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| 1 | Appraisal of needle-based confocal laser endomicroscopy inthe diagnosis of pancreatic cysts显示文摘Nearly 2.5% of cross-sectional imaging studies will report a finding of a cystic pancreatic lesion. Eventhough most of these are incidental findings, it remains very concerning for both patients and treating clinicians. Differentiating and predicting malignant transformation in pancreatic cystic lesions is clinically challenging. Current evaluation of suspicious cystic lesions includes a combination of radiologic imaging, endoscopic ultrasound(EUS) and cyst fluid analyses. Despite these attempts, precise diagnostic stratification among nonmucinous, mucinous, and malignant cystic lesions is often not possible until surgical resection. EUS-guided needle based confocal laser endomicroscopy(n CLE) for evaluation of pancreatic cysts is emerging as a powerful technique with remarkable potential. Though limited imaging data from 3 large clinical trials(INSPECT, DETECT and CONTACT) are currently the reference standard for n CLE imaging, nonetheless these have not been validated in large studies. The aim of this review article is to review the evolving role of EUS-guided n CLE in management of pancreatic cystic lesions in terms of its significance, adverse events, limitations, and implications. | Somashekar G Krishna Jeffery H Lee | 2016 | World Journal of Gastroenterology2016，22，4： | 4 |
| 2 | Comparison of the utility of covered metal stents versus uncovered metal stents in the management of malignant biliary strictures in 749 patients显示文摘 | Jeffrey H. Lee Somashekar G. Krishna Amanpal Singh Harshad S. Ladha Rebecca S. Slack Srinivas Ramireddy Gottumukkala S. Raju Marta Davila William A. Ross | 2013 | Gastrointestinal Endoscopy2013，，2： | 3 |
| 3 | Recent advances in the diagnostic evaluation of pancreatic cystic lesions显示文摘Pancreatic cystic lesions(PCLs)are becoming more prevalent due to more frequent abdominal imaging and the increasing age of the general population.It has become crucial to identify these PCLs and subsequently risk stratify them to guide management.Given the high morbidity associated with pancreatic surgery,only those PCLs at high risk for malignancy should undergo such treatment.However,current diagnostic testing is suboptimal at accurately diagnosing and risk stratifying PCLs.Therefore,research has focused on developing new techniques for differentiating mucinous from non-mucinous PCLs and identifying high risk lesions for malignancy.Cross sectional imaging radiomics can potentially improve the predictive accuracy of primary risk stratification of PCLs at the time of detection to guide invasive testing.While cyst fluid glucose has reemerged as a potential biomarker,cyst fluid molecular markers have improved accuracy for identifying specific types of PCLs.Endoscopic ultrasound guided approaches such as confocal laser endomicroscopy and through the needle microforceps biopsy have shown a good correlation with histopathological findings and are evolving techniques for identifying and risk stratifying PCLs.While most of these recent diagnostics are only practiced at selective tertiary care centers,they hold a promise that management of PCLs will only get better in the future. | Devarshi R Ardeshna Troy Cao Brandon Rodgers Chidiebere Onongaya Dan Jones Wei Chen Eugene J Koay Somashekar G Krishna | 2022 | World Journal of Gastroenterology2022，28，6： | 3 |
| 4 | Confocal endomicroscopy and cyst fluid molecular analysis: Comprehensive evaluation of pancreatic cysts显示文摘Increases in the quality as well as utilization of cross-sectional imaging have led to rising diagnoses of pancreatic cystic lesions(PCL). Accurate presurgical diagnosis enables appropriate triage of PCLs. Unfortunately, current diagnostic approaches have suboptimal accuracy and may lead to unnecessary surgical resections or missed diagnoses of advanced neoplasia. Additionally, early detection represents an opportunity for intervention to prevent the progression to pancreatic adenocarcinoma. Our aim for this review is to systematically review the current literature on confocal endomicroscopy and molecular biomarkers in the evaluation of PCLs. Confocal laser endomicroscopy is a novel technology that allows for real-time in vivo microscopic imaging with multiple clinical trials identifying characteristic endomicroscopy findings of various pancreatic cystic lesions. DNA-based molecular markers have also emerged as another diagnostic modality as the pattern of genetic alternations present in cyst fluid can provide both diagnostic and prognostic data. We propose that both techniques can be utilized to improve patient outcomes. | Feng Li Ahmad Malli Zobeida Cruz-Monserrate Darwin L Conwell Somashekar G Krishna | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，1： | 2 |
