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| 1 | Prevalence and medical management of erectile :lysfunction in Asia显示文摘可勃起的机能障碍(编辑) 是在生活的质量和影响个人和他的搭挡的生活满足上有重要否定影响的一个重要世界范围的健康问题。这里,我们在亚洲,可以影响性态度的联系因素和在亚洲人评估 PDE-5 禁止者的临床的功效和安全的性行为,和 phosphodiesterase-5 (PDE-5 ) 的使随机化的临床的试用(RCT ) 禁止者考察编辑的流行。我们从 2000 年 1 月在 MEDLINE 和 PubMed 寻找了英语语言的文章到 2010 年 9 月。我们的结果证明在亚洲的编辑的总的来说报导的流行率广泛地变化了,从 2 %到 88 %。这发现显示编辑是在这个区域的一个普通、主要的健康问题。然而,在亚洲的社会文化、经济的因素阻止人寻求并且获得适当医疗保健。我们为编辑的管理在五种 PDE-5 禁止者上发现了报告:sildenafil, vardenafil, tadalafil, udenafil 和 mirodenafil。RCT 的结果证明这五个 PDE-5 禁止者是比在与编辑在亚洲人改进可勃起的功能的安慰剂更有效的并且这些药有类似的功效和安全侧面。 | Kwangsung Park Eu Chang Hwang Sun-Ouck Kim | 2011 | Asian Journal of Andrology2011，13，4： | 13 |
| 2 | 直肠癌低位前切除术后辅助性回肠造口不能预防吻合口漏:一项前瞻性、对照研究显示文摘PURPOSE: Defunctioning ileostomy or colostomy is still routinely performed after low anterior resection in the belief that diverting the fecal stream will prevent anastomotic dehiscence. However, an ileostomy is not without morbidity for the patient. This study aims to determine if a diverting stoma is really necessary after a low anastomosis. METHODS: All low or ultralow anterior resections done in this department were performed by consultant-grade surgeons in a standardized manner. The patients were all monitored closely after surgery for clinical signs of an anastomotic leak. There were 1078 patients who underwent elective low or ultralow anterior resections in a ten-year period between 1994 and 2004. Twelve of them were irradiated before surgery; they were excluded from the study. During a seven-month period from February 2004 through August 2004, 324 patients who underwent such procedures were not defunctioned. These were compared with 742 patients who were previously defunctioned with a proximal stoma. The results were analyzed using the Pearson chi-squared test. RESULTS: Thirteen (4 percent) patients who were not defunctioned developed a clinical anastomotic leak, whereas the leak rate for those who were defunctioned was 3.8 percent. There was no statistical difference demonstrated. Ninety-five percent of patients who developed a leak required surgical intervention; the remaining 5 percent could be dealt with by radiologic drainage. The overall mortality rate for anastomotic leak in this department is 7.3 percent. CONCLUSION: A diverting stoma does not reduce postoperative anastomotic leak rate. Rather, it reduces the otherwise catastrophic effects of an anastomotic leak such as fecal peritonitis and septicemia. An ileostomy carries certain morbidity and also adds to the cost of the entire operation. Therefore, it should not be performed routinely. Instead, it should be performed selectively in patients with poorly prepared bowels, coupled with a distal limb washout, and in patients with significant comorbidities who can ill afford the complications of a leak. | Wong N. Y. Eu K. W. 程妍(译) 王顺涛(校) | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，2，6： | 10 |
| 3 | Efficacy of small-volume simethicone given at least 30 min before gastroscopy显示文摘AIM To evaluate the efficacy of 5 m L simethicone solution in decreasing gastric foam if given at least 30 min before gastroscopy.METHODS This was a randomized, placebo controlled, endoscopist blinded study performed at Changi General Hospital. Patients were at least 21 years old, had no prior sur-gical resection of the upper gastrointestinal tract, and scheduled for elective diagnostic gastroscopies. The primary outcome was the total mucosal visibility score(TMVS) which was evaluated using Mc Nally score. The sample size was calculated to be 24 per group(SD 2.4, 80% power, P < 0.05, 2-sample t test). RESULTS Fifty-four patients were randomised to receive either simethicone [1 m L liquid simethicone(100 mg) in 5 m L of water] or placebo(5 m L of water) at least 30 min before their gastroscopy. Six accredited consultants conductedthe gastroscopy, and the interobserver agreement of scoring TMVS was good with a Kappa statistic of 0.73. The simethicone group had significantly better mean TMVS compared to placebo(5.78 ± SD 1.65 vs 8.89 ± SD 1.97, P < 0.001). The