of TIR,HESC and FESC increased(P<0.001).Regression analysis demonstrated that TIR was inversely and independently linked with the prevalence of sudomotor dysfunction after adjusting for confounding values(odds ratio=0.979,95%CI:0.971-0.987,P<0.001).CONCLUSION The tight glycemic control assessed by TIR is of vitally protective value for sudomotor dysfunction in type 2 diabetes mellitus. | Qing-Yu Guo Bin Lu Zhan-Hong Guo Zhou-Qin Feng Yan-Yu Yuan Xu-Guang Jin Pu Zang Ping Gu Jia-Qing Shao | 2020 | World Journal of Diabetes2020，11，11： | 4 |
| 4 | An Interdisciplinary Educational Trial for Adolescent Health and Development in Urbanising China显示文摘 | Zang Y L Liu Q Pu L Z | 2013 | J Clin Nurs2013，22，56： | 1 |
| 5 | The primary use of artificial intelligence in cardiovascular diseases: what kind of potential role does artificial intelligence play in future medicine?显示文摘Cardiovascular diseases (CVD) is a major threat to human health and the leading cause of death worldwide.[1] The incidence of CVD caused 17.6 million deaths in 2016, an increase of 14.5% from 2006 to 2016.[2] Unfortunately, the mortality and morbidity rates of CVD are increasing year by year, especially in developing regions. Studies have shown that approximately 80% of CVD-related deaths occur in low- and middle-income countries. Besides, these deaths occur at a younger age than in high-income countries.[3]? | Yang YAN Jia-Wen ZHANG Guang-Yao ZANG Jun PU | 2019 | Journal of Geriatric Cardiology2019，16，8： | 1 |
| 6 | Profiling the m^(6)A-regulated RNA expression patterns and alternative splicing features in esophageal carcinoma显示文摘The m^(6)A modification involves almost all aspects of RNA biology,including the alternative splicing of mRNA precursors,mRNA transport and stability,and miRNA processing and regulation of target genes.1,2 Alternative splicing controlling the information storage and RNA translation involves the regulation of various biological processes.3,4,5 Here,we integrated the genomic information of 161 esophageal cancer(EC)samples to comprehensively evaluate the m^(6)A modification patterns and correlated the m^(6)A modification pattern with the prognosis of EC patients,where two distinct m^(6)A modification patterns were proposed.The combined effects of high m^(6)Ascore and low TMB correlated with a better prognosis of EC patients.In addition,we found an inherent correlation between m^(6)A modification and the occurrence of alternative splicing events in EC patients.Altogether,we established a scoring system to quantify the m^(6)A modification pattern with RNA alternative splicing events in individual EC patients(Fig.S1). | Lingsuo Kong Fei Gao Fangfang Zhao Ran Xia Cifeng Cai Weixin Wang Dabing Huang Zhenyu Li Qiyi Yi Chunbao Zang Youguang Pu | 2023 | Genes & Diseases2023，10，5： | 0 |
| 7 | In-situ growth of low-dimensional perovskite-based insular nanocrystals for highly efficient light emitting diodes显示文摘Regulation of perovskite growth plays a critical role in the development of high-performance optoelectronic devices.However,judicious control of the grain growth for perovskite light emitting diodes is elusive due to its multiple requirements in terms of morphology,composition,and defect.Herein,we demonstrate a supramolecular dynamic coordination strategy to regulate perovskite crystallization.The combined use of crown ether and sodium trifluoroacetate can coordinate with A site and B site cations in ABX_(3) perovskite,respectively.The formation of supramolecular structure retard perovskite nucleation,while the transformation of supramolecular intermediate structure enables the release of components for slow perovskite growth.This judicious control enables a segmented growth,inducing the growth of insular nanocrystal consist of low-dimensional structure.Light emitting diode based on this perovskite film eventually brings a peak external quantum efficiency up to 23.9%,ranking among the highest efficiency achieved.The homogeneous nano-island structure also enables high-efficiency large area(1 cm^(2))device up to 21.6%,and a record high value of 13.6%for highly semi-transparent ones. | Hao Wang Weidong Xu Qi Wei Si Peng Yuequn Shang Xianyuan Jiang Danni Yu Kai Wang Ruihua Pu Chenxi Zhao Zihao Zang Hansheng Li Yile Zhang Ting Pan Zijian Peng Xiaoqin Shen Shengjie Ling Weimin Liu Feng Gao Zhijun Ning | 2023 | Light(Science & Applications)2023，12，3： | 0 |
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