| 5 | Evolution of pancreatoduodenectomy in a tertiary cancer center in India: Improved results from service reconfiguration显示文摘 | Shailesh V. Shrikhande Savio George Barreto B.A. Somashekar Kunal Suradkar Guruprasad S. Shetty Sanjay Talole Bhawna Sirohi Mahesh Goel Parul J. Shukla | 2013 | Pancreatology2013，，1： | 2 |
| 6 | Advanced diagnostics for pancreatic cysts: Confocal endomicroscopy and molecular analysis显示文摘Technological advances and the widespread use of medical imaging have led to an increase in the identification of pancreatic cysts in patients who undergo crosssectional imaging. Current methods for the diagnosis and risk-stratification of pancreatic cysts are suboptimal, resulting in both unnecessary surgical resection and overlooked cases of neoplasia. Accurate diagnosis is crucial for guiding how a pancreatic cyst is managed, whether with surveillance for low-risk lesions or surgical resection for high-risk lesions. This review aims to summarize the current literature on confocal endomicroscopy and cyst fluid molecular analysis for the evaluation of pancreatic cysts. These recent technologies are promising adjuncts to existing approaches with the potential to improve diagnostic accuracy and ultimately patient outcomes. | Claire Durkin Somashekar G Krishna | 2019 | World Journal of Gastroenterology2019，25，22： | 2 |
| 7 | Simple pulse-acquire NMR methods for the quantitative analysis of calcium, magnesium and sodium in human serum显示文摘 | Somashekar B S Ijare O B Gowda G A N | 2006 | Spectrochim Acta A2006，65，2： | 1 |
| 8 | Assessment of sustainable non-plantation biomass re- sources potential for energy in India 显示文摘 | Ravindranath N H Somashekar H I Nagaraja M S | 2005 | Biomass and Bioenergy2005，29，3： | 1 |
| 9 | 1 H and 13C- NMR Characterization and Stereochemical Assignments of Bile Acids in Aqueous Media显示文摘 | Ijare OB Somashekar BS Jadegoud Y | 2005 | Lipids2005，40，10： | 1 |
| 10 | Sliding wear behaviour of zircon particles reinforced ZA-27 alloy composite materials 显示文摘 | Sharma S C Girish B M Somashekar D R | 1999 | Wear1999，224，1： | 1 |
| 11 | Effect of culture conditions on lipid and gamma-linolenic acid production by mucoraceous fungi 显示文摘 | Somashekar D Venkateshwaran G Sambaiah K | 2002 | Process Biochemistry2002，38，： | 1 |
| 12 | Partial purification and properties of a novel chitosanase secreted by Rhodotorula gracilis显示文摘 | Somashekar D Joseph R | 1992 | Letters in Applied Microbiology1992，14，1： | 1 |
| 13 | Chitosanases-properties and applications: a review显示文摘 | SOMASHEKAR D JOSEPH R | 1996 | Bioresource Technol1996，55，1： | 1 |
| 14 | Heavy metal contamination in roadside soil and their mobility in relations to pH and organic carbon显示文摘 | H Ramakrishnaiah R K Somashekar | 2002 | Soil and sediment contamination2002，11，5： | 1 |
| 15 | Sliding wear behaviour of Ziron particle reinforced ZA-27 alloy composite materials显示文摘 | Sharma S C Girish B M Somashekar D R | 1999 | Wear1999，，224： | 1 |
| 16 | Sliding wear behavior of zircon particles reinforced ZA27 alloy composite materials显示文摘 | Sharma S C Girish B M Somashekar D R | | 0，，01： | 1 |
| 17 | Chitosanases-properties and applications:A Rewiew显示文摘 | Somashekar D Richard Joseph | 1996 | Bioresoure technology1996，55，： | 1 |
| 18 | Mechanical properties and fractography of zircon-particle-reinforced ZA-27 alloy composite materials 显示文摘 | SHARMA S C GIRISH B M SOMASHEKAR D R KAMATH R SATISH B M | 1999 | Composite Science and Technology1999，59，： | 1 |
| 19 | Mesopanereas: Myth or Reality?显示文摘 | Manish K Agrawal Dilip Singh Thakur Uday Somashekar | 2010 | J O P2010，11，3： | 1 |
| 20 | Sliding wear behavior of zircon particles reinforced ZA-27 alloy composite materials 显示文摘 | SHARMA S C GIRISH B M SOMASHEKAR D R SATISH B M KAMATH R | 1999 | Wear1999，224，： | 1 |
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