improvement was statistically significant for the duodenum and the gastric antrum, angularis, body, and fundus. Percent 51.9 of patients in the simethicone group had a TMVS of 4(no bubbles at all) to 5(only 1 area with minimal bubbles), while in the placebo group 3.7% of patients had TMVS of 4 or 5. The number needed to treat was 2.1 to avoid a TMVS of 6 and more. The simethicone group also had a significantly shorter procedure time with less volume of additional flushes required during gastroscopy to clear away obscuring gastric foam.CONCLUSION With a premedication time of at least 30 min, 5 m L simethicone can significantly decrease gastric foam, decrease the volume of additional flushes, and shorten gastroscopy time. | Mingjun Song Andrew Boon Eu Kwek Ngai Moh Law Jeannie Peng Lan Ong Jessica Yi-Lyn Tan Prem Harichander Thurairajah Daphne Shih Wen Ang Tiing Leong Ang | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，4： | 10 |
| 4 | Pretreatment neutrophil-to-lymphocyte ratio predicts worse survival outcomes and advanced tumor staging in patients undergoing radical cystectomy for bladder cancer显示文摘Objective:To determine the role of neutrophil-to-lymphocyte ratio(NLR)in prognosticating survival outcomes in patients with advanced/metastatic urothelial bladder cancer.Methods:We retrospectively reviewed 84 patients undergoing radical cystectomy(RC)for UCB from January 2002 to June 2012.NLR was computed(median:5 days)prior to surgery.No patients received neoadjuvant chemotherapy.NLR was analyzed as a continuous variable and a cut-off point of 2.7 was obtained,with a statistical receiver operating characteristics of 0.74.KaplaneMeier curves,multivariate Cox proportional hazard and logistics regression models were used to predict NLR association with survival outcomes.Results:The median follow-up period was 30.1 months(range:3.2e161.7)owing to high recurrence rate and subsequent mortalities,compared to the median 64.7 months in patients alive at the end of study period.NLR2.7 was associated with worse survival outcomes(5-year disease-specific survival:22%vs 58%,p Z 0.017,95%CI:1.193e6.009;5-year overall survival:23%vs 60%,p Z 0.008,95%CI:1.322e6.147).Furthermore,on multivariate analyses,higher NLR was independently associated with higher recurrence rate(p Z 0.007,HR Z6.999,95%CI:1.712e28.606),higher T staging(p Z 0.021,HR Z 3.479,95%CI:1.212e9.990)and lymph node involvement(p Z 0.009,HR Z 4.534,95%CI:1.465e14.034). | Yu Guang Tan Ernest Eu Weber Lau Kam On Hong Hong Huang | 2017 | Asian Journal of Urology2017，4，4： | 9 |
| 5 | 新加坡SUT公司用抗污染反渗透膜成功回收废水显示文摘新加坡政府运用抗污染(FoulingResistant)反渗透膜技术建立起一个全球最大(1248m3/h)的工业及市政污水回用工厂。该系统设计具有坚实的试验基础,独具匠心,运行效果良好。本文旨在分享该项目的成功经验。 | 曾宏伟 Eu Hong Gay C Ravi Kai-Uwe Hoehn | 2003 | 水处理技术2003，29，2： | 7 |
| 6 | Clinical applications, limitations and future role of transient elastography in the management of liver disease显示文摘Transient elastography(TE) is a reliable tool for the non-invasive assessment of liver fibrosis in routine clinical practice. TE is currently approved for use in Europe, Asia and the United States. The widespread adoption of this technology is certain to increase the use of TE worldwide. Although TE has been well validated in chronic viral hepatitis, its clinical role in other liver diseases remains less clear. The advent of new treatment for chronic hepatitis C and emerging prevalence of non-alcoholic steatohepatitis raises new questions on the role of TE in current clinical practice. This review aims to examine the clinical applications, limitations and future role of TE in current clinical practice in light of the changing epidemiology of liver diseases and new clinical management paradigms. In current clinical practice, TE is the most accurate noninvasive method for diagnosis of liver cirrhosis. TE is useful to rule out fibrosis and cirrhosis but does not have sufficient accuracy to discern between various stages of fibrosis. The clinical role of TE has evolved from cross-sectional point-in-time assessment of fibrosis and cirrhosis to the more relevant role of prediction of vital clinical end-points. This provides clinicians with the ability to modify treatment strategies based on the information provided by TE. TE has evolved over the past decade to become an essential tool to assist the clinician in the management of chronic liver disease. | Pik Eu Chang George Boon-Bee Goh Jing Hieng Ngu Hiang Keat Tan Chee Kiat Tan | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，1： | 5 |
| 7 | Effect of serum testosterone and percent tumor volume on extra-prostatic extension and biochemical recurrence after laparoscopic radical prostatectomy显示文摘几研究表明了外科手术前的浆液睾丸激素和百分比肿瘤体积(PTV ) 在激进的前列腺切除术以后预言 extra-prostatic 扩展(EPE ) 和生物化学的复发(BCR ) 。这研究在 laparoscopic 激进分子前列腺切除术(LRP ) 以后在与 EPE 和 BCR 的关系调查了浆液睾丸激素和 PTV 的预示的意义。我们考察了经历了在 2004 和 2012 之间的 LRP 的 520 个病人。PTV 在每节作为所有视觉上估计的肿瘤 foci 的和被决定。BCR 被定义为手术后的前列腺特定的抗原(PSA ) 的二连续增加 > 0.2 ng ml 1 。为浆液总数睾丸激素的阀值是 3.0 ng ml 1 。Multivariate 逻辑回归被用来在 EPE 和 BCR 的风险上定义变量的效果。低浆液睾丸激素(< 3.0 ng ml 1) 与高浆液 PSA,格利森分数,前列腺活体检视的积极核心百分比, PTV,和所有病理学的变量被联系。在 multivariate 分析上,类似于以前的研究,浆液 PSA,活体检视积极核心百分比,格利森分数,和病理学的变量预言了 EPE 和 BCR。另外,低浆液睾丸激素(< 3.0 ng ml 1 ,调整或, 8.52;95% CI, 5.04-14.4, P= 0.001 ) 预言的 EPE 和 PTV (调整或, 1.02;95% CI, 1.01-1.05, P= 0.046 ) 预言的 BCR。除了 EPE 和 BCR 的以前的预言者,低浆液睾丸激素和 PTV 在 LRP 以后是 EPE 和 BCR 的珍贵预言者。 | Eu Chang Hwang Seong Hyeon Yu Yang Hyun Jo Seung I1 Jung Taek Won Kang Dong Deuk Kwon Chan Choi Suk Hee Heo Jun Eul Hwang Sung-Hoon Jung Tae-Young Jung | 2016 | Asian Journal of Andrology2016，18，1： | 3 |
| 8 | ^(177)Lu-octreotate治疗神经内分泌胃肠胰腺肿瘤的SPECT显像研究显示文摘目前对于转移性神经内分泌胃肠胰腺肿瘤(NET)没有很好的治疗方法。分化良好的神经内分泌肿瘤多过度表达生长抑素受体(SSTR),尤其是亚型SSTR2。人工合成生长抑素衍生物如奥曲肽(octreotide)能治疗激素过度表达的症状,而采用放射性核素标记octreotide及其衍生物对NET进行靶向治疗效果更好,称为肽类受体介导的放射性核素治疗(PRRT),早期主要应用^111In-octreotide, | 王国慧 EddieW.F.Lau Ramdave Shakher Peter Eu Val Johnston Rodney J.Hicks | 2007 | 中华核医学杂志2007，27，5： | 3 |
| 9 | Issues of cultural appropriateness and pedagogical efficacy: exploring peer review in a second language writing class显示文摘 | Guangwei Hu Sandra Tsui Eu Lam | 2010 | Instructional Science2010，，4： | 3 |
| 10 | Carbon dioxide insufflation during colonoscopy in deeply sedated patients显示文摘AIM:To compare the impact of carbon dioxide(CO2) and air insufflation on patient tolerance/safety in deeply sedated patients undergoing colonoscopy.METHODS:Patients referred for colonoscopy were randomized to receive either CO2 or air insufflation during the procedure.Both the colonoscopist and patient were blinded to the type of gas used.During the procedure,insertion and withdrawal times,caecal intubationrates,total sedation given and capnography readings were recorded.The level of sedation and magnitude of patient discomfort during the procedure was assessed by a nurse using a visual analogue scale(VAS)(0-3).Patients then graded their level of discomfort and abdominal bloating using a similar VAS.Complications during and after the procedure were recorded.RESULTS:A total of 142 patients were randomized with 72 in the air arm and 70 in the CO2 arm.Mean age between the two study groups were similar.Insertion time to the caecum was quicker in the CO2 group at 7.3 min vs 9.9 min with air(P = 0.0083).The average withdrawal times were not significantly different between the two groups.Caecal intubation rates were 94.4% and 100% in the air and CO2 groups respectively(P = 0.012).The level of discomfort assessed by the nurse was 0.69(air) and 0.39(CO2)(P = 0.0155) and by the patient 0.82(air) and 0.46(CO2)(P = 0.0228).The level of abdominal bloating was 0.97(air) and 0.36(CO2)(P = 0.001).Capnography readings trended to be higher in the CO2 group at the commencement,caecal intubation,and conclusion of the procedure,even though this was not significantly different when compared to readings obtained during air insufflation.There were no complications in both arms.CONCLUSION:CO2 insufflation during colonoscopy is more efficacious than air,allowing quicker and better cecal intubation rates.Abdominal discomfort and bloating were significantly less with CO2 insufflation. | Rajvinder Singh Eu Nice Neo Nazree Nordeen Ganesananthan Shanmuganathan Angelie Ashby Sharon Drummond Garry Nind Elizabeth Murphy Andrew Luck Graeme Tucker William Tam | 2012 | World Journal of Gastroenterology2012，18，25： | 3 |
| 11 | Prevalence,intensity of infection and risk factors of urinary schistosomiasis in preschool and school aged children in Guma Local Government Area,Nigeria显示文摘Objective:To determine the prevalence and intensity of infection and the risk factors associated with urinary schistosomiasis in pre—school and school aged children in Cuma Local Government Area of Benue State,Nigeria.Methods:Urine filtration technique using polycarbonate membrane filters was employed to process urine specimens and to determine presence of Schistosoma haematobium eggs in urine.Questionnaires were also administered to children to collect information on socio-demographic data and water-contact activities.Results:An overall prevalence of 55.0%(165/300)was recorded out of the 300 urine samples examined.Prevalence of infection varied between 36.0%-64.0%with a significant difference(X^2=11.59,P=0.041)between the different communities visited.Males were more infected(60.6%,103/170)than females(47.7%,62/130)with a significant difference(X^2=4.95,P=0.026).The age-related prevalence showed higher prevalence(70.5%,36/52)in the 11-15 year old children than that in the 1-5 year old ones(44.9%,53/118).A significant difference was observed in the prevalence between the age groups(X^2=10.56,P=0.014).The prevalence of light intensity of infection(1-49 eggs/10 mL of urine)(86.6%)was significantly higher than that of heavy intensity of infection(5=50 eggs/10 mL of urine)(13.3%)in the area(t=16.48,P=0.000).Water contact activities of the children revealed that children that were involved in irrigation and those that went swimming in water bodies were observed to be at higher risk of becoming infected with urinary schistosomiasis in the area with odd ratios(risk factors)of 2.756(1.334-5.693)and 2.366(1.131-4.948)respectively at P<0.05 level.Conclusions:The study revealed the hyperendemicily of urinary schistosomiasis in the preschool and school aged children in Guma Local Government Area.It is therefore recommended that praziquantel should be administered to children in the area and systematic epidemiological studies should be undertaken in the whole Local Government Area and the State at large to discover new foci of infection. | EU Amuta RS Houmsou | 2014 | Asian Pacific Journal of Tropical Medicine2014，7，1： | 2 |
| 12 | Alpha(2)-adrenoceptor agonists inhibit vitreal glutamate and aspartate accumulation and preserve retinal function after transient ischemia显示文摘 | Donello JE Padillo EU Webster ML | 2000 | J Pharmacol Exp Ther2000，296，1： | 2 |
| 13 | Perforation of the Gastrointestinal Tract Secondary to Ingestion of Foreign Bodies显示文摘 | Brian K.P. Goh MBBS MMed(Surgery) Pierce K.H. Chow MBBS PhD Hak-Mien Quah MBChB MMed(Surgery) Hock-Soo Ong MBBS Kong-Weng Eu MBBS London L.P.J. Ooi MBBS MD Wai-Keong Wong MBBS | 2006 | World Journal of Surgery2006，，3： | 2 |
| 14 | Endoscopic stenting and elective surgery versus emergency surgery for left-sided malignant colonic obstruction: a prospective randomized trial显示文摘 | Kok-Sun Ho Hak-Mien Quah Jit-Fong Lim Choong-Leong Tang Kong-Weng Eu | 2012 | International Journal of Colorectal Disease2012，，3： | 2 |
| 15 | Ten‐day triple therapy versus sequential therapy versus concomitant therapy as first‐line treatment for H elicobacter pylori infection显示文摘 | Tiing Leong Ang Kwong Ming Fock Mingjun Song Daphne Ang Andrew Boon Eu Kwek Jeannie Ong Jessica Tan Eng Kiong Teo Subbiah Dhamodaran | 2015 | J Gastroenterol Hepatol2015，，7： | 2 |
| 16 | ^(68)Gallium-labelled PSMA-PET/CT as a diagnostic and clinical decision-making tool in Asian prostate cancer patients following prostatectomy显示文摘Objective: Prostate cancers(PCa) in Asian individuals are molecularly distinct from those found in their Caucasian counterparts.There is no risk stratification tool for Asian men with rapid biochemical recurrence(BCR) following radical prostatectomy(Rad P). This study aims to assess the detection rate of ^(68)Ga-prostate-specific membrane antigen-positron emission tomography/computed tomography(PSMA-PET/CT) for diagnosis of clinical recurrence and as a treatment decision making tool in Asian patients with BCR post-Rad P.Methods: ^(68)Ga PSMA-PET and CT body with/without bone scan [conventional workup(CWU)] were performed in 55 Asian patients with BCR within 36 months post-Rad P. Two blinded reviewers assessed the images. Detection rates of ^(68)Ga PSMAPET/CT were evaluated, and impact on management was reviewed by comparison with CWU.Results: Median time to BCR post-Rad P was 8.1 months. Detection rate for ^(68)Ga PSMA-PET/CT was 80%(44/55). A positive scan was significantly associated with increasing prostate-specific antigen(PSA) level [odds ratio(OR) = 1.13(95% CI 1.05–1.30), P =0.017], but not with higher Gleason grade or shorter PSA doubling time. Compared to CWU, ^(68)Ga PSMA-PET/CT detected an additional 106 lesions in 33/44 patients with a positive scan, resulting in a change in management in 25/44(56.8%) patients: 10 to hormonal therapy(HT) and whole pelvis radiotherapy(RT) in addition to bed RT, and 15 to palliative HT alone.Conclusions: In the present report, we demonstrated the diagnostic and treatment decision utility of ^(68)Ga PSMA-PET/CT in Asian men with rapid BCR. Detection of small volume nodal and systemic recurrences at low PSA levels(< 1.0 ng/mL) highlights the role of the tool in assigning patients to treatment intensification with HT-RT or palliative HT in polymetastatic disease. | Janice S.H.Tan Charles X.Y.Goh Yen Sin Koh Youquan Li Jeffrey K.L.Tuan Eu Tiong Chua Terence W.K.Tan Michael L.C.Wang Lui Shiong Lee Kae Jack Tay Ravindran Kanesvaran Chee Keong Toh Aaron K.T.Tong Winnie W.C.Lam Melvin L.K.Chua | 2019 | Cancer Biology & Medicine2019，16，1： | 2 |
| 17 | Initial leucocytosis and other significant indicators of poor outcome in severe traumatic brain injury: an observational study显示文摘Background:Globally,severe traumatic brain injury(TBI)has been the principal cause of mortality among individuals aged 45 and below.The incidence of road traffic accidents in Malaysia is one of the highest in the world with thousands of victims sustaining severe disabilities.The aim of this study is to determine the association between leucocytosis and extended Glasgow Outcome Scale(GOSE)scores as well the relationship of other factors and the outcomes of severe TBI.Methods:This was a retrospective observational study.A total of 44 consecutive patients who were admitted to Sarawak General Hospital from January 1,2018,to September 30,2018,with severe TBI were included.Data were collected from discharge summaries and hospital medical records.Chi-square and t test were used.SPSS was employed.Results:Of a total of 44 patients with severe TBI,18 patients(41%)died during the same admission.The mean age of patients was 37.1 years with 93.2%of affected patients being male.56.9%of patients presented with a Glasgow Coma Scale(GCS)of 6 and less.A large percentage(86.3%)were discharged with a GOSE of less than 7.Older age and low admission GCS(6 and less)were significantly associated with poor GOSE scores on discharge and after 6 months(p<0.05)on multivariate analysis.Leucocytosis on admission was also associated with poor outcomes where patients with higher total white counts on presentation attaining lower GOSE scores(p<0.05).Conclusion:We concluded that leucocytosis was significantly associated with poor outcomes in severe TBI patients in addition to other factors such as advanced age and poor GCS on arrival. | Kugan Vijian Eu Gene Teo Davendran Kanesen Albert Sii Hieng Wong | 2020 | Chinese Neurosurgical Journal2020，6，4： | 2 |
| 18 | Activation of the cardiac calcium release channel (ryanodine receptor) by poly -S - nitrosylation 显示文摘 | Xu L Eu JP Meissner G | 1998 | Science1998，279，5348： | 1 |
| 19 | The effect of crude extract from Radix Dipsaci on bone in mice显示文摘 | Wong RW Rabie AB Hagg EU | 2007 | Phytother Res2007，21，6： | 1 |
| 20 | A prospective randomized study of drains in infra-peritoneal rectal anastomoses显示文摘 | Brown SR Seow-Choen F Eu KW | 2001 | Tech Coloproctol2001，5，2： | 1 |